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Olen nõus

Katrin Trummal

https://etis.ee/CV/Katrin_Trummal/est
20.05.1964
6398372
53447993
katrin.trummal@kbfi.ee

Teenistuskäik

Töökohad ja ametid
2010–31.12.2015   
Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (1,00)
1996–2010   
Keemilise ja Bioloogilise Füüsika Instituut, Teadur (1,00)
01.01.1988–31.12.1996   
Keemilise ja Bioloogilise Füüsika Instituut, nooremteadur
01.01.1987–31.12.1988   
Keemilise ja Bioloogilise Füüsika Instituut, insener
 
 
Haridustee
2006–2007   
Tallinna Tehnikaülikool, doktorantuur
1988–1990   
KBFI, aspirantuur
1982–1987   
Tartu Riiklik Ülikool, keemik (bioorgaaniline keemia), cum laude
1971–1982   
Tallinna 44. Keskkool

Kvalifikatsioon

Teaduskraadid
Katrin Trummal, doktorikraad, 2007, (juh) Jüri Siigur; Aivar Lõokene, Purification, characterization and specificity studies of metalloproteinases from Vipera lebetina Snake venom. (Vipera lebetina maomürgi metalloproteinaaside eraldamine , iseloomustamine ja spetsiifilisuse uurimine), Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut.
Katrin Trummal, magistrikraad, 1987, (juh) Jaak Järv; Uno Mäeorg, m- ja p-asendatud N-atseetaniliidide ja fenüülboorhapete süntees ja vastastoime koliinesteraasidega, Tartu Ülikool.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; TÄPSUSTUS: orgaaniline ja bioorgaaniline keemia; madude mürkidest bioaktiivsete komponentide eraldamine ja iseloomustamine; kromatograafilised ja mass-spektromeetrilised meetodid

Lõppenud projektid

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2015
Trummal, Katrin; Samel, Mari; Aaspõllu, Anu; Tõnismägi, Külli; Titma, Tiina; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2015). 5´-Nucleotidase from Vipera lebetina venom. Toxicon, 93, 155−163.10.1016/j.toxicon.2014.11.234.
5.1.
2015
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2015). Vipera lebetina venom nucleases. Toxicon, 103S: The 18th World Congress of the International Society on Toxinology; 25-30 September 2015; Oxford, UK. Elsevier Sci, 111−112.
1.1.
2014
Trummal, K., Aaspõllu, A, Tõnismägi, K., Samel, M., Subbi, J., Siigur, J., Siigur, E. (2014). Phosphodiesterase from Vipera lebetina venom - Structure and characterization. Biochimie, 106, 48−55.10.1016/j.biochi.2014.07.020.
5.1.
2014
Titma, T.; Trummal, K.; Tõnismägi, K.; Siigur, E.; Subbi, J.; Shimmo, R.; Ivask, A.; Kahru, A.; Siigur, J. (2014). New C-type lectin-like protein and 5′-nucleotidase from Vipera lebetina snake venom. Toxicology Letters. Elsevier Ireland Ltd, S234−S234. (229; 10). DOI: 10.1016/j.toxlet.2014.06.784.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223.10.3390/toxins5020203.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
1.1.
2012
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri (2012). Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. Toxicon, 60, 648−655.10.1016/j.toxicon.2012.03.023.
5.1.
2012
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri. (2012). Vipera Lebetina Venom Nucleases and Nucleotidases. Toxicon, 60, 200−200. DOI: 10.1016/j.toxicon.2012.04.205.
1.1.
2011
Trummal, Katrin; Tõnismägi, Külli; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jüri; Siigur, Ene (2011). Molecular diversity of snake venom nerve growth factors. Toxicon, 58 (4), 363−368. DOI: 10.1016/j.toxicon.2011.07.005.
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri. (2011). Effect of HUVEC apoptosis inducing proteinase fromVipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 159−159.
5.2.
2011
Trummal, Katrin; Tõnismägi, Külli; Bragina, Olga; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jür; Siigur, Ene. (2011). Similarities and differences of snake venom nerve growth factors. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 158−158.
5.2.
2011
Siigur, Ene; Tõnismäg, Külli; Vassiljeva, Olga; Trummal, Katrin; Aaspõllu, Anu; Subb, Juhani; Siigur, Jüri (2011). Hyaluronidase from Vipera lebetina venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 157−157.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology, Part B, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2009). Nerve growth factor from Vipera lebetina venom: isolation and characterization. XVI World Congress of the International Society on Toxinology;15-20 March 2009, Recife, Brazil. 346-1.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
5.2.
2008
Siigur, Ene; Paalme, Viiu; Trummal, Katrin; Tõnismägi, Küll; Järvekülg, Lilian; Subbi, Juhan; Siigur, Jüri (2008). Vipera lebetina venom nerve growth factor. 16th European Section Meeting of the International Society on Toxinology;Book of abstracts. Leuven,Belgium, 7-10 September 2008,p. 55. 16th European Section Meeting of the International Society on Toxinology; Book of abstracts.: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 55−55.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
2.3.
2007
Trummal, Katrin (2007). Purification, Characterization and Specificity Studies of Metalloproteinases from Vipera lebetina Snake Venom. (Tallinna Tehnikaülikool). Tallinn: TTU Press.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Tõnismägi, K.; Samel M., Trummal K., Rönnholm G., Siigur J., Kalkkinen N., Siigur, E. (2006). L-Amino acid oxidase from Vipera lebetina venom: Isolation. characterization, effects on platelets and bacteria. Toxicon, 48, 227−237.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
5.2.
2006
Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Rönnholm, Gunilla; Siigur, Jüri; Kalkkinen, Nisse; Siigur, Ene. (2006). A comparative study of the enzymatic and physiological activities of two viper venom L-amino acid oxidases. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. _EditorsAbbr Alan Harvey and Edward Rowan. 274−274.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2005
Trummal, K.; Tõnismägi, K.; Siigur, E.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon, 46 (1), 46−61.
5.1.
2005
Siigur, E.;Trummal, K.; Tõnismägi, K.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A heterodimeric metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Journal of Thrombosis and Haemostasis, 3. 1158. (Supplement 1).
5.1.
2005
Siigur, E.; Samel, M.; Tõnismägi, K.; Trummal, K.; Siigur, J. (2005). Snake venom apoptotic L-amino acid oxidase ( LAAO ) inhibits platelet aggregation. Journal of Thrombosis and Haemostasis, 3: XX Congress of the International Society on Thrombosis and Haemostasis, Sydney, Australia, Aug. 6-12, 2005.. P0293.
1.1.
2004
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tõnismagi, K.; Tammiste, I.; Kalkkinen, N.; Siigur, J. (2004). Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochimica et Biophysica Acta - Proteins and Proteomics, 1702 (1), 41−51.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
5.2.
2003
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tammiste, I.; Siigur, J. (2003). Vipera lebetina factor X activating enzyme- cloning and sequencing. Journal of Thrombosis and Haemostasis, Supplement 1, 1096.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
26.04.2019

Katrin Trummal

https://etis.ee/CV/Katrin_Trummal/eng
20.05.1964
6398372
53447993
katrin.trummal@kbfi.ee

Career

Institutions and positions
2010–31.12.2015   
National Institute of Chemical Physics and Biophysics, Senior Researcher (1,00)
1996–2010   
National Institute of Chemical Physics and Biophysics, Researcher (1,00)
01.01.1988–31.12.1996   
Institute of Chemical Physics and Biophysics, junior research scientist
01.01.1987–31.12.1988   
Institute of Chemical Physics and Biophysics, engineer
 
 
Education
2006–2007   
Tallinn University of Technology
1988–1990   
NICPB, post graduate student
1982–1987   
Tartu State University, chemist (bioorganic chemistry), cum laude
1971–1982   
Tallinn Secondary School No 44

Qualifications

Academic degrees
Katrin Trummal, Doctor's Degree, 2007, (sup) Jüri Siigur; Aivar Lõokene, Purification, characterization and specificity studies of metalloproteinases from Vipera lebetina Snake venom., Tallinn University of Technology Faculty of Science, Department of Gene Technology.
Katrin Trummal, Master's Degree, 1987, (sup) Jaak Järv; Uno Mäeorg, m- ja p-asendatud N-atseetaniliidide ja fenüülboorhapete süntees ja vastastoime koliinesteraasidega (Synthesis of m- and p-substituted N-acetanilides and phenylboronic acids and their interaction with cholinesterases), University of Tartu.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIFICATION: organic and bioorganic chemistry; purification and characterization of bioactive components from snake venoms; chromatographic and mass-spectrometric methods
 
 

Completed projects

Publications

Category
Year
Publication
 
1.1.
2015
Trummal, Katrin; Samel, Mari; Aaspõllu, Anu; Tõnismägi, Külli; Titma, Tiina; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2015). 5´-Nucleotidase from Vipera lebetina venom. Toxicon, 93, 155−163.10.1016/j.toxicon.2014.11.234.
5.1.
2015
Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2015). Vipera lebetina venom nucleases. Toxicon, 103S: The 18th World Congress of the International Society on Toxinology; 25-30 September 2015; Oxford, UK. Elsevier Sci, 111−112.
1.1.
2014
Trummal, K., Aaspõllu, A, Tõnismägi, K., Samel, M., Subbi, J., Siigur, J., Siigur, E. (2014). Phosphodiesterase from Vipera lebetina venom - Structure and characterization. Biochimie, 106, 48−55.10.1016/j.biochi.2014.07.020.
5.1.
2014
Titma, T.; Trummal, K.; Tõnismägi, K.; Siigur, E.; Subbi, J.; Shimmo, R.; Ivask, A.; Kahru, A.; Siigur, J. (2014). New C-type lectin-like protein and 5′-nucleotidase from Vipera lebetina snake venom. Toxicology Letters. Elsevier Ireland Ltd, S234−S234. (229; 10). DOI: 10.1016/j.toxlet.2014.06.784.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223.10.3390/toxins5020203.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
1.1.
2012
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri (2012). Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. Toxicon, 60, 648−655.10.1016/j.toxicon.2012.03.023.
5.1.
2012
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Siigur, Jüri. (2012). Vipera Lebetina Venom Nucleases and Nucleotidases. Toxicon, 60, 200−200. DOI: 10.1016/j.toxicon.2012.04.205.
1.1.
2011
Trummal, Katrin; Tõnismägi, Külli; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jüri; Siigur, Ene (2011). Molecular diversity of snake venom nerve growth factors. Toxicon, 58 (4), 363−368. DOI: 10.1016/j.toxicon.2011.07.005.
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Samel, Mari; Trummal, Katrin; Siigur, Ene; Siigur, Jüri. (2011). Effect of HUVEC apoptosis inducing proteinase fromVipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 159−159.
5.2.
2011
Trummal, Katrin; Tõnismägi, Külli; Bragina, Olga; Paalme, Viiu; Järvekülg, Lilian; Siigur, Jür; Siigur, Ene. (2011). Similarities and differences of snake venom nerve growth factors. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 158−158.
5.2.
2011
Siigur, Ene; Tõnismäg, Külli; Vassiljeva, Olga; Trummal, Katrin; Aaspõllu, Anu; Subb, Juhani; Siigur, Jüri (2011). Hyaluronidase from Vipera lebetina venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 157−157.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology, Part B, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri; Siigur, Ene. (2009). Nerve growth factor from Vipera lebetina venom: isolation and characterization. XVI World Congress of the International Society on Toxinology;15-20 March 2009, Recife, Brazil. 346-1.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
5.2.
2008
Siigur, Ene; Paalme, Viiu; Trummal, Katrin; Tõnismägi, Küll; Järvekülg, Lilian; Subbi, Juhan; Siigur, Jüri (2008). Vipera lebetina venom nerve growth factor. 16th European Section Meeting of the International Society on Toxinology;Book of abstracts. Leuven,Belgium, 7-10 September 2008,p. 55. 16th European Section Meeting of the International Society on Toxinology; Book of abstracts.: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 55−55.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
2.3.
2007
Trummal, Katrin (2007). Purification, Characterization and Specificity Studies of Metalloproteinases from Vipera lebetina Snake Venom. (Tallinna Tehnikaülikool). Tallinn: TTU Press.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Tõnismägi, K.; Samel M., Trummal K., Rönnholm G., Siigur J., Kalkkinen N., Siigur, E. (2006). L-Amino acid oxidase from Vipera lebetina venom: Isolation. characterization, effects on platelets and bacteria. Toxicon, 48, 227−237.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
5.2.
2006
Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Rönnholm, Gunilla; Siigur, Jüri; Kalkkinen, Nisse; Siigur, Ene. (2006). A comparative study of the enzymatic and physiological activities of two viper venom L-amino acid oxidases. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. _EditorsAbbr Alan Harvey and Edward Rowan. 274−274.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2005
Trummal, K.; Tõnismägi, K.; Siigur, E.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon, 46 (1), 46−61.
5.1.
2005
Siigur, E.;Trummal, K.; Tõnismägi, K.; Aaspõllu, A.; Lopp, A.; Sillat, T.; Saat, R.; Kasak, L.; Tammiste, I.; Kogerman, P.; Kalkkinen, N.; Siigur, J. (2005). A heterodimeric metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Journal of Thrombosis and Haemostasis, 3. 1158. (Supplement 1).
5.1.
2005
Siigur, E.; Samel, M.; Tõnismägi, K.; Trummal, K.; Siigur, J. (2005). Snake venom apoptotic L-amino acid oxidase ( LAAO ) inhibits platelet aggregation. Journal of Thrombosis and Haemostasis, 3: XX Congress of the International Society on Thrombosis and Haemostasis, Sydney, Australia, Aug. 6-12, 2005.. P0293.
1.1.
2004
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tõnismagi, K.; Tammiste, I.; Kalkkinen, N.; Siigur, J. (2004). Factor X activator from Vipera lebetina venom is synthesized from different genes. Biochimica et Biophysica Acta - Proteins and Proteomics, 1702 (1), 41−51.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
5.2.
2003
Siigur, E.; Aaspõllu, A.; Trummal, K.; Tammiste, I.; Siigur, J. (2003). Vipera lebetina factor X activating enzyme- cloning and sequencing. Journal of Thrombosis and Haemostasis, Supplement 1, 1096.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
26.04.2019

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF7251Biomeditsiiniliselt olulised valgud ja peptiidid madude mürkidestl01.01.200731.12.2010Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut54 053,92 EUR
SFSF0222603s03Funktsionaalne proteoomika - struktuuri-aktiivsuse seosed ning molekulaarne äratundmine looduslikes valgukooslustes01.01.200331.12.2007Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut643 270,75 EUR
ETFETF5554Hemostaasi, angiogeneesi ja apoptoosi mõjutavad valgud viperiidsete madude mürkidest.01.01.200331.12.2006Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut29 542,52 EUR
ETFETF5938L-Aminohapete oksüdaas. Eraldamine, primaarne struktuur ja interaktsioonid rakkudega.01.01.200431.12.2007Ene SiigurKeemilise ja Bioloogilise Füüsika Instituut25 820,30 EUR
ETFETF9458Maomürkide nukleaasid, nukleotidaasid ja fosfataasid. Struktuuri ja funktsiooni vahelised seosed01.01.201231.12.2015Ene SiigurKeemilise ja Bioloogilise Füüsika Instituut48 508,80 EUR
ETFETF8899Maomürkide valgud ja peptiidid kui bioloogiliste protsesside modulaatorid01.01.201131.12.2014Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut48 000,00 EUR
SFSF0690063s08Mehhanismid ja interaktsioonid toksikoloogias ja toksinoloogias: in vitro mudelid01.01.200831.12.2013Anne KahruKeemilise ja Bioloogilise Füüsika Instituut1 126 446,52 EUR
MUUKBFI,MG-8Rästiku mürgi kvaliteedi hindamine27.11.200731.05.2008Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut6 391,16 EUR
ETFETF7694Valk-valk interaktsioonid maomürgi närvi kasvu faktoriga01.01.200831.12.2011Ene SiigurKeemilise ja Bioloogilise Füüsika Instituut70 822,85 EUR