See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Kaiu Prikk

https://etis.ee/CV/Kaiu_Prikk/est
10.01.1966
56988426
6204439
kaiu.prikk@gmail.com

Teenistuskäik

Töökohad ja ametid
01.01.2010–...   
AS Medicum- pulmonoloog
2007–31.12.2016   
Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut , Dotsent (0,50)
2007–31.08.2012   
Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut , Vanemteadur (0,50)
2006–2007   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, Teadur (0,50)
01.01.2003–31.12.2010   
pulmonoloog- vanemarst, SA Põhja- Eesti Regionaalhaigla, Sisekliinik, Pulmonoloogiakeskus
01.01.2001–31.12.2002   
Kopsuarst, Ida-Tallinna Keskhaigla
01.01.2001–31.12.2005   
Teadur Kopsuhaiguste Uurimise Ühing, Tervise Arengu Instituut
01.01.1994–31.12.2000   
Kopsuarst Tartu Ülikooli Kopsukliinik
01.01.1991–31.12.1994   
Resident Tartu ülikooli Kopsukliinik
01.01.1990–31.12.1991   
Intern Tartu Ülikooli Kopsukliinik
 
 
Haridustee
2006–2006   
Emerging Leaders in Respiratory Medicine
2006–2006   
Majandusalane baaskursus meditsiinitöötajatele
2001–2001   
Good clinical practice in clinical trials
1999–2003   
Helsingi Ülikool, Arstiteaduskond, doktorantuur
1996–1996   
Helsingi Ülikooli Biomeditsiini Instituut, õppetöö
1996–2000   
Tartu Ülikool, Artsiteaduskond, doktorantuur
1991–1994   
Tartu Ülikooli Kopsukliinik, residentuur
1990–1991   
Tartu Ülikool, Arstiteaduskond, internatuur
1984–1990   
Tartu Ülikool, Arstiteaduskond, ravi eriala
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2014−...   
Study 117106: Mepolizumab vs. Placebo as add-on treatment for frequently exacerbating COPD patients
2013−...   
liige, American Thoracic Society
1992−...   
Kopsuarstide Seltsi liige
2011−2012   
vastutav uurija, ravimimuuring Koormustaluvuse uuring, et hinnata ravi toimeid kahte kombineeritud bronhodilataatorit (GSK573719/GW642444) saavatel KOK-i haigetel patsientidel
2010−2011   
vastutav uurija, ravimuurnin Mitmekeskuseline, avatud, annuseid võrdlev uuring selgitamaks intravenoosselt ja subkutaanselt manustatava mepolizumabi farmakokineetikat ja farmakodünaamikat astmahaigetel täiskasvanutel, kellel on tõusnud eosinofiilide
2010−2011   
pal investigator, clinical tria; AC4113589- A randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of GSK573719 delivered once-daily over 28 days in subjects with COPD
 
 
Lisainfo
Õppetöö aruanne:
Õppetöö
Loengukursused:
1) DMK0041- Biomeditsiin; kursus on TTÜ geenitehnoloogia bakalaureuse õppe I kursuse üliõpilastele alates 20007/2008 õppeaasta kevadsemestrist
2) DMK1070- "Inimese õpetus" 2009/2010, 2010/2011 õppeaasta sügissemester
3) DMK1020- "Haigusõpetus ja arstiabii" alates 2011/12 õppeaasta sügissemestrist.

Loengud:
1. Loeng "Inimmaterjali kasutamine laboratoorses praktikas“ loengukursuse YXX0010 „Riski- ja ohutusõpetus keemia ja biotehnoloogia“ raames
2. Loeng „Morfoloogilised uuringud haiguste diagnoosimisel“ loengukursuse YTD0011 Molekulaardiagnostika raames

Õppekavade koostamine:
Tervihoiutehnoloogia magistriõppekavad YVEM09/09 ja YVEM09/11


Bakalaureuse tööde juhendamine
1. Maarika Rool, lõpetas 2007
2. Anna Ussatjuk, lõpetas 2008
3. Ester Orav, lõpetas 2008
4. Berit Pilden, lõpetas 2009
5. Ruth Küüsmaa, lõpetas 2010
6. Maria Kärm, lõpetas 2011

Kvalifikatsioon

Teaduskraadid
Kaiu Prikk, doktorikraad, 2003, (juh) Ruth Sepper; Timo Sorsa; Päivi Maisi, Development of tissue injury in chronic inflammatory airway diseases with special respect to matrix metalloproteinases, University of Helsinki, Medical Faculty, Helsinki, Finland.
 
 
Teaduspreemiad ja tunnustused
2005, Kaiu Prikk, Ruth Sepper, aastapreemia kandidaat, Eesti Vabariigi teaduspreemia arstiteadustes
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin; TÄPSUSTUS: Proteolüütiliste ensüümide osa koekahjustuse tekkes ja arengus krooniliste põletikuliste kopsuhaiguste korral nagu bronhiaalastma, krooniline obstruktiivne kopsuhaigus, bronhiektaasitõbi
 
 
Lisainfo
doctor of medical science
Unversity of Helsinki, Medical Faculty, Finland, 2003

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
5.2.
2013
Prikk, K.; Pilden, B.; Sepper, R. (2013). Lung Volume And Diffusing Capacity Changes In Chronic Smokers Can Predict The Early-Onset Of COPD. American Thoracic Society International Conference Abstracts: American Thoracic Society 2013 International Conference, Philadelphia Pennsylvania, May 17-22, 2013.
5.2.
2013
Sepper, R.; Prikk, K.; Pilden, B.; Karm, M.; Fehniger, T. (2013). Macrophage Polarization Is Associated With Accelerated MUC5B Expression By BALF Alveolar Macrophages In Smokers' Lung. American Thoracic Society International Conference Abstracts: American Thoracic Society 2013 International Conference, Philadelphia Pennsylvania, May 17-22, 2013.
1.1.
2012
Brjalin, V.; Salupere, R.; Tefanova, V.; Prikk, K.; Lapidus, N.; Jõeste, E. (2012). Sarcoidosis and chronic hepatitis C: A case report. World Journal of Gastroenterology, 18 (40), 5816−5820.10.3748/wjg.v18.i40.5816.
1.1.
2012
Sepper, R.; Prikk, K.; Metsis, M.; Sergejeva, S.; Pugatsjova, N.; Bragina, O.; Marran, S.; Fehniger, T. (2012). Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. Journal of Leukocyte Biology, 92 (2), 319−324.10.1189/jlb.0111047.
1.2.
2012
Marko-Varga, G.; Végvári, Á.; Rezeli, M.; Prikk, K.; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Fehniger, T. (2012). Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine. Clinical and Translational Medicine, 1, 9 pp. DOI: 10.1186/2001-1326-1-8.
1.1.
2011
Fehniger, T.E.; Végvári, A.; Rezeli, M.; Prikk, K; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Marko-Varga, G. (2011). Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Analytical Chemistry, 83 (21), 8329−8336. DOI: 10.1021/ac2014349.
1.1.
2011
Nagelmann, A.; Tonnov, A.; Laks, T.; Sepper, R.; Prikk, K. (2011). Lung Dysfunction of Chronic Smokers with No Signs of COPD. International Journal of Chronic Obstructive Pulmonary Disease, 7, 1−7.
5.2.
2010
Nagelmann, A.; Laks, T.; Sepper, R.; Prikk, K. (2010). Lung function abnormalities in chronic smokers with no signs of COPD. Amrerican Thoracic Society Annual Meeting, New-Orleans, 14-19.2010.
3.4.
2009
Prikk, K; Nagelmann, A; Minajeva, A; Sergejeva, S; Sepper, R. (2009). Changes In Bronchial Morphology Do Not Correspond To Clinical Signs Of COPD Patients Staged By GOLD. American Thoracic Society Interantional Conference, San-Diego, USA, 15-20 mai 2009.
6.6.
2007
Prikk, Kaiu (2007). Kombinatsioonravi võimalused astma raviskeemis-uus kontseptsioon. (19−20)..
5.2.
2006
Prikk, Kaiu; Anion, Eveli;Voodla, Caroli, Fehniger, Thomas, Dahlback, Magnus; Sepper, Ruth (2006). MUC5AC and MUC5B expression in epithelial cells and glandular cells of patients with chronic obstructive pulmonary disease. In: (A688).American Thoracic Society Annual Meeting, San-Diego, USA 2006.
5.2.
2005
Prikk, Kaiu; Lapidus, Natalia; Mukk, Pille; Sorsa, Timo;Sepper, Ruth (2005). Soluble laminin-5 gamma 2-chain in bronchoalveolar lavage fluid (BALF) from healthy controls and chronic inflammatory airway diseases. American Thoracic Society Annual Meeting, San-Diego, USA, 2005. A92.
1.1.
2004
Sepper, R.; Prikk, K. (2004). Proteomics: is it an approach to understand the progression of chronic lung disorders? Journal of Proteome Research, 3 (2), 277−281.
3.2.
2003
Prikk, K; Reintam, M-A.; Pirila, E.; Maisi, P.; Sorsa, T.; Sepper, R. (2003). Collagenase-2 expression by bronchial epithelial cells and macrophages in asthmatics´ airways. Journal of Allergy & Clinical Immunology, 40. JGC Editions, 295−300.
5.2.
2003
Prikk, Kaiu, Anion, Eveli; Voodla, Caroli; Sorsa, Timo; Sepper, Ruth (2003). MMP-8 cellular origins differ in the different chronic obstructive pulmonary diseases. A193.
1.1.
2002
Pirila, E.; Parikka, M.; Ramamurthy, N.S.; Maisi, P.; McClain, S.; Kucine, A.; Tervahartiala, T.; Prikk, K.; Golub, L.M.; Salo, T.; Sorsa, T. (2002). Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats:effects on matrix metalloproteinase-2, membrane type I matrix metalloproteinase, and laminin-5 gamma2-chain. Wound Repair and Regeneration, 10, 38−51.
1.1.
2002
Prikk, K.; Maisi, P.; Pirila, E.; Reintam, M. A.; Salo, T.; Sorsa, T.; Sepper, R. (2002). Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma. Laboratory Investigation, 82 (11), 1535−1545.
1.1.
2002
Maisi, P.; Prikk, K.; Sepper, R.; Pirila, E.; Salo, T.; Sorsa, T. (2002). Soluble membrane-type I matrix metalloproteinase (MMP-14) and gelatinase-A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis. Apmis, 110 (11), 771−782.
1.1.
2002
Henry, M. T.; McMahon, K.; Mackarel, A. J.; Prikk, K.; Sorsa, T.; Maisi, P.; Sepper, R.; Fitzgerald, M. X.; OConnor, C. M. (2002). Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF. European Respiratory Journal, 20 (5), 1220−1227.
1.1.
2001
Prikk, K.; Pirilä, E.; Sepper, R.; Maisi, P.; Walghren, J.; Salo, T.; Sorsa, T. (2001). In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. The Journal of Pathology, 194 (2), 232−238.
1.1.
2001
Prikk, K.; Maisi, P.; Sepper, R.; Stenman, U. H.; Salo, T.; Sorsa, T. (2001). Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human lbronchoalveolar lavage fluid in vivo. Annals of Medicine, 33 (6), 437−444.
1.1.
2001
Maisi, P.; Sorsa, T.; Raulo, S. M.; Prikk, K.; Sepper, R.; McGorum, B.; Kelly, E. A. (2001). Increased matrix metalloproteinase (MMP)-9 in the airway after allergen. American Journal of Respiratory and Critical Care Medicine, 164 (9), 1740.
1.1.
1999
Sepper, R.; Prikk, K.; Tervahartiala, T.; Konttinen, Y. T.; Maisi, P.; Lopez-Otin, C.; Sorsa, T. (1999). Collagense-2, and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis. Annals of New York Academy of Sciences, 30 (878), 683−685.
5.2.
1998
Sepper, R.; Prikk, K.; Altraja, A.; Meriste, S.; Sorsa, R. (1998). Novel collagenase-3/MMP-13 in BALF of severe bronchiectatics. European Respiratory Journal, 12. 134.
5.2.
1998
Prikk, K.; Altraja, A.; Sorsa, R.; Sepper, R. (1998). Highly activated MMP-9/type IV collagenase in asthma. European Respiratory Journal, 12. 31s.

Tööstusomand

25.11.2020

Kaiu Prikk

https://etis.ee/CV/Kaiu_Prikk/eng
10.01.1966
56988426
6204439
kaiu.prikk@gmail.com

Career

Institutions and positions
01.01.2010–...   
Lasnamäe Health Centre MEDICUM Ltd- pulmonologist
2007–31.12.2016   
Tallinn University of Technology , Technomedicum of TUT, Department of Clinical Medicine, Associate Professor (0,50)
2007–31.08.2012   
Tallinn University of Technology , Technomedicum of TUT, Department of Clinical Medicine, Senior Researcher (0,50)
2006–2007   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Researcher (0,50)
01.01.2003–31.12.2010   
North-Estonia Regional Hospital, Clinic of Internal Medicine, Centre of Pulmonology, pulmonary physician, senior doctor
01.01.2001–31.12.2002   
Tallinn Central Hospital , pulmonologist
01.01.2001–31.12.2005   
Researcher at the Unit for Lung Investigations, National Institute for Health Development
01.01.1994–31.12.2000   
Tartu University Lung Clinic, pulmonologist
01.01.1991–31.12.1994   
Tartu University Lung Clinic, special training on pulmonology
01.01.1990–31.12.1991   
Tartu University Lung Clinic, intership
 
 
Education
2006–2006   
Emerging Leaders in Respiratory Medicine
2006–2006   
Economic base course for health care workers
2001–2001   
Good clinical practice in clinical trials
1999–2003   
Ph.D. student at the University of Helsinki, Medical Faculty
1996–1996   
Post-graduate student, Institute of Biomedicine, University of Helsinki, Finland,
1996–2000   
Ph.D. student at the Tartu University from 1996-2000
1991–1994   
Tartu University Lung Clinic, special training on pulmonology
1990–1991   
Licentiate of internal medicine, Tartu University, medical doctor's licence
1984–1990   
Tartu University Medical Faculty
 
 
R&D related managerial and administrative work
2014−...   
principal investigator; clinical trial ; Study 117106: Mepolizumab vs. Placebo as add-on treatment for frequently exacerbating COPD patients
2013−...   
member, American Thoracic Society
1992−...   
member of Estonian Society of Lung Physicians
2011−2012   
principal investigator; clinical trial DB2114417 An exercise endurance study to evaluate the effects of treatment of COPD patients with a dual bronchodilator. GSK573719/GW642444
2010−2011   
principal investigator; clinical trial; A multicentre open label dose ranging study to determine the pharmacokinetics and pharmacodynamics of mepolizumab via subcutaneous administration in mild and moderate asthma subjects. [MEA114092]
2010−2011   
principal investigator, clinical trial; AC4113589- A randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of GSK573719 delivered once-daily over 28 days in subjects with COPD
 
 
Additional information
Õppetöö aruanne:
Õppetöö
Loengukursused:
1) DMK0041- Biomeditsiin; kursus on TTÜ geenitehnoloogia bakalaureuse õppe I kursuse üliõpilastele alates 20007/2008 õppeaasta kevadsemestrist
2) DMK1070- "Inimese õpetus" 2009/2010, 2010/2011 õppeaasta sügissemester
3) DMK1020- "Haigusõpetus ja arstiabii" alates 2011/12 õppeaasta sügissemestrist.

Loengud:
1. Loeng "Inimmaterjali kasutamine laboratoorses praktikas“ loengukursuse YXX0010 „Riski- ja ohutusõpetus keemia ja biotehnoloogia“ raames
2. Loeng „Morfoloogilised uuringud haiguste diagnoosimisel“ loengukursuse YTD0011 Molekulaardiagnostika raames

Õppekavade koostamine:
Tervihoiutehnoloogia magistriõppekavad YVEM09/09 ja YVEM09/11


Bakalaureuse tööde juhendamine
1. Maarika Rool, lõpetas 2007
2. Anna Ussatjuk, lõpetas 2008
3. Ester Orav, lõpetas 2008
4. Berit Pilden, lõpetas 2009
5. Ruth Küüsmaa, lõpetas 2010
6. Maria Kärm, lõpetas 2011

Qualifications

Academic degrees
Kaiu Prikk, Doctor's Degree, 2003, (sup) Ruth Sepper; Timo Sorsa; Päivi Maisi, Development of tissue injury in chronic inflammatory airway diseases with special respect to matrix metalloproteinases, University of Helsinki, Medical Faculty, Helsinki, Finland.
 
 
Honours & awards
2005, Kaiu Prikk, Ruth Sepper, nominee of yearly award, The National Science Award in medical sciences
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine
 
 
Additional information
The degree of Doctor of Medical Science University of Helsinki, Faculty of Medicine, 2003

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
5.2.
2013
Prikk, K.; Pilden, B.; Sepper, R. (2013). Lung Volume And Diffusing Capacity Changes In Chronic Smokers Can Predict The Early-Onset Of COPD. American Thoracic Society International Conference Abstracts: American Thoracic Society 2013 International Conference, Philadelphia Pennsylvania, May 17-22, 2013.
5.2.
2013
Sepper, R.; Prikk, K.; Pilden, B.; Karm, M.; Fehniger, T. (2013). Macrophage Polarization Is Associated With Accelerated MUC5B Expression By BALF Alveolar Macrophages In Smokers' Lung. American Thoracic Society International Conference Abstracts: American Thoracic Society 2013 International Conference, Philadelphia Pennsylvania, May 17-22, 2013.
1.1.
2012
Brjalin, V.; Salupere, R.; Tefanova, V.; Prikk, K.; Lapidus, N.; Jõeste, E. (2012). Sarcoidosis and chronic hepatitis C: A case report. World Journal of Gastroenterology, 18 (40), 5816−5820.10.3748/wjg.v18.i40.5816.
1.1.
2012
Sepper, R.; Prikk, K.; Metsis, M.; Sergejeva, S.; Pugatsjova, N.; Bragina, O.; Marran, S.; Fehniger, T. (2012). Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. Journal of Leukocyte Biology, 92 (2), 319−324.10.1189/jlb.0111047.
1.2.
2012
Marko-Varga, G.; Végvári, Á.; Rezeli, M.; Prikk, K.; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Fehniger, T. (2012). Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine. Clinical and Translational Medicine, 1, 9 pp. DOI: 10.1186/2001-1326-1-8.
1.1.
2011
Fehniger, T.E.; Végvári, A.; Rezeli, M.; Prikk, K; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Marko-Varga, G. (2011). Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Analytical Chemistry, 83 (21), 8329−8336. DOI: 10.1021/ac2014349.
1.1.
2011
Nagelmann, A.; Tonnov, A.; Laks, T.; Sepper, R.; Prikk, K. (2011). Lung Dysfunction of Chronic Smokers with No Signs of COPD. International Journal of Chronic Obstructive Pulmonary Disease, 7, 1−7.
5.2.
2010
Nagelmann, A.; Laks, T.; Sepper, R.; Prikk, K. (2010). Lung function abnormalities in chronic smokers with no signs of COPD. Amrerican Thoracic Society Annual Meeting, New-Orleans, 14-19.2010.
3.4.
2009
Prikk, K; Nagelmann, A; Minajeva, A; Sergejeva, S; Sepper, R. (2009). Changes In Bronchial Morphology Do Not Correspond To Clinical Signs Of COPD Patients Staged By GOLD. American Thoracic Society Interantional Conference, San-Diego, USA, 15-20 mai 2009.
6.6.
2007
Prikk, Kaiu (2007). Kombinatsioonravi võimalused astma raviskeemis-uus kontseptsioon. (19−20)..
5.2.
2006
Prikk, Kaiu; Anion, Eveli;Voodla, Caroli, Fehniger, Thomas, Dahlback, Magnus; Sepper, Ruth (2006). MUC5AC and MUC5B expression in epithelial cells and glandular cells of patients with chronic obstructive pulmonary disease. In: (A688).American Thoracic Society Annual Meeting, San-Diego, USA 2006.
5.2.
2005
Prikk, Kaiu; Lapidus, Natalia; Mukk, Pille; Sorsa, Timo;Sepper, Ruth (2005). Soluble laminin-5 gamma 2-chain in bronchoalveolar lavage fluid (BALF) from healthy controls and chronic inflammatory airway diseases. American Thoracic Society Annual Meeting, San-Diego, USA, 2005. A92.
1.1.
2004
Sepper, R.; Prikk, K. (2004). Proteomics: is it an approach to understand the progression of chronic lung disorders? Journal of Proteome Research, 3 (2), 277−281.
3.2.
2003
Prikk, K; Reintam, M-A.; Pirila, E.; Maisi, P.; Sorsa, T.; Sepper, R. (2003). Collagenase-2 expression by bronchial epithelial cells and macrophages in asthmatics´ airways. Journal of Allergy & Clinical Immunology, 40. JGC Editions, 295−300.
5.2.
2003
Prikk, Kaiu, Anion, Eveli; Voodla, Caroli; Sorsa, Timo; Sepper, Ruth (2003). MMP-8 cellular origins differ in the different chronic obstructive pulmonary diseases. A193.
1.1.
2002
Pirila, E.; Parikka, M.; Ramamurthy, N.S.; Maisi, P.; McClain, S.; Kucine, A.; Tervahartiala, T.; Prikk, K.; Golub, L.M.; Salo, T.; Sorsa, T. (2002). Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats:effects on matrix metalloproteinase-2, membrane type I matrix metalloproteinase, and laminin-5 gamma2-chain. Wound Repair and Regeneration, 10, 38−51.
1.1.
2002
Prikk, K.; Maisi, P.; Pirila, E.; Reintam, M. A.; Salo, T.; Sorsa, T.; Sepper, R. (2002). Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma. Laboratory Investigation, 82 (11), 1535−1545.
1.1.
2002
Maisi, P.; Prikk, K.; Sepper, R.; Pirila, E.; Salo, T.; Sorsa, T. (2002). Soluble membrane-type I matrix metalloproteinase (MMP-14) and gelatinase-A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis. Apmis, 110 (11), 771−782.
1.1.
2002
Henry, M. T.; McMahon, K.; Mackarel, A. J.; Prikk, K.; Sorsa, T.; Maisi, P.; Sepper, R.; Fitzgerald, M. X.; OConnor, C. M. (2002). Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF. European Respiratory Journal, 20 (5), 1220−1227.
1.1.
2001
Prikk, K.; Pirilä, E.; Sepper, R.; Maisi, P.; Walghren, J.; Salo, T.; Sorsa, T. (2001). In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. The Journal of Pathology, 194 (2), 232−238.
1.1.
2001
Prikk, K.; Maisi, P.; Sepper, R.; Stenman, U. H.; Salo, T.; Sorsa, T. (2001). Association of trypsin-2 with activation of gelatinase B and collagenase-2 in human lbronchoalveolar lavage fluid in vivo. Annals of Medicine, 33 (6), 437−444.
1.1.
2001
Maisi, P.; Sorsa, T.; Raulo, S. M.; Prikk, K.; Sepper, R.; McGorum, B.; Kelly, E. A. (2001). Increased matrix metalloproteinase (MMP)-9 in the airway after allergen. American Journal of Respiratory and Critical Care Medicine, 164 (9), 1740.
1.1.
1999
Sepper, R.; Prikk, K.; Tervahartiala, T.; Konttinen, Y. T.; Maisi, P.; Lopez-Otin, C.; Sorsa, T. (1999). Collagense-2, and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis. Annals of New York Academy of Sciences, 30 (878), 683−685.
5.2.
1998
Sepper, R.; Prikk, K.; Altraja, A.; Meriste, S.; Sorsa, R. (1998). Novel collagenase-3/MMP-13 in BALF of severe bronchiectatics. European Respiratory Journal, 12. 134.
5.2.
1998
Prikk, K.; Altraja, A.; Sorsa, R.; Sepper, R. (1998). Highly activated MMP-9/type IV collagenase in asthma. European Respiratory Journal, 12. 31s.

Industrial property

25.11.2020

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Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MUULep10121A randomised, double-blind, placebo -controlled, parallel-group, multicentre, dose ranging study to evaluate the efficacy and safety of Losmapimod (GW856553) tablets administred twice daily compared with placebo for 25 weeks in adults subjects with c01.12.201031.12.2011Kaiu PrikkTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 62 621,00 EUR
MUULep10007A randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of GSK573719 delivered once-daily over 28 days in subjects with COPD01.12.200901.09.2010Kaiu PrikkTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 28 990,32 EUR
MUUVFP558CHROMED: Clinical evaluation of a new multi-parametric monitoring system for patients affected by COPD with CHF or sleep disorders comorbidities01.10.201231.12.2015Ruth SepperTallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 275 795,00 EUR
MUUAR9082eHealth: Cooperation between higher education institutions and enterprises for development and marketing of the eHealth Technology joint curriculum01.11.200831.08.2013Ruth SepperTallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 282 042,10 EUR
ETFETF7242Eosinofilopoeetilised mehhanismid hingamisteede põletikus astma korral01.01.200731.12.2010Svetlana SergejevaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum57 024,27 EUR
SFSF0190823Bs99Koekahjustuse regulatsioon kroonilise obstruktiivse kopsuhaiguse (KOK) tekkes ja arengus.01.01.200231.12.2006Ruth SepperTallinna Tehnikaülikool, Matemaatika-loodusteaduskond91 010,20 EUR
MUUBF134Markers of systemic inflammation in chronic obstructive airway diseases01.11.200931.10.2010Svetlana SergejevaTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 12 782,33 EUR
MUUVE430Measurement of airway wall thickness in COPD with identification of new biological markers in airway tissue from COPD patients11.08.200930.09.2011Ruth SepperTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 119 994,12 EUR
MUULep11009Mitmekeskuseline, avatud, annuseid võrdlev uuring selgitamaks intravenoosselt ja subkutaanselt manustatava mepolizumabi farmakokineetikat ja farmakodünaamikat astmahaigetel täiskasvanutel, kellel on tõusnud eosinofiilide tase veres19.01.201131.12.2011Kaiu PrikkTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 12 270,00 EUR
MUUVIR553PrimCareIT - Counteracting brain drain and professional isolation of health professionals in remote primary health care through tele-consultation and tele-mentoring to strengthen social conditions in remote BSR01.01.201201.03.2014Madis TiikTallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 73 316,00 EUR
MTTMTT12Põletiku biomõõdikud01.01.201031.12.2012Thomas FehnigerTallinna Tehnikaülikool, TTÜ Tehnomeedikum287 602,42 EUR
ETFETF7120Rakumembraan-seotud kollagenaas-2 mõju kroonilise põletiku kulgu ravim-allumatu raske kuluga astma korral. 01.01.200731.12.2009Kaiu PrikkTallinna Tehnikaülikool, Matemaatika-loodusteaduskond; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum33 030,55 EUR