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Olen nõus

Merli Saare

https://etis.ee/CV/Merli_Saare/est
28.11.1976
merli.saare@ut.ee
Endine perekonnanimi OJARAND

Teenistuskäik

Töökohad ja ametid
01.04.2018–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut, reproduktiivmeditsiini teadur (1,00)
01.01.2010–...   
Tervisetehnoloogiate Arenduskeskus AS (endine Reproduktiivmeditsiini TAK AS) , Teadur (0,50)
01.01.2016–31.01.2018   
Tartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut, reproduktiivmeditsiini teadur (1,00)
01.02.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, reproduktiivmeditsiini teadur (1,00)
01.02.2013–30.04.2014   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, spetsialist (1,00)
01.02.2012–31.01.2015   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, reproduktiivmeditsiini teadur (1,00)
01.08.2009–31.01.2012   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, teadur (1,00)
01.02.2009–31.07.2009   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, teadur (0,50)
2009–2012   
Tartu Ülikool, Arstiteaduskond, Naistekliinik, Sünnitusabi ja günekoloogia õppetool, teadur (1,00)
01.08.2008–31.12.2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (0,50)
2008–2009   
Eesti Biokeskus, Erakorraline teadur (0,10)
01.01.1999–31.12.2001   
Tähe Erakliinik, sekretär-administraator
01.01.1998–31.12.1999   
Tartu Ülikooli kliinikum, Neuroloogia osakond, hooldusõde
 
 
Haridustee
2011–14.06.2016   
TÜ arstiteaduskond doktorantuur
2005–2008   
Tartu Ülikool, Arstiteaduskond, biomeditsiini magistriõpe
2001–2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, geenitehnoloogia eriala.

Kvalifikatsioon

Teaduskraadid
Merli Saare, doktorikraad, 2016, (juh) Helle Karro; Maire Peters; Andres Salumets, Molecular Profiling of Endometriotic Lesions and Endometria of Endometriosis Patients, Tartu Ülikool.
Merli Saare, magistrikraad (teaduskraad), 2008, (juh) Maire Peters; Helle Karro, Androgeeni retseptori ja 5α-reduktaasi tüüp 2 geenide polümorfismide seos idiopaatilise mehepoolse viljatusega, Tartu Ülikool, Arstiteaduskond.
 
 
Teaduspreemiad ja tunnustused
2016, Merli Saare, TÜ Sihtasutus, Andreas ja Elmerice Traksi stipendium
2008, Merli Saare, Ecogene Naisteadlase stipendium
2006, Merli Saare, TÜ kliinikumi teadustöö preemia
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS KLASSIFIKAATOR: B220 Geneetika, tsütogeneetika
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin

Jooksvad projektid

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Stepanjuk, Artjom; Koel, Mariann; Pook, Martin; Saare, Merli; Jääger, Kersti; Peters, Maire; Krjutškov, Kaarel; Ingerpuu, Sulev; Salumets, Andres (2019). MUC20 expression marks the receptive phase of the human endometrium. Reproductive BioMedicine Online, 39 (5), 725−736. DOI: 10.1016/j.rbmo.2019.05.004.
 
Saare, Merli; Krigul, Kertu Liis; Laisk-Podar, Triin; Ponandai-Srinivasan, Sakthivignesh; Rahmioglu, Nilufer; Kumar, Parameswaran Grace Lalit; Zondervan, Krina; Salumets, Andres; Peters, Maire (2018). DNA methylation alterations-potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity? Biology of Reproduction, 99 (2), 273−282. DOI: 10.1093/biolre/ioy067.
 
Ponandai-Srinivasan, Sakthivignesh; Andersson, Karin L; Nister, Monica; Saare, Merli; Hassan, Halima A; Varghese, Suby J; Peters, Maire; Salumets, Andres; Gemzell-Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther (2018). Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis. Human Reproduction, 33 (10), 1924−1938. DOI: 10.1093/humrep/dey241.
 
Rekker, K.; Tasa, T.; Saare, M.; Samuel, K.; Kadastik, Ü.; Karro, H.; Götte, M.; Salumets, A.; Peters, M. (2018). Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375. International Journal of Molecular Sciences, 19 (12), 3789−3789. DOI: 10.3390/ijms19123789.
 
Rekker, Kadri; Saare, Merli; Eriste, Elo; Tasa, Tõnis; Kukuškina, Viktorija; Roost, Anne Mari; Anderson, Kristi; Samuel, Külli; Karro, Helle; Salumets, Andres; Peters, Maire (2017). High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium. Reproduction, 154 (1), 93−100. DOI: 10.1530/REP-17-0092.
 
Saare, Merli; Rekker, Kadri; Laisk-Podar, Triin; Rahmioglu, Nilufer; Zondervan, Krina; Salumets, Andres; Götte, Martin; Peters, Maire (2017). Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs. BBA Molecular Basis of Disease, 1863 (9), 2282−2292. DOI: 10.1016/j.bbadis.2017.06.018.
 
Rahmioglu, Nilufer; Drong, Alexander W; Lockstone, Helen; Tapmeier, Thomas; Hellner, Karin; Saare, Merli; Laisk-Podar, Triin; Dew, Christine; Tough, Emily; Nicholson, George; Peters, Maire; Morris, Andrew P; Lindgren, Cecilia M; Becker, Christian M; Zondervan, Krina T (2017). Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues. Epigenetics, 12 (10), 897−908. DOI: 10.1080/15592294.2017.1367475.
 
Altmäe, Signe; Koel, Mariann; Võsa, Urmo; Adler, Priit; Suhorutšenko, Marina; Laisk-Podar, Triin; Kukushkina, Viktorija; Saare, Merli; Velthut-Meikas, Agne; Krjutškov, Kaarel; Aghajanova, Lusine; Lalitkumar, Parameswaran G; Gemzell-Danielsson, Kristina; Giudice, Linda; Simón, Carlos; Salumets, Andres (2017). Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Scientific Reports, 7 (1), 10077−10077. DOI: 10.1038/s41598-017-10098-3.
 
Saare, Merli; Modhukur, Vijayachitra; Suhorutshenko, Marina; Rajashekar, Balaji; Rekker, Kadri; Sõritsa, Deniss; Karro, Helle; Soplepmann, Pille; Sõritsa, Andrei; Lindgren, Cecilia M; Rahmioglu, Nilufer; Drong, Alexander; Becker, Christian M; Zondervan, Krina T; Salumets, Andres; Peters, Maire (2016). The influence of menstrual cycle and endometriosis on endometrial methylome. Clinical Epigenetics, 8 (2), 1−10. DOI: 10.1186/s13148-015-0168-z.
 
Krjutškov, K; Katayama, S; Saare, M; Vera-Rodriguez, M; Lubenets, D; Samuel, K; Laisk-Podar, T; Teder, H; Einarsdottir, E; Salumets, A; Kere, J (2016). Single-cell transcriptome analysis of endometrial tissue. Human Reproduction, 31 (4), 844−853. DOI: 10.1093/humrep/dew008.
 
Rekker, K.; Saare, M.; Roost, AM.; Kaart, T.; Sõritsa, D.; Karro, H.; Sõritsa, A.; Simón, C.; Salumets, A.; Peters, M. (2015). Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. Fertility and Sterility, 104 (4), 938−946. DOI: 10.1016/j.fertnstert.2015.06.029.
 
Sõritsa, Deniss; Saare, Merli;, Laisk-Podar, Triin; Peters, Maire; Sõritsa, Andrei; Matt, Kadri; Karro, Helle; Salumets, Andres (2015). Pregnancy Rate in Endometriosis Patients according to the Severity of the Disease after Using a Combined Approach of Laparoscopy, GnRH Agonist Treatment and in vitro Fertilization. Gynecologic and Obstetric Investigation, 79 (1), 34−39. DOI: 10.1159/000365329.
 
Saare, M.; Rekker, K.; Laisk-Podar, T.; Sõritsa, D.; Roost, AM.; Simm, J.; Velthut-Meikas, A.; Samuel, K.; Metsalu, T.; Karro, H.; Sõritsa, A.; Salumets, A.; Peters, M. (2014). High-Throughput Sequencing Approach Uncovers the miRNome of Peritoneal Endometriotic Lesions and Adjacent Healthy Tissues. PLoS ONE, 9 (11), e112630. DOI: 10.1371/journal.pone.0112630.
 
Rekker, K.; Saare, M.; Roost, AM.; Kubo, AL.; Zarovni, N.; Chiesi, A.; Salumets, A.; Peters, M. (2014). Comparison of serum exosome isolation methods for microRNA profiling. Clinical Biochemistry, 47, 135−138. DOI: 10.1016/j.clinbiochem.2013.10.020.
 
Rekker, K; Saare, M; Roost, AM; Salumets, A; Peters, M. (2013). Circulating microRNA Profile throughout the Menstrual Cycle. PLoS ONE, 8 (11), e81166. DOI: 10.1371/journal.pone.0081166.
 
Lamp, Merit; Saare, Merli; Kadastik, Ülle; Karro, Helle; Salumets, Andres; Uibo, Raivo; Peters, Maire. (2012). Survivin promoter polymorphisms and autoantibodies in endometriosis. Journal of Reproductive Immunology, 96 (1), 95−100. DOI: 10.1016/j.jri.2012.10.001.
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; D'Hooghe, Thomas; Peters, Maire (2012). No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis. Human Reproduction, 27 (6), 1857−1864. DOI: 10.1093/humrep/des125.
 
Altmäe, S.; Reimand, J.; Hovatta, O.; Zhang, P.; Kere, J.; Laisk, T.; Saare, M.; Peters, M.; Vilo, J.; Stavreus-Evers, A.; Salumets, A. (2012). Research Resource: Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks. Molecular Endocrinology, 26 (1), 203−217.
 
Lamp, M; Saare, M; Laisk, T; Karro, H; Kadastik, Ü; Metspalu, A; Peters, M; Salumets, A. (2010). Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 153 (1), 85−89. DOI: 10.1016/j.ejogrb.2010.07.021.
 
Laisk, T; Peters, M; Saare, M; Haller-Kikkatalo, K; Karro, H; Salumets, A. (2010). Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility. Journal of Reproductive Immunology, 87 (1), 74−81. DOI: 10.1016/j.jri.2010.06.001.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2010). Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis. Fertility and Sterility, 94 (4), 1560−1563. DOI: 10.1016/j.fertnstert.2009.12.024.
 
Peters, M.; Saare, M.; Kaart, T.; Haller-Kikkatalo, K.; Lend, A. K.; Punab, M.; Metspalu, A.; Salumets, A. (2010). Analysis of polymorphisms in the SRD5A2 gene and semen parameters in Estonian men. Journal of Andrology, 31 (4), 372−378. DOI: 10.2164/jandrol.109.008714.
 
Altmäe, S.; Haller, K.; Peters, M.; Saare, M.; Hovatta, O.; Stavreus-Evers, A.; Velthut, A.; Karro, H.; Metspalu, A.; Salumets, A. (2009). Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report. Reproductive BioMedicine Online, 18 (5), 651−657.
 
Saare, M.; Belousova, A.; Punab, M.; Peters, M.; Haller, K.; Ausmees, K.; Poolamets, O.; Karro, H.; Metspalu, A.; Salumets, A. (2008). Androgen receptor gene haplotype is associated with male infertility. International Journal of Andrology, 31 (4), 395−402. DOI: 10.1111/j.1365-2605.2007.00782.x.
 
Laasik, E.; Ojarand, M.; Pajunen, M.; Savilahti, H.; Mae, A. (2005). Novel mutants of Erwinia carotovora subsp carotovora defective in the production of plant cell wall degrading enzymes generated by Mu transpososome-mediated insertion mutagenesis. FEMS Microbiology Letters, 243 (1), 93−99.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Saare, Merli; Anderson, Kristi; Karro, Helle; Salumets, Andres; Peters, Maire (2017). Otsides nõela heinakuhjast – endometrioosi biomarkerid. Eesti Arst, 96 (6), 335−341.
 
Saare, Merli; Lamp, Merit; Kadasti, Ülle; Karro, Helle; Laisk, Triin; Salumets, Andres; Matt, Kadri; Peters, Maire. (2011). Endometrioos - anamneesist diagnoosini. Eesti Arst, 90 (7), 321−326.
 
Saare, M.; Lend, A.K.; Sikut, A.; Salumets, A.; Peters, M. (2008). Mehe geneetiline viljatus. Eesti Arst, 628−634.
3.1. Artiklid/peatükid lisas loetletud kirjastuste välja antud kogumikes (kaasa arvatud Web of Science Book Citation Index, Web of Science Conference Proceedings Citation Index, Scopus refereeritud kogumikud)
 
Saare, Merli; Peters, Maire; Aints, Alar; Laisk-Podar, Triin; Salumets, Andres; Altmäe, Signe (2019). OMICs studies and endometriosis biomarker identification. In: Biomarkers for Endometriosis: State of the Art (227−258). Springer. DOI: 10.1007/978-3-319-59856-7_12.
5.1. Konverentsiteesid, mida kajastab Thomson Reuters Web of Science
 
Peters, Maire; Altmäe, Signe; Reimand, Jüri; Laisk, Triin; Saare, Merli; Hovatta, Outti; Kolde, Raivo; Vilo, Jaak; Stavreus-Evers, Anneli; Salumets, Andres. (2011). Human embryo-endometrium interactions at the time of implantation. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 216−216. (1).
 
Saare, Merli; Sõritsa, Deniss; Järva, Liis; Vaidla, Kadri; Palta, Priit; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Detection of Genomic alterations in endometriosis using high-density SNP-arrays. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 213−214. (1).
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Sõritsa, G; Saare, M; Laisk-Podar, T; Padrik, L; Kadastik, Ü; Sõritsa, A; Soplepmann, P; Matt, K; Karro, H; Salumets, A. (2013). Endometrioosiga seotud viljatus: erineva endometrioosi raskusastmega patsientide rasestumine 12 kuu jooksul pärast laparoskoopiat. Eesti Arst, 9.
 
Saare, M; Vaidla, K; Laisk-Podar, T; Sõritsa, D; Simm, J; Velthut-Meikas, A; Karro, H; Metsis, M; Sõritsa, A; Salumets, A; Peters, M. (2013). High-Throughput miRNA sequencing reveals two endometriotic foci-specific miRNAs. In: . European Human Genetics Conference 2013, 08. juuni – 11. juuni 2013, Pariis, Prantsusmaa.
 
Saare, M; Vaidla, K; Laisk-Podar, T; Sõritsa, D; Simm, J; Velthut-Meikas, A; Karro, H; Sõritsa, A; Salumets, A; Peters, M. (2013). miRNA-based molecular test for diagnosing endometriosis − a possible new alternative for routine histological examination? Journal of Endometriosis and Pelvic Pain Disorders: 2nd European Congress on Endometriosis 2013. Wichting Editore, 27−27. (Vol 5 Suppl 1 (October-December 2013)).
 
Sõritsa, Denis; Saare, Merli; Laisk-Podar, Triin; Sõritsa, Andrei; Matt, Kadri; Salumets, Andres. (2012). Endometriosis and infertility: pregnancy outcome in different stages of endometriosis during 12 months after laparoscopy. The Book of Abstracts: 22nd EBCOG. Tallinn, Estonia, FC09.03.
 
Saare, Merli; Vaidla, Kadri; Salumets, Andres; Peters, Maire. (2012). Plasma miRNA profile during the menstrual cycle. Human Reproduction, 27: ESHRE 2012, Istanbul, 01-04.07.2012. , 226−227.
 
Saare, Merli; Vaidla, Kadri; Salumets, Andres; Peters, Maire. (2012). A hunt for endometriosis specific plasma miRNAs. Journal of Endometriosis, 4: 1st European Congress on Endometriosis, 29 november-1 detsember, Siena, Itaalia. Milano, Itaalia: Wichtig Editore, 222−223. (4; 4).
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Genomic alterations in Endometriosis. European Human Genetics Conference 2011, 28 - 31 Mai , Amsterdam, Holland. , 159.
 
Deniss, Sõritsa; Andrei, Sõritsa; Triin, Laisk; Saare, Merli; Helle, Karro; Andres, Salumets. (2011). Combined treatment of endometriosis: IVF Results. 11th World Congress on Endometriosis, 4-7 september, Montpellier, Prantsusmaa. , 171.
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). High-density snp-array analysis- no evidence of genomic alterations in endometriosis patients. 11th World Congress on Endometriosis, 4-7 september 2011, Montpellier, Prantsusmaa. , 91−92.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2009). Single nucleotide polymorphisms in the VEGF, MMP-2 and MMP-9 are associated with risk of endometriosis. 59th Annual Meeting of The American Society of Human Genetics; Honolulu, USA; 20.10-24.10.2009.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2009). Single nucleotide polymorphisms in promoters of MMP-2 and MMP-9 are associated with endometriosis risk. In: European Journal of Human Genetics. European Human Genetics Conference 2009; Vienna, Austria; 23.05-26.05.2009. Nature Publishing Group. (2).
 
Altmäe, S.; Haller, K.; Saare, M.; Peters, M.; Karro, H.; Metspalu, A.; Salumets, A. (2007). Aromataasi CYP19 geeni (TTTA)n variatsioon mõjutab FSH-stimulatsiooni tulemuslikkust lastetuse ravis. Eesti Arst, 86 (9), 685−686.
6.8. Lühikirjutised teadusajakirjades ja kogumikes
 
Saare, Merli; Laisk, Triin; Teder, Hindrek; Paluoja, Priit; Palta, Priit; Koel, Mariann; Kirss, Fred; Karro, Helle; Soritsa, Deniss; Salumets, Andres; Krjutškov, Kaarel; Peters, Maire (2019). A molecular tool for menstrual cycle phase dating of endometrial samples in endometriosis transcriptome studies. Biology of Reproduction, 101 (1), 1−3. DOI: 10.1093/biolre/ioz072.
21.02.2021

Merli Saare

https://etis.ee/CV/Merli_Saare/eng
28.11.1976
merli.saare@ut.ee

Career

Institutions and positions
01.04.2018–...   
University of Tartu, Faculty of Medicine, Institute of Clinical Medicine, Research Fellow of Reproductive Medicine (1,00)
01.01.2010–...   
Competence Centre on Health Technologies, Researcher (0,50)
01.01.2016–31.01.2018   
University of Tartu, Faculty of Medicine, Institute of Clinical Medicine, Research Fellow (1,00)
01.02.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Research Fellow (1,00)
01.02.2013–30.04.2014   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Specialist (1,00)
01.02.2012–31.01.2015   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Research Fellow (1,00)
01.08.2009–31.01.2012   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Research Fellow (1,00)
01.02.2009–31.07.2009   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Research Fellow (0,50)
2009–2012   
University of Tartu, Faculty of Medicine, Department of Obstetrics and Gynecology, Chair of Obstetrics and Gynaecology, researcher (1,00)
01.08.2008–31.12.2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (0,50)
2008–2009   
Estonian Biocentre, Extraordinary Researcher (0,10)
01.01.1999–31.12.2001   
Other staff
01.01.1998–31.12.1999   
Other staff
 
 
Education
2011–14.06.2016   
Ph studies in Medicine, University of Tartu
2005–2008   
University of Tartu, MSc biomedicine
2001–2005   
University of Tartu, Faculty of Biology and Geography, Bachelor's degree of genetechnology

Qualifications

Academic degrees
Merli Saare, Doctor's Degree, 2016, (sup) Helle Karro; Maire Peters; Andres Salumets, Molecular Profiling of Endometriotic Lesions and Endometria of Endometriosis Patients (Genetic and epigenetic changes in endometriotic tissue), University of Tartu.
Merli Saare, Research Master's Degree, 2008, (sup) Maire Peters; Helle Karro, Androgeeni retseptori ja 5α-reduktaasi tüüp 2 geenide polümorfismide seos idiopaatilise mehepoolse viljatusega (Androgen receptor and 5α-reductase type2 gene polymorphisms in idiopathic male infertility), University of Tartu, Faculty of Medicine.
 
 
Honours & awards
2016, Merli Saare, TÜ Sihtasutus, Andreas ja Elmerice Traksi stipendium
2008, Merli Saare, Ecogene Women in Science grant
2006, Merli Saare, TU clinicum research award
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS CLASSIFICATION: B220 Genetics, cytogenetics
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine
 
 

Projects in progress

Completed projects

Supervised dissertations

Publications

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Stepanjuk, Artjom; Koel, Mariann; Pook, Martin; Saare, Merli; Jääger, Kersti; Peters, Maire; Krjutškov, Kaarel; Ingerpuu, Sulev; Salumets, Andres (2019). MUC20 expression marks the receptive phase of the human endometrium. Reproductive BioMedicine Online, 39 (5), 725−736. DOI: 10.1016/j.rbmo.2019.05.004.
 
Saare, Merli; Krigul, Kertu Liis; Laisk-Podar, Triin; Ponandai-Srinivasan, Sakthivignesh; Rahmioglu, Nilufer; Kumar, Parameswaran Grace Lalit; Zondervan, Krina; Salumets, Andres; Peters, Maire (2018). DNA methylation alterations-potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity? Biology of Reproduction, 99 (2), 273−282. DOI: 10.1093/biolre/ioy067.
 
Ponandai-Srinivasan, Sakthivignesh; Andersson, Karin L; Nister, Monica; Saare, Merli; Hassan, Halima A; Varghese, Suby J; Peters, Maire; Salumets, Andres; Gemzell-Danielsson, Kristina; Lalitkumar, Parameswaran Grace Luther (2018). Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis. Human Reproduction, 33 (10), 1924−1938. DOI: 10.1093/humrep/dey241.
 
Rekker, K.; Tasa, T.; Saare, M.; Samuel, K.; Kadastik, Ü.; Karro, H.; Götte, M.; Salumets, A.; Peters, M. (2018). Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375. International Journal of Molecular Sciences, 19 (12), 3789−3789. DOI: 10.3390/ijms19123789.
 
Rekker, Kadri; Saare, Merli; Eriste, Elo; Tasa, Tõnis; Kukuškina, Viktorija; Roost, Anne Mari; Anderson, Kristi; Samuel, Külli; Karro, Helle; Salumets, Andres; Peters, Maire (2017). High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium. Reproduction, 154 (1), 93−100. DOI: 10.1530/REP-17-0092.
 
Saare, Merli; Rekker, Kadri; Laisk-Podar, Triin; Rahmioglu, Nilufer; Zondervan, Krina; Salumets, Andres; Götte, Martin; Peters, Maire (2017). Challenges in endometriosis miRNA studies - from tissue heterogeneity to disease specific miRNAs. BBA Molecular Basis of Disease, 1863 (9), 2282−2292. DOI: 10.1016/j.bbadis.2017.06.018.
 
Rahmioglu, Nilufer; Drong, Alexander W; Lockstone, Helen; Tapmeier, Thomas; Hellner, Karin; Saare, Merli; Laisk-Podar, Triin; Dew, Christine; Tough, Emily; Nicholson, George; Peters, Maire; Morris, Andrew P; Lindgren, Cecilia M; Becker, Christian M; Zondervan, Krina T (2017). Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues. Epigenetics, 12 (10), 897−908. DOI: 10.1080/15592294.2017.1367475.
 
Altmäe, Signe; Koel, Mariann; Võsa, Urmo; Adler, Priit; Suhorutšenko, Marina; Laisk-Podar, Triin; Kukushkina, Viktorija; Saare, Merli; Velthut-Meikas, Agne; Krjutškov, Kaarel; Aghajanova, Lusine; Lalitkumar, Parameswaran G; Gemzell-Danielsson, Kristina; Giudice, Linda; Simón, Carlos; Salumets, Andres (2017). Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Scientific Reports, 7 (1), 10077−10077. DOI: 10.1038/s41598-017-10098-3.
 
Saare, Merli; Modhukur, Vijayachitra; Suhorutshenko, Marina; Rajashekar, Balaji; Rekker, Kadri; Sõritsa, Deniss; Karro, Helle; Soplepmann, Pille; Sõritsa, Andrei; Lindgren, Cecilia M; Rahmioglu, Nilufer; Drong, Alexander; Becker, Christian M; Zondervan, Krina T; Salumets, Andres; Peters, Maire (2016). The influence of menstrual cycle and endometriosis on endometrial methylome. Clinical Epigenetics, 8 (2), 1−10. DOI: 10.1186/s13148-015-0168-z.
 
Krjutškov, K; Katayama, S; Saare, M; Vera-Rodriguez, M; Lubenets, D; Samuel, K; Laisk-Podar, T; Teder, H; Einarsdottir, E; Salumets, A; Kere, J (2016). Single-cell transcriptome analysis of endometrial tissue. Human Reproduction, 31 (4), 844−853. DOI: 10.1093/humrep/dew008.
 
Rekker, K.; Saare, M.; Roost, AM.; Kaart, T.; Sõritsa, D.; Karro, H.; Sõritsa, A.; Simón, C.; Salumets, A.; Peters, M. (2015). Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. Fertility and Sterility, 104 (4), 938−946. DOI: 10.1016/j.fertnstert.2015.06.029.
 
Sõritsa, Deniss; Saare, Merli;, Laisk-Podar, Triin; Peters, Maire; Sõritsa, Andrei; Matt, Kadri; Karro, Helle; Salumets, Andres (2015). Pregnancy Rate in Endometriosis Patients according to the Severity of the Disease after Using a Combined Approach of Laparoscopy, GnRH Agonist Treatment and in vitro Fertilization. Gynecologic and Obstetric Investigation, 79 (1), 34−39. DOI: 10.1159/000365329.
 
Saare, M.; Rekker, K.; Laisk-Podar, T.; Sõritsa, D.; Roost, AM.; Simm, J.; Velthut-Meikas, A.; Samuel, K.; Metsalu, T.; Karro, H.; Sõritsa, A.; Salumets, A.; Peters, M. (2014). High-Throughput Sequencing Approach Uncovers the miRNome of Peritoneal Endometriotic Lesions and Adjacent Healthy Tissues. PLoS ONE, 9 (11), e112630. DOI: 10.1371/journal.pone.0112630.
 
Rekker, K.; Saare, M.; Roost, AM.; Kubo, AL.; Zarovni, N.; Chiesi, A.; Salumets, A.; Peters, M. (2014). Comparison of serum exosome isolation methods for microRNA profiling. Clinical Biochemistry, 47, 135−138. DOI: 10.1016/j.clinbiochem.2013.10.020.
 
Rekker, K; Saare, M; Roost, AM; Salumets, A; Peters, M. (2013). Circulating microRNA Profile throughout the Menstrual Cycle. PLoS ONE, 8 (11), e81166. DOI: 10.1371/journal.pone.0081166.
 
Lamp, Merit; Saare, Merli; Kadastik, Ülle; Karro, Helle; Salumets, Andres; Uibo, Raivo; Peters, Maire. (2012). Survivin promoter polymorphisms and autoantibodies in endometriosis. Journal of Reproductive Immunology, 96 (1), 95−100. DOI: 10.1016/j.jri.2012.10.001.
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; D'Hooghe, Thomas; Peters, Maire (2012). No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis. Human Reproduction, 27 (6), 1857−1864. DOI: 10.1093/humrep/des125.
 
Altmäe, S.; Reimand, J.; Hovatta, O.; Zhang, P.; Kere, J.; Laisk, T.; Saare, M.; Peters, M.; Vilo, J.; Stavreus-Evers, A.; Salumets, A. (2012). Research Resource: Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks. Molecular Endocrinology, 26 (1), 203−217.
 
Lamp, M; Saare, M; Laisk, T; Karro, H; Kadastik, Ü; Metspalu, A; Peters, M; Salumets, A. (2010). Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 153 (1), 85−89. DOI: 10.1016/j.ejogrb.2010.07.021.
 
Laisk, T; Peters, M; Saare, M; Haller-Kikkatalo, K; Karro, H; Salumets, A. (2010). Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility. Journal of Reproductive Immunology, 87 (1), 74−81. DOI: 10.1016/j.jri.2010.06.001.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2010). Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis. Fertility and Sterility, 94 (4), 1560−1563. DOI: 10.1016/j.fertnstert.2009.12.024.
 
Peters, M.; Saare, M.; Kaart, T.; Haller-Kikkatalo, K.; Lend, A. K.; Punab, M.; Metspalu, A.; Salumets, A. (2010). Analysis of polymorphisms in the SRD5A2 gene and semen parameters in Estonian men. Journal of Andrology, 31 (4), 372−378. DOI: 10.2164/jandrol.109.008714.
 
Altmäe, S.; Haller, K.; Peters, M.; Saare, M.; Hovatta, O.; Stavreus-Evers, A.; Velthut, A.; Karro, H.; Metspalu, A.; Salumets, A. (2009). Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report. Reproductive BioMedicine Online, 18 (5), 651−657.
 
Saare, M.; Belousova, A.; Punab, M.; Peters, M.; Haller, K.; Ausmees, K.; Poolamets, O.; Karro, H.; Metspalu, A.; Salumets, A. (2008). Androgen receptor gene haplotype is associated with male infertility. International Journal of Andrology, 31 (4), 395−402. DOI: 10.1111/j.1365-2605.2007.00782.x.
 
Laasik, E.; Ojarand, M.; Pajunen, M.; Savilahti, H.; Mae, A. (2005). Novel mutants of Erwinia carotovora subsp carotovora defective in the production of plant cell wall degrading enzymes generated by Mu transpososome-mediated insertion mutagenesis. FEMS Microbiology Letters, 243 (1), 93−99.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Saare, Merli; Anderson, Kristi; Karro, Helle; Salumets, Andres; Peters, Maire (2017). Otsides nõela heinakuhjast – endometrioosi biomarkerid. Eesti Arst, 96 (6), 335−341.
 
Saare, Merli; Lamp, Merit; Kadasti, Ülle; Karro, Helle; Laisk, Triin; Salumets, Andres; Matt, Kadri; Peters, Maire. (2011). Endometrioos - anamneesist diagnoosini. Eesti Arst, 90 (7), 321−326.
 
Saare, M.; Lend, A.K.; Sikut, A.; Salumets, A.; Peters, M. (2008). Mehe geneetiline viljatus. Eesti Arst, 628−634.
3.1. Artiklid/peatükid lisas loetletud kirjastuste välja antud kogumikes (kaasa arvatud Web of Science Book Citation Index, Web of Science Conference Proceedings Citation Index, Scopus refereeritud kogumikud)
 
Saare, Merli; Peters, Maire; Aints, Alar; Laisk-Podar, Triin; Salumets, Andres; Altmäe, Signe (2019). OMICs studies and endometriosis biomarker identification. In: Biomarkers for Endometriosis: State of the Art (227−258). Springer. DOI: 10.1007/978-3-319-59856-7_12.
5.1. Konverentsiteesid, mida kajastab Thomson Reuters Web of Science
 
Peters, Maire; Altmäe, Signe; Reimand, Jüri; Laisk, Triin; Saare, Merli; Hovatta, Outti; Kolde, Raivo; Vilo, Jaak; Stavreus-Evers, Anneli; Salumets, Andres. (2011). Human embryo-endometrium interactions at the time of implantation. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 216−216. (1).
 
Saare, Merli; Sõritsa, Deniss; Järva, Liis; Vaidla, Kadri; Palta, Priit; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Detection of Genomic alterations in endometriosis using high-density SNP-arrays. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 213−214. (1).
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Sõritsa, G; Saare, M; Laisk-Podar, T; Padrik, L; Kadastik, Ü; Sõritsa, A; Soplepmann, P; Matt, K; Karro, H; Salumets, A. (2013). Endometrioosiga seotud viljatus: erineva endometrioosi raskusastmega patsientide rasestumine 12 kuu jooksul pärast laparoskoopiat. Eesti Arst, 9.
 
Saare, M; Vaidla, K; Laisk-Podar, T; Sõritsa, D; Simm, J; Velthut-Meikas, A; Karro, H; Metsis, M; Sõritsa, A; Salumets, A; Peters, M. (2013). High-Throughput miRNA sequencing reveals two endometriotic foci-specific miRNAs. In: . European Human Genetics Conference 2013, 08. juuni – 11. juuni 2013, Pariis, Prantsusmaa.
 
Saare, M; Vaidla, K; Laisk-Podar, T; Sõritsa, D; Simm, J; Velthut-Meikas, A; Karro, H; Sõritsa, A; Salumets, A; Peters, M. (2013). miRNA-based molecular test for diagnosing endometriosis − a possible new alternative for routine histological examination? Journal of Endometriosis and Pelvic Pain Disorders: 2nd European Congress on Endometriosis 2013. Wichting Editore, 27−27. (Vol 5 Suppl 1 (October-December 2013)).
 
Sõritsa, Denis; Saare, Merli; Laisk-Podar, Triin; Sõritsa, Andrei; Matt, Kadri; Salumets, Andres. (2012). Endometriosis and infertility: pregnancy outcome in different stages of endometriosis during 12 months after laparoscopy. The Book of Abstracts: 22nd EBCOG. Tallinn, Estonia, FC09.03.
 
Saare, Merli; Vaidla, Kadri; Salumets, Andres; Peters, Maire. (2012). Plasma miRNA profile during the menstrual cycle. Human Reproduction, 27: ESHRE 2012, Istanbul, 01-04.07.2012. , 226−227.
 
Saare, Merli; Vaidla, Kadri; Salumets, Andres; Peters, Maire. (2012). A hunt for endometriosis specific plasma miRNAs. Journal of Endometriosis, 4: 1st European Congress on Endometriosis, 29 november-1 detsember, Siena, Itaalia. Milano, Itaalia: Wichtig Editore, 222−223. (4; 4).
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Genomic alterations in Endometriosis. European Human Genetics Conference 2011, 28 - 31 Mai , Amsterdam, Holland. , 159.
 
Deniss, Sõritsa; Andrei, Sõritsa; Triin, Laisk; Saare, Merli; Helle, Karro; Andres, Salumets. (2011). Combined treatment of endometriosis: IVF Results. 11th World Congress on Endometriosis, 4-7 september, Montpellier, Prantsusmaa. , 171.
 
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). High-density snp-array analysis- no evidence of genomic alterations in endometriosis patients. 11th World Congress on Endometriosis, 4-7 september 2011, Montpellier, Prantsusmaa. , 91−92.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2009). Single nucleotide polymorphisms in the VEGF, MMP-2 and MMP-9 are associated with risk of endometriosis. 59th Annual Meeting of The American Society of Human Genetics; Honolulu, USA; 20.10-24.10.2009.
 
Saare, M.; Lamp, M.; Kaart, T.; Karro, H.; Kadastik, Ü.; Metspalu, A.; Peters, M.; Salumets, A. (2009). Single nucleotide polymorphisms in promoters of MMP-2 and MMP-9 are associated with endometriosis risk. In: European Journal of Human Genetics. European Human Genetics Conference 2009; Vienna, Austria; 23.05-26.05.2009. Nature Publishing Group. (2).
 
Altmäe, S.; Haller, K.; Saare, M.; Peters, M.; Karro, H.; Metspalu, A.; Salumets, A. (2007). Aromataasi CYP19 geeni (TTTA)n variatsioon mõjutab FSH-stimulatsiooni tulemuslikkust lastetuse ravis. Eesti Arst, 86 (9), 685−686.
6.8. Lühikirjutised teadusajakirjades ja kogumikes
 
Saare, Merli; Laisk, Triin; Teder, Hindrek; Paluoja, Priit; Palta, Priit; Koel, Mariann; Kirss, Fred; Karro, Helle; Soritsa, Deniss; Salumets, Andres; Krjutškov, Kaarel; Peters, Maire (2019). A molecular tool for menstrual cycle phase dating of endometrial samples in endometriosis transcriptome studies. Biology of Reproduction, 101 (1), 1−3. DOI: 10.1093/biolre/ioz072.
21.02.2021

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MUUEU48695CCHT01.09.201531.08.2022Andres SalumetsTervisetehnoloogiate Arenduskeskus AS (endine Reproduktiivmeditsiini TAK AS) 6 916 472,93 EUR
PRGPRG1076Endomeetriumi roll naise viljakust ja raseduse tulemit mõjutava olulise tegurina01.01.202131.12.2025Helle KarroTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut183 250,00 EUR
ETFETF6585Endometrioosi geneetilise eelsoodumuse ja immunoloogiliste parameetrite uuring01.01.200631.12.2009Maire PetersTartu Ülikool, Arstiteaduskond47 014,05 EUR
SFSF0180044s09Infertiilsus – epidemioloogia, diagnostika ja ravi01.01.200931.12.2014Helle KarroTartu Ülikool, Arstiteaduskond518 923,82 EUR
SFSF0182641s04Reproduktiivtervis ja fertiilsus - mõjurid Eestis01.01.200431.12.2008Helle KarroTartu Ülikool, Arstiteaduskond160 609,97 EUR
IUTIUT34-16Teaduslik ja rakenduslik lähenemine naise reproduktiivmeditsiinis: munarakust lapse sünnini 01.01.201531.12.2020Helle KarroTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut466 800,00 EUR