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Age Utt

https://etis.ee/CV/Age_Utt/est
26.12.1986
737 4843
age.utt@ut.ee
G-6335-2019

Teenistuskäik

Töökohad ja ametid
01.09.2016–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia teadur (1,00)
01.01.2016–31.08.2016   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia nooremteadur (1,00)
01.09.2015–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (1,00)
01.01.2015–31.08.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (0,75)
01.04.2014–31.12.2014   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (0,93)
01.02.2014–31.03.2014   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia nooremteadur (1,00)
 
 
Haridustee
2010–2016   
Tartu Ülikool, filosoofiadoktor biomeditsiini erialal
2008–2010   
Tartu Ülikool, magister, loodusteaduse magister (MSc), biotehnoloogia ja biomeditsiin, cum laude
2005–2008   
Tartu Ülikool, bakalaureus, loodusteaduse bakalaureus (BSc), bioloogia

Kvalifikatsioon

Teaduskraadid
Age Utt, doktorikraad, 2016, (juh) Andres Merits, „Role of alphavirus replicase in viral RNA synthesis, virus-induced cytotoxicity and recognition of viral infections in host cells“, Tartu Ülikool.
Age Utt, magistrikraad, 2010, (juh) Andres Merits, Chikungunya viirusel põhinevate test-süsteemide väljatöötamine ja kasutamine, Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut.
 
 
Teaduspreemiad ja tunnustused
2016, Age Utt, 2016 a üliõpilaste teadustööde riikliku konkursi 3. preemia saaja doktoriõppe üliõpilaste astmes

Jooksvad projektid

Lõppenud projektid

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine.10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567.10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93.10.1128/JVI.00794-19.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236.10.3389/fmicb.2019.02236.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18.10.1128/mBio.00044-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18.10.1128/JVI.00152-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91.10.1128/JVI.00787-17.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124.10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437.10.1128/JVI.01579-15.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162.10.1128/JVI.03213-14.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923.10.1371/journal.pone.0028923.

Tööstusomand

2.02.2021

Age Utt

https://etis.ee/CV/Age_Utt/eng
26.12.1986
737 4843
age.utt@ut.ee
G-6335-2019

Career

Institutions and positions
01.09.2016–...   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Research Fellow in Virology (1,00)
01.01.2016–31.08.2016   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Junior Research Fellow in Virology (1,00)
01.09.2015–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow in Applied Virology (1,00)
01.01.2015–31.08.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow in Applied Virology (0,75)
01.04.2014–31.12.2014   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow of Applied Virology (0,93)
01.02.2014–31.03.2014   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Junior Research Fellow of Applied Virology (1,00)
 
 
Education
2010–2016   
University of Tartu, doctoral studies, Engineering and Technology
2008–2010   
University of Tartu, master´s studies (MSc), Gene Technology
2005–2008   
University of Tartu, bachelor´s studies (BSc), Biology

Qualifications

Academic degrees
Age Utt, Doctor's Degree, 2016, (sup) Andres Merits, „Role of alphavirus replicase in viral RNA synthesis, virus-induced cytotoxicity and recognition of viral infections in host cells“, University of Tartu.
Age Utt, Master's Degree, 2010, (sup) Andres Merits, Chikungunya viirusel põhinevate test-süsteemide väljatöötamine ja kasutamine, University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu.
 
 

Projects in progress

Completed projects

Publications

Category
Year
Publication
 
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine.10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567.10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93.10.1128/JVI.00794-19.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236.10.3389/fmicb.2019.02236.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18.10.1128/mBio.00044-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18.10.1128/JVI.00152-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91.10.1128/JVI.00787-17.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124.10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437.10.1128/JVI.01579-15.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162.10.1128/JVI.03213-14.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923.10.1371/journal.pone.0028923.

Industrial property

2.02.2021

Otsi projekti

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Asutus on projekti finantseerija   Asutus on projekti teostaja  
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Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 6 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF7407Alfaviiruste replikatsioon, interaktsioonid peremeestega ja nende protsesside inhibiitorid01.01.200831.12.2011Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond66 495,46 EUR
PRGPRG1154Arboviiruste replikaasi valkude roll viiruse RNA sünteesil, viiruse ja peremehe vahelistest interaktsioonides ning viiruse vektorlevikus01.01.202131.12.2025Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut257 125,00 EUR
TKSLTTI16143T (TK143)Molekulaarse Rakutehnoloogia Tippkeskus (TK143)01.01.201601.03.2023Tanel TensonTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut3 917 568,00 EUR
ETFETF9400Peremeesraku radade ja resursside hõivamine alfaviiruste poolt lühikeste lineaarsete interaktsioonimotiivide kaudu vahendatud interaktsioonide abil 01.01.201231.12.2014Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut29 736,00 EUR
SFSF0180087s08RNA genoomsete viiruste replikatsiooni, viirus-peremees interaktsioonide ja patogeneesi uurimine ning nende protsesside inhibeerimine ja praktiline kasutamine.01.01.200831.12.2013Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut653 945,96 EUR
IUTIUT20-27Viiruse ja peremehe vaheliste interaktsioonide uurimine ja kasutamine biomeditsiinitehnoloogias01.01.201431.12.2019Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut2 341 200,00 EUR