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Hanna Tähti

https://etis.ee/CV/Hanna_Tähti/est
5.09.1939
hanna.tahti@uta.fi

Teenistuskäik

Töökohad ja ametid
01.01.2000–...   
Tampere Ülikool, Meditsiini teaduskond, Professor
01.03.2008–31.12.2009   
Keemilise ja Bioloogilise Füüsika Instituut, Erakorraline juhtivteadur (0,25)
01.01.1997–31.12.2000   
Tampere Ülikool, Meditsiini teaduskond
01.01.1996–31.12.1997   
Tampere Ülikool, Meditsiini teaduskond
01.01.1994–31.12.1996   
Tampere Ülikool, Meditsiini teaduskond, vanemtedur
01.01.1990–31.12.1993   
Soome Teaduste Akadeemia
01.01.1988–31.12.1989   
Tampere Ülikool, vanemtedur
01.01.1987–31.12.1988   
Tampere Farmaatsia Teaduskeskus
01.01.1973–31.12.1987   
Tampere Ülikool
01.01.1962–31.12.1973   
Helsingi Ülikool
 
 
Haridustee
1978–1982   
Helsingi Ülikool, doktorantuur
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2006−...   
Honorary member of EUROTOX (Federation of European Toxicologist and European Societies of Toxicology)
2005−...   
Honorary member of SSCT (Scandinavian Society for Cell Toxicology )
2003−...   
President of FINCOP (Finnish National Consensus Platform for Alternatives)
1996−...   
EUROTOX, Federation of European Toxicologist and European Societies of Toxicology
1984−...   
Soome Toksikoloogia Selts
1974−...   
Soome Farmakoloogia Selts
1998−2004   
SSCT, Skandinaavia Rakutoksikoloogia Seltsi juhatuse liige
1994−2004   
Rahvusvahelise Toksikoloogia Konverentsi Organiseerimiskomitee juht
1986−1989   
Soome Haridusministeeriumi loodusteaduste komisjoni liige
 
 
Lisainfo
Editoreal Board Memberships and memberships in scientific expert boards
Toxicology in Vitro, An international journal published in association with BIBRA,
Pergamon Press, Oxford, New York, Soul, Tokyo, Editorial board member 1990- onwards
Pharmacol & Toxicol, Vol 70, No 5, Quest Editor 1992-
Archiv of Toxicology, Editorial board member 2001-
Chief Editor of EUROTOX Proceedings 1999-
Member in the EDIT scientific expert board, Expertrådet, Sollentuna, Sweden 2003-

Kvalifikatsioon

Teaduskraadid
Hanna Tähti, doktorikraad, 1982, (juh) Henrik Wallgren, Periodicity of hibernation in the hedgehog (Erinaceus europaeus L.). Seasonal respiratory variation with special reference to the regulation of Cheyne-Stokes respiration, University of Helsinki.
 
 
Teaduspreemiad ja tunnustused
2008, Hanna Tähti, Doktoriteeside retsensent: Kaisa Klemola, University of Kuopio: Textile toxicity: cytotoxicity and spermatozoa motility inhibition resulting from reactive dues and dyed fabrics.
2004, Hanna Tähti, Björn Ekwall fondi auhind
1998, Hanna Tähti, Põhjamaaade teadustöö auhind alternatiivsete in vitro meetodite väljatöötamise eest
1991, Hanna Tähti, Soome Teaduste Akadeemia stipendium
1979, Hanna Tähti, Noore teadlase rahvusvaheline stipendium, Briti Nõukogu
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin
 
 
Lisainfo
The research grant of the Environmental Research Council of the State,
the Academy of Finland 1990-1993
The research grant of the Environmenta Research Council of the State
the Academy of Finland 1993-1995
The research grant of EU (Biomed 3) 1997-2000

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2008
Toimela, T.; Tähti, H.; Ylikomi, T. (2008). Comparison of an automated pattern analysis machine vision time-lapse system with traditional endpoint measurements in the analysis of cell growth and cytotoxicity. Atla-Alternatives to Laboratory Animals, 36, 313−325.
1.2.
2008
Mannerström, M.; Mäenpää, H.; Räty, S.; Sand, J; Ylikomi, T.; Tähti, H. (2008). Metabolism-induced toxicity of selegeline and carbamazepine studied with an in vitro method. TheOpen Toxicology Journal, 61−70.
1.1.
2006
Mannerstrom, M.; Toimela, T.; Ylikomi, T.; Tahti, H . (2006). The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs. Toxicology Letters, 165, 195−202.
5.1.
2006
Toimela, T.; Tahti, H .; Tarvainen, J.; Korpinen, J.; Ylikomi, T. (2006). Automated analysis of cells by machine vision - Application in toxicity studies. Toxicology Letters: EUROTOX 2006/6 CTDC Congress - 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries. Elsevier Sci, S220−S221.
5.1.
2006
Mannerstrom, M .; Toimela, T.; Ylikomi, T.; Tahti, H. (2006). Development of a simple in vitro method for the screening of metabolism-induced toxicity of drugs. Toxicology Letters: EUROTOX 2006/6 CTDC Congress - 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries. Elsevier Ireland Ltd, S219−S220.
1.1.
2004
Maenpaa, H.; Toimela, T.; Mannerstrom, M.; Saransaari, P.; Tahti, H. (2004). Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines. Neurochemical Research, 29, 305−311.
1.1.
2004
Kakko, I.; Toimela, T.; Tahti, H. (2004). The toxicity of pyrethroid compounds in neural cell cultures studied with total ATP, mitochondrial enzyme activity and microscopic photographing. Environmental Toxicology and Pharmacology, 15, 95−102.
1.1.
2004
Toimela, T.; Maenpaa, H.; Mannerstrom, M.; Tahti, H. (2004). Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicology and Applied Pharmacology, 73−82.
1.1.
2004
Maenpaa, H.; Gegelashvili, G.; Tahti, H. (2004). Expression of glutamate transporter subtypes in cultured retinal pigment epithelial and retinoblastoma cells. Current Eye Research, 28, 159−165.
1.1.
2004
Prieto, P.; Blaauboer, B.J.; de Boer, A.G.; Boveri, M.; Cecchelli, R.; Clemedson, C.; Coecke, S.; Forsby, A.; Galla, H.J.; Garberg, P.; Greenwood, J.; Price, A.; Tahti, H. (2004). Blood-brain barrier in vitro models and their application in toxicology - The report and recommendations of ECVAM workshop 49. Atla-Alternatives to Laboratory Animals, 32, 37−50.
1.1.
2004
Kohila, T.; Parkkonen, E.; Tahti, H. (2004). Evaluation of the effects of aluminium, ethanol and their combination on rat brain synaptosomal integral proteins in vitro and after 90-day oral exposure. Archives of Toxicology, 78, 276−282.
1.1.
2004
Szabo, A.; Varga, V.; Toimela, T.; Hiitela, K.; Tahti, H.; Oja, S.S.; Suveges, I.; Salminen, L. (2004). Laser treatment of cultured retinal pigment epithelial cells - Evaluation of the cellular damage in vitro. Journal of Ocular Pharmacology and Therapeutics, 20, 246−255.
1.1.
2004
Mannerstrom, M.; Tahti, H. (2004). Modulation of glucose uptake in glial and neuronal cell lines by selected neurological drugs. Toxicology Letters, 151, 87−97.
1.1.
2004
Toimela, T.; Tahti, H. (2004). Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin. Archives of Toxicology, 78, 565−574.
1.1.
2004
Kakko, I.; Toimela, T.; Tahti, H. (2004). Oestradiol potentiates the effects of certain pyrethroid compounds in the MCF7 human breast carcinoma cell line. Atla-Alternatives to Laboratory Animals, 32, 383−390.
1.1.
2004
Kohila, T.; Tahti, H. (2004). Effects of aluminium and lead on ATPase activity of knockout GDNF +/- mouse cerebral synaptosomes in vitro. Atla-Alternatives to Laboratory Animals, 32, 361−367.
5.1.
2004
Mannerstrom, M.; Maenpaa, H.; Tahti, H. (2004). Evaluation of drugs and their metabolic effects in vitro. Toxicology and Applied Pharmacology. Academic Press, 181−182. (197).
1.1.
2003
Huhtala, A.; Alajuuma, P.; Burgalassi, S.; Chetoni, P.; Diehl, H.; Engelke, M.; Marselos, M.; Monti, D.; Pappas, P.; Saettone, M.F.; Salminen, L.; Sotiropoulou, M.; Tahti, H.; Uusitalo, H.; Zorn-Kruppa, M. (2003). A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test. Journal of Ocular Pharmacology and Therapeutics, 19, 11−21.
1.1.
2003
Kakko, I.; Toimela, T.; Tahti, H. (2003). The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin. Chemosphere, 51, 475−480.
1.1.
2003
Tahti, H.; Nevala, H.; Toimela, T. (2003). Refining in vitro neurotoxicity testing - The development of blood-brain barrier models. Atla-Alternatives to Laboratory Animals, 31, 273−276.
1.1.
2003
Huhtala, A.; Nurmi, S.K.; Tahti, H.; Salminen, L.; Alajuuma, P.; Rantala, I.; Helin, H.; Uusitalo, H. (2003). The immunohistochemical characterisation of an SV40-immortalised human corneal epithelial cell line. Atla-Alternatives to Laboratory Animals, 31, 409−417.
1.1.
2003
Maenpaa, H.; Saransaari, P.; Tahti, H. (2003). Kinetics of inhibition of glutamate uptake by antioestrogens. Pharmacology & Toxicology, 93, 174−179.
1.1.
2003
Mannerstrom, M.; Tahti, H.; Tiihonen, K; Salama, A. (2003). D-glucose uptake in fish hepatocytes: mediated by transporter in rainbow trout (Oncorhynchus mykiss), but only by diffusion in prespawning lamprey (Lampetra fluviatilis) and in RTH-149 cell line. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 136, 779−790.
1.1.
2002
Huhtala, A.; Mannerstrom, M.; Alajuuma, P.; Nurmi, S.; Toimela, T.; Tahti, H.; Salminen, L.; Uusitalo, H. (2002). Comparison of an immortalized human corneal epithelial cell line and rabbit corneal epithelial cell culture in cytotoxicity testing. Journal of Ocular Pharmacology and Therapeutics, 18, 163−175.
1.1.
2002
Mannerstrom, M.; Zorn-Kruppa, M.; Diehl, H.; Engelke, M.; Toimela, T.; Maenpaa, H.; Huhtala, A.; Uusitalo, H.; Salminen, L.; Pappas, P.; Marselos, M.; Mantyla, M.; Mantyla, E.; Tahti, H. (2002). Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells. Toxicology in vitro, 16, 193−200.
1.1.
2002
Maenpaa, H.; Mannerstrom, M.; Toimela, T.; Salminen, L.; Saransaari, P.; Tahti, H. (2002). Glutamate uptake is inhibited by tamoxifen and toremifene in cultured retinal pigment epithelial cells. Pharmacology & Toxicology, 91, 116−122.
1.1.
2002
Huhtala, A.; Tahti, H.; Salminen, L.; Uusitalo, H. (2002). Evaluation of adverse ocular effects of 5-fluorouracil by using human corneal epithelial cell cultures. Journal of Toxicology-Cutaneous and Ocular Toxicology, 21, 283−292.
1.1.
2001
Mannerstrom, M.; Maenpaa, H.; Toimela, T.; Salminen, L.; Tahti, H. (2001). The phagocytosis of rod outer segments is inhibited by selected drugs in retinal pigment epithelial cell cultures. Pharmacology & Toxicology, 88, 27−33.
1.1.
2001
Toimela, T.A.; Tahti, H. (2001). Effects of mercuric chloride exposure on the glutamate uptake by cultured retinal pigment epithelial cells. Toxicology in vitro, 15, 7−12.
1.1.
2001
Raunio, S.; Tahti, H. (2001). Glutamate and calcium uptake in astrocytes after acute lead exposure. Chemosphere, 44, 355−359.
1.1.
2000
Kakko, I.; Toimela, T.; Tahti, H. (2000). Piperonyl butoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin. Chemosphere, 40, 301−305.
1.1.
2000
Toimela, T.; Maenpaa, H.; Tahti, H. (2000). Retinal Muller cell culture. Atla-Alternatives to Laboratory Animals, 28, 477−482.
1.1.
1999
Tahti, H.; Maenpaa, H.; Salminen, L.; Toimela, T. (1999). Retinal pigment epithelial cell cultures as a tool for evaluating retinal toxicity in vitro. Atla-Alternatives to Laboratory Animals, 27, 417−424.
1.1.
1997
Maenpaa, H.; Toimela, T.; Saransaari, P.; Salminen, L.; Tahti, H. (1997). Mechanism of tamoxifen's retinal toxicity, studied in pig pigment epithelial cell cultures. Atla-Alternatives to Laboratory Animals, 25, 297−302.
1.1.
1996
Engelke, M.; Tahti, H.; Vaalavirta, L. (1996). Perturbation of artificial and biological membranes by organic compounds of aliphatic, alicyclic and aromatic structure. Toxicology in vitro, 10, 111−115.
5.04.2018

Hanna Tähti

https://etis.ee/CV/Hanna_Tähti/eng
5.09.1939
hanna.tahti@uta.fi

Career

Institutions and positions
01.01.2000–...   
University of Tampere, Medical Faculty, Professor of Biomedicine
01.03.2008–31.12.2009   
National Institute of Chemical Physics and Biophysics, Extraordinary Research Professor (0,25)
01.01.1997–31.12.2000   
University of Tampere, Medical Faculty, Research Director
01.01.1996–31.12.1997   
University of Tampere, Medical Faculty, Head assistant
01.01.1994–31.12.1996   
University of Tampere, Medical Faculty, Senior Scientist
01.01.1990–31.12.1993   
Environmental Research Council of Academy of Finland, Advanced scientist
01.01.1988–31.12.1989   
University of Tampere, Environmental Research Unit, Senior Scientist
01.01.1987–31.12.1988   
Pharmaceutical Research Center, Tampere
01.01.1973–31.12.1987   
University of Tampere, Department of Biomedical Sciences, Head assistant and assistant in physiology
01.01.1962–31.12.1973   
University of Helsinki, Amanuesis (research) and assistant in physiological zoology
 
 
Education
1978–1982   
University of Helsinki, PhD studies
 
 
R&D related managerial and administrative work
2006−...   
Honorary member of EUROTOX (Federation of European Toxicologist and European Societies of Toxicology)
2005−...   
Honorary member of SSCT (Scandinavian Society for Cell Toxicology )
2003−...   
President of FINCOP (Finnish National Consensus Platform for Alternatives)
1996−...   
EUROTOX, Federation of European Toxicologist and European Societies of Toxicology
1984−...   
Finnish Society of Toxicology
1974−...   
Finnish Society of Paharmacology
1998−2004   
SSCT, Scandinavian Society for Cell Toxicology bord member
1994−2004   
International Congress of Toxicology, Secretary General of the Organization Committee
1986−1989   
Ministry of Education, member of the division of Natural Sciences
 
 
Additional information
Editoreal Board Memberships and memberships in scientific expert boards
Toxicology in Vitro, An international journal published in association with BIBRA,
Pergamon Press, Oxford, New York, Soul, Tokyo, Editorial board member 1990- onwards
Pharmacol & Toxicol, Vol 70, No 5, Quest Editor 1992-
Archiv of Toxicology, Editorial board member 2001-
Chief Editor of EUROTOX Proceedings 1999-
Member in the EDIT scientific expert board, Expertrådet, Sollentuna, Sweden 2003-

Qualifications

Academic degrees
Hanna Tähti, Doctor's Degree, 1982, (sup) Henrik Wallgren, Periodicity of hibernation in the hedgehog (Erinaceus europaeus L.). Seasonal respiratory variation with special reference to the regulation of Cheyne-Stokes respiration, University of Helsinki.
 
 
Honours & awards
2004, Hanna Tähti, Björn Ekwall Prise
1998, Hanna Tähti, Nordic Research Prise on the development of alternative methods
1991, Hanna Tähti, A scolarship of Advanced Scientist, the Environmental Research Council of the State, Academy of Finland
1979, Hanna Tähti, YRWIS, Young Research Workers International stipendium, British Council
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine
 
 
Additional information
The research grant of the Environmental Research Council of the State,
the Academy of Finland 1990-1993
The research grant of the Environmenta Research Council of the State
the Academy of Finland 1993-1995
The research grant of EU (Biomed 3) 1997-2000

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2008
Toimela, T.; Tähti, H.; Ylikomi, T. (2008). Comparison of an automated pattern analysis machine vision time-lapse system with traditional endpoint measurements in the analysis of cell growth and cytotoxicity. Atla-Alternatives to Laboratory Animals, 36, 313−325.
1.2.
2008
Mannerström, M.; Mäenpää, H.; Räty, S.; Sand, J; Ylikomi, T.; Tähti, H. (2008). Metabolism-induced toxicity of selegeline and carbamazepine studied with an in vitro method. TheOpen Toxicology Journal, 61−70.
1.1.
2006
Mannerstrom, M.; Toimela, T.; Ylikomi, T.; Tahti, H . (2006). The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs. Toxicology Letters, 165, 195−202.
5.1.
2006
Toimela, T.; Tahti, H .; Tarvainen, J.; Korpinen, J.; Ylikomi, T. (2006). Automated analysis of cells by machine vision - Application in toxicity studies. Toxicology Letters: EUROTOX 2006/6 CTDC Congress - 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries. Elsevier Sci, S220−S221.
5.1.
2006
Mannerstrom, M .; Toimela, T.; Ylikomi, T.; Tahti, H. (2006). Development of a simple in vitro method for the screening of metabolism-induced toxicity of drugs. Toxicology Letters: EUROTOX 2006/6 CTDC Congress - 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries. Elsevier Ireland Ltd, S219−S220.
1.1.
2004
Maenpaa, H.; Toimela, T.; Mannerstrom, M.; Saransaari, P.; Tahti, H. (2004). Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines. Neurochemical Research, 29, 305−311.
1.1.
2004
Kakko, I.; Toimela, T.; Tahti, H. (2004). The toxicity of pyrethroid compounds in neural cell cultures studied with total ATP, mitochondrial enzyme activity and microscopic photographing. Environmental Toxicology and Pharmacology, 15, 95−102.
1.1.
2004
Toimela, T.; Maenpaa, H.; Mannerstrom, M.; Tahti, H. (2004). Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicology and Applied Pharmacology, 73−82.
1.1.
2004
Maenpaa, H.; Gegelashvili, G.; Tahti, H. (2004). Expression of glutamate transporter subtypes in cultured retinal pigment epithelial and retinoblastoma cells. Current Eye Research, 28, 159−165.
1.1.
2004
Prieto, P.; Blaauboer, B.J.; de Boer, A.G.; Boveri, M.; Cecchelli, R.; Clemedson, C.; Coecke, S.; Forsby, A.; Galla, H.J.; Garberg, P.; Greenwood, J.; Price, A.; Tahti, H. (2004). Blood-brain barrier in vitro models and their application in toxicology - The report and recommendations of ECVAM workshop 49. Atla-Alternatives to Laboratory Animals, 32, 37−50.
1.1.
2004
Kohila, T.; Parkkonen, E.; Tahti, H. (2004). Evaluation of the effects of aluminium, ethanol and their combination on rat brain synaptosomal integral proteins in vitro and after 90-day oral exposure. Archives of Toxicology, 78, 276−282.
1.1.
2004
Szabo, A.; Varga, V.; Toimela, T.; Hiitela, K.; Tahti, H.; Oja, S.S.; Suveges, I.; Salminen, L. (2004). Laser treatment of cultured retinal pigment epithelial cells - Evaluation of the cellular damage in vitro. Journal of Ocular Pharmacology and Therapeutics, 20, 246−255.
1.1.
2004
Mannerstrom, M.; Tahti, H. (2004). Modulation of glucose uptake in glial and neuronal cell lines by selected neurological drugs. Toxicology Letters, 151, 87−97.
1.1.
2004
Toimela, T.; Tahti, H. (2004). Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin. Archives of Toxicology, 78, 565−574.
1.1.
2004
Kakko, I.; Toimela, T.; Tahti, H. (2004). Oestradiol potentiates the effects of certain pyrethroid compounds in the MCF7 human breast carcinoma cell line. Atla-Alternatives to Laboratory Animals, 32, 383−390.
1.1.
2004
Kohila, T.; Tahti, H. (2004). Effects of aluminium and lead on ATPase activity of knockout GDNF +/- mouse cerebral synaptosomes in vitro. Atla-Alternatives to Laboratory Animals, 32, 361−367.
5.1.
2004
Mannerstrom, M.; Maenpaa, H.; Tahti, H. (2004). Evaluation of drugs and their metabolic effects in vitro. Toxicology and Applied Pharmacology. Academic Press, 181−182. (197).
1.1.
2003
Huhtala, A.; Alajuuma, P.; Burgalassi, S.; Chetoni, P.; Diehl, H.; Engelke, M.; Marselos, M.; Monti, D.; Pappas, P.; Saettone, M.F.; Salminen, L.; Sotiropoulou, M.; Tahti, H.; Uusitalo, H.; Zorn-Kruppa, M. (2003). A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test. Journal of Ocular Pharmacology and Therapeutics, 19, 11−21.
1.1.
2003
Kakko, I.; Toimela, T.; Tahti, H. (2003). The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin. Chemosphere, 51, 475−480.
1.1.
2003
Tahti, H.; Nevala, H.; Toimela, T. (2003). Refining in vitro neurotoxicity testing - The development of blood-brain barrier models. Atla-Alternatives to Laboratory Animals, 31, 273−276.
1.1.
2003
Huhtala, A.; Nurmi, S.K.; Tahti, H.; Salminen, L.; Alajuuma, P.; Rantala, I.; Helin, H.; Uusitalo, H. (2003). The immunohistochemical characterisation of an SV40-immortalised human corneal epithelial cell line. Atla-Alternatives to Laboratory Animals, 31, 409−417.
1.1.
2003
Maenpaa, H.; Saransaari, P.; Tahti, H. (2003). Kinetics of inhibition of glutamate uptake by antioestrogens. Pharmacology & Toxicology, 93, 174−179.
1.1.
2003
Mannerstrom, M.; Tahti, H.; Tiihonen, K; Salama, A. (2003). D-glucose uptake in fish hepatocytes: mediated by transporter in rainbow trout (Oncorhynchus mykiss), but only by diffusion in prespawning lamprey (Lampetra fluviatilis) and in RTH-149 cell line. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 136, 779−790.
1.1.
2002
Huhtala, A.; Mannerstrom, M.; Alajuuma, P.; Nurmi, S.; Toimela, T.; Tahti, H.; Salminen, L.; Uusitalo, H. (2002). Comparison of an immortalized human corneal epithelial cell line and rabbit corneal epithelial cell culture in cytotoxicity testing. Journal of Ocular Pharmacology and Therapeutics, 18, 163−175.
1.1.
2002
Mannerstrom, M.; Zorn-Kruppa, M.; Diehl, H.; Engelke, M.; Toimela, T.; Maenpaa, H.; Huhtala, A.; Uusitalo, H.; Salminen, L.; Pappas, P.; Marselos, M.; Mantyla, M.; Mantyla, E.; Tahti, H. (2002). Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells. Toxicology in vitro, 16, 193−200.
1.1.
2002
Maenpaa, H.; Mannerstrom, M.; Toimela, T.; Salminen, L.; Saransaari, P.; Tahti, H. (2002). Glutamate uptake is inhibited by tamoxifen and toremifene in cultured retinal pigment epithelial cells. Pharmacology & Toxicology, 91, 116−122.
1.1.
2002
Huhtala, A.; Tahti, H.; Salminen, L.; Uusitalo, H. (2002). Evaluation of adverse ocular effects of 5-fluorouracil by using human corneal epithelial cell cultures. Journal of Toxicology-Cutaneous and Ocular Toxicology, 21, 283−292.
1.1.
2001
Mannerstrom, M.; Maenpaa, H.; Toimela, T.; Salminen, L.; Tahti, H. (2001). The phagocytosis of rod outer segments is inhibited by selected drugs in retinal pigment epithelial cell cultures. Pharmacology & Toxicology, 88, 27−33.
1.1.
2001
Toimela, T.A.; Tahti, H. (2001). Effects of mercuric chloride exposure on the glutamate uptake by cultured retinal pigment epithelial cells. Toxicology in vitro, 15, 7−12.
1.1.
2001
Raunio, S.; Tahti, H. (2001). Glutamate and calcium uptake in astrocytes after acute lead exposure. Chemosphere, 44, 355−359.
1.1.
2000
Kakko, I.; Toimela, T.; Tahti, H. (2000). Piperonyl butoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin. Chemosphere, 40, 301−305.
1.1.
2000
Toimela, T.; Maenpaa, H.; Tahti, H. (2000). Retinal Muller cell culture. Atla-Alternatives to Laboratory Animals, 28, 477−482.
1.1.
1999
Tahti, H.; Maenpaa, H.; Salminen, L.; Toimela, T. (1999). Retinal pigment epithelial cell cultures as a tool for evaluating retinal toxicity in vitro. Atla-Alternatives to Laboratory Animals, 27, 417−424.
1.1.
1997
Maenpaa, H.; Toimela, T.; Saransaari, P.; Salminen, L.; Tahti, H. (1997). Mechanism of tamoxifen's retinal toxicity, studied in pig pigment epithelial cell cultures. Atla-Alternatives to Laboratory Animals, 25, 297−302.
1.1.
1996
Engelke, M.; Tahti, H.; Vaalavirta, L. (1996). Perturbation of artificial and biological membranes by organic compounds of aliphatic, alicyclic and aromatic structure. Toxicology in vitro, 10, 111−115.
5.04.2018

Otsi projekti

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Uus Frascati (2015)
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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0690063s08Mehhanismid ja interaktsioonid toksikoloogias ja toksinoloogias: in vitro mudelid01.01.200831.12.2013Anne KahruKeemilise ja Bioloogilise Füüsika Instituut1 126 446,52 EUR