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Olen nõus

Jüri Siigur

https://etis.ee/CV/Jüri_Siigur/est
11.04.1941
639 8360
56568469
juri.siigur@kbfi.ee

Teenistuskäik

Töökohad ja ametid
01.09.2016–31.12.2019   
National Institute of Chemical Physics and Biophysics, Vanemteadur (0,25)
01.01.2014–28.02.2015   
Keemilise ja Bioloogilise Füüsika Instituut, Juhtivteadur (0,50)
01.09.2007–31.12.2013   
Keemilise ja Bioloogilise Füüsika Instituut, Juhtivteadur (1,00)
09.08.1996–31.08.2007   
Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (1,00)
1991–31.08.2016   
Keemilise ja Bioloogilise Füüsika Instituut, KBFI Bioorgaanilise keemia laboratooriumi juhataja (0,25)
1980–31.08.2016   
Keemilise ja Bioloogilise Füüsika Instituut, KBFI teadussekretär (0,25)
01.01.1974–31.12.1980   
Eesti TA Küberneetika Instituut, vanemteadur
01.01.1971–31.12.1974   
Eesti Põllumajanduse Akadeemia, vanemõpetaja
01.01.1970–31.12.1971   
Tartu Ülikool,Keemilise Kineetika ja Katalüüsi laboratoorium, nooremteadur
01.01.1965–31.12.1967   
Eesti TA Keemia Instituut, nooremteadur
 
 
Haridustee
1967–1970   
Tartu Ülikool, orgaanilise keemia kateeder, aspirantuur, füüsikaline orgaaniline keemia
1959–1964   
Tartu Ülikool, keemia osakond , diplom- orgaaniline keemia
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2014−...   
artiklite retsenseerimine: Basic&Clinical Pharmacology&Toxicology; British Biotecnology Journal;Current Topics in Medicinal Chemistry; J.of Venomous Animals and Toxins,including Tropical Diseases
2009−...   
teadusprojektide taotluse hindamine (National Science Foundation,USA)
1994−...   
artiklite retsenseerimine: BBA,Thromb.Res., Comp.Biochem.Phys., Toxicon, FEBS J., FEBS Letters, Biochimie, Journal of Pharmacy and Pharmacology
1998−2006   
ETF keemia ja molekulaarbioloogia ekspertkomisjoni liige
1991−2016   
KBFI Bioorgaanilise keemia laboratooriumi juhatamine
1980−2016   
KBFIi teadussekretar
1980−2016   
KBFI Teadusnõukogu liige
 
 
Loometöö
Uurimused järgnevates valdkondades: Bio- ja keskkonnateadused, Biokeemia (proteoomika, valkude ja ensüümide struktuur ja funktsioon; rekombinantsete ja mutantsete valkude saamine, toksinoloogia, madude mürkide koostise uurimine)

Kvalifikatsioon

Teaduskraadid
Jüri Siigur, doktorikraad, 1971, (juh) Ülo Haldna, Issledovanie osnovnosti nekotorõh alifatitseskih karbonovõh kislot i sloznõh efirov (Mõningate karboksüülhapete ja estrite aluselisuse uurimine), Tartu Ülikool.
 
 
Teaduspreemiad ja tunnustused
2007, Jüri Siigur, AAAS liige(American Association for the Advancement of Science)
1995, Jüri Siigur, Fogarty Grant-auhind
1993, Jüri Siigur, George Sorose (Rahvusvahelise Teadusfondi) Stipendium
1993, Jüri Siigur, Fogarty Grant-auhind
1991, Jüri Siigur, Eesti Teaduste Akadeemia Aukiri
1989, Jüri Siigur, Ülemaailmse Toksinoloogia Ühingu liige (IST);
1987, Jüri Siigur, ENSV Teaduse ja Tehnika Preemia
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; TÄPSUSTUS: proteoomika, valkude ja ensüümide struktuur ja funktsioon; rekombinantsete ja mutantsete valkude saamine, toksinoloogia, madude mürkide koostise uurimine
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; CERCS KLASSIFIKAATOR: P310 Proteiinid, ensümoloogia
 
 
Lisainfo
Keemiakandidaat, Ph.D, Tartu Riiklik Ülikool, 1971
vanemteadur, NSVL Teaduste Akadeemia,Moskva,1985

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Siigur, Jüri; Aaspõllu, Anu; Siigur, Ene (2019). Biochemistry and pharmacology of proteins and peptides purified from the venoms of the snakes Macrovipera lebetina subspecies. Toxicon : Official Journal of The International Society On Toxinology, 158 (Feb.), 16−32.10.1016/j.toxicon.2018.11.294.
1.1.
2016
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri; Siigur, Ene (2016). Vipera lebetina venom nucleases. Toxicon, 119, 39−45.10.1016/j.toxicon.2016.05.004.
1.1.
2015
Trummal, Katrin; Samel, Mari; Aaspõllu, Anu; Tõnismägi, Külli; Titma, Tiina; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2015). 5´-Nucleotidase from Vipera lebetina venom. Toxicon, 93, 155−163.10.1016/j.toxicon.2014.11.234.
5.1.
2015
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2015). Vipera lebetina venom nucleases. Toxicon, 103S: The 18th World Congress of the International Society on Toxinology; 25-30 September 2015; Oxford, UK. Elsevier Sci, 111−112.
1.1.
2014
Trummal, K., Aaspõllu, A, Tõnismägi, K., Samel, M., Subbi, J., Siigur, J., Siigur, E. (2014). Phosphodiesterase from Vipera lebetina venom - Structure and characterization. Biochimie, 106, 48−55.10.1016/j.biochi.2014.07.020.
5.1.
2014
Titma, T.; Trummal, K.; Tõnismägi, K.; Siigur, E.; Subbi, J.; Shimmo, R.; Ivask, A.; Kahru, A.; Siigur, J. (2014). New C-type lectin-like protein and 5′-nucleotidase from Vipera lebetina snake venom. Toxicology Letters. Elsevier Ireland Ltd, S234−S234. (229; 10). DOI: 10.1016/j.toxlet.2014.06.784.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223.10.3390/toxins5020203.
3.1.
2013
Siigur, Jüri; Siigur, Ene (2013). Lebetase. In: Neil D. Rawlings; Guy S. Salvesen (_EditorsAbbr). Handbook of Proteolytic Enzymes 3rd Edition (1054−1057).. Elsevier Sci.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
6.3.
2013
Siigur, Ene; Siigur, Jüri (2013). Madu ja maomürk - tapja ja ravija. Horisont, 5, 14−22.
1.1.
2012
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri (2012). Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. Toxicon, 60, 648−655.10.1016/j.toxicon.2012.03.023.
5.1.
2012
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri. (2012). Vipera Lebetina Venom Nucleases and Nucleotidases. Toxicon, 60, 200−200. DOI: 10.1016/j.toxicon.2012.04.205.
1.1.
2011
Trummal, Katrin; Tõnismägi, Külli; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jüri; Siigur, Ene (2011). Molecular diversity of snake venom nerve growth factors. Toxicon, 58 (4), 363−368. DOI: 10.1016/j.toxicon.2011.07.005.
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Samel, Mari; Vija, Heiki ; Kurvet, Imbi; Subbi, Juhan; Kahru, Anne; Siigur, Jüri. (2011). Antiplatelet, antibacterial and anticancer effect of PLA2-S from Vipera lebetina, Vipera berus berus and Naja naja oxiana venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 160−160.
5.2.
2011
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri. (2011). Effect of HUVEC apoptosis inducing proteinase fromVipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 159−159.
5.2.
2011
Trummal, Katrin; Tõnismägi, Külli; Bragina, Olga; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jür; Siigur, Ene. (2011). Similarities and differences of snake venom nerve growth factors. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 158−158.
5.2.
2011
Siigur, Ene; Tõnismäg, Külli; Vassiljeva, Olga; Trummal, Katrin; Aaspõllu, Anu; Subb, Juhani; Siigur, Jüri (2011). Hyaluronidase from Vipera lebetina venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 157−157.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
3.1.
2010
Siigur, Jüri; Siigur, Ene. (2010). Activation of Factor X by Snake Venom Proteases. In: Kini, R.M.; Clemetson, K.J.; Markland, F.S.; Morita, T. (Ed.). Toxins and Hemostasis. From Bench to Bedside (447−464).. Springer.10.1007/978-90-481-9295-3_26.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology, Part B, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2009). Nerve growth factor from Vipera lebetina venom: isolation and characterization. XVI World Congress of the International Society on Toxinology;15-20 March 2009, Recife, Brazil. 346-1.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
1.1.
2008
Samel, M.; Tõnismägi, K.; Rönnholm, G.; Vija, H.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2008). L-Amino acid oxidase from Naja naja oxiana venom. Comparative Biochemistry and Physiology, 149 (4), 572−580. DOI: 10.1016/j.cbpb.2007.11.008.
5.2.
2008
Siigur, Ene; Paalme, Viiu; Trummal, Katrin; Tõnismägi, Küll; Järvekülg, Lilian; Subbi, Juhan; Siigur, Jüri (2008). Vipera lebetina venom nerve growth factor. 16th European Section Meeting of the International Society on Toxinology;Book of abstracts. Leuven,Belgium, 7-10 September 2008,p. 55. 16th European Section Meeting of the International Society on Toxinology; Book of abstracts.: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 55−55.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Siigur, Jüri; Siigur, Ene (2006). Factor X activating proteases from snake venoms. Toxin Reviews, 25 (3, 1), 235−255. DOI: 10.1080/15569540600567305.
1.1.
2006
Tõnismägi, K.; Samel M., Trummal K., Rönnholm G., Siigur J., Kalkkinen N., Siigur, E. (2006). L-Amino acid oxidase from Vipera lebetina venom: Isolation. characterization, effects on platelets and bacteria. Toxicon, 48, 227−237.
1.1.
2006
Samel, M.; Vija, H.; Rönnholm, G.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2006). Isolation and characterization of an apoptotic and platelet aggragation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. Biochimica et Biophysica Acta, 1764, 707−714.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
5.2.
2006
Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Rönnholm, Gunilla; Siigur, Jüri; Kalkkinen, Nisse; Siigur, Ene. (2006). A comparative study of the enzymatic and physiological activities of two viper venom L-amino acid oxidases. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. _EditorsAbbr Alan Harvey and Edward Rowan. 274−274.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2005
Aaspõllu, Anu; Siigur, Jüri; Siigur, Ene. (2005). cDNA cloning of a novel P–I lebetase isoform Le-4. Toxicon, 46 (5), 591−594.
1.1.
2005
Trummal, K.; Tõnismägi, K.; Siigur, E.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon, 46 (1), 46−61.
5.1.
2005
Siigur, E.;Trummal, K.; Tõnismägi, K.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A heterodimeric metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Journal of Thrombosis and Haemostasis, 3. 1158. (Supplement 1).
5.1.
2005
Siigur, E.; Samel, M.; Tõnismägi, K.; Trummal, K.; Siigur, J. (2005). Snake venom apoptotic L-amino acid oxidase ( LAAO ) inhibits platelet aggregation. Journal of Thrombosis and Haemostasis, 3: XX Congress of the International Society on Thrombosis and Haemostasis, Sydney, Australia, Aug. 6-12, 2005.. P0293.
1.1.
2004
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tõnismagi, K.; Tammiste, I.; Kalkkinen, N.; Siigur, J. (2004). Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochimica et Biophysica Acta - Proteins and Proteomics, 1702 (1), 41−51.
3.1.
2004
Siigur, J.; Siigur, E. (2004). Lebetase. In: Barrett, A.J., Rawlings, N.D., Woessner, J.F. (Ed.). Handbook of Proteolytic Enzymes (707−709). . London: Elsevier.
1.1.
2003
Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2003). Metalloproteinase with factor X activating and fibrinogenolytic activities from Vipera berus berus venom. Comparative Biochemistry and Physiology, 135B, 575−582.
1.1.
2003
Siigur, E.; Aaspollu, A.; Siigur, J. (2003). Anticoagulant serine fibrinogenases from Vipera lebetina venom. Journal of Thrombosis and Haemostasis, 89 (5), 826−831.
5.2.
2003
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tammiste, I.; Siigur, J. (2003). Vipera lebetina factor X activating enzyme- cloning and sequencing. Journal of Thrombosis and Haemostasis, Supplement 1, 1096.
5.2.
2003
Siigur, Ene; Aaspõllu, Anu; Siigur, Jüri. (2003). UNIQUE ALPHA-FIBRINOGENASE FROM Vipera lebetina VENOM – CLONING AND EXPRESSION. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Toim. Julian White and Vaughan Williams. 136−136.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
1.1.
2002
Samel, M.; Subbi, J.; Siigur, J.; Siigur, E. (2002). Biochemical characterization of fibrinogenolytic serine proteinases from Vipera lebetina snake venom. Toxicon, 40 (1), 51−54.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2001
Siigur, E.; Aaspõllu, A.; Siigur, J. (2001). Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs – result of alternative splicing or genome alteration. Gene, 263, 199−203.
1.1.
2000
Siigur, E.; Samel, M.; Tonismagi, K.; Siigur, J. (2000). Cross-reactivities of polyclonal antibodies against factor V activating enzyme,a serine proteinase from Vipera lebetina (snake) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 126B, 377−382.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
3.1.
2000
Siigur, J.; Siigur, E. (2000). Polypeptides and proteins active in the coagulation process. In: Herve Rochat and Marie-France Martin-Eauclaire (Ed.). Methods and Tools in Biosciences and Medicine. Animal Toxins. Facts and Protocols (320−346). . Basel; Boston; Berlin: Birkhauser Verlag AG. (Methods and Tools in Biosciences and Medicine.).
1.1.
1999
Saidi, N.; Samel, M.; Siigur, J.; Jensen, P. E. H. (1999). Lebetase, an α(β)-fibrin(ogen)olytic metalloproteinase of Vipera lebetina snake venom, is inhibited by hyman α-macroglobulins. Biochimica et Biophysica Acta, 1434 (1), 94−102.
1.1.
1999
Siigur, E.; Aaspõllu, A.; Siigur, J. (1999). Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme, a coagulant protein from Vipera lebetina snake venom. Biochemical and Biophysical Research Communications, 262 (2), 328−332.
5.2.
1999
Siigur, E.; Tõnismägi, K.; Merits, A.; Drews, M.; Siigur, J. (1999). Expression of fibrinolytic enzyme, lebetase, from Vipera lebetina snake venom by baculovirus system. Toxicon, 37, 305.
1.1.
1998
Siigur, J.; Samel, M.; Tõnismägi, K.; Subbi, J.; Siigur, E.; Tu, A. T. (1998). Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thrombosis Research, 90 (1), 39−49.
1.1.
1998
Siigur, E.; Samel, M.; Tõnismägi, K.; Subbi, J.; Reintamm, T.; Siigur, J. (1998). Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1429 (1), 239−248.
5.2.
1998
Siigur, E.; Tõnismägi, K.; Merits, A.; Drews, M.; Siigur, J. (1998). Expression of prolebetase from Vipera lebetina by baculovirus system. Plasminogen activating activity of SF-9 cell lysates. Fibrinolysis & Proteolysis, 12 (Suppl. 1), 66.
5.2.
1998
Siigur, E.; Aaspõllu, A.; Tõnismägi, K.; Samel, M.; Drews, M.; Merits, A.; Tu, A.; Siigur, J. (1998). Biochemical characterization, cDNA cloning and expression of the fibrinolytic enzyme. Lebetase from Vipera lebetina venom. Toxicon, 36. 1258.
1.1.
1996
Siigur, J.; Tõnismägi, K.; Tu, A.T.; Siigur, E. (1996). Cross-reactivities of polyclonal antibodies against lebetase, fibrinolytic enzyme of Levantine viper (Vipera lebetina) venom. Toxicon, 34 (5), 608−613.
1.1.
1996
Siigur, E.; Aaspõllu, A.; Tu, A.T.; Siigur, J. (1996). cDNA cloning and deduced amino acid sequence of a fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochemical and Biophysical Research Communications, 224 (1), 229−236.
1.1.
1995
Samel, M.; Siigur, J. (1995). Medium molecular weight factor X activating enzyme from Vipera berus berus venom. Toxicon, 33 (1), 41−52.
1.1.
1993
Križaj, I.; Siigur, J.; Samel, M.; Cotic, V.; Gubenšek, F. (1993). Isolation, partial characterization and complete amino acid sequence of the toxic phospholipase A2 from the venom of the common viper, Vipera berus berus. Biochimica et Biophysica Acta, 1157, 81−85.
1.1.
1991
Joachimiak, A.; Giel, M.; Otwinowski, Z.; Arumäe, U.; Siigur, J.; Saarma, M.; Sigler, P. B.; Barciszewski, J. (1991). Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina. Journal of Crystal Growth, 214−219.
1.1.
1991
Siigur, Ene; Siigur, Jüri (1991). Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina ( snake) venom. Biochimica et Biophysica Acta, 1074, 223−229.
1.1.
1990
Samel, M.; Siigur, J: (1990). Isolation and characterization of hemorrhagic metalloproteinase from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 97 (2), 209−214.
1.1.
1988
Siigur, E.; Samel, M.; Siigur, J. (1988). Inhibitors of trypsin and chymotrypsin from common viper (Vipera berus berus) venom. Biokhimiya, 53 (2), 302−308.
1.1.
1987
Glinsky, G. V., Ivanova, A. B., Vinnitsky, P. V., Arumäe, U., Siigur, J., Neuman T. (1987). NGF may be the metastase growth factor. Annals of New York Academy of Sciences, 656−659.
1.1.
1987
Arumäe, Urmas; Siigur, Jüri; Neuman, Toomas; Saarma, Mart. (1987). Monoclonal antibodies against Vipera lebetina venom nerve growth factor cross-react with other snake venom nerve growth factors. Molecular Immunology, 24 (12), 1295−1302.
1.1.
1987
Mähar, Andres; Siigur, Ene; Siigur, Jüri (1987). Purification and properties of a proteinase from Vipera lebetina (snake) venom. Biochimica et Biophysica Acta, 925, 272−281.
1.1.
1987
Siigur, Jüri; Arumäe, Urmas; Neuman, Toomas; Siigur, Ene; Saarma, Mart (1987). Monoclonal antibody immunoaffinity chromatography of the nerve growth factor from snake venoms. Comparative Biochemistry and Physiology, 87B (2), 329−384.
1.1.
1987
Samel, M.; Siigur, E.; Siigur, J. (1987). Purification and characterization of two arginine ester hydrolases from Vipera berus berus (common viper) venom. Toxicon, 25 (4), 379−388.
1.1.
1986
Siigur, J.; Arumäe, U.; Neuman, T.; Samel, M.; Siigur, E.; Saarma, M. (1986). Isolation and characterization of nerve growth factor from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 83 (3), 621−625.
1.1.
1985
Siigur, Ene; Neuman, Toomas; Järve, Viive; Ants, Tara; Siigur, Järi (1985). Isolation and characterization of nerve growth factor from Vipera lebetina (snake) venom. Comparative Biochemistry and Physiology, 81B (1), 211−215.
1.1.
1982
Siigur, Ene; Siigur, Jüri; Aaviksaar, Aavo; Kibirev, Vladimir; Fedoryak, Dimitri (1982). Separation of bradykinin-releasing enzyme from the proteolytic complex of Levantine viper venom. Biokhimia, 47 (10), 1730−1737.
1.1.
1979
Raba, Raivo; Aaviksaar, Aavo;, Raba, Mari; Siigur, Jüri (1979). Cobra Venom Acetylcholinesterase. Purification and Molecular Properties. European Journal of Biochemistry, 96, 151−158.
1.1.
1979
Siigur, E.; Siigur, J.; Nõmmeots (Samel), M.; Ilomets, T. (1979). Fractionation and enzymatic activities of common viper (Vipera berus berus) venom. Toxicon, 17 (6), 623−630.
22.04.2019

Jüri Siigur

https://etis.ee/CV/Jüri_Siigur/eng
11.04.1941
639 8360
56568469
juri.siigur@kbfi.ee

Career

Institutions and positions
01.09.2016–31.12.2019   
National Institute of Chemical Physics and Biophysics, senior research scientist (0,25)
01.01.2014–28.02.2015   
National Institute of Chemical Physics and Biophysics, Research Professor (0,50)
01.09.2007–31.12.2013   
National Institute of Chemical Physics and Biophysics, Research Professor (1,00)
09.08.1996–31.08.2007   
National Institute of Chemical Physics and Biophysics, Senior Researcher (1,00)
1991–31.08.2016   
National Institute of Chemical Physics and Biophysics, Head of laboratory of bioorganic chemistry (0,25)
1980–31.08.2016   
National Institute of Chemical Physics and Biophysics, Scientific secretary (0,25)
01.01.1974–31.12.1980   
1974-1980 senior research scientist, Institute of Cybernetics, Tallinn,
01.01.1971–31.12.1974   
1971-1974 senior lecturer, Estonian Agricultural Academy, Tartu,
01.01.1970–31.12.1971   
1971 junior research scientist, Tartu State University,
01.01.1965–31.12.1967   
1965-1967 junior research scientist, Institute of Chemistry, Tallinn,
 
 
Education
1967–1970   
Tartu University, chair of organic chemistry, Ph.D studies, physical organic chemistry
1959–1964   
Tartu University, Department of Chemistry, Diploma-organic chemistry
 
 
R&D related managerial and administrative work
2014−...   
referee of articles in: Basic&Clinical Pharmacology&Toxicology; British Biotecnology Journal;Current Topics in Medicinal Chemistry; J.of Venomous Animals and Toxins,including Tropical Diseases
2009−...   
proposal evaluation (National Science Foundation,USA)
1994−...   
referee of articles in: FEBS Letters, Biochim. Biophys. Acta, Thromb. Res., Comp. Biochem.Phys., Toxicon, FEBS J.,Biochimie, Journal of Pharmacy and Pharmacology
1998−2006   
member of expert commission of chemistry and molecular biology of Estonian Science Foundation
1991−2016   
Head of laboratory of Bioorganic chemistryof NICPB
1980−2016   
Scientific secretary of NICPB
1980−2016   
member of scientific council of NICPBi
 
 
Creative work
Sudies in the fields: Biosciences and Environment, Biochemistry (Proteomics, structure and function of proteins and enzymes, recombinant technology, toxinology, composition of snake venoms)

Qualifications

Academic degrees
Jüri Siigur, Doctor's Degree, 1971, (sup) Ülo Haldna, Issledovanie osnovnosti nekotorõh alifatitseskih karbonovõh kislot i sloznõh efirov (Study of basicity some carboxylic acids and esters), University of Tartu.
 
 
Honours & awards
2007, Jüri Siigur, member of American Association for the Advancement of Science (AAAS)
1995, Jüri Siigur, Fogarty Grant Award
1993, Jüri Siigur, George Soros stipend
1993, Jüri Siigur, Fogarty Grant Award
1991, Jüri Siigur, Honour Certificate of Estonian Academy of Sciences
1989, Jüri Siigur, member of International Society on toxinology (IST)
1987, Jüri Siigur, Estonian State prize for Science and technology
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIFICATION: Proteomics, structure and function of proteins and enzymes, recombinant technology, toxinology, composition of snake venoms
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; CERCS CLASSIFICATION: P310 Proteins, enzymology
 
 
Additional information
candidate of chemistry,Ph.D, Tartu State University, 1971
senior research scientist, Academy of Sciences of the USSR,1985

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Siigur, Jüri; Aaspõllu, Anu; Siigur, Ene (2019). Biochemistry and pharmacology of proteins and peptides purified from the venoms of the snakes Macrovipera lebetina subspecies. Toxicon : Official Journal of The International Society On Toxinology, 158 (Feb.), 16−32.10.1016/j.toxicon.2018.11.294.
1.1.
2016
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri; Siigur, Ene (2016). Vipera lebetina venom nucleases. Toxicon, 119, 39−45.10.1016/j.toxicon.2016.05.004.
1.1.
2015
Trummal, Katrin; Samel, Mari; Aaspõllu, Anu; Tõnismägi, Külli; Titma, Tiina; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2015). 5´-Nucleotidase from Vipera lebetina venom. Toxicon, 93, 155−163.10.1016/j.toxicon.2014.11.234.
5.1.
2015
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2015). Vipera lebetina venom nucleases. Toxicon, 103S: The 18th World Congress of the International Society on Toxinology; 25-30 September 2015; Oxford, UK. Elsevier Sci, 111−112.
1.1.
2014
Trummal, K., Aaspõllu, A, Tõnismägi, K., Samel, M., Subbi, J., Siigur, J., Siigur, E. (2014). Phosphodiesterase from Vipera lebetina venom - Structure and characterization. Biochimie, 106, 48−55.10.1016/j.biochi.2014.07.020.
5.1.
2014
Titma, T.; Trummal, K.; Tõnismägi, K.; Siigur, E.; Subbi, J.; Shimmo, R.; Ivask, A.; Kahru, A.; Siigur, J. (2014). New C-type lectin-like protein and 5′-nucleotidase from Vipera lebetina snake venom. Toxicology Letters. Elsevier Ireland Ltd, S234−S234. (229; 10). DOI: 10.1016/j.toxlet.2014.06.784.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223.10.3390/toxins5020203.
3.1.
2013
Siigur, Jüri; Siigur, Ene (2013). Lebetase. In: Neil D. Rawlings; Guy S. Salvesen (_EditorsAbbr). Handbook of Proteolytic Enzymes 3rd Edition (1054−1057).. Elsevier Sci.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
6.3.
2013
Siigur, Ene; Siigur, Jüri (2013). Madu ja maomürk - tapja ja ravija. Horisont, 5, 14−22.
1.1.
2012
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri (2012). Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. Toxicon, 60, 648−655.10.1016/j.toxicon.2012.03.023.
5.1.
2012
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri. (2012). Vipera Lebetina Venom Nucleases and Nucleotidases. Toxicon, 60, 200−200. DOI: 10.1016/j.toxicon.2012.04.205.
1.1.
2011
Trummal, Katrin; Tõnismägi, Külli; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jüri; Siigur, Ene (2011). Molecular diversity of snake venom nerve growth factors. Toxicon, 58 (4), 363−368. DOI: 10.1016/j.toxicon.2011.07.005.
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Samel, Mari; Vija, Heiki ; Kurvet, Imbi; Subbi, Juhan; Kahru, Anne; Siigur, Jüri. (2011). Antiplatelet, antibacterial and anticancer effect of PLA2-S from Vipera lebetina, Vipera berus berus and Naja naja oxiana venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 160−160.
5.2.
2011
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri. (2011). Effect of HUVEC apoptosis inducing proteinase fromVipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 159−159.
5.2.
2011
Trummal, Katrin; Tõnismägi, Külli; Bragina, Olga; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jür; Siigur, Ene. (2011). Similarities and differences of snake venom nerve growth factors. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 158−158.
5.2.
2011
Siigur, Ene; Tõnismäg, Külli; Vassiljeva, Olga; Trummal, Katrin; Aaspõllu, Anu; Subb, Juhani; Siigur, Jüri (2011). Hyaluronidase from Vipera lebetina venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 157−157.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
3.1.
2010
Siigur, Jüri; Siigur, Ene. (2010). Activation of Factor X by Snake Venom Proteases. In: Kini, R.M.; Clemetson, K.J.; Markland, F.S.; Morita, T. (Ed.). Toxins and Hemostasis. From Bench to Bedside (447−464).. Springer.10.1007/978-90-481-9295-3_26.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology, Part B, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2009). Nerve growth factor from Vipera lebetina venom: isolation and characterization. XVI World Congress of the International Society on Toxinology;15-20 March 2009, Recife, Brazil. 346-1.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
1.1.
2008
Samel, M.; Tõnismägi, K.; Rönnholm, G.; Vija, H.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2008). L-Amino acid oxidase from Naja naja oxiana venom. Comparative Biochemistry and Physiology, 149 (4), 572−580. DOI: 10.1016/j.cbpb.2007.11.008.
5.2.
2008
Siigur, Ene; Paalme, Viiu; Trummal, Katrin; Tõnismägi, Küll; Järvekülg, Lilian; Subbi, Juhan; Siigur, Jüri (2008). Vipera lebetina venom nerve growth factor. 16th European Section Meeting of the International Society on Toxinology;Book of abstracts. Leuven,Belgium, 7-10 September 2008,p. 55. 16th European Section Meeting of the International Society on Toxinology; Book of abstracts.: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 55−55.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Siigur, Jüri; Siigur, Ene (2006). Factor X activating proteases from snake venoms. Toxin Reviews, 25 (3, 1), 235−255. DOI: 10.1080/15569540600567305.
1.1.
2006
Tõnismägi, K.; Samel M., Trummal K., Rönnholm G., Siigur J., Kalkkinen N., Siigur, E. (2006). L-Amino acid oxidase from Vipera lebetina venom: Isolation. characterization, effects on platelets and bacteria. Toxicon, 48, 227−237.
1.1.
2006
Samel, M.; Vija, H.; Rönnholm, G.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2006). Isolation and characterization of an apoptotic and platelet aggragation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. Biochimica et Biophysica Acta, 1764, 707−714.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
5.2.
2006
Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Rönnholm, Gunilla; Siigur, Jüri; Kalkkinen, Nisse; Siigur, Ene. (2006). A comparative study of the enzymatic and physiological activities of two viper venom L-amino acid oxidases. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. _EditorsAbbr Alan Harvey and Edward Rowan. 274−274.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2005
Aaspõllu, Anu; Siigur, Jüri; Siigur, Ene. (2005). cDNA cloning of a novel P–I lebetase isoform Le-4. Toxicon, 46 (5), 591−594.
1.1.
2005
Trummal, K.; Tõnismägi, K.; Siigur, E.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon, 46 (1), 46−61.
5.1.
2005
Siigur, E.;Trummal, K.; Tõnismägi, K.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A heterodimeric metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Journal of Thrombosis and Haemostasis, 3. 1158. (Supplement 1).
5.1.
2005
Siigur, E.; Samel, M.; Tõnismägi, K.; Trummal, K.; Siigur, J. (2005). Snake venom apoptotic L-amino acid oxidase ( LAAO ) inhibits platelet aggregation. Journal of Thrombosis and Haemostasis, 3: XX Congress of the International Society on Thrombosis and Haemostasis, Sydney, Australia, Aug. 6-12, 2005.. P0293.
1.1.
2004
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tõnismagi, K.; Tammiste, I.; Kalkkinen, N.; Siigur, J. (2004). Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochimica et Biophysica Acta - Proteins and Proteomics, 1702 (1), 41−51.
3.1.
2004
Siigur, J.; Siigur, E. (2004). Lebetase. In: Barrett, A.J., Rawlings, N.D., Woessner, J.F. (Ed.). Handbook of Proteolytic Enzymes (707−709). . London: Elsevier.
1.1.
2003
Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2003). Metalloproteinase with factor X activating and fibrinogenolytic activities from Vipera berus berus venom. Comparative Biochemistry and Physiology, 135B, 575−582.
1.1.
2003
Siigur, E.; Aaspollu, A.; Siigur, J. (2003). Anticoagulant serine fibrinogenases from Vipera lebetina venom. Journal of Thrombosis and Haemostasis, 89 (5), 826−831.
5.2.
2003
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tammiste, I.; Siigur, J. (2003). Vipera lebetina factor X activating enzyme- cloning and sequencing. Journal of Thrombosis and Haemostasis, Supplement 1, 1096.
5.2.
2003
Siigur, Ene; Aaspõllu, Anu; Siigur, Jüri. (2003). UNIQUE ALPHA-FIBRINOGENASE FROM Vipera lebetina VENOM – CLONING AND EXPRESSION. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Toim. Julian White and Vaughan Williams. 136−136.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
1.1.
2002
Samel, M.; Subbi, J.; Siigur, J.; Siigur, E. (2002). Biochemical characterization of fibrinogenolytic serine proteinases from Vipera lebetina snake venom. Toxicon, 40 (1), 51−54.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2001
Siigur, E.; Aaspõllu, A.; Siigur, J. (2001). Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs – result of alternative splicing or genome alteration. Gene, 263, 199−203.
1.1.
2000
Siigur, E.; Samel, M.; Tonismagi, K.; Siigur, J. (2000). Cross-reactivities of polyclonal antibodies against factor V activating enzyme,a serine proteinase from Vipera lebetina (snake) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 126B, 377−382.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
3.1.
2000
Siigur, J.; Siigur, E. (2000). Polypeptides and proteins active in the coagulation process. In: Herve Rochat and Marie-France Martin-Eauclaire (Ed.). Methods and Tools in Biosciences and Medicine. Animal Toxins. Facts and Protocols (320−346). . Basel; Boston; Berlin: Birkhauser Verlag AG. (Methods and Tools in Biosciences and Medicine.).
1.1.
1999
Saidi, N.; Samel, M.; Siigur, J.; Jensen, P. E. H. (1999). Lebetase, an α(β)-fibrin(ogen)olytic metalloproteinase of Vipera lebetina snake venom, is inhibited by hyman α-macroglobulins. Biochimica et Biophysica Acta, 1434 (1), 94−102.
1.1.
1999
Siigur, E.; Aaspõllu, A.; Siigur, J. (1999). Molecular cloning and sequence analysis of a cDNA for factor V activating enzyme, a coagulant protein from Vipera lebetina snake venom. Biochemical and Biophysical Research Communications, 262 (2), 328−332.
5.2.
1999
Siigur, E.; Tõnismägi, K.; Merits, A.; Drews, M.; Siigur, J. (1999). Expression of fibrinolytic enzyme, lebetase, from Vipera lebetina snake venom by baculovirus system. Toxicon, 37, 305.
1.1.
1998
Siigur, J.; Samel, M.; Tõnismägi, K.; Subbi, J.; Siigur, E.; Tu, A. T. (1998). Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom. Thrombosis Research, 90 (1), 39−49.
1.1.
1998
Siigur, E.; Samel, M.; Tõnismägi, K.; Subbi, J.; Reintamm, T.; Siigur, J. (1998). Isolation, properties and N-terminal amino acid sequence of a factor V activator from Vipera lebetina (Levantine viper) snake venom. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1429 (1), 239−248.
5.2.
1998
Siigur, E.; Tõnismägi, K.; Merits, A.; Drews, M.; Siigur, J. (1998). Expression of prolebetase from Vipera lebetina by baculovirus system. Plasminogen activating activity of SF-9 cell lysates. Fibrinolysis & Proteolysis, 12 (Suppl. 1), 66.
5.2.
1998
Siigur, E.; Aaspõllu, A.; Tõnismägi, K.; Samel, M.; Drews, M.; Merits, A.; Tu, A.; Siigur, J. (1998). Biochemical characterization, cDNA cloning and expression of the fibrinolytic enzyme. Lebetase from Vipera lebetina venom. Toxicon, 36. 1258.
1.1.
1996
Siigur, J.; Tõnismägi, K.; Tu, A.T.; Siigur, E. (1996). Cross-reactivities of polyclonal antibodies against lebetase, fibrinolytic enzyme of Levantine viper (Vipera lebetina) venom. Toxicon, 34 (5), 608−613.
1.1.
1996
Siigur, E.; Aaspõllu, A.; Tu, A.T.; Siigur, J. (1996). cDNA cloning and deduced amino acid sequence of a fibrinolytic enzyme (lebetase) from Vipera lebetina snake venom. Biochemical and Biophysical Research Communications, 224 (1), 229−236.
1.1.
1995
Samel, M.; Siigur, J. (1995). Medium molecular weight factor X activating enzyme from Vipera berus berus venom. Toxicon, 33 (1), 41−52.
1.1.
1993
Križaj, I.; Siigur, J.; Samel, M.; Cotic, V.; Gubenšek, F. (1993). Isolation, partial characterization and complete amino acid sequence of the toxic phospholipase A2 from the venom of the common viper, Vipera berus berus. Biochimica et Biophysica Acta, 1157, 81−85.
1.1.
1991
Joachimiak, A.; Giel, M.; Otwinowski, Z.; Arumäe, U.; Siigur, J.; Saarma, M.; Sigler, P. B.; Barciszewski, J. (1991). Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina. Journal of Crystal Growth, 214−219.
1.1.
1991
Siigur, Ene; Siigur, Jüri (1991). Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina ( snake) venom. Biochimica et Biophysica Acta, 1074, 223−229.
1.1.
1990
Samel, M.; Siigur, J: (1990). Isolation and characterization of hemorrhagic metalloproteinase from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 97 (2), 209−214.
1.1.
1988
Siigur, E.; Samel, M.; Siigur, J. (1988). Inhibitors of trypsin and chymotrypsin from common viper (Vipera berus berus) venom. Biokhimiya, 53 (2), 302−308.
1.1.
1987
Glinsky, G. V., Ivanova, A. B., Vinnitsky, P. V., Arumäe, U., Siigur, J., Neuman T. (1987). NGF may be the metastase growth factor. Annals of New York Academy of Sciences, 656−659.
1.1.
1987
Arumäe, Urmas; Siigur, Jüri; Neuman, Toomas; Saarma, Mart. (1987). Monoclonal antibodies against Vipera lebetina venom nerve growth factor cross-react with other snake venom nerve growth factors. Molecular Immunology, 24 (12), 1295−1302.
1.1.
1987
Mähar, Andres; Siigur, Ene; Siigur, Jüri (1987). Purification and properties of a proteinase from Vipera lebetina (snake) venom. Biochimica et Biophysica Acta, 925, 272−281.
1.1.
1987
Siigur, Jüri; Arumäe, Urmas; Neuman, Toomas; Siigur, Ene; Saarma, Mart (1987). Monoclonal antibody immunoaffinity chromatography of the nerve growth factor from snake venoms. Comparative Biochemistry and Physiology, 87B (2), 329−384.
1.1.
1987
Samel, M.; Siigur, E.; Siigur, J. (1987). Purification and characterization of two arginine ester hydrolases from Vipera berus berus (common viper) venom. Toxicon, 25 (4), 379−388.
1.1.
1986
Siigur, J.; Arumäe, U.; Neuman, T.; Samel, M.; Siigur, E.; Saarma, M. (1986). Isolation and characterization of nerve growth factor from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 83 (3), 621−625.
1.1.
1985
Siigur, Ene; Neuman, Toomas; Järve, Viive; Ants, Tara; Siigur, Järi (1985). Isolation and characterization of nerve growth factor from Vipera lebetina (snake) venom. Comparative Biochemistry and Physiology, 81B (1), 211−215.
1.1.
1982
Siigur, Ene; Siigur, Jüri; Aaviksaar, Aavo; Kibirev, Vladimir; Fedoryak, Dimitri (1982). Separation of bradykinin-releasing enzyme from the proteolytic complex of Levantine viper venom. Biokhimia, 47 (10), 1730−1737.
1.1.
1979
Raba, Raivo; Aaviksaar, Aavo;, Raba, Mari; Siigur, Jüri (1979). Cobra Venom Acetylcholinesterase. Purification and Molecular Properties. European Journal of Biochemistry, 96, 151−158.
1.1.
1979
Siigur, E.; Siigur, J.; Nõmmeots (Samel), M.; Ilomets, T. (1979). Fractionation and enzymatic activities of common viper (Vipera berus berus) venom. Toxicon, 17 (6), 623−630.
22.04.2019

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF7251Biomeditsiiniliselt olulised valgud ja peptiidid madude mürkidestl01.01.200731.12.2010Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut54 053,92 EUR
SFSF0222603s03Funktsionaalne proteoomika - struktuuri-aktiivsuse seosed ning molekulaarne äratundmine looduslikes valgukooslustes01.01.200331.12.2007Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut643 270,75 EUR
ETFETF5554Hemostaasi, angiogeneesi ja apoptoosi mõjutavad valgud viperiidsete madude mürkidest.01.01.200331.12.2006Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut29 542,52 EUR
HLKHLK04-4Loodusteaduslikud kogud rakubioloogilistes ja –toksikoloogilistes uuringutes01.01.200431.12.2008Anne KahruKeemilise ja Bioloogilise Füüsika Instituut63 763,07 EUR
ETFETF8899Maomürkide valgud ja peptiidid kui bioloogiliste protsesside modulaatorid01.01.201131.12.2014Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut48 000,00 EUR
SFSF0690063s08Mehhanismid ja interaktsioonid toksikoloogias ja toksinoloogias: in vitro mudelid01.01.200831.12.2013Anne KahruKeemilise ja Bioloogilise Füüsika Instituut1 126 446,52 EUR
IUTIUT23-5Nanoökotoksikoloogia ja sidusuuringud (ToxBe)01.01.201431.12.2019Anne KahruKeemilise ja Bioloogilise Füüsika Instituut1 327 800,00 EUR
MUUKBFI,MG-8Rästiku mürgi kvaliteedi hindamine27.11.200731.05.2008Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut6 391,16 EUR