See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Vladimir Stepanov

https://etis.ee/CV/Vladimir_Stepanov/est
21.04.1982
737 5240
vladimir.stepanov@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2012–...   
Karolinska Instituut, Stockholm, Rootsi (Uurimuslikku radiokeemia osakonna juhataja)
2009–...   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut, Orgaanilise keemia õppetool, Erakorraline teadur (1,00)
01.01.2009–31.12.2012   
Karolinska Instituut, Stockholm, Rootsi (radiokeemik, post-dok)
01.01.2004–31.12.2009   
Pharmasynth AS (keemik), Tartu, Eesti
2003–2004   
Tartu Ülikool, Füüsika-keemiateaduskond, Orgaanilise ja bioorgaanilise keemia instituut, Orgaanilise keemia õppetool, keemik (0,50)
 
 
Haridustee
2006–2009   
Tartu Ülikool - doktorikraad PhD (keemia)
2004–2006   
Tartu Ülikool - magistrikraad MSc (biokeemia)
2000–2004   
Tartu Ülikool – kõrgharidus BSc (keemia) (Cum Laude)
1988–2000   
Pärnu Vene Gümnaasium – keskharidus (kuldmedaliga)

Kvalifikatsioon

Teaduskraadid
Vladimir Stepanov, doktorikraad, 2009, (juh) Jaak Järv, Slow conformational changes in dopamine transporter interaction with its ligands (Ligandide seostumisega kaasnevad dopamiini transporteri aeglased konformatsiooniuutused), Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut, Orgaanilise keemia õppetool.
Vladimir Stepanov, magistrikraad, 2006, (juh) Jaak Järv, Synthesis And Preliminary Characterization Of A New Radioactive Ligand For Dopamine Transporter - N-(3-Iodoprop-2E-Enyl)-2β-Carbo-[3H]Methoxy-3β-4'-Methylphenyl)Nortropane ([3H]PE2I), Tartu Ülikool, Füüsika-keemiateaduskond.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 4. Loodusteadused ja tehnika; 4.11. Keemia ja keemiatehnika; TÄPSUSTUS: Bioaktiivsete ainete konstrueerimine. Dopamiin transporteri inhibiitorite süntees. Dopamiini transporteri kineetika uurimine.
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; TÄPSUSTUS: G valkuga setud retseptorite retseptor-ligand interaktsioonide uurimine ja modeleerimine.

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2011
Varrone, A., Stepanov, V., Nakao, R., Tóth, M., Halldin, C., et al. (2011). Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates. Journal of Nuclear Medicine, 52 (8), 1313−1321.10.2967/jnumed.111.089953.
5.2.
2011
Stepanov, V.; Krasikova, R.; Raus, L.; Loog, O.; Hiltunen, J.; Halldin, C. (2011). An efficient one-step synthesis of [18F]FE-PE2I via nucleophilic fluorination of tosylated precursor. Journal of Labelled Compounds and Radiopharmaceuticals, 54: 19th International Symposium on Radiopharmaceutical Sciences. _EditorsAbbr Lawrie K M W. Wiley InterScience, S506. (Supplement 1).
5.2.
2011
Stepanov, V.; Finnema, S.; Neumeyer, J.; Seeman, P.; Farde, L.; Halldin, C. et al. (2011). Radiolabeling and monkey PET evaluation of the dopamine D2 and D3 receptor agonist radioligand [18F]MCL-524. Journal of Labelled Compounds and Radiopharmaceuticals, 54: 19th International Symposium on Radiopharmaceutical Sciences. _EditorsAbbr Lawrie K M W. Wiley InterScience, S9. (Supplement 1).
1.1.
2010
Vellemäe, E.; Stepanov, V.; Mäeorg, U. (2010). A mild approach to the deprotection of Troc from protectedamines using Mischmetal and TMSCI. Synthetic Communications, 40 (22), 3397−3404.10.1080/00397910903419910.
5.1.
2010
Varrone, A.; Toth, M.; Stepanov, V.; Halldin, C.; Guilloteau, D. (2010). Quantification of [18F]LBT-999 binding to the dopamine transporter in the rhesus monkey brain with the HRRT system. NEUROIMAGE, 52: 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain; Glasgow, Scotland; 22-24 July, 2010. Elsevier, S118−S119. DOI: 10.1016/j.neuroimage.2010.04.097.
5.1.
2010
Finnema, S.; Varnas, K.; Stepanov, V.; Farde, L.; Halldin, C. (2010). Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain. NEUROIMAGE, 52: 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain; Glasgow, Scotland; 22-24 July, 2010. Elsevier, S61−S62. (Suppl. 1). DOI: 10.1016/j.neuroimage.2010.04.047.
5.2.
2010
Varrone, A.; Toth, M.; Stepanov, V.; Nakao, R.; Guilloteau, D.; Halldin, C. (2010). Quantification, biodistribution and radiation dosimetry of the dopamine transporter radioligand [18F]LBT-999 in non-human primates. European Journal of Nuclear Medicine & Molecular Imaging, 37: European Association of Nuclear Medicine (EANM) Congress; Vienna, Austria; Oct. 9-13, 2010. Springer, S274−S275. (Suppl 2:S198-S311).
1.1.
2008
Stepanov, V.; Järv, J. (2008). Kinetic mechanism of Dopamine Transporter Interaction with1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909). Neurochemistry International, 53, 370−373. DOI: 10.1016/j.neuint.2008.09.005.
5.1.
2008
Stepanov, V.; Varikmaa, M.; Herm, L.; Rinken, A.; Järv, J. (2008). Comparison of the (3H)PE2I ja (3H)GBR12935 as practical tools for dopamine transporter assay in vitro. FEBS Journal, 275, 431−431.
5.1.
2008
Stepanov, V.; Uustare, A.; Järv, J. (2008). Allosteric ligand binding at G-protein coupled receptors. FEBS Journal, 275, 231−231.
1.1.
2007
Stepanov, V.; Schou, M.; Järv, J.; Halldin, C. (2007). Synthesis of 3H-labeled N-(3-iodoprop-2E-enyl)-2<beta>-carbomethoxy-3<beta>-(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments. Applied Radiation and Isotopes, 65 (3), 293−300.
5.2.
2007
Varikmaa, Minna; Herm, Laura; Stepanov, V., Rinken, A. (2007). Dopamiini transporteri määramine [3H]GBR 12935 ja [3H]PE2I-ga roti juttkehas ja naalduvas tuumas. Eesti XXX keemiapäevad, Tartu.
5.2.
2007
Stepanov, V.; Järv, J. (2007). Kinetic analysis of the interaction between rat dopamine transporter (rDAT) and its inhibitors. FEBS Journal, 274: 32nd FEBS Congress: Molecular Machines, Vienna, Austria. 251−251. (Suppl. 1).
1.1.
2006
Stepanov, V.; Järv, J. (2006). Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2 beta-carbo-[3H]methoxy-3 beta-(4'-methylphenyl)nortropane. Neuroscience Letters, 410 (3), 218−221.
1.2.
2006
Stepanov, V.; Järv, J. (2006). Interaction of tritium-labelled dopamine transporter inhibitor PE2I with mice striatal membrane fragments. Proceedings of the Estonian Academy of Sciences. Chemistry, 55 (3), 166−172.
18.04.2019

Vladimir Stepanov

https://etis.ee/CV/Vladimir_Stepanov/eng
21.04.1982
737 5240
vladimir.stepanov@ut.ee

Career

Institutions and positions
01.01.2012–...   
Karolinska Institutet, Stockholm, Sweden (Head of Research Radiochemistry)
2009–...   
University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry, Tartu University, Chair of Organic Chemistry, Extraordinary Researcher (1,00)
01.01.2009–31.12.2012   
Karolinska Institutet, Stockholm, Sweden (radiochemist, post-doc)
 
 
Education
2006–2009   
Tartu University - Doctoral Degree PhD (chemistry)
2004–2006   
Tartu University - Master's Degree MSc (biochemistry)
2000–2004   
Tartu University – BSc Chemistry (Cum Laude)

Qualifications

Academic degrees
Vladimir Stepanov, Doctor's Degree, 2009, (sup) Jaak Järv, Slow conformational changes in dopamine transporter interaction with its ligands, University of Tartu, Faculty of Science and Technology (old), Institute of Chemistry, Tartu University, Chair of Organic Chemistry.
Vladimir Stepanov, Master's Degree, 2006, (sup) Jaak Järv, Synthesis And Preliminary Characterization Of A New Radioactive Ligand For Dopamine Transporter - N-(3-Iodoprop-2E-Enyl)-2β-Carbo-[3H]Methoxy-3β-4'-Methylphenyl)Nortropane ([3H]PE2I), University of Tartu, Faculty of Physics and Chemistry.
 
 
Fields of research
ETIS CLASSIFICATION: 4. Natural Sciences and Engineering; 4.11. Chemistry and Chemical Technology; SPECIFICATION: Synthesis of bioactive compounds. Dopamine transporter inhibitor synthesis. Investigation of dopamine transporter kinetics.
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIFICATION: G-protein coupled receptors and kinetics of their interactions with different ligands.
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2011
Varrone, A., Stepanov, V., Nakao, R., Tóth, M., Halldin, C., et al. (2011). Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates. Journal of Nuclear Medicine, 52 (8), 1313−1321.10.2967/jnumed.111.089953.
5.2.
2011
Stepanov, V.; Krasikova, R.; Raus, L.; Loog, O.; Hiltunen, J.; Halldin, C. (2011). An efficient one-step synthesis of [18F]FE-PE2I via nucleophilic fluorination of tosylated precursor. Journal of Labelled Compounds and Radiopharmaceuticals, 54: 19th International Symposium on Radiopharmaceutical Sciences. _EditorsAbbr Lawrie K M W. Wiley InterScience, S506. (Supplement 1).
5.2.
2011
Stepanov, V.; Finnema, S.; Neumeyer, J.; Seeman, P.; Farde, L.; Halldin, C. et al. (2011). Radiolabeling and monkey PET evaluation of the dopamine D2 and D3 receptor agonist radioligand [18F]MCL-524. Journal of Labelled Compounds and Radiopharmaceuticals, 54: 19th International Symposium on Radiopharmaceutical Sciences. _EditorsAbbr Lawrie K M W. Wiley InterScience, S9. (Supplement 1).
1.1.
2010
Vellemäe, E.; Stepanov, V.; Mäeorg, U. (2010). A mild approach to the deprotection of Troc from protectedamines using Mischmetal and TMSCI. Synthetic Communications, 40 (22), 3397−3404.10.1080/00397910903419910.
5.1.
2010
Varrone, A.; Toth, M.; Stepanov, V.; Halldin, C.; Guilloteau, D. (2010). Quantification of [18F]LBT-999 binding to the dopamine transporter in the rhesus monkey brain with the HRRT system. NEUROIMAGE, 52: 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain; Glasgow, Scotland; 22-24 July, 2010. Elsevier, S118−S119. DOI: 10.1016/j.neuroimage.2010.04.097.
5.1.
2010
Finnema, S.; Varnas, K.; Stepanov, V.; Farde, L.; Halldin, C. (2010). Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain. NEUROIMAGE, 52: 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain; Glasgow, Scotland; 22-24 July, 2010. Elsevier, S61−S62. (Suppl. 1). DOI: 10.1016/j.neuroimage.2010.04.047.
5.2.
2010
Varrone, A.; Toth, M.; Stepanov, V.; Nakao, R.; Guilloteau, D.; Halldin, C. (2010). Quantification, biodistribution and radiation dosimetry of the dopamine transporter radioligand [18F]LBT-999 in non-human primates. European Journal of Nuclear Medicine & Molecular Imaging, 37: European Association of Nuclear Medicine (EANM) Congress; Vienna, Austria; Oct. 9-13, 2010. Springer, S274−S275. (Suppl 2:S198-S311).
1.1.
2008
Stepanov, V.; Järv, J. (2008). Kinetic mechanism of Dopamine Transporter Interaction with1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909). Neurochemistry International, 53, 370−373. DOI: 10.1016/j.neuint.2008.09.005.
5.1.
2008
Stepanov, V.; Varikmaa, M.; Herm, L.; Rinken, A.; Järv, J. (2008). Comparison of the (3H)PE2I ja (3H)GBR12935 as practical tools for dopamine transporter assay in vitro. FEBS Journal, 275, 431−431.
5.1.
2008
Stepanov, V.; Uustare, A.; Järv, J. (2008). Allosteric ligand binding at G-protein coupled receptors. FEBS Journal, 275, 231−231.
1.1.
2007
Stepanov, V.; Schou, M.; Järv, J.; Halldin, C. (2007). Synthesis of 3H-labeled N-(3-iodoprop-2E-enyl)-2<beta>-carbomethoxy-3<beta>-(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments. Applied Radiation and Isotopes, 65 (3), 293−300.
5.2.
2007
Varikmaa, Minna; Herm, Laura; Stepanov, V., Rinken, A. (2007). Dopamiini transporteri määramine [3H]GBR 12935 ja [3H]PE2I-ga roti juttkehas ja naalduvas tuumas. Eesti XXX keemiapäevad, Tartu.
5.2.
2007
Stepanov, V.; Järv, J. (2007). Kinetic analysis of the interaction between rat dopamine transporter (rDAT) and its inhibitors. FEBS Journal, 274: 32nd FEBS Congress: Molecular Machines, Vienna, Austria. 251−251. (Suppl. 1).
1.1.
2006
Stepanov, V.; Järv, J. (2006). Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2 beta-carbo-[3H]methoxy-3 beta-(4'-methylphenyl)nortropane. Neuroscience Letters, 410 (3), 218−221.
1.2.
2006
Stepanov, V.; Järv, J. (2006). Interaction of tritium-labelled dopamine transporter inhibitor PE2I with mice striatal membrane fragments. Proceedings of the Estonian Academy of Sciences. Chemistry, 55 (3), 166−172.
18.04.2019

Otsi projekti

  • {{item.Name}}
Asutus on projekti finantseerija   Asutus on projekti teostaja  
  • {{searchListItem.Name}}
Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 3 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0182592s03Biomimeetikute konstrueerimine, keemiline süntees ja bioloogilise aktiivsuse uurimine01.01.200331.12.2007Jaak JärvTartu Ülikool, Füüsika-keemiateaduskond451 727,54 EUR
ETFETF6698Ligandide seostumise mehhanismi kineetiline uurimine dopamiini transportvalgu korral ja selle võimalikud rakendused aju tomograafiliste uurimismeetodite arendamisel01.01.200631.12.2009Jaak JärvTartu Ülikool, Füüsika-keemiateaduskond; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond42 519,15 EUR
SFSF0180064s08Uute biomimeetikute kui võimalike bioaktiivsete materjalide konstrueerimine, süntees ja testimine01.01.200831.12.2013Jaak JärvTartu Ülikool, Füüsika-keemiateaduskond; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond988 870,12 EUR