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Age Utt

https://etis.ee/CV/Age_Utt/eng
26.12.1986
737 4843
age.utt@ut.ee
G-6335-2019

Career

Institutions and positions
01.09.2016–...   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Research Fellow in Virology (1,00)
01.01.2016–31.08.2016   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Junior Research Fellow in Virology (1,00)
01.09.2015–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow in Applied Virology (1,00)
01.01.2015–31.08.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow in Applied Virology (0,75)
01.04.2014–31.12.2014   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow of Applied Virology (0,93)
01.02.2014–31.03.2014   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow of Applied Virology (1,00)
 
 
Education
2010–2016   
University of Tartu, doctoral studies, Engineering and Technology
2008–2010   
University of Tartu, master´s studies (MSc), Gene Technology
2005–2008   
University of Tartu, bachelor´s studies (BSc), Biology

Qualifications

Academic degrees
Age Utt, Doctor's Degree, 2016, (sup) Andres Merits, „Role of alphavirus replicase in viral RNA synthesis, virus-induced cytotoxicity and recognition of viral infections in host cells“, University of Tartu.
Age Utt, Master's Degree, 2010, (sup) Andres Merits, Chikungunya viirusel põhinevate test-süsteemide väljatöötamine ja kasutamine, University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu.
 
 

Projects in progress

Completed projects

Publications

Category
Year
Publication
 
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine.10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567.10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93.10.1128/JVI.00794-19.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236.10.3389/fmicb.2019.02236.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18.10.1128/mBio.00044-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18.10.1128/JVI.00152-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91.10.1128/JVI.00787-17.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124.10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437.10.1128/JVI.01579-15.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162.10.1128/JVI.03213-14.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923.10.1371/journal.pone.0028923.

Industrial property

2.02.2021

Age Utt

https://etis.ee/CV/Age_Utt/est
26.12.1986
737 4843
age.utt@ut.ee
G-6335-2019

Teenistuskäik

Töökohad ja ametid
01.09.2016–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia teadur (1,00)
01.01.2016–31.08.2016   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia nooremteadur (1,00)
01.09.2015–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (1,00)
01.01.2015–31.08.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (0,75)
01.04.2014–31.12.2014   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (0,93)
01.02.2014–31.03.2014   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (1,00)
 
 
Haridustee
2010–2016   
Tartu Ülikool, filosoofiadoktor biomeditsiini erialal
2008–2010   
Tartu Ülikool, magister, loodusteaduse magister (MSc), biotehnoloogia ja biomeditsiin, cum laude
2005–2008   
Tartu Ülikool, bakalaureus, loodusteaduse bakalaureus (BSc), bioloogia

Kvalifikatsioon

Teaduskraadid
Age Utt, Doctor's Degree, 2016, (sup) Andres Merits, „Role of alphavirus replicase in viral RNA synthesis, virus-induced cytotoxicity and recognition of viral infections in host cells“, University of Tartu.
Age Utt, Master's Degree, 2010, (sup) Andres Merits, Chikungunya viirusel põhinevate test-süsteemide väljatöötamine ja kasutamine, University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu.
 
 
Teaduspreemiad ja tunnustused
2016, Age Utt, 2016 a üliõpilaste teadustööde riikliku konkursi 3. preemia saaja doktoriõppe üliõpilaste astmes

Jooksvad projektid

Lõppenud projektid

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine.10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567.10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93.10.1128/JVI.00794-19.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236.10.3389/fmicb.2019.02236.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18.10.1128/mBio.00044-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18.10.1128/JVI.00152-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91.10.1128/JVI.00787-17.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124.10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437.10.1128/JVI.01579-15.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162.10.1128/JVI.03213-14.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923.10.1371/journal.pone.0028923.

Tööstusomand

2.02.2021

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ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
ETFETF7407Alphavirus replication, inhibition and virus-host interactions.01.01.200831.12.2011Andres MeritsUniversity of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu; University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu; University of Tartu, Faculty of Science and Technology (old)66 495,46 EUR
PRGPRG1154Role of arbovirus replicase proteins in RNA replication, virus-host interactions and vector transmission01.01.202131.12.2025Andres MeritsUniversity of Tartu, Faculty of Science and Technology, Institute of Technology257 125,00 EUR
TKSLTTI16143T (TK143)Center of Excellence in Molecular Cell Engineering (TK143)01.01.201601.03.2023Tanel TensonUniversity of Tartu, Faculty of Science and Technology, Institute of Technology3 917 568,00 EUR
ETFETF9400Exploration of space of alphavirus-encoded short linear interaction motifs mediating hijacking of host pathways and facilities.01.01.201231.12.2014Andres MeritsUniversity of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu29 736,00 EUR
SFSF0180087s08Analysis of the replication, viral-host interactions and virus induce pathogenesis of viruses with RNA genomes and inhibition or practical usage of these processes.01.01.200831.12.2013Andres MeritsUniversity of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu653 945,96 EUR
IUTIUT20-27Interaction between virus and host: expanding knowledge for the development of biomedical tools01.01.201431.12.2019Andres MeritsUniversity of Tartu, Faculty of Science and Technology, Institute of Technology2 341 200,00 EUR