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Anu Aonurm-Helm

https://etis.ee/CV/Anu_Aonurm-Helm/est
10.04.1979
737 4354
anu1@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2016–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, farmakoloogia teadur (1,00)
01.09.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, farmakoloogia teadur (1,00)
01.02.2014–31.08.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, farmakoloogia teadur (1,00)
01.11.2013–30.04.2015   
Helsingi Ülikool, Järeldoktor (0,80)
21.05.2013–31.01.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, farmakoloogia teadur (1,00)
01.02.2011–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia teadur (1,00)
01.05.2010–31.01.2011   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, teadur (1,00)
01.09.2009–30.04.2010   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, laborant (1,00)
01.04.2009–31.08.2009   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, laborant (0,50)
01.11.2008–31.03.2009   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, laborant (1,00)
01.06.2008–31.10.2008   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, laborant (0,75)
01.02.2006–31.05.2008   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, laborant (0,50)
2005–2010   
Tartu Ülikool, doktorant (1,00)
 
 
Haridustee
2005–2010   
Tartu Ülikool, Arstiteaduskond, Neuroteaduste doktorikool
1997–2005   
Tartu Ülikool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2005−...   
Farmakoloogia Seltsi liige

Kvalifikatsioon

Teaduskraadid
Anu Aonurm-Helm, doktorikraad, 2010, (juh) Aleksandr Žarkovski, Depressive-like phenotype and altered intracellular signalling in neural cell adhesion (NCAM)-deficient mice (Depressioonisarnane fenotüüp ja häiritud rakusisene signalliülekanne närviraku adhesioonimolekuli (NCAM) defitsiitsetel hiirtel), Tartu Ülikool.
 
 
Teaduspreemiad ja tunnustused
2009, Anu Aonurm-Helm, Depressioonisarnane käitumine närviraku adhesioonimolekuli (NCAM) efitsiitsetel hiirtel ja selle kõrvaldamine NCAM-mimeetikumi FGL peptiidi poolt
2007, Anu Aonurm-Helm, Muutused FosB ekspressioonis NCAM defitsiitsetel hiirtel

Lõppenud projektid

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2016
Jaako, Külli; Waniek,Alexander; Parik,Keiti; Klimaviciusa, Linda; Aonurm-Helm, Anu; Noortoots, Aveli; Anier, Kaili; Van Elzen, Roos; Gérard,Melanie; Lambeir, Anne-Marie; Roßner,Steffen; Morawski, Markus; Zharkovsky, Alexander (2016).

Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro.

. Journal of Cell Science, 129 (20), 3792−3802.10.1242/jcs.181891.
1.1.
2016
Tammimaki, A.; Aonurm-Helm, A.; Kaenmaki, M.; Mannisto, P.T. (2016). Elimination of extracellular dopamine in the medial prefrontal cortex of conscious mice analysed using selective enzyme and uptake inhibitors. Journal of Physiology and Pharmacology, 67 (2), 301−309.
1.1.
2016
Aonurm-Helm, Anu, Jaako, Külli, Jürgenson, Monika, Zharkovsky Aleksandr (2016).

Pharmacological approach for targeting dysfunctional brain plasticity: Focus on neural cell adhesion molecule (NCAM).

. Pharmacological Research, 113 (part B), 731−738. DOI: 10.1016/j.phrs.2016.04.011.
1.1.
2015
Kröcher, Tim; Malinovskaja, Kristina; Jürgenson, Monika; Aonurm-Helm, Anu; Zharkovskaya, Tamara; Kalda, Anti; Röckle, Iris; Schiff, Miriam; Weinhold, Birgit; Gerardy-Schahn, Rita; Hildebrandt, Herbert; Zharkovsky, Alexander (2015). Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Structure and Function, 220 (1), 1863−2653.10.1007/s00429-013-0638-z.
1.1.
2015
Aonurm-Helm, A.; Anier, K.; Zharkovsky, T.; Castrén, E.; Rantamäki, T.; Stepanov, V.; Järv, J.; Zharkovsky, A. (2015). NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European Neuropsychopharmacology, 25 (12), 2394−2403. DOI: 10.1016/j.euroneuro.2015.10.001.
1.1.
2015
Lobanovskaya, N.; Zharkovsky, T.; Jaako, K.; Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2015). PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood. Brain Research, 1625, 9−17.10.1016/j.brainres.2015.08.008.
1.1.
2014
Anier, Kaili; Malinovskaja, Kristina; Pruus, Katrin; Aonurm-Helm, Anu; Zharkovsky, Alexander; Kalda, Anti (2014). Maternal separation is associated with DNA methylation and behavioural changes in adult rats. European Neuropsychopharmacology, 24 (3), 459−468. DOI: 10.1016/j.euroneuro.2013.07.012.
1.1.
2012
Jürgenson, Monika; Aonurm-Helm, Anu; Zharkovsky, Alexander (2012). Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-like behaviour without cognitive impairment. Brain Research, 1447, 106−118.10.1016/j.brainres.2012.01.056.
1.1.
2011
Jaako, K.; Aonurm-Helm, A.; Kalda, A.; Anier, K.; Zharkovsky, T.; Shastin, A.; Zharkovsky, A. (2011). Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus. European Journal of Pharmacology, 666, 61−71.10.1016/j.ejphar.2011.05.008.
1.1.
2010
Anier, K.; Malinovskaja, K.; Aonurm-Helm, A.; Zharkovsky, A.; Kalda, A. (2010). DNA methylation regulates cocaine-induced behavioral sensitization in mice. Neuropsychopharmacology, 35 (12), 2450−2461.10.1038/npp.2010.128.
1.1.
2010
Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2010). Behavioral profile of mice with impaired cognition in the elevated plus-maze due to a deficiency in neural cell adhesion molecule. Pharmacology Biochemistry and Behavior, 96 (4), 461−468.10.1016/j.pbb.2010.07.006.
1.1.
2010
Aonurm-Helm, A.; Berezin, V.; Bock, E.; Zharkovsky, A. (2010). NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice. Brain Research, 1309, 1−8.10.1016/j.brainres.2009.11.003.
1.1.
2008
Aonurm-Helm, A.; Jurgenson, M.; Zharkovsky, T.; Sonn, K.; Berezin, V.; Bock, E.; Zharkovsky, A. (2008). Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficent mice and its reversal by an NCAM-derived peptide, FGL. European Journal of Neuroscience, 28 (8), 1618−1628. DOI: 10.1111/j.1460-9568.2008.06471.x.
1.1.
2008
Aonurm-Helm, A.; Zharkovsky, T.; Jürgenson, M.; Kalda, A.; Zharkovsky, A. (2008). Dysregulated CREB signaling pathway in the brain of neural cell adhesion molecule (NCAM) deficent mice. Brain Research, 1243, 104−112. DOI: 10.1016/j.brainres.2008.08.091.
1.1.
2007
Kaasik, A.; Kuum, M.; Aonurm, A.; Kalda, A.; Vaarmann, A.; Zharkovsky, A. (2007). Seizures, ataxia, and neuronal loss in cystatin B heterozygous mice. Epilepsia, 48 (4), 752−757.
20.02.2020

Anu Aonurm-Helm

https://etis.ee/CV/Anu_Aonurm-Helm/eng
10.04.1979
737 4354
anu1@ut.ee

Career

Institutions and positions
01.01.2016–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Research Fellow in Pharmacology (1,00)
01.09.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Research Fellow in Pharmacology (1,00)
01.02.2014–31.08.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Research Fellow in Pharmacology (1,00)
01.11.2013–30.04.2015   
University of Helsinki, Post-Doc (0,80)
21.05.2013–31.01.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Research Fellow in Pharmacology (1,00)
01.02.2011–20.05.2013   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Research Fellow in Pharmacology (1,00)
01.05.2010–31.01.2011   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Research Fellow (1,00)
01.09.2009–30.04.2010   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Laboratory Assistant (1,00)
01.04.2009–31.08.2009   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Laboratory Assistant (0,50)
01.11.2008–31.03.2009   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Laboratory Assistant (1,00)
01.06.2008–31.10.2008   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Laboratory Assistant (0,75)
01.02.2006–31.05.2008   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Laboratory Assistant (0,50)
2005–2010   
University of Tartu, PhD student (1,00)
 
 
Education
2005–2010   
University of Tartu, Faculty of Medicine, Doctoral program in Neuroscience
1997–2005   
University of Tartu
 
 
R&D related managerial and administrative work
2005−...   
Member of Association of Pharmacology

Qualifications

Academic degrees
Anu Aonurm-Helm, Doctor's Degree, 2010, (sup) Aleksandr Žarkovski, Depressive-like phenotype and altered intracellular signalling in neural cell adhesion (NCAM)-deficient mice, University of Tartu.
 
 
Honours & awards
2009, Anu Aonurm-Helm, Depression-like behaviour in neural cell adhesion molecule (NCAM) deficient mice and its reversal by NCAM mimetic, FGL peptide
2007, Anu Aonurm-Helm, Changes in FosB expression in NCAM deficient mice
 
 

Completed projects

Publications

Category
Year
Publication
 
1.1.
2016
Jaako, Külli; Waniek,Alexander; Parik,Keiti; Klimaviciusa, Linda; Aonurm-Helm, Anu; Noortoots, Aveli; Anier, Kaili; Van Elzen, Roos; Gérard,Melanie; Lambeir, Anne-Marie; Roßner,Steffen; Morawski, Markus; Zharkovsky, Alexander (2016).

Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro.

. Journal of Cell Science, 129 (20), 3792−3802.10.1242/jcs.181891.
1.1.
2016
Tammimaki, A.; Aonurm-Helm, A.; Kaenmaki, M.; Mannisto, P.T. (2016). Elimination of extracellular dopamine in the medial prefrontal cortex of conscious mice analysed using selective enzyme and uptake inhibitors. Journal of Physiology and Pharmacology, 67 (2), 301−309.
1.1.
2016
Aonurm-Helm, Anu, Jaako, Külli, Jürgenson, Monika, Zharkovsky Aleksandr (2016).

Pharmacological approach for targeting dysfunctional brain plasticity: Focus on neural cell adhesion molecule (NCAM).

. Pharmacological Research, 113 (part B), 731−738. DOI: 10.1016/j.phrs.2016.04.011.
1.1.
2015
Kröcher, Tim; Malinovskaja, Kristina; Jürgenson, Monika; Aonurm-Helm, Anu; Zharkovskaya, Tamara; Kalda, Anti; Röckle, Iris; Schiff, Miriam; Weinhold, Birgit; Gerardy-Schahn, Rita; Hildebrandt, Herbert; Zharkovsky, Alexander (2015). Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice. Brain Structure and Function, 220 (1), 1863−2653.10.1007/s00429-013-0638-z.
1.1.
2015
Aonurm-Helm, A.; Anier, K.; Zharkovsky, T.; Castrén, E.; Rantamäki, T.; Stepanov, V.; Järv, J.; Zharkovsky, A. (2015). NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European Neuropsychopharmacology, 25 (12), 2394−2403. DOI: 10.1016/j.euroneuro.2015.10.001.
1.1.
2015
Lobanovskaya, N.; Zharkovsky, T.; Jaako, K.; Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2015). PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood. Brain Research, 1625, 9−17.10.1016/j.brainres.2015.08.008.
1.1.
2014
Anier, Kaili; Malinovskaja, Kristina; Pruus, Katrin; Aonurm-Helm, Anu; Zharkovsky, Alexander; Kalda, Anti (2014). Maternal separation is associated with DNA methylation and behavioural changes in adult rats. European Neuropsychopharmacology, 24 (3), 459−468. DOI: 10.1016/j.euroneuro.2013.07.012.
1.1.
2012
Jürgenson, Monika; Aonurm-Helm, Anu; Zharkovsky, Alexander (2012). Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-like behaviour without cognitive impairment. Brain Research, 1447, 106−118.10.1016/j.brainres.2012.01.056.
1.1.
2011
Jaako, K.; Aonurm-Helm, A.; Kalda, A.; Anier, K.; Zharkovsky, T.; Shastin, A.; Zharkovsky, A. (2011). Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus. European Journal of Pharmacology, 666, 61−71.10.1016/j.ejphar.2011.05.008.
1.1.
2010
Anier, K.; Malinovskaja, K.; Aonurm-Helm, A.; Zharkovsky, A.; Kalda, A. (2010). DNA methylation regulates cocaine-induced behavioral sensitization in mice. Neuropsychopharmacology, 35 (12), 2450−2461.10.1038/npp.2010.128.
1.1.
2010
Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2010). Behavioral profile of mice with impaired cognition in the elevated plus-maze due to a deficiency in neural cell adhesion molecule. Pharmacology Biochemistry and Behavior, 96 (4), 461−468.10.1016/j.pbb.2010.07.006.
1.1.
2010
Aonurm-Helm, A.; Berezin, V.; Bock, E.; Zharkovsky, A. (2010). NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice. Brain Research, 1309, 1−8.10.1016/j.brainres.2009.11.003.
1.1.
2008
Aonurm-Helm, A.; Jurgenson, M.; Zharkovsky, T.; Sonn, K.; Berezin, V.; Bock, E.; Zharkovsky, A. (2008). Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficent mice and its reversal by an NCAM-derived peptide, FGL. European Journal of Neuroscience, 28 (8), 1618−1628. DOI: 10.1111/j.1460-9568.2008.06471.x.
1.1.
2008
Aonurm-Helm, A.; Zharkovsky, T.; Jürgenson, M.; Kalda, A.; Zharkovsky, A. (2008). Dysregulated CREB signaling pathway in the brain of neural cell adhesion molecule (NCAM) deficent mice. Brain Research, 1243, 104−112. DOI: 10.1016/j.brainres.2008.08.091.
1.1.
2007
Kaasik, A.; Kuum, M.; Aonurm, A.; Kalda, A.; Vaarmann, A.; Zharkovsky, A. (2007). Seizures, ataxia, and neuronal loss in cystatin B heterozygous mice. Epilepsia, 48 (4), 752−757.
20.02.2020

Otsi projekti

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Asutus on projekti finantseerija   Asutus on projekti teostaja  
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Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 6 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF8740Antidepressantide toime põletiku patogeneetilistele mehhanismidele ajus01.01.201131.12.2012Külli JaakoTartu Ülikool, Arstiteaduskond28 308,00 EUR
ETFETF9316NCAM/PSA-NCAM roll järglaste aju plastilisusele täiskasvanueas vastusena kroonilisele stressile või antidepressantravile varases aju arengufaasis01.01.201231.12.2012Anu Aonurm-HelmTartu Ülikool, Arstiteaduskond11 610,00 EUR
IUTIUT2-3Neuraalsed adhesioonimolekulid kui potentsiaalsed terapeutilised sihtmärgid aju plastilisuse häirete korral01.01.201331.12.2018Aleksandr ŽarkovskiTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut1 008 000,00 EUR
ETFETF6504Neuronaalse raku adhesioonimolekuli (NCAM) roll aju plastilisuses ja regeneratsioonis01.01.200531.12.2008Aleksandr ŽarkovskiTartu Ülikool, Arstiteaduskond77 844,37 EUR
ETFETF7955Närviraku adhesioonimolekuli (NCAM) roll aju plastilisuses: uus farmakoloogiline suund depressiooni ravis.01.01.200931.12.2012Aleksandr ŽarkovskiTartu Ülikool, Arstiteaduskond73 626,70 EUR
SFSF0180059s07Uued ravistrateegiad neurodegeneratsiooni ja psüühiliste häirete ravis01.01.200731.12.2012Aleksandr ŽarkovskiTartu Ülikool, Arstiteaduskond791 857,51 EUR