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Külli Jaako

https://etis.ee/CV/Külli Jaako/eng
4.12.1976
737 4354
kulli.jaako@ut.ee

Career

Institutions and positions
01.07.2019–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Senior Research Fellow in Pharmacology (0,30)
01.07.2019–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Associate Professor in Pharmacology (0,70)
01.07.2017–30.06.2019   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Senior Research Fellow in Pharmacology (0,50)
01.01.2016–30.06.2019   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Associate Professor in Pharmacology (0,50)
21.05.2013–31.08.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Assistant in Pharmacology (0,50)
2012–2013   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, farmakoloogia vanemteadur (1,00)
01.09.2011–31.08.2015   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, Assistant (0,50)
01.09.2011–20.05.2013   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Senior Assistant in Pharmacology (0,50)
2011–2013   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, farmakoloogia vanemassistent (1,00)
01.07.2009–30.06.2012   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Research Fellow in Pharmacology (0,50)
15.02.2007–31.08.2007   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Senior Assistant extraordinarius (0,50)
2007–31.08.2011   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, farmakoloogia vanemassistent (0,50)
01.07.2006–30.06.2009   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Research Fellow (0,50)
01.02.2006–31.10.2006   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Assistant extraordinarius (0,50)
2006–2007   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, farmakoloogia assistent (1,00)
01.09.2005–31.01.2006   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Assistant extraordinarius (1,00)
07.02.2005–31.08.2005   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Senior Assistant extraordinarius (0,25)
01.09.2004–06.02.2005   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Senior Assistant extraordinarius (0,50)
2004–2005   
University of Tartu, Faculty of Medicine, Department of Pharmacology, Chair of Pharmacology and Toxicology, erakorraline vanemassistent (0,50)
2003–2003   
University of Tartu, Assistant (0,25)
2000–2002   
University of Tartu, Extraordinary Researcher (0,50)
 
 
Education
2000–2006   
Postgraduate student ad the Department of Pharmacology, University of Tartu
1995–2000   
Medical Faculty of Universty of Tartu. Department of Pharmay
 
 
R&D related managerial and administrative work
2000−...   
Member of the Estonian Society of Pharmacology
2009−2016   
Member of Ethics Review Committee on Human Research of the University of Tartu

Qualifications

Academic degrees
Külli Jaako, Doctor's Degree, 2006, (sup) Aleksandr Žarkovski, Studies on the role of adult neurogenesis in brain plasticity (Studies on the role of adult neurogenesis in brain plasticity), University of Tartu, Faculty of Medicine.
 
 
Honours & awards
2012, Külli Jaako, ECNP Poster Awards at the 25th ECNP Congress, Vienna, Austria
2009, Külli Jaako, Poster award in 10th ECNP Regional Meeting
2003, Külli Jaako, Raefond Scholarship
2003, Külli Jaako, III award from Ministry of Education
2002, Külli Jaako, Liisa Kolumbus Foundation Scholarship
2000, Külli Jaako, III award from Ministry of Education
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS CLASSIFICATION: B760 Psychonomics
ETIS CLASSIFICATION: 3. Health; 3.3. Pharmacy; CERCS CLASSIFICATION: B740 Pharmacological sciences, pharmacognosy, pharmacy, toxicology
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

1.1. Scholarly articles indexed by Web of Science Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index and/or indexed by Scopus (excluding chapters in books)
 
Natunen Teemu, Gynther Mikko, Rostalski Hannah, Jaako Külli, Jalkanen Aaro (2019).

Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.

. Basic & Clinical Pharmacology & Toxicology, 124 (1), 40−49.10.1111/bcpt.13094.
 
Koiv, Kadri; Vares, Marten; Kroon, Cristina; Metelitsa, Mait; Tiitsaar, Kai; Laugus, Karita; Jaako, Kulli; Harro, Jaanus (2019). Effect of chronic variable stress on sensitization to amphetamine in high and low sucrose-consuming rats. Journal of Psychopharmacology, 33 (12), 1512−1523.10.1177/0269881119856000.
 
Höfling, C.; Kulesskaya, N.; Jaako, K.; Peltonen, L.; Männistö, P.T.; Nurmi, A.; Vartiainen, N.; Morawski, M.; Zharkovsky, A.; Võikar, V.; Rössner, S.; Garcia-horsman, J.A. (2016). Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume. European Neuropsychopharmacology, 1−14.10.1016/j.euroneuro.2016.02.015.
 
Kõiv, Kadri; Metelitsa, Mait, Vares, Marten, Tiitsaar, Kai, Raudkivi, Karita; Jaako, Külli; Vulla, Kaspar; Shimmo, Ruth; Harro, Jaanus (2016). Chronic variable stress prevents amphetamine-elicited 50-kHz calls in rats with low positive affectivity. European Neuropsychopharmacology, 26 (4), 631−643.
 
Jaako, Külli; Waniek,Alexander; Parik,Keiti; Klimaviciusa, Linda; Aonurm-Helm, Anu; Noortoots, Aveli; Anier, Kaili; Van Elzen, Roos; Gérard,Melanie; Lambeir, Anne-Marie; Roßner,Steffen; Morawski, Markus; Zharkovsky, Alexander (2016).

Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro.

. Journal of Cell Science, 129 (20), 3792−3802.10.1242/jcs.181891.
 
Aonurm-Helm, Anu, Jaako, Külli, Jürgenson, Monika, Zharkovsky Aleksandr (2016).

Pharmacological approach for targeting dysfunctional brain plasticity: Focus on neural cell adhesion molecule (NCAM).

. Pharmacological Research, 113 (part B), 731−738.10.1016/j.phrs.2016.04.011.
 
Lobanovskaya, N.; Zharkovsky, T.; Jaako, K.; Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2015). PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood. Brain Research, 1625, 9−17.10.1016/j.brainres.2015.08.008.
 
Klimaviciusa, Linda; Jain, Rajeev Kumar; Jaako, Külli; Van Elzen, Roos; Gerard, Melanie ; van Der Veken, Pieter; Lambeir, Anne-Marie ; Zharkovsky, Alexander (2012). In situ prolyl oligopeptidase activity assay in neural cell cultures. Journal of Neuroscience Methods, 204 (1), 104−110.10.1016/j.jneumeth.2011.11.011.
 
Enevoldsen, M.i; Kochoyan, A.; Jürgenson, M.; Jaako, K.; Dmytriyeva, O.; Walmod, P.r; Nielsen, J.; Nielsen, J.; Li, S.; Korshunova, I.; Klementiev, B.; Novikova, T.; Zharkovsky, A.; Berezin, V.; Bock, E. (2012). Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM. Neurobiology of Disease, 48 (3), 533−545.10.1016/j.nbd.2012.07.016.
 
Jaako, K.; Aonurm-Helm, A.; Kalda, A.; Anier, K.; Zharkovsky, T.; Shastin, A.; Zharkovsky, A. (2011). Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus. European Journal of Pharmacology, 666, 61−71.10.1016/j.ejphar.2011.05.008.
 
Procaccini, Chiara; Aitta-Aho, Teemu; Jaako-Movits, Külli; Zharkovsky, Aleksander; Panhelainen, Anne; Sprengel, Rolf; Linden, Anni-Maia; Korpi, Esa (2011). Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. European Journal of Neuroscience, 33 (1), 161−174.10.1111/j.1460-9568.2010.07485.
 
Jaako K., Zharkovskaja T., Zharkovski A. (2009). Effects of repeated citalopram treatment on kainic acid-induced neurogenesis in adult mouse hippocampus. Brain Research, 1288, 18−28.10.1016/j.brainres.2009.06.089.
 
Jaako, K.; Zharkovsky, T.; Zharkovsky, A. (2009). Effects of repeated citalopram administration on kainic acid-induced neurogenesis in adult mouse hippocampus. Brain Research, 1288, 18−28.10.1016/j.brainres.2009.06.089.
 
Jaako-Movits, K., Zharkovsky, T.; Pedersen, M.; Zharkovsky, A. (2006). Decreased Hippocampal Neurogenesis Following Olfactory Bulbectomy is Reversed by Repeated Citalopram Administration. Cellular and Molecular Neurobiology, 26, 1559−1570.10.1007/s10571-006-9090-4.
 
Heidmets, L.T.; Zharkovsky, T.; Jurgenson, M.; Jaako-Movits, K.; Zharkovsky, A. (2006). Early post-natal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus. Neurotoxicology, 27 (1), 39−43.
 
Jaako-Movits, K.; Zharkovsky, A. (2005). Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats. European Journal of Neuroscience, 22 (11), 2871−2878.
 
Jaako-Movits, K.; Zharkovsky, T.; Romantchik, O.; Jürgenson, M.; Merisalu, E.; Heidmets, L.T.; Zharkovsky, A. (2005). Developmental lead exposure impairs contextual fear conditioning and reduces adult hippocampal neurogenesis in the rat brain. International Journal of Developmental Neuroscience, 23 (7), 627−635.10.1016/j.ijdevneu.2005.07.005.
 
Zharkovsky, T.; Kaasik, A.; Jaako, K.; Zharkovsky, A. (2003). Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after a single administration of ethanol. Brain Research, 978, 115−123.
 
Jaako, K.; Zharkovsky, T.; Kaasik, A.; Zharkovsky, A. (2003). Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances, production of the neural progenitor cells in the adult mouse dentate gyrus. Neuroscience Research Communications, 33 (3), 158−167.
 
Kaasik, A.; Kalda, A.; Jaako, K.; Zharkovsky, A. (2001). Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. Neuroscience, 102 (2), 427−432.
5.1. Conference abstracts indexed by Thomson Reuters Web of Science
 
Jaako K., Žarkovskaja T., Žarkovski A. (2009). Effects of chronic citalopram treatment on the kainic acid induced neurogenesis in adult mouse hippocampus. European Neuropsychopharmacology, 19, S132−S133.10.1016/S0924-977X(09)70139-7.
 
Jaako-Movits, K.; Zharkovsky, T.; Kaasik, A.; Zharkovsky, A. (2005). Chronic ethanol administration and hippocampal neurogenesis. European Neuropsychopharmacology, 15, S271−S271.
 
Zharkovsky, A.; Jaako, K.; Zharkovsky, T.; Beljaev, S. (2003). Addictive drugs and hippocampal neurogenesis. European Journal of Pharmaceutical Sciences, 19, S6−S6.
5.2. Conference abstracts that do not belong to section 5.1
 
Jaako, Külli; Zharkovsky, Aleksander (2012). The effect of citalopram treatment on lipopolysaccharide-induced alterations in contextual learning and brain plasticity in the adult mouse hippocampus. European Neuropsychopharmacology, 22: 25th ECNP Congress. x, S302−S303. (2).10.1016/S0924-977X(12)70461-3.
 
Jaako, K.; Shastin, D.; Zharkovsky, A. (2010). Impaired contextual learning and alterations in hippocampal neurogenesis in adult mouse brain following subchronic LPS administration is reversed by chronic citalopram administration. In: FENS Abstr., vol.5, 050.60, 2010 (x).FENS Forum 2010 - Amsterdam. (050.60).
 
Jaako, K.; Helmdorf, M.; Zharkovski, A. (2008). Chronic citalopram treatment counteracts kainic aic induced increase in the PSA-NCAM expressing cells and avoids migration. European Neuropharmacology, 18: 21. ECNP Kongress; Barcelona, Hispaania; 30.08-3008-03.09.2008. _EditorsAbbr van Ree, J.M.; Montgomery, S.A. Holland: Elsevier, 288. (4).
 
Jaako, K.; Zharkovsky, T.; Pedersen, M.; Zharkovsky, A. (2006). Decreased hippocampal neurogenesis following olfactory bulbectomy is reversed by repeated citalopram administration. Central/East European CINP Regional Meeting; Tallinn, Estonia; October 5-7, 2006. Tartu Ülikooli Kirjastus, 36−37.
 
Romantchik, O.; Zharkovskaja, T.; Jaako, K.; Jürgenson, M.; Zharkovsky, A. (2004). Lead exposure during the early postnatal period reduces neurogenesis and causes a deficit in spatial learning and memory consolidation. Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact and Applied Sciences, 58 (1): International Conference "Pharmacology in Latvia: Stepping into the 21st century". Riga: The Latvian Academy of Sciences, A10.
 
Jaako, K.; Zharkovskja, T., Kaasik, A.; Zharkovsky, A. (2004). Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances. Production of the neural progenitor cells in the adult mouse dentate gyrus. Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact and Applied Sciences, 58 (1): International Conference "Pharmacology in Latvia: Stepping into the 21st century". The Latvian Academy of Sciences, A9.
 
Zharkovsky, A.; Jaako, K.; Zharkovsky, T.; Beljaev, S.; Kaasik, A. (2003). Effects of addictive drugs on adult hippocampal neurogenesis. Trastornos adictivos. Spain: Centro de Documentacion del Plan Nacional sobre Drogas, 130. (5(2)).
6.2. Textbooks and other study materials (excluding university textbooks)
 
Žarkovskaja, T.; Jaako, K.; Žarkovski, A. (2009). Raviainete klassifikatsioon.
6.3. Popular science articles
 
Jaako, Külli (2010). Kas on õige müüa käsimüügiravimeid poes? Lege Artis, 2, 33−35.
 
Jaako, Külli (2010). Reumatoidartriidi ravimid. Lege Artis, 2, 19−24.
24.04.2020

Külli Jaako

https://etis.ee/CV/Külli Jaako/est
4.12.1976
737 4354
kulli.jaako@ut.ee

Teenistuskäik

Töökohad ja ametid
01.07.2019–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, farmakoloogia vanemteadur (0,30)
01.07.2019–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, farmakoloogia dotsent (0,70)
01.07.2017–30.06.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, farmakoloogia vanemteadur (0,50)
01.01.2016–30.06.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, farmakoloogia dotsent (0,50)
21.05.2013–31.08.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, farmakoloogia vanemassistent (0,50)
2012–2013   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, farmakoloogia vanemteadur (1,00)
01.09.2011–31.08.2015   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, Farmakoloogia vanemassistent (0,50)
01.09.2011–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia vanemassistent (0,50)
2011–2013   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, farmakoloogia vanemassistent (1,00)
01.07.2009–30.06.2012   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia teadur (0,50)
15.02.2007–31.08.2007   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia erakorraline vanemassistent (0,50)
2007–31.08.2011   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, farmakoloogia vanemassistent (0,50)
01.07.2006–30.06.2009   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia teadur (0,50)
01.02.2006–31.10.2006   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia erakorraline assistent (0,50)
2006–2007   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, farmakoloogia assistent (1,00)
01.09.2005–31.01.2006   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, farmakoloogia erakorraline assistent (1,00)
07.02.2005–31.08.2005   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, erakorraline vanemassistent (0,25)
01.09.2004–06.02.2005   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, erakorraline vanemassistent (0,50)
2004–2005   
Tartu Ülikool, Arstiteaduskond, Farmakoloogia instituut, Farmakoloogia ja toksikoloogia õppetool, erakorraline vanemassistent (0,50)
2003–2003   
Tartu Ülikool, erakorraline assistent (0,25)
2000–2002   
Tartu Ülikool, Erakorraline teadur (0,50)
 
 
Haridustee
2000–2006   
Tartu Ülikool. Arstiteaduskond. Doktoriõpe
1995–2000   
Tartu Ülikool. Arstiteaduskond. Proviisoriõpe
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2000−...   
Eesti Farmakoloogia Seltsi liige
2009−2016   
Tartu Ülikooli inimuuringute eetika komitee liige

Kvalifikatsioon

Teaduskraadid
Külli Jaako, Doctor's Degree, 2006, (sup) Aleksandr Žarkovski, Studies on the role of adult neurogenesis in brain plasticity (Studies on the role of adult neurogenesis in brain plasticity), University of Tartu, Faculty of Medicine.
 
 
Teaduspreemiad ja tunnustused
2012, Külli Jaako, ECNP 25. Kongressi postriauhind, Viin, Austria
2009, Külli Jaako, 10. ECNP Regionaalkonverentsi postri auhind
2003, Külli Jaako, Raefondi Stipendium
2003, Külli Jaako, Haridusministeeriumi poolt välja kuulutatud teadustööde konkursi III premia
2002, Külli Jaako, Liisa Kolumbuse nimelise Fondi Stipendium
2000, Külli Jaako, Haridusministeeriumi poolt välja kuulutatud teadustööde konkursi III premia
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS KLASSIFIKAATOR: B760 Psühhonoomika
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.3. Farmaatsia; CERCS KLASSIFIKAATOR: B740 Farmakoloogia, farmakognoosia, farmaatsia, toksikoloogia

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

1.1. Scholarly articles indexed by Web of Science Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index and/or indexed by Scopus (excluding chapters in books)
 
Natunen Teemu, Gynther Mikko, Rostalski Hannah, Jaako Külli, Jalkanen Aaro (2019).

Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.

. Basic & Clinical Pharmacology & Toxicology, 124 (1), 40−49.10.1111/bcpt.13094.
 
Koiv, Kadri; Vares, Marten; Kroon, Cristina; Metelitsa, Mait; Tiitsaar, Kai; Laugus, Karita; Jaako, Kulli; Harro, Jaanus (2019). Effect of chronic variable stress on sensitization to amphetamine in high and low sucrose-consuming rats. Journal of Psychopharmacology, 33 (12), 1512−1523.10.1177/0269881119856000.
 
Höfling, C.; Kulesskaya, N.; Jaako, K.; Peltonen, L.; Männistö, P.T.; Nurmi, A.; Vartiainen, N.; Morawski, M.; Zharkovsky, A.; Võikar, V.; Rössner, S.; Garcia-horsman, J.A. (2016). Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume. European Neuropsychopharmacology, 1−14.10.1016/j.euroneuro.2016.02.015.
 
Kõiv, Kadri; Metelitsa, Mait, Vares, Marten, Tiitsaar, Kai, Raudkivi, Karita; Jaako, Külli; Vulla, Kaspar; Shimmo, Ruth; Harro, Jaanus (2016). Chronic variable stress prevents amphetamine-elicited 50-kHz calls in rats with low positive affectivity. European Neuropsychopharmacology, 26 (4), 631−643.
 
Jaako, Külli; Waniek,Alexander; Parik,Keiti; Klimaviciusa, Linda; Aonurm-Helm, Anu; Noortoots, Aveli; Anier, Kaili; Van Elzen, Roos; Gérard,Melanie; Lambeir, Anne-Marie; Roßner,Steffen; Morawski, Markus; Zharkovsky, Alexander (2016).

Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro.

. Journal of Cell Science, 129 (20), 3792−3802.10.1242/jcs.181891.
 
Aonurm-Helm, Anu, Jaako, Külli, Jürgenson, Monika, Zharkovsky Aleksandr (2016).

Pharmacological approach for targeting dysfunctional brain plasticity: Focus on neural cell adhesion molecule (NCAM).

. Pharmacological Research, 113 (part B), 731−738.10.1016/j.phrs.2016.04.011.
 
Lobanovskaya, N.; Zharkovsky, T.; Jaako, K.; Jürgenson, M.; Aonurm-Helm, A.; Zharkovsky, A. (2015). PSA modification of NCAM supports the survival of injured retinal ganglion cells in adulthood. Brain Research, 1625, 9−17.10.1016/j.brainres.2015.08.008.
 
Klimaviciusa, Linda; Jain, Rajeev Kumar; Jaako, Külli; Van Elzen, Roos; Gerard, Melanie ; van Der Veken, Pieter; Lambeir, Anne-Marie ; Zharkovsky, Alexander (2012). In situ prolyl oligopeptidase activity assay in neural cell cultures. Journal of Neuroscience Methods, 204 (1), 104−110.10.1016/j.jneumeth.2011.11.011.
 
Enevoldsen, M.i; Kochoyan, A.; Jürgenson, M.; Jaako, K.; Dmytriyeva, O.; Walmod, P.r; Nielsen, J.; Nielsen, J.; Li, S.; Korshunova, I.; Klementiev, B.; Novikova, T.; Zharkovsky, A.; Berezin, V.; Bock, E. (2012). Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM. Neurobiology of Disease, 48 (3), 533−545.10.1016/j.nbd.2012.07.016.
 
Jaako, K.; Aonurm-Helm, A.; Kalda, A.; Anier, K.; Zharkovsky, T.; Shastin, A.; Zharkovsky, A. (2011). Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus. European Journal of Pharmacology, 666, 61−71.10.1016/j.ejphar.2011.05.008.
 
Procaccini, Chiara; Aitta-Aho, Teemu; Jaako-Movits, Külli; Zharkovsky, Aleksander; Panhelainen, Anne; Sprengel, Rolf; Linden, Anni-Maia; Korpi, Esa (2011). Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. European Journal of Neuroscience, 33 (1), 161−174.10.1111/j.1460-9568.2010.07485.
 
Jaako K., Zharkovskaja T., Zharkovski A. (2009). Effects of repeated citalopram treatment on kainic acid-induced neurogenesis in adult mouse hippocampus. Brain Research, 1288, 18−28.10.1016/j.brainres.2009.06.089.
 
Jaako, K.; Zharkovsky, T.; Zharkovsky, A. (2009). Effects of repeated citalopram administration on kainic acid-induced neurogenesis in adult mouse hippocampus. Brain Research, 1288, 18−28.10.1016/j.brainres.2009.06.089.
 
Jaako-Movits, K., Zharkovsky, T.; Pedersen, M.; Zharkovsky, A. (2006). Decreased Hippocampal Neurogenesis Following Olfactory Bulbectomy is Reversed by Repeated Citalopram Administration. Cellular and Molecular Neurobiology, 26, 1559−1570.10.1007/s10571-006-9090-4.
 
Heidmets, L.T.; Zharkovsky, T.; Jurgenson, M.; Jaako-Movits, K.; Zharkovsky, A. (2006). Early post-natal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus. Neurotoxicology, 27 (1), 39−43.
 
Jaako-Movits, K.; Zharkovsky, A. (2005). Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats. European Journal of Neuroscience, 22 (11), 2871−2878.
 
Jaako-Movits, K.; Zharkovsky, T.; Romantchik, O.; Jürgenson, M.; Merisalu, E.; Heidmets, L.T.; Zharkovsky, A. (2005). Developmental lead exposure impairs contextual fear conditioning and reduces adult hippocampal neurogenesis in the rat brain. International Journal of Developmental Neuroscience, 23 (7), 627−635.10.1016/j.ijdevneu.2005.07.005.
 
Zharkovsky, T.; Kaasik, A.; Jaako, K.; Zharkovsky, A. (2003). Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after a single administration of ethanol. Brain Research, 978, 115−123.
 
Jaako, K.; Zharkovsky, T.; Kaasik, A.; Zharkovsky, A. (2003). Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances, production of the neural progenitor cells in the adult mouse dentate gyrus. Neuroscience Research Communications, 33 (3), 158−167.
 
Kaasik, A.; Kalda, A.; Jaako, K.; Zharkovsky, A. (2001). Dehydroepiandrosterone sulphate prevents oxygen-glucose deprivation-induced injury in cerebellar granule cell culture. Neuroscience, 102 (2), 427−432.
5.1. Conference abstracts indexed by Thomson Reuters Web of Science
 
Jaako K., Žarkovskaja T., Žarkovski A. (2009). Effects of chronic citalopram treatment on the kainic acid induced neurogenesis in adult mouse hippocampus. European Neuropsychopharmacology, 19, S132−S133.10.1016/S0924-977X(09)70139-7.
 
Jaako-Movits, K.; Zharkovsky, T.; Kaasik, A.; Zharkovsky, A. (2005). Chronic ethanol administration and hippocampal neurogenesis. European Neuropsychopharmacology, 15, S271−S271.
 
Zharkovsky, A.; Jaako, K.; Zharkovsky, T.; Beljaev, S. (2003). Addictive drugs and hippocampal neurogenesis. European Journal of Pharmaceutical Sciences, 19, S6−S6.
5.2. Conference abstracts that do not belong to section 5.1
 
Jaako, Külli; Zharkovsky, Aleksander (2012). The effect of citalopram treatment on lipopolysaccharide-induced alterations in contextual learning and brain plasticity in the adult mouse hippocampus. European Neuropsychopharmacology, 22: 25th ECNP Congress. x, S302−S303. (2).10.1016/S0924-977X(12)70461-3.
 
Jaako, K.; Shastin, D.; Zharkovsky, A. (2010). Impaired contextual learning and alterations in hippocampal neurogenesis in adult mouse brain following subchronic LPS administration is reversed by chronic citalopram administration. In: FENS Abstr., vol.5, 050.60, 2010 (x).FENS Forum 2010 - Amsterdam. (050.60).
 
Jaako, K.; Helmdorf, M.; Zharkovski, A. (2008). Chronic citalopram treatment counteracts kainic aic induced increase in the PSA-NCAM expressing cells and avoids migration. European Neuropharmacology, 18: 21. ECNP Kongress; Barcelona, Hispaania; 30.08-3008-03.09.2008. _EditorsAbbr van Ree, J.M.; Montgomery, S.A. Holland: Elsevier, 288. (4).
 
Jaako, K.; Zharkovsky, T.; Pedersen, M.; Zharkovsky, A. (2006). Decreased hippocampal neurogenesis following olfactory bulbectomy is reversed by repeated citalopram administration. Central/East European CINP Regional Meeting; Tallinn, Estonia; October 5-7, 2006. Tartu Ülikooli Kirjastus, 36−37.
 
Romantchik, O.; Zharkovskaja, T.; Jaako, K.; Jürgenson, M.; Zharkovsky, A. (2004). Lead exposure during the early postnatal period reduces neurogenesis and causes a deficit in spatial learning and memory consolidation. Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact and Applied Sciences, 58 (1): International Conference "Pharmacology in Latvia: Stepping into the 21st century". Riga: The Latvian Academy of Sciences, A10.
 
Jaako, K.; Zharkovskja, T., Kaasik, A.; Zharkovsky, A. (2004). Ethanol intoxication reduces, whereas ethanol withdrawal transiently enhances. Production of the neural progenitor cells in the adult mouse dentate gyrus. Proceedings of the Latvian Academy of Sciences. Section B: Natural, Exact and Applied Sciences, 58 (1): International Conference "Pharmacology in Latvia: Stepping into the 21st century". The Latvian Academy of Sciences, A9.
 
Zharkovsky, A.; Jaako, K.; Zharkovsky, T.; Beljaev, S.; Kaasik, A. (2003). Effects of addictive drugs on adult hippocampal neurogenesis. Trastornos adictivos. Spain: Centro de Documentacion del Plan Nacional sobre Drogas, 130. (5(2)).
6.2. Textbooks and other study materials (excluding university textbooks)
 
Žarkovskaja, T.; Jaako, K.; Žarkovski, A. (2009). Raviainete klassifikatsioon.
6.3. Popular science articles
 
Jaako, Külli (2010). Kas on õige müüa käsimüügiravimeid poes? Lege Artis, 2, 33−35.
 
Jaako, Külli (2010). Reumatoidartriidi ravimid. Lege Artis, 2, 19−24.
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ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
SFSF0182135As02Pharmacotherapy of affective disorders and neurodegenerative diseases01.01.200231.12.2006Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine360 589,52 EUR
ETFETF7482The modulatory effects of citalopram on brain plasticity01.01.200831.12.2009Külli JaakoUniversity of Tartu, Faculty of Medicine29 312,44 EUR
ETFETF8740The effects of antidepressant treatment in the pathogenetic mechanisms of neuroinflammation in the brain01.01.201131.12.2012Külli JaakoUniversity of Tartu, Faculty of Medicine28 308,00 EUR
PRGPRG878Exploration of the therapeutic potential of the active vitamin D analogues: focus on the mood disorders and obesity01.01.202031.12.2024Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine257 125,00 EUR
IUTIUT2-3Neural cell adhesion molecules as potential therapeutic targets for the correction of dysfunctional brain plasticity01.01.201331.12.2018Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine1 008 000,00 EUR
ETFETF6504The role of neuronal plasticity molecules (NCAMs) in the brain plasticity and repair01.01.200531.12.2008Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine77 844,37 EUR
ETFETF7955The roles of neural cell adhesion molecule (NCAM) in brain plasticity: new pharmacological approach for treatment of depression 01.01.200931.12.2012Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine73 626,70 EUR
SFSF0180059s07Novel therapeutic strategies for treatment of neurodegeneration and psychiatric disorders.01.01.200731.12.2012Aleksandr ŽarkovskiUniversity of Tartu, Faculty of Medicine791 857,51 EUR