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Olen nõus

Ivar Järving

https://etis.ee/CV/Ivar_Järving/est
13.07.1957
6204388
-
ivar.jarving@ttu.ee
A-1864-2019
*

Teenistuskäik

Töökohad ja ametid
01.09.2018–...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, vanemlektor (1,00)
01.01.2017–...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, direktor (1,00)
01.01.1979–...   
1979-1990 töötanud vaneminseneri ja nooremteaduri ametikohal tollases TA Keemia Instituudis.
01.01.2017–31.08.2018   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, vanemteadur (1,00)
2008–31.12.2013   
Vähiuuringute Tehnoloogia Arenduskeskus AS, Projektijuht (0,20)
1991–31.12.2016   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool, Vanemteadur (1,00)
01.12.1980–31.12.1981   
Moscow State University, 1980-1981 stazeerimine Moskva Riiklikus Ülikoolis. (1,00)
 
 
Haridustee
01.09.1975–01.06.1980   
Tallinna Tehnikaülikool 1980.a. keemiatööstuse protsesside ja keemiaküberneetika eriala, keemiatehnoloogiainsener.
 
 
Loometöö
*
 
 
Lisainfo
*
Meditsiiniline keemia, Looduslike ühendite keemia, Protsessid ja seadmed toidu töötlemisel - loeng, praktikum, üliõpilaste juhendamine

Kvalifikatsioon

Teaduskraadid
Ivar Järving, doktorikraad, 1991, (juh) Nigulas Samel; Ülo Lille, Tromboksaan A2 metaboliitide ja looduslike E prostaglandiinide süntees, Eesti Teaduste Akadeemia Keemia Instituut.
 
 
Teaduspreemiad ja tunnustused
2002, Ivar Järving, Riigi Teaduspreemia keemia ja molekulaarbioloogia alal tööde tsükli “Prostaglandiinide biosüntees korallides" eest
1986, Ivar Järving, Üleliiduline Leninliku Komsomoli preemia teaduse ja tehnika ala 1986.a.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: T360 Biokeemiatehnoloogia
 
 
Lisainfo
keemiakandidaat
Eesti NSV TA Keemia Instituut 1991
Meditsiiniline keemia, Looduslike ühendite keemia, Toiduainete tööstuse põhiprotsessid ja seadmed - loeng, praktikum, Üliõpilaste juhendamine

Jooksvad projektid

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2020
Bhadoria, R.; Ping, K.; Lohk, C.; Järving, I.; Starkov, P. (2020). A phenotypic approach to probing cellular outcomes using heterobivalent constructs. Chemical Communications, 4216−4219. DOI: 10.1039/C9CC09595K.
1.1.
2020
Trubitsõn, Dmitri; Martõnova, Jevgenija; Erkman, Kristin; Metsala, Andrus; Saame, Jaan; Kõster, Kristjan; Järving, Ivar; Leito, Ivo; Kanger, Tõnis (2020). Enantioselective N-Alkylation of Nitroindoles under Phase-Transfer Catalysis. Synthesis, 52 (07), 1047−1059. DOI: 10.1055/s-0039-1690751.
1.1.
2019
Ermolovich, Y.; Barysevich, M. V.; Adamson, J.; Rogova, O.; Kaabel, S.; Järving, I.; Gathergood, N.; Snieckus, V.; Kananovich, D. G. (2019). Site-Selective and Stereoselective C–H Functionalization of N-Cyclopropylamides via a Directed Remote Metalation Strategy. Organic Letters.10.1021/acs.orglett.8b03955.
1.1.
2019
Kaabel, S.; Stein, R. S.; Fomitšenko, M. Järving, I.; Friščić, T.; Aav, R. (2019). Size-Control by Anion Templating in Mechanochemical Synthesis of Hemicucurbiturils in the Solid State. Angewandte Chemie International Edition.10.1002/anie.201813431.
1.1.
2019
Kaasik, M.; Metsala, A.; Kaabel, S.; Kriis, K.; Järving, I.; Kanger, T. (2019). Halo-1,2,3-triazolium Salts as Halogen Bond Donors for the Activation of Imines in Dihydropyridinone Synthesis. The Journal of Organic Chemistry, 84, 4294−4303.10.1021/acs.joc.9b00248.
1.1.
2019
Kaasik, M.; Kaabel, S.; Kriis, K.; Järving, I.; Kanger, T. (2019). Synthesis of Chiral Triazole-Based Halogen Bond Donors. Synthesis, 51, 2128−2135.10.1055/s-0037-1610864.
1.1.
2019
Peterson, Anna; Kaasik, Mikk; Metsala, Andrus; Järving, Ivar; Adamson, Jasper; Kanger, Tõnis (2019). Tunable chiral triazole-based halogen bond donors: assessment of donor strength in solution with nitrogen-containing acceptors. RSC Advances, 9 (21), 11718−11721.10.1039/c9ra01692a.
1.1.
2019
Ping, K.; Alam, M.; Käärik, M.; Leis, J.; Kongi, N.; Järving, I.; Starkov, P. (2019). Surveying Iron–Organic Framework TAL-1 Derived Materials in Ligandless Heterogenous Oxidative Catalytic Transformations of Alkylarenes. Synlett, 30, 1536−1540. DOI: 10.1055/s-0037-1611877.
1.1.
2019
Kimm, Mariliis; Oseka, Maksim; Kaabel, Sandra; Metsala, Andrus; Järving, Ivar; Kanger, Tõnis (2019). [2,3]-Wittig Rearrangement as a Formal Asymmetric Alkylation of alpha-Branched Ketones. Organic Letters, 21 (13), 4976−4980.10.1021/acs.orglett.9b01495.
1.1.
2019
Põldemaa, K.; Lipp, M.; Järving, I.; Samel, N.; Eek, P. (2019). Gly188Arg substitution eliminates substrate inhibition in arachidonate 11R-lipoxygenase. Biochemical and Biophysical Research Communications, 519 (1), 81−85.10.1016/j.bbrc.2019.08.132.
1.1.
2019
Elek, G. Z.; Koppel, K.; Zubrytski, D. M.; Konrad, N.; Järving, I.; Lopp, M.; Kananovich, D. G. (2019). Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin. Organic Letters, 21 (20), 8473−8478.10.1021/acs.orglett.9b03305.
1.1.
2019
Silm, Estelle; Kaabel, Sandra; Järving, Ivar; Kanger, Tõnis (2019). Asymmetric Organocatalytic Michael Addition-Cyclisation Cascade of Cyclopentane-1,2-dione with Alkylidene Malononitriles. Synthesis, 51 (22), 4198−4204. DOI: 10.1055/s-0039-1690484.
1.1.
2019
Murre, A.; Erkman, K.; Kaabel, S.; Järving, I.; Kanger, T. (2019). Diastereoselective [2,3]-Sigmatropic Rearrangement of N-Allyl Ammonium Ylides. Synthesis, 51 (22), 4183−4197. DOI: 10.1055/s-0039-1690185.
1.1.
2018
Maljutenko, K.; Borovkov, V.; Kananovich, D.; Järving, I.; Lopp, M. (2018). Aerobic cascade oxidation of substituted cyclopentane-1,2-diones using metalloporphyrin catalysts. Tetrahedron, 74 (6), 661−664.10.1016/j.tet.2017.12.009.
1.1.
2018
Smirnova, J.; Kabin, E.; Järving, I.; Bragina, O.; Tõugu, V.; Plitz, T.; Palumaa, P. (2018). Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent. Scientific Reports, 8 (1, 1463), 1−9.10.1038/s41598-018-19873-2.
1.1.
2018
Trubitsõn, D.; Žari, S.; Kaabel, S.; Kudrjashova, M.; Kriis, K.; Järving, I.; Pehk, T.; Kanger, T. (2018). Asymmetric Organocatalytic Cascade Synthesis of Tetrahydro­furanyl Spirooxindoles. Synthesis, 50 (02), 314−322.10.1055/s-0036-1590918.
1.1.
2018
Lopušanskaja, E.; Paju, A.; Järving, I.; Lopp, M. (2018). Synthesis of Cyclic 3-Aryl-Substituted 1,2-Dicarbonyl Compounds via Suzuki Cross-Coupling Reactions. Synthesis, 50 (9), 1883−1890.10.1055/s-0036-1591543.
1.1.
2018
Reitel, K.; Kriis, K.; Järvin, I.; Kanger, T. (2018). Study of the asymmetric organocatalyzed [3+2] annulation of cyclopropenone and β-keto ester. Chemistry of Heterocyclic Compounds, 54 (10), 929−933.10.1007/s10593-018-2372-1.
1.1.
2017
Kriis, K.; Melnik, T.; Lips, K.; Juhanson, I.; Kaabel, S.; Järving, I.; Kanger, T. (2017). Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines. Synthesis, 49 (3), 604−614.10.1055/s-0036-1588299.
1.1.
2017
Fomitšenko, M.; Peterson, A.; Reile, I.; Cong, H.; Kaabel, K.; Prigorchenko, E.; Järving I.; Aav R. (2017). A quantitative method for analysis of mixtures of homologues and stereoisomers of hemicucurbiturils that allows us to follow their formation and stability. New Journal of Chemistry, 41, 2490−2497.10.1039/C6NJ03050E.
1.1.
2017
Ošeka, M.; Kimm, M.; Järving, I.; Lippur, K.; Kanger, T. (2017). Two Catalytic Methods of an Asymmetric Wittig [2,3]-Rearrangement. The Journal of Organic Chemistry, 82 (6), 2889−2897.10.1021/acs.joc.6b02786.
1.1.
2017
Kaasik, M.; Kaabel, S.; Kriis, K.; Järving, I.; Aav, R.; Rissanen, K.; Kanger, T. (2017). Synthesis and Characterisation of Chiral Triazole-Based Halogen-Bond Donors: Halogen Bonds in the Solid State and in Solution. Chemistry - A European Journal, 23 (30), 7337−7344.10.1002/chem.201700618.
1.1.
2017
Konik, Y. A.; Kudrjashova, M.; Konrad, N.; Kaabel, S.; Järving, I.; Lopp, M.; Kananovich, D. (2017). Two-step Conversion of Carboxylic Esters into Distally Fluorinated Ketones via Ring Cleavage of Cyclopropanol Intermediates: Application of Sulfinate Salts as Fluoroalkylating Reagents. Organic & Biomolecular Chemistry, 15, 4635−4643.10.1039/C7OB00680B.
1.1.
2017
Eek, P.; Põldemaa, K.; Kasvandik, S.; Järving, I.; Samel, N. (2017).

A PDZ-like domain mediates the dimerization of 11R-lipoxygenase

. BBA Molecular and Cell Biology of Lipids, 1862 (10, A), 1121−1128.10.1016/j.bbalip.2017.07.012.
1.1.
2017
Konik, Y. A.; Elek, G. Z.; Kaabel, S.; Järving, I.; Lopp, M.; Kananovich, D. G. (2017). Synthesis of γ-keto sulfones by copper-catalyzed oxidative sulfonylation of tertiary cyclopropanols. Organic & Biomolecular Chemistry, 15 (39), 8334−8340.10.1039/C7OB01605K.
1.1.
2017
Preegel, G.; Silm, E.; Kaabel, S.; Järving, I.; Rissanen, K.; Lopp, M. (2017). Asymmetric Organocatalytic Michael Addition–Cyclization Cascade of Cyclopentane-1,2-dione with Substituted α,β-Unsaturated Aldehydes. Synthesis, 49 (14), 3118−3125.10.1055/s-0036-1588787.
5.1.
2017
Smirnova, J.; Golendukhina, E.; Järving, I.; Tõugu, V.; Plitz, T.; Palumaa, P. (2017). Copper(I)-binding properties of de-coppering drugs for treatment of Wilson disease. FEBS Journal, 284 (S1), 337.
1.1.
2016
Ošeka, M.; Kimm, M.; Kaabel, S.; Järving, I.; Rissanen, K.; Kanger, T. (2016). Asymmetric Organocatalytic Wittig [2,3]-Rearrangement of Oxindoles. Organic Letters, 18 (6), 1358−1361.10.1021/acs.orglett.6b00291.
1.1.
2016
Maljutenko, Karolin; Paju, Anne; Järving, Ivar; Pehk, Tõnis; Lopp, Margus (2016). Kinetic resolution of epoxy alcohols with the Sharpless Ti-isopropoxide/tartaric ester complex. Tetrahedron-Asymmetry, 27, 608−613.10.1016/j.tetasy.2016.05.007.
5.2.
2016
Fomitšenko, M.; Prigorchenko, E.; Peterson, A.; Trunin, M.; Järving, I.; Aav, R. (2016). ANALYSIS OF INTERMEDIATES AND QUANTIFICATION OF PRODUCTS IN SYNTHESIS OF HEMICUCURBITURILS. International Conference in Organic Synthesis: Balticum Organicum Syntheticum, Riga, Latvia, 3-6. July 2016. BOS, 61.
5.2.
2016
Eek, P.; Põldemaa, K.; Kasvandik, S.; Järving, I.; Samel, N. (2016). Investigation of 11R-lipoxygenase quaternary structure. Book of Abstracts: 6th European Workshop on Lipid Mediators, Goethe University in Frankfurt am Main, Germany, 27-30.09.2016. Frankfurt am Main, Saksamaa: Goethe University, 112.
1.1.
2015
Lippur, K.; Kaabel, S.; Järving, I.; Rissanen, K.; Kanger, T. (2015). CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction. The Journal of Organic Chemistry, 80 (12), 6336−6341.10.1021/acs.joc.5b00769.
1.1.
2015
Kananovich, D. G.; Konik, Y. A.; Zubrytski, D. M.; Järving, I.; Lopp, M. (2015). A Simple Access to β-Trifluoromethyl-Substituted Ketones via Copper-Catalyzed Ring-Opening Trifluoromethylation of Substituted Cyclopropanols. Chemical Communications, 51, 8349−8352.10.1039/c5cc02386f.
1.1.
2015
Kaasik, M.; Noole, A.; Reitel, K.; Järving, I.; Kanger, T. (2015). Organocatalytic Conjugate Addition of Cyclopropylacetaldehyde Derivatives to Nitro Olefins: en Route to β- and γ-Amino Acids. European Journal of Organic Chemistry, 8, 1745−1753.10.1002/ejoc.201403387.
1.1.
2015
Žari, S.; Metsala, A.; Kudrjashova, M.; Kaabel, S.; Järving, I.; Kanger, T. (2015). Asymmetric Organocatalytic Aza-Michael Reactions of Isatin Derivatives. Synthesis, 47 (6), 875−886.10.1055/s-0034-1379956.
1.1.
2015
Preegel, Gert; Ilmarinen, Kaja; Järving, Ivar; Kanger, Tõnis; Pehk, Tõnis; Lopp, Margus (2015). Enantioselective Organocatalytic Michael Addition-Cyclization Cascade of Cyclopentane-1,2-dione with Substituted (E)-2-oxobut-3-enoates. Synthesis, 3805−3812.
1.1.
2015
Prigorchenko, E.; Öeren, M.; Kaabel, S.; Fomitšenko, M.; Reile, I.; Järving, I.; Tamm, T.; Topic, F.; Rissanen, K.; Aav, R. (2015). Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril. Chemical Communications, 51, 10921−10924.
1.1.
2015
Prigorchenko, E.; Öeren, M.; Kaabel, S.; Fomitšenko, M.; Reile, I.; Järving, I.; Tamm, T.; Topic, F.; Rissanen, K.; Aav, R. (2015). Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril. Chemical Communications, 51 (54), 10921−10924.10.1039/c5cc04101e.
5.2.
2015
Fomitšenko, M.; Peterson, A.; Prigorchenko, E.; Järving, I.; Aav, R. (2015). Analysis and quantification of remacrocyclisation of cyclohexylhemicucurbituril homologues. Euroanalysis2015, Bordeaux; France, 6th - 10th September 2015.
1.1.
2014
Preegel, G.; Noole, A.; Ilmarinen, K.; Järving, I.; Kanger, T.; Pehk, T.; Lopp, M. (2014). Enantioselective Organocatalytic Michael Addition of Cyclopentane-1,2-diones to Nitroolefins. Synthesis, 46 (19), 2595−2600.10.1055/s-0034-1378374.
1.1.
2014
Hansen, K.; Varvas, K.; Järving, I.; Samel, N. (2014). Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 174, 45−52.10.1016/j.cbpb.2014.05.004.
1.1.
2014
Fomitšenko, M.; Shmatova, E.; Öeren, M.; Järving, I.; Aav, R. (2014). New homologues of chiral cyclohexylhemicucurbit[n]urils. Supramolecular Chemistry, 26 (9), 698−703.10.1080/10610278.2014.926362.
1.1.
2014
Villo, L.; Metsala, A.; Tamp, S.; Parve, J.; Vallikivi, I.; Järving, I.; Samel, N.; Lille, Ü.; Pehk, T.; Parve, O. (2014). Thermomyces lanuginosus Lipase with Closed Lid Catalyzes Elimination of Acetic Acid from 11-Acetyl-Prostaglandin E2. ChemCatChem, 6, 1998−2010.
1.1.
2014
Reile, Indrek; Kalle, Sigrid; Werner, Franz; Järving, Ivar; Kudrjashova, Marina; Paju, Anne; Lopp, Margus (2014). Heterogeneous Platinum Catalytic Aerobic Oxidation of Cyclopentane-1,2-diols to Cyclopentane-1,2-diones. Tetrahedron, 70 (22), 3608−3613.
1.1.
2014
Paju , Anne; Oja, Karolin; Matkevitš, Katharina; Lumi, Priit; Järving, Ivar; Pehk, Tõnis. (2014). Asymmetric synthesis of tertiary 2-substituted 5-oxotetrahydrofuran-2-carboxylic acids. Heterocycles, 88 (2), 981−995.
5.2.
2014
Fomitšenko, M.; Shmatova, E.; Öeren, M.; Järving, I.; Aav, R. (2014). Separation and analysis of new cyclohexylhemicucurbituril homologues. 20th International Symposium on Separation Sciences, Prague, Czech Republic, 30.08.14-02.09.14. , 110.
1.1.
2013
Reitel, K.; Lippur, K.; Järving, I.; Kudrjašova, M.; Lopp, M.; Kanger, T. (2013). Asymmetric Aminocatalytic Michael Addition of Cyclopropane-Containing Aldehydes to Nitroalkenes. Synthesis, 45 (19), 2679−2683.10.1055/s-0033-1338704.
1.1.
2013
Noole, A.; Ilmarinen, K.; Järving, I.; Lopp, M.; Kanger, T. (2013). Asymmetric Synthesis of Congested Spiro-cyclopentaneoxindoles via an Organocatalytic Cascade Reaction. The Journal of Organic Chemistry, 78 (16), 8117−8122.10.1021/jo4008223.
1.1.
2013
Niidu, A.; Paju, A.; Müürisepp, A.-M.; Järving, I.; Kailas, T.; Pehk, T.; Lopp, M. (2013). Stereoselective synthesis of 1-methyl-1,2-and 1,3-cyclopentanediols via g-lactones. Chemistry of Heterocyclic Compounds, 48 (12), 1751−1760.10.1007/s10593-013-1206-4.
1.1.
2013
Noole, Artur; Ošeka, Maksim; Pehk, Tõnis; Öeren, Mario; Järving, Ivar; Elsegood, Mark; Malkov, Andrei; Lopp, Margus; Kanger, Tõnis. (2013). 3-Chlorooxindoles: Versatile Starting Materials for Asymmetric Organocatalytic Synthesis of Spirooxindoles. Advanced Synthesis & Catalysis, 355 (5), 829−835.
1.1.
2013
Varvas, K., Kasvandik, S., Hansen, K., Järving, I., Morell, I., Samel, N. (2013). Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831 (4), 863−871.10.1016/j.bbalip.2012.11.010.
1.1.
2012
Ausmees, K.; Kriis, K.; Pehk, T.; Werner, F.; Järving, I.; Lopp, M.; Kanger, T. (2012). Diastereoselective Multicomponent Cascade Reaction Leading to [3.2.0]-Heterobicyclic Compounds. The Journal of Organic Chemistry, 77 (23), 10680−10687.10.1021/jo3019413.
1.1.
2012
Noole, A.; Järving, I.; Werner, F.; Lopp, M.; Malkov, A.; Kanger, T. (2012).

Organocatalytic Asymmetric Synthesis of 3-Chlorooxindoles Bearing Adjacent Quaternary–Tertiary Centers

. Organic Letters, 14 (18), 4922−4925. DOI: 10.1021/ol302245b.
1.1.
2012
Lippur, K.; Tiirik, T.; Kudrjashova, M.; Järving, I.; Lopp, M.; Kanger, T. (2012). Amination of quinolones with morpholine derivatives. Tetrahedron, 68 (47), 9550−9555.10.1016/j.tet.2012.09.082.
1.1.
2012
Žari, S.; Kailas, T.; Kudrjashova, M.; Öeren, M.; Järving, I.; Tamm, T.; Lopp, M.; Kanger, T. (2012). Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones. Beilstein Journal of Organic Chemistry, 8, 1452−1457.10.3762/bjoc.8.165.
1.1.
2012
Eek, P.; Järving, R.; Järving, I.; Gilbert, N. C.; Newcomer, M. E.; Samel, N. (2012). Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation. Journal of Biological Chemistry, 287 (26), 22377−22386.10.1074/jbc.M112.343285.
1.1.
2012
Reile, I.; Paju, A.; Kanger, T.; Järving, I.; Lopp, M. (2012). Cyclopentane-1,2-dione bis(tert-butyldimethylsilyl) enol ether in asymmetric organocatalytic Mukaiyama–Michael reactions. Tetrahedron Letters, 53 (12), 1476−1478.10.1016/j.tetlet.2012.01.041.
1.1.
2012
Järving, R.; Lõokene, A.; Kurg, R.; Siimon, L.; Järving, I.; Samel, N. (2012). Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane. Biochemistry, 51 (15), 3310−3320.10.1021/bi201690z.
1.1.
2012
Noole, A.; Pehk, T.; Järving, I.; Lopp, M.; Kanger, T. (2012). Organocatalytic asymmetric synthesis of trisubstituted pyrrolidines via a cascade reaction. Tetrahedron-Asymmetry, 23 (2), 188−198.10.1016/j.tetasy.2012.01.021.
5.2.
2011
Eek, P.; Järving, R.; Järving, I.; Newcomer, M. E.; Samel, N. (2011). 11R-lipoksügenaasi kristallstruktuuri mudel. Teaduskonverentsi teesid: XXXII Eesti keemiapäevad, Tartu, 14.-15. aprill 2011. Tartu: Tartu Ülikooli Kirjastus, 18.
1.2.
2010
Parve, O.; Järving, I.; Martin, I.; Metsala, A.; Vallikivi, I.; Aidnik, M.; Pehk, T.; Samel, N. (2010). Lipase-Catalysed Acylation of Prostanoids. ChemInform, On-Line, -. DOI: 10.1002/chin.199945282.
5.1.
2010
Lõhelaid, H.; Järving, R.; Järving, I.; Samel, N. (2010). Chimeric allene oxide synthase-lipoxygenase fusion proteins. FEBS Journal, 277, 251.
1.1.
2009
Varvas, K.; Kurg, R.; Hansen, K.; Järving, R.; Järving, I.; Valmsen, K.; Lõhelaid, H.; Samel, N. (2009). Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: Genetic and biochemical characterization of two crustacean cyclooxygenases. Insect Biochemistry and Molecular Biology, 39 (12), 851−860.
5.2.
2009
Villo, L.; Tamp, S.; Vallikivi, I.; Järving, I.; Pehk, T.; Parve, O. (2009). An NMR Spectroscopic Investigation of Functional Group Selectivity of Lipase-Catalysed Reactions of 11-Acetyl Prostaglandins E1 and E2. Biotrans 2009; Berne, Switzerland; July 5-9, 2009. 66.
1.1.
2008
Lõhelaid, H.; Järving, R.; Valmsen, K.; Varvas, K.; Kreen, M.; Järving, I.; Samel, N. (2008). Identification of a functional allene oxide synthase-lipoxygenase fusion protein in the soft coral Gersemia fruticosa suggests the generality of this pathway in octocorals. Biochimica et Biophysica Acta (BBA) - General Subjects, 1780 (2), 315−321.
5.1.
2008
Hansen, K.; Kurg, R.; Varvas, K.; Valmsen, K.; Järving, I.; Järving, R.; Samel, N. (2008). Cloning, expression and characterization of cyclooxygenase gene from amphipods. FEBS Journal: Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference. Athens, GREECE, JUN 28-JUL 03, 2008. , 403. (275).
1.1.
2007
Valmsen, K.; Boeglin, W. E.; Järving, R.; Järving, I.; Varvas, K.; Brash, A.R.; Samel, N. (2007). A Critical Role of Non-active Site Residues on Cyclooxygenase Helices 5 and 6 in the Control of Prostaglandin Stereochemistry at Carbon 15. Journal of Biological Chemistry, 282 (38), 28157−28163.
5.2.
2007
Lõhelaid, H.; Järving, R.; Järving, I.; Samel, N. (2007). Alleenoksiidi süntaas-lipoksügenaas liitvalgu rada on üldlevinud korallides. XXX Eesti Keemiapäevad Teaduskonverentsi teesid: XXX Eesti Keemiapäevad Tartus 16. november 2007. Toim. Rinken, A. Tartu: Tartu Ülikooli Kirjastus, 84−85.
5.2.
2007
Hansen, K.; Kurg, R.; Varvas, K.; Järving, I.; Järving, R.; Valmsen, K.; Samel, N. (2007). Tsüklooksügenaas kirpvähilistest: kloneerimine, ekspresseerimine ja iseloomustamine. XXX Eesti Keemiapäevad Teaduskonverentsi teesid: XXX Eesti Keemiapäevad Tartus 16. november 2007. Toim. Rinken, A. Tartu: Tartu Ülikooli Kirjastus, 30−31.
1.1.
2006
Mortimer, M.; Jarving, R.; Brash, AR.; Samel, N.; Jarving, I (2006). Identification and characterization of an arachidonate 11R-lipoxygenase. Archives of Biochemistry and Biophysics, 445 (1), 147−155.
5.1.
2006
Järving, R.; Mortimer, M.; Brash, A.R.; Samel, N.; Järving, I. (2006). Identification and characterization of a naturally occurring 11R-lipoxygenase. Prostaglandins & Other Lipid Mediators, 79, 184−184.
1.1.
2005
Vallikivi, I.; Fransson, L.; Hult, K.; Jarving, I.; Pehk, T.; Samel, N.; Tõugu, V.; Villo, L.; Parve, O. (2005). The modelling and kinetic investigation of the lipase-catalysed acetylation of stereoisomeric prostaglandins. Journal of Molecular Catalysis B-Enzymatic, 35, 62−69.
1.1.
2004
Vallikivi, Imre; Järving, Ivar; Pehk, Tõnis; Samel, Nigulas; Tõugu, Vello; Parve, Omar (2004). NMR Monitoring of Lipase-catalysed Reactions of Prostaglandins: Preliminary Estimation of Reaction Velocities. Journal of Molecular Catalysis B-Enzymatic, 32, 15−19.
1.1.
2004
Valmsen, K.; Boeglin, WE.; Jarving, I.; Schneider, C.; Varvas, K.; Brash, AR.; Samel, N (2004). Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. European Journal of Biochemistry, 271 (17), 3533−3538.
1.1.
2004
Jarving, R.; Jarving, I.; Kurg, R.; Brash, AR.; Samel, N. (2004). On the evolutionary origin of cyclooxygenase (COX) isozymes - Characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages. Journal of Biological Chemistry, 279 (14), 13624−13633.
1.1.
2001
Valmsen, K.; Jarving, I.; Boeglin, WE.; Varvas, K.; Koljak, R.; Pehk, T.; Brash, AR.; Samel, N (2001). The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase. Proceedings of the National Academy of Sciences, 98 (14), 7700−7705.
1.1.
2001
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N (2001). Comparison of anti-aggregatory effects of PGI(2), PGI(3) and iloprost on human and rabbit platelets. Cellular Physiology and Biochemistry, 11 (5), 279−284.
1.1.
2001
Koljak, R.; Jarving, I.; Kurg, R.; Boeglin, WE.; Varvas, K.; Valmsen, K.; Ustav, M.; Brash, AR.; Samel, N. (2001). The basis of prostaglandin synthesis in coral - Molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. Journal of Biological Chemistry, 276 (10), 7033−7040.
1.2.
2001
Mardla, V.; Kobzar, G.; Rätsep, I.; Lõhmus, M.; Järving, I.; Samel, N. (2001). Sensitivity of platelets to prostaglandins in patients with coronary artery disease. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 50 (1), 33−36.
1.1.
1999
Parve, O.; Jarving, I.; Martin, I.; Metsala, A.; Vallikivi, I.; Aidnik, M.; Pehk, T.; Samel, N (1999). Lipase-catalysed acylation of prostanoids. Bioorganic & Medicinal Chemistry Letters, 9 (13), 1853−1858.
1.1.
1999
Varvas, K.; Jarving, I.; Koljak, R.; Valmsen, K.; Brash, AR.; Samel, N (1999). Evidence of a cyclooxygenase-related prostaglandin synthesis in coral - The allene oxide pathway is not involved in prostaglandin biosynthesis. Journal of Biological Chemistry, 274 (15), 9923−9929.
1.2.
1999
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N. (1999). Blood plasma antiaggregatory potency of prostaglandins: effects of albumin. Inflammopharmacology, 7 (2), 179−185.
5.2.
1999
Parve, Omar; Vallikivi, Imre; Martin, Ivar; Järving, Ivar; Samel, Nigulas (1999). Lipase-Catalysed Derivatisation of Prostanoids. Programme and Abstracts: 11th European Symposium on Organic Chemistry, Göteborg, Sweden, July 23-28, 1999. Göteborg, P179.
1.1.
1998
Koljak, R.; Lopp, A.; Pehk, T.; Varvas, K.; Müürisepp, AM.; Järving, I.; Samel, N. (1998). New Cytotoxic Sterols from the Soft Coral Gersemia fruticosa. Tetrahedron, 54, 179−186.
1.1.
1997
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N.; Lõhmus, M. (1997). Modulatory effect of 8-iso PGE2 on platelets. General Pharmacology, 28, 317−321.
5.2.
1997
Jäälaid, R.; Veressinina, J.; Järving, I.; Pehk, T.; Lille, Ü. (1997). Ergosterooli muundamine 9,11-secosteroolide saamiseks. 23rd Estonian Chemistry Days.Tallinn, 1997. 37.
5.1.
1996
Varvas, K.; Järving, I.; Valmsen, K.; Koljak, R.; Samel, N. (1996). Effect of Selective Inhibitors on Arachidonic Acid Metabolism in the Soft Coral Gersemia fruticosa. Prostaglandins Leukotrienes and Essential Fatty Acids, 55, Supplement 1: 10th International Conference on Prostaglandins and Related Compounds, Vienna, Austria, 1996. , 82−82.
1.1.
1994
Varvas, K.; Koljak, R.; Järving, I.; Pehk, T.; Samel, N. (1994). Endoperoxide Pathway in Prostaglandin Biosynthesis in the Soft Coral Gersemia fruticosa. Tetrahedron Letters, 35, 8267−8270.
1.1.
1993
Varvas, K.; Järving, I.; Koljak, R.; Vahemets, A.; Pehk, T.; Müürisepp, A.-M.; Lille, Ü.; Samel, N. (1993). In vitro Biosynthesis of Prostaglandins in the White Sea Soft Coral Gersemia fruticosa. Formation of Optically Active PGD2, PGE2, PGF2a and 15-keto-PGF2a from Arachidonic Acid. Tetrahedron Letters, 34, 3643−3646.
1.1.
1993
Koljak, R.; Pehk, T.; Järving, I.; Liiv, M.; Lopp, A.; Varvas, K.; Lille, Ü.; Samel, N. (1993). New Antiproliferative 9,11-Secosterol from the Soft Coral Gersemia fruticosa. Tetrahedron Letters, 34, 1985−1986.
1.1.
1982
Mevkh, A. T.; Basevich, V. V.; Jarving, I.; Varfolomeev, S. D. (1982). Inactivation of prostaglandin endoperoxide synthetase from the microsomal fraction of human platelets during the enzyme reaction. Biokhimiya (Moscow), 47 (11), 1852−1858.

Tööstusomand

25.08.2020

Ivar Järving

https://etis.ee/CV/Ivar_Järving/eng
13.07.1957
6204388
-
ivar.jarving@ttu.ee
http://
A-1864-2019

Career

Institutions and positions
01.09.2018–...   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Senior Lecturer (1,00)
01.01.2017–...   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Director (1,00)
01.01.1979–...   
Other staff
01.01.2017–31.08.2018   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Senior Researcher (1,00)
2008–31.12.2013   
Competence Center for Cancer Research, Senior Researcher (0,20)
1991–31.12.2016   
Tallinn University of Technology , Faculty of Science, Department of Chemistry, Chair of Bioorganic Chemistry, Senior Researcher (1,00)
01.12.1980–31.12.1981   
Moscow State University, 1980-1981 Research Fellow, Moscow State University (1,00)
 
 
Education
01.09.1975–01.06.1980   
Faculty of Chemistry, TTU; Graduated as a Dipl. Chemical Engineer,1980
 
 
Creative work
*
 
 
Additional information
*
Meditsiiniline keemia, Looduslike ühendite keemia, Protsessid ja seadmed toidu töötlemisel - loeng, praktikum, üliõpilaste juhendamine

Qualifications

Academic degrees
Ivar Järving, Doctor's Degree, 1991, (sup) Nigulas Samel; Ülo Lille, Tromboksaan A2 metaboliitide ja looduslike E prostaglandiinide süntees (Synthesis of thromboxane A2 metabolits and E prostaglandins), Eesti Teaduste Akadeemia Keemia Instituut.
 
 
Honours & awards
2002, Ivar Järving, National Prize in Chemistry and Molecular Biology for studies on "Biosynthesis of prostaglandins in coral"
1986, Ivar Järving, All-Union Prize for Leninsky Komsomol for Science and Technology in 1986.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: T360 Biochemical technology
 
 
Additional information
candidate of sciences
Estonian Academy of Sciences, Institute of Chemistry, 1991
Medicinal Chemistry, Natural products chemistry, Main processes of food technology - lecture,laboratory practical training, Supervision of students.

Projects in progress

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2020
Bhadoria, R.; Ping, K.; Lohk, C.; Järving, I.; Starkov, P. (2020). A phenotypic approach to probing cellular outcomes using heterobivalent constructs. Chemical Communications, 4216−4219. DOI: 10.1039/C9CC09595K.
1.1.
2020
Trubitsõn, Dmitri; Martõnova, Jevgenija; Erkman, Kristin; Metsala, Andrus; Saame, Jaan; Kõster, Kristjan; Järving, Ivar; Leito, Ivo; Kanger, Tõnis (2020). Enantioselective N-Alkylation of Nitroindoles under Phase-Transfer Catalysis. Synthesis, 52 (07), 1047−1059. DOI: 10.1055/s-0039-1690751.
1.1.
2019
Ermolovich, Y.; Barysevich, M. V.; Adamson, J.; Rogova, O.; Kaabel, S.; Järving, I.; Gathergood, N.; Snieckus, V.; Kananovich, D. G. (2019). Site-Selective and Stereoselective C–H Functionalization of N-Cyclopropylamides via a Directed Remote Metalation Strategy. Organic Letters.10.1021/acs.orglett.8b03955.
1.1.
2019
Kaabel, S.; Stein, R. S.; Fomitšenko, M. Järving, I.; Friščić, T.; Aav, R. (2019). Size-Control by Anion Templating in Mechanochemical Synthesis of Hemicucurbiturils in the Solid State. Angewandte Chemie International Edition.10.1002/anie.201813431.
1.1.
2019
Kaasik, M.; Metsala, A.; Kaabel, S.; Kriis, K.; Järving, I.; Kanger, T. (2019). Halo-1,2,3-triazolium Salts as Halogen Bond Donors for the Activation of Imines in Dihydropyridinone Synthesis. The Journal of Organic Chemistry, 84, 4294−4303.10.1021/acs.joc.9b00248.
1.1.
2019
Kaasik, M.; Kaabel, S.; Kriis, K.; Järving, I.; Kanger, T. (2019). Synthesis of Chiral Triazole-Based Halogen Bond Donors. Synthesis, 51, 2128−2135.10.1055/s-0037-1610864.
1.1.
2019
Peterson, Anna; Kaasik, Mikk; Metsala, Andrus; Järving, Ivar; Adamson, Jasper; Kanger, Tõnis (2019). Tunable chiral triazole-based halogen bond donors: assessment of donor strength in solution with nitrogen-containing acceptors. RSC Advances, 9 (21), 11718−11721.10.1039/c9ra01692a.
1.1.
2019
Ping, K.; Alam, M.; Käärik, M.; Leis, J.; Kongi, N.; Järving, I.; Starkov, P. (2019). Surveying Iron–Organic Framework TAL-1 Derived Materials in Ligandless Heterogenous Oxidative Catalytic Transformations of Alkylarenes. Synlett, 30, 1536−1540. DOI: 10.1055/s-0037-1611877.
1.1.
2019
Kimm, Mariliis; Oseka, Maksim; Kaabel, Sandra; Metsala, Andrus; Järving, Ivar; Kanger, Tõnis (2019). [2,3]-Wittig Rearrangement as a Formal Asymmetric Alkylation of alpha-Branched Ketones. Organic Letters, 21 (13), 4976−4980.10.1021/acs.orglett.9b01495.
1.1.
2019
Põldemaa, K.; Lipp, M.; Järving, I.; Samel, N.; Eek, P. (2019). Gly188Arg substitution eliminates substrate inhibition in arachidonate 11R-lipoxygenase. Biochemical and Biophysical Research Communications, 519 (1), 81−85.10.1016/j.bbrc.2019.08.132.
1.1.
2019
Elek, G. Z.; Koppel, K.; Zubrytski, D. M.; Konrad, N.; Järving, I.; Lopp, M.; Kananovich, D. G. (2019). Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via a Late-Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin. Organic Letters, 21 (20), 8473−8478.10.1021/acs.orglett.9b03305.
1.1.
2019
Silm, Estelle; Kaabel, Sandra; Järving, Ivar; Kanger, Tõnis (2019). Asymmetric Organocatalytic Michael Addition-Cyclisation Cascade of Cyclopentane-1,2-dione with Alkylidene Malononitriles. Synthesis, 51 (22), 4198−4204. DOI: 10.1055/s-0039-1690484.
1.1.
2019
Murre, A.; Erkman, K.; Kaabel, S.; Järving, I.; Kanger, T. (2019). Diastereoselective [2,3]-Sigmatropic Rearrangement of N-Allyl Ammonium Ylides. Synthesis, 51 (22), 4183−4197. DOI: 10.1055/s-0039-1690185.
1.1.
2018
Maljutenko, K.; Borovkov, V.; Kananovich, D.; Järving, I.; Lopp, M. (2018). Aerobic cascade oxidation of substituted cyclopentane-1,2-diones using metalloporphyrin catalysts. Tetrahedron, 74 (6), 661−664.10.1016/j.tet.2017.12.009.
1.1.
2018
Smirnova, J.; Kabin, E.; Järving, I.; Bragina, O.; Tõugu, V.; Plitz, T.; Palumaa, P. (2018). Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent. Scientific Reports, 8 (1, 1463), 1−9.10.1038/s41598-018-19873-2.
1.1.
2018
Trubitsõn, D.; Žari, S.; Kaabel, S.; Kudrjashova, M.; Kriis, K.; Järving, I.; Pehk, T.; Kanger, T. (2018). Asymmetric Organocatalytic Cascade Synthesis of Tetrahydro­furanyl Spirooxindoles. Synthesis, 50 (02), 314−322.10.1055/s-0036-1590918.
1.1.
2018
Lopušanskaja, E.; Paju, A.; Järving, I.; Lopp, M. (2018). Synthesis of Cyclic 3-Aryl-Substituted 1,2-Dicarbonyl Compounds via Suzuki Cross-Coupling Reactions. Synthesis, 50 (9), 1883−1890.10.1055/s-0036-1591543.
1.1.
2018
Reitel, K.; Kriis, K.; Järvin, I.; Kanger, T. (2018). Study of the asymmetric organocatalyzed [3+2] annulation of cyclopropenone and β-keto ester. Chemistry of Heterocyclic Compounds, 54 (10), 929−933.10.1007/s10593-018-2372-1.
1.1.
2017
Kriis, K.; Melnik, T.; Lips, K.; Juhanson, I.; Kaabel, S.; Järving, I.; Kanger, T. (2017). Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines. Synthesis, 49 (3), 604−614.10.1055/s-0036-1588299.
1.1.
2017
Fomitšenko, M.; Peterson, A.; Reile, I.; Cong, H.; Kaabel, K.; Prigorchenko, E.; Järving I.; Aav R. (2017). A quantitative method for analysis of mixtures of homologues and stereoisomers of hemicucurbiturils that allows us to follow their formation and stability. New Journal of Chemistry, 41, 2490−2497.10.1039/C6NJ03050E.
1.1.
2017
Ošeka, M.; Kimm, M.; Järving, I.; Lippur, K.; Kanger, T. (2017). Two Catalytic Methods of an Asymmetric Wittig [2,3]-Rearrangement. The Journal of Organic Chemistry, 82 (6), 2889−2897.10.1021/acs.joc.6b02786.
1.1.
2017
Kaasik, M.; Kaabel, S.; Kriis, K.; Järving, I.; Aav, R.; Rissanen, K.; Kanger, T. (2017). Synthesis and Characterisation of Chiral Triazole-Based Halogen-Bond Donors: Halogen Bonds in the Solid State and in Solution. Chemistry - A European Journal, 23 (30), 7337−7344.10.1002/chem.201700618.
1.1.
2017
Konik, Y. A.; Kudrjashova, M.; Konrad, N.; Kaabel, S.; Järving, I.; Lopp, M.; Kananovich, D. (2017). Two-step Conversion of Carboxylic Esters into Distally Fluorinated Ketones via Ring Cleavage of Cyclopropanol Intermediates: Application of Sulfinate Salts as Fluoroalkylating Reagents. Organic & Biomolecular Chemistry, 15, 4635−4643.10.1039/C7OB00680B.
1.1.
2017
Eek, P.; Põldemaa, K.; Kasvandik, S.; Järving, I.; Samel, N. (2017).

A PDZ-like domain mediates the dimerization of 11R-lipoxygenase

. BBA Molecular and Cell Biology of Lipids, 1862 (10, A), 1121−1128.10.1016/j.bbalip.2017.07.012.
1.1.
2017
Konik, Y. A.; Elek, G. Z.; Kaabel, S.; Järving, I.; Lopp, M.; Kananovich, D. G. (2017). Synthesis of γ-keto sulfones by copper-catalyzed oxidative sulfonylation of tertiary cyclopropanols. Organic & Biomolecular Chemistry, 15 (39), 8334−8340.10.1039/C7OB01605K.
1.1.
2017
Preegel, G.; Silm, E.; Kaabel, S.; Järving, I.; Rissanen, K.; Lopp, M. (2017). Asymmetric Organocatalytic Michael Addition–Cyclization Cascade of Cyclopentane-1,2-dione with Substituted α,β-Unsaturated Aldehydes. Synthesis, 49 (14), 3118−3125.10.1055/s-0036-1588787.
5.1.
2017
Smirnova, J.; Golendukhina, E.; Järving, I.; Tõugu, V.; Plitz, T.; Palumaa, P. (2017). Copper(I)-binding properties of de-coppering drugs for treatment of Wilson disease. FEBS Journal, 284 (S1), 337.
1.1.
2016
Ošeka, M.; Kimm, M.; Kaabel, S.; Järving, I.; Rissanen, K.; Kanger, T. (2016). Asymmetric Organocatalytic Wittig [2,3]-Rearrangement of Oxindoles. Organic Letters, 18 (6), 1358−1361.10.1021/acs.orglett.6b00291.
1.1.
2016
Maljutenko, Karolin; Paju, Anne; Järving, Ivar; Pehk, Tõnis; Lopp, Margus (2016). Kinetic resolution of epoxy alcohols with the Sharpless Ti-isopropoxide/tartaric ester complex. Tetrahedron-Asymmetry, 27, 608−613.10.1016/j.tetasy.2016.05.007.
5.2.
2016
Fomitšenko, M.; Prigorchenko, E.; Peterson, A.; Trunin, M.; Järving, I.; Aav, R. (2016). ANALYSIS OF INTERMEDIATES AND QUANTIFICATION OF PRODUCTS IN SYNTHESIS OF HEMICUCURBITURILS. International Conference in Organic Synthesis: Balticum Organicum Syntheticum, Riga, Latvia, 3-6. July 2016. BOS, 61.
5.2.
2016
Eek, P.; Põldemaa, K.; Kasvandik, S.; Järving, I.; Samel, N. (2016). Investigation of 11R-lipoxygenase quaternary structure. Book of Abstracts: 6th European Workshop on Lipid Mediators, Goethe University in Frankfurt am Main, Germany, 27-30.09.2016. Frankfurt am Main, Saksamaa: Goethe University, 112.
1.1.
2015
Lippur, K.; Kaabel, S.; Järving, I.; Rissanen, K.; Kanger, T. (2015). CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction. The Journal of Organic Chemistry, 80 (12), 6336−6341.10.1021/acs.joc.5b00769.
1.1.
2015
Kananovich, D. G.; Konik, Y. A.; Zubrytski, D. M.; Järving, I.; Lopp, M. (2015). A Simple Access to β-Trifluoromethyl-Substituted Ketones via Copper-Catalyzed Ring-Opening Trifluoromethylation of Substituted Cyclopropanols. Chemical Communications, 51, 8349−8352.10.1039/c5cc02386f.
1.1.
2015
Kaasik, M.; Noole, A.; Reitel, K.; Järving, I.; Kanger, T. (2015). Organocatalytic Conjugate Addition of Cyclopropylacetaldehyde Derivatives to Nitro Olefins: en Route to β- and γ-Amino Acids. European Journal of Organic Chemistry, 8, 1745−1753.10.1002/ejoc.201403387.
1.1.
2015
Žari, S.; Metsala, A.; Kudrjashova, M.; Kaabel, S.; Järving, I.; Kanger, T. (2015). Asymmetric Organocatalytic Aza-Michael Reactions of Isatin Derivatives. Synthesis, 47 (6), 875−886.10.1055/s-0034-1379956.
1.1.
2015
Preegel, Gert; Ilmarinen, Kaja; Järving, Ivar; Kanger, Tõnis; Pehk, Tõnis; Lopp, Margus (2015). Enantioselective Organocatalytic Michael Addition-Cyclization Cascade of Cyclopentane-1,2-dione with Substituted (E)-2-oxobut-3-enoates. Synthesis, 3805−3812.
1.1.
2015
Prigorchenko, E.; Öeren, M.; Kaabel, S.; Fomitšenko, M.; Reile, I.; Järving, I.; Tamm, T.; Topic, F.; Rissanen, K.; Aav, R. (2015). Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril. Chemical Communications, 51, 10921−10924.
1.1.
2015
Prigorchenko, E.; Öeren, M.; Kaabel, S.; Fomitšenko, M.; Reile, I.; Järving, I.; Tamm, T.; Topic, F.; Rissanen, K.; Aav, R. (2015). Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril. Chemical Communications, 51 (54), 10921−10924.10.1039/c5cc04101e.
5.2.
2015
Fomitšenko, M.; Peterson, A.; Prigorchenko, E.; Järving, I.; Aav, R. (2015). Analysis and quantification of remacrocyclisation of cyclohexylhemicucurbituril homologues. Euroanalysis2015, Bordeaux; France, 6th - 10th September 2015.
1.1.
2014
Preegel, G.; Noole, A.; Ilmarinen, K.; Järving, I.; Kanger, T.; Pehk, T.; Lopp, M. (2014). Enantioselective Organocatalytic Michael Addition of Cyclopentane-1,2-diones to Nitroolefins. Synthesis, 46 (19), 2595−2600.10.1055/s-0034-1378374.
1.1.
2014
Hansen, K.; Varvas, K.; Järving, I.; Samel, N. (2014). Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 174, 45−52.10.1016/j.cbpb.2014.05.004.
1.1.
2014
Fomitšenko, M.; Shmatova, E.; Öeren, M.; Järving, I.; Aav, R. (2014). New homologues of chiral cyclohexylhemicucurbit[n]urils. Supramolecular Chemistry, 26 (9), 698−703.10.1080/10610278.2014.926362.
1.1.
2014
Villo, L.; Metsala, A.; Tamp, S.; Parve, J.; Vallikivi, I.; Järving, I.; Samel, N.; Lille, Ü.; Pehk, T.; Parve, O. (2014). Thermomyces lanuginosus Lipase with Closed Lid Catalyzes Elimination of Acetic Acid from 11-Acetyl-Prostaglandin E2. ChemCatChem, 6, 1998−2010.
1.1.
2014
Reile, Indrek; Kalle, Sigrid; Werner, Franz; Järving, Ivar; Kudrjashova, Marina; Paju, Anne; Lopp, Margus (2014). Heterogeneous Platinum Catalytic Aerobic Oxidation of Cyclopentane-1,2-diols to Cyclopentane-1,2-diones. Tetrahedron, 70 (22), 3608−3613.
1.1.
2014
Paju , Anne; Oja, Karolin; Matkevitš, Katharina; Lumi, Priit; Järving, Ivar; Pehk, Tõnis. (2014). Asymmetric synthesis of tertiary 2-substituted 5-oxotetrahydrofuran-2-carboxylic acids. Heterocycles, 88 (2), 981−995.
5.2.
2014
Fomitšenko, M.; Shmatova, E.; Öeren, M.; Järving, I.; Aav, R. (2014). Separation and analysis of new cyclohexylhemicucurbituril homologues. 20th International Symposium on Separation Sciences, Prague, Czech Republic, 30.08.14-02.09.14. , 110.
1.1.
2013
Reitel, K.; Lippur, K.; Järving, I.; Kudrjašova, M.; Lopp, M.; Kanger, T. (2013). Asymmetric Aminocatalytic Michael Addition of Cyclopropane-Containing Aldehydes to Nitroalkenes. Synthesis, 45 (19), 2679−2683.10.1055/s-0033-1338704.
1.1.
2013
Noole, A.; Ilmarinen, K.; Järving, I.; Lopp, M.; Kanger, T. (2013). Asymmetric Synthesis of Congested Spiro-cyclopentaneoxindoles via an Organocatalytic Cascade Reaction. The Journal of Organic Chemistry, 78 (16), 8117−8122.10.1021/jo4008223.
1.1.
2013
Niidu, A.; Paju, A.; Müürisepp, A.-M.; Järving, I.; Kailas, T.; Pehk, T.; Lopp, M. (2013). Stereoselective synthesis of 1-methyl-1,2-and 1,3-cyclopentanediols via g-lactones. Chemistry of Heterocyclic Compounds, 48 (12), 1751−1760.10.1007/s10593-013-1206-4.
1.1.
2013
Noole, Artur; Ošeka, Maksim; Pehk, Tõnis; Öeren, Mario; Järving, Ivar; Elsegood, Mark; Malkov, Andrei; Lopp, Margus; Kanger, Tõnis. (2013). 3-Chlorooxindoles: Versatile Starting Materials for Asymmetric Organocatalytic Synthesis of Spirooxindoles. Advanced Synthesis & Catalysis, 355 (5), 829−835.
1.1.
2013
Varvas, K., Kasvandik, S., Hansen, K., Järving, I., Morell, I., Samel, N. (2013). Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1831 (4), 863−871.10.1016/j.bbalip.2012.11.010.
1.1.
2012
Ausmees, K.; Kriis, K.; Pehk, T.; Werner, F.; Järving, I.; Lopp, M.; Kanger, T. (2012). Diastereoselective Multicomponent Cascade Reaction Leading to [3.2.0]-Heterobicyclic Compounds. The Journal of Organic Chemistry, 77 (23), 10680−10687.10.1021/jo3019413.
1.1.
2012
Noole, A.; Järving, I.; Werner, F.; Lopp, M.; Malkov, A.; Kanger, T. (2012).

Organocatalytic Asymmetric Synthesis of 3-Chlorooxindoles Bearing Adjacent Quaternary–Tertiary Centers

. Organic Letters, 14 (18), 4922−4925. DOI: 10.1021/ol302245b.
1.1.
2012
Lippur, K.; Tiirik, T.; Kudrjashova, M.; Järving, I.; Lopp, M.; Kanger, T. (2012). Amination of quinolones with morpholine derivatives. Tetrahedron, 68 (47), 9550−9555.10.1016/j.tet.2012.09.082.
1.1.
2012
Žari, S.; Kailas, T.; Kudrjashova, M.; Öeren, M.; Järving, I.; Tamm, T.; Lopp, M.; Kanger, T. (2012). Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones. Beilstein Journal of Organic Chemistry, 8, 1452−1457.10.3762/bjoc.8.165.
1.1.
2012
Eek, P.; Järving, R.; Järving, I.; Gilbert, N. C.; Newcomer, M. E.; Samel, N. (2012). Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation. Journal of Biological Chemistry, 287 (26), 22377−22386.10.1074/jbc.M112.343285.
1.1.
2012
Reile, I.; Paju, A.; Kanger, T.; Järving, I.; Lopp, M. (2012). Cyclopentane-1,2-dione bis(tert-butyldimethylsilyl) enol ether in asymmetric organocatalytic Mukaiyama–Michael reactions. Tetrahedron Letters, 53 (12), 1476−1478.10.1016/j.tetlet.2012.01.041.
1.1.
2012
Järving, R.; Lõokene, A.; Kurg, R.; Siimon, L.; Järving, I.; Samel, N. (2012). Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane. Biochemistry, 51 (15), 3310−3320.10.1021/bi201690z.
1.1.
2012
Noole, A.; Pehk, T.; Järving, I.; Lopp, M.; Kanger, T. (2012). Organocatalytic asymmetric synthesis of trisubstituted pyrrolidines via a cascade reaction. Tetrahedron-Asymmetry, 23 (2), 188−198.10.1016/j.tetasy.2012.01.021.
5.2.
2011
Eek, P.; Järving, R.; Järving, I.; Newcomer, M. E.; Samel, N. (2011). 11R-lipoksügenaasi kristallstruktuuri mudel. Teaduskonverentsi teesid: XXXII Eesti keemiapäevad, Tartu, 14.-15. aprill 2011. Tartu: Tartu Ülikooli Kirjastus, 18.
1.2.
2010
Parve, O.; Järving, I.; Martin, I.; Metsala, A.; Vallikivi, I.; Aidnik, M.; Pehk, T.; Samel, N. (2010). Lipase-Catalysed Acylation of Prostanoids. ChemInform, On-Line, -. DOI: 10.1002/chin.199945282.
5.1.
2010
Lõhelaid, H.; Järving, R.; Järving, I.; Samel, N. (2010). Chimeric allene oxide synthase-lipoxygenase fusion proteins. FEBS Journal, 277, 251.
1.1.
2009
Varvas, K.; Kurg, R.; Hansen, K.; Järving, R.; Järving, I.; Valmsen, K.; Lõhelaid, H.; Samel, N. (2009). Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: Genetic and biochemical characterization of two crustacean cyclooxygenases. Insect Biochemistry and Molecular Biology, 39 (12), 851−860.
5.2.
2009
Villo, L.; Tamp, S.; Vallikivi, I.; Järving, I.; Pehk, T.; Parve, O. (2009). An NMR Spectroscopic Investigation of Functional Group Selectivity of Lipase-Catalysed Reactions of 11-Acetyl Prostaglandins E1 and E2. Biotrans 2009; Berne, Switzerland; July 5-9, 2009. 66.
1.1.
2008
Lõhelaid, H.; Järving, R.; Valmsen, K.; Varvas, K.; Kreen, M.; Järving, I.; Samel, N. (2008). Identification of a functional allene oxide synthase-lipoxygenase fusion protein in the soft coral Gersemia fruticosa suggests the generality of this pathway in octocorals. Biochimica et Biophysica Acta (BBA) - General Subjects, 1780 (2), 315−321.
5.1.
2008
Hansen, K.; Kurg, R.; Varvas, K.; Valmsen, K.; Järving, I.; Järving, R.; Samel, N. (2008). Cloning, expression and characterization of cyclooxygenase gene from amphipods. FEBS Journal: Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference. Athens, GREECE, JUN 28-JUL 03, 2008. , 403. (275).
1.1.
2007
Valmsen, K.; Boeglin, W. E.; Järving, R.; Järving, I.; Varvas, K.; Brash, A.R.; Samel, N. (2007). A Critical Role of Non-active Site Residues on Cyclooxygenase Helices 5 and 6 in the Control of Prostaglandin Stereochemistry at Carbon 15. Journal of Biological Chemistry, 282 (38), 28157−28163.
5.2.
2007
Lõhelaid, H.; Järving, R.; Järving, I.; Samel, N. (2007). Alleenoksiidi süntaas-lipoksügenaas liitvalgu rada on üldlevinud korallides [Generality of the allene oxide synthase-lipoxygenase fusion protein pathway in corals]. XXX Eesti Keemiapäevad Teaduskonverentsi teesid: XXX Eesti Keemiapäevad Tartus 16. november 2007. Toim. Rinken, A. Tartu: Tartu Ülikooli Kirjastus, 84−85.
5.2.
2007
Hansen, K.; Kurg, R.; Varvas, K.; Järving, I.; Järving, R.; Valmsen, K.; Samel, N. (2007). Tsüklooksügenaas kirpvähilistest: kloneerimine, ekspresseerimine ja iseloomustamine [Cloning, expression and characterization of cyclooxygenase gene from amphipods]. XXX Eesti Keemiapäevad Teaduskonverentsi teesid: XXX Eesti Keemiapäevad Tartus 16. november 2007. Toim. Rinken, A. Tartu: Tartu Ülikooli Kirjastus, 30−31.
1.1.
2006
Mortimer, M.; Jarving, R.; Brash, AR.; Samel, N.; Jarving, I (2006). Identification and characterization of an arachidonate 11R-lipoxygenase. Archives of Biochemistry and Biophysics, 445 (1), 147−155.
5.1.
2006
Järving, R.; Mortimer, M.; Brash, A.R.; Samel, N.; Järving, I. (2006). Identification and characterization of a naturally occurring 11R-lipoxygenase. Prostaglandins & Other Lipid Mediators, 79, 184−184.
1.1.
2005
Vallikivi, I.; Fransson, L.; Hult, K.; Jarving, I.; Pehk, T.; Samel, N.; Tõugu, V.; Villo, L.; Parve, O. (2005). The modelling and kinetic investigation of the lipase-catalysed acetylation of stereoisomeric prostaglandins. Journal of Molecular Catalysis B-Enzymatic, 35, 62−69.
1.1.
2004
Vallikivi, Imre; Järving, Ivar; Pehk, Tõnis; Samel, Nigulas; Tõugu, Vello; Parve, Omar (2004). NMR Monitoring of Lipase-catalysed Reactions of Prostaglandins: Preliminary Estimation of Reaction Velocities. Journal of Molecular Catalysis B-Enzymatic, 32, 15−19.
1.1.
2004
Valmsen, K.; Boeglin, WE.; Jarving, I.; Schneider, C.; Varvas, K.; Brash, AR.; Samel, N (2004). Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. European Journal of Biochemistry, 271 (17), 3533−3538.
1.1.
2004
Jarving, R.; Jarving, I.; Kurg, R.; Brash, AR.; Samel, N. (2004). On the evolutionary origin of cyclooxygenase (COX) isozymes - Characterization of marine invertebrate COX genes points to independent duplication events in vertebrate and invertebrate lineages. Journal of Biological Chemistry, 279 (14), 13624−13633.
1.1.
2001
Valmsen, K.; Jarving, I.; Boeglin, WE.; Varvas, K.; Koljak, R.; Pehk, T.; Brash, AR.; Samel, N (2001). The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase. Proceedings of the National Academy of Sciences, 98 (14), 7700−7705.
1.1.
2001
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N (2001). Comparison of anti-aggregatory effects of PGI(2), PGI(3) and iloprost on human and rabbit platelets. Cellular Physiology and Biochemistry, 11 (5), 279−284.
1.1.
2001
Koljak, R.; Jarving, I.; Kurg, R.; Boeglin, WE.; Varvas, K.; Valmsen, K.; Ustav, M.; Brash, AR.; Samel, N. (2001). The basis of prostaglandin synthesis in coral - Molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. Journal of Biological Chemistry, 276 (10), 7033−7040.
1.2.
2001
Mardla, V.; Kobzar, G.; Rätsep, I.; Lõhmus, M.; Järving, I.; Samel, N. (2001). Sensitivity of platelets to prostaglandins in patients with coronary artery disease. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 50 (1), 33−36.
1.1.
1999
Parve, O.; Jarving, I.; Martin, I.; Metsala, A.; Vallikivi, I.; Aidnik, M.; Pehk, T.; Samel, N (1999). Lipase-catalysed acylation of prostanoids. Bioorganic & Medicinal Chemistry Letters, 9 (13), 1853−1858.
1.1.
1999
Varvas, K.; Jarving, I.; Koljak, R.; Valmsen, K.; Brash, AR.; Samel, N (1999). Evidence of a cyclooxygenase-related prostaglandin synthesis in coral - The allene oxide pathway is not involved in prostaglandin biosynthesis. Journal of Biological Chemistry, 274 (15), 9923−9929.
1.2.
1999
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N. (1999). Blood plasma antiaggregatory potency of prostaglandins: effects of albumin. Inflammopharmacology, 7 (2), 179−185.
5.2.
1999
Parve, Omar; Vallikivi, Imre; Martin, Ivar; Järving, Ivar; Samel, Nigulas (1999). Lipase-Catalysed Derivatisation of Prostanoids. Programme and Abstracts: 11th European Symposium on Organic Chemistry, Göteborg, Sweden, July 23-28, 1999. Göteborg, P179.
1.1.
1998
Koljak, R.; Lopp, A.; Pehk, T.; Varvas, K.; Müürisepp, AM.; Järving, I.; Samel, N. (1998). New Cytotoxic Sterols from the Soft Coral Gersemia fruticosa. Tetrahedron, 54, 179−186.
1.1.
1997
Kobzar, G.; Mardla, V.; Järving, I.; Samel, N.; Lõhmus, M. (1997). Modulatory effect of 8-iso PGE2 on platelets. General Pharmacology, 28, 317−321.
5.2.
1997
Jäälaid, R.; Veressinina, J.; Järving, I.; Pehk, T.; Lille, Ü. (1997). Ergosterooli muundamine 9,11-secosteroolide saamiseks. 23rd Estonian Chemistry Days.Tallinn, 1997. 37.
5.1.
1996
Varvas, K.; Järving, I.; Valmsen, K.; Koljak, R.; Samel, N. (1996). Effect of Selective Inhibitors on Arachidonic Acid Metabolism in the Soft Coral Gersemia fruticosa. Prostaglandins Leukotrienes and Essential Fatty Acids, 55, Supplement 1: 10th International Conference on Prostaglandins and Related Compounds, Vienna, Austria, 1996. , 82−82.
1.1.
1994
Varvas, K.; Koljak, R.; Järving, I.; Pehk, T.; Samel, N. (1994). Endoperoxide Pathway in Prostaglandin Biosynthesis in the Soft Coral Gersemia fruticosa. Tetrahedron Letters, 35, 8267−8270.
1.1.
1993
Varvas, K.; Järving, I.; Koljak, R.; Vahemets, A.; Pehk, T.; Müürisepp, A.-M.; Lille, Ü.; Samel, N. (1993). In vitro Biosynthesis of Prostaglandins in the White Sea Soft Coral Gersemia fruticosa. Formation of Optically Active PGD2, PGE2, PGF2a and 15-keto-PGF2a from Arachidonic Acid. Tetrahedron Letters, 34, 3643−3646.
1.1.
1993
Koljak, R.; Pehk, T.; Järving, I.; Liiv, M.; Lopp, A.; Varvas, K.; Lille, Ü.; Samel, N. (1993). New Antiproliferative 9,11-Secosterol from the Soft Coral Gersemia fruticosa. Tetrahedron Letters, 34, 1985−1986.
1.1.
1982
Mevkh, A. T.; Basevich, V. V.; Jarving, I.; Varfolomeev, S. D. (1982). Inactivation of prostaglandin endoperoxide synthetase from the microsomal fraction of human platelets during the enzyme reaction. Biokhimiya (Moscow), 47 (11), 1852−1858.

Industrial property

25.08.2020

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF827611R-lipoksügenaasi katalüütiliste omaduste modifitseerimine01.01.201031.12.2013Ivar JärvingTallinna Tehnikaülikool, Matemaatika-loodusteaduskond47 750,23 EUR
MUUBF2Analüütilise baasi kaasajastamine bioorgaanilise keemia õppetoolis17.06.200531.12.2007Nigulas SamelTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool17 256,15 EUR
MUU1.7. (EU30013)Anticancer vaccines based on Plant Virus Coat Protein (CP) Virus Like Particles (VLPs)01.07.200930.06.2015Ivar JärvingVähiuuringute Tehnoloogia Arenduskeskus AS166 170,29 EUR
SFSF0140010s08Bioaktiivsed lipiidid - metabolism, signaaliülekanne ja regulatsioon01.01.200831.12.2013Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond893 128,26 EUR
MUUG5100 (ETF5100)Enatiomeerselt puhaste monohüdroperoksühapete preparatiivne biokatalüütiline süntees rekombinantsete lipoksügenaasidega01.01.200231.12.2005Ivar JärvingTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool18 125,34 EUR
IUTIUT19-9Lipiidide ja lipoproteiinide metabolismi struktuursed ja regulatoorsed aspektid01.01.201431.12.2019Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond; Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut1 182 000,00 EUR
MUUV204NIH GM Grant - Arahhidoonhappe uut tüüpi oksüdatsioonid01.09.200231.08.2006Nigulas SamelTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool103 536,87 EUR
MUUT314 (0350314s98)Rasvhapete dioksügenaasid ja eikosanoid-hormoonid01.01.199831.12.2002Nigulas SamelTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool93 311,01 EUR
SFSF0142499s03Rasvhappe dioksügenaasid ja eikosanoidhormoonid01.01.200331.12.2007Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond424 245,52 EUR
ETFETF6831Rekombinantse 11R-lipoksügenaasi katalüütiliste omaduste uurimine ja modifitseerimine01.01.200631.12.2009Ivar JärvingTallinna Tehnikaülikool, Matemaatika-loodusteaduskond31 889,36 EUR
RESTARESTA12Toidu säilivusaja pikendamine ning kvaliteedi ja ohutuse tagamine01.07.202030.06.2023Ivar JärvingTallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut549 720,00 EUR
ETFETF6911Tsüklooksügenaasi katalüüsi ja inhibeerimise iseärasused01.01.200731.12.2010Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond63 073,14 EUR
MUUG3783 (ETF3783)Uus prostaglandiinsüntetaas - võrdlus imetajate tsüklooksügenaasidega01.01.199931.12.2002Nigulas SamelTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool22 049,52 EUR
ETFETF5639Uute tsüklooksügenaaside mehhanismiuuringud01.01.200331.12.2006Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond44 696,05 EUR