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Olen nõus

Aivar Lõokene

https://etis.ee/CV/Aivar_Lõokene/est
56159006
aivar.lookene@ttu.ee
A-1985-2019

Teenistuskäik

Töökohad ja ametid
01.01.2017–...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, Juhtivteadur (1,00)
01.09.2013–31.12.2016   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool, Juhtivteadur (1,00)
01.01.2010–31.08.2013   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool, Vanemteadur (1,00)
01.01.2008–31.12.2009   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool, Vanemteadur (1,00)
01.01.2004–31.12.2008   
2003 - TTÜ Geenitehnoloogia Instituut, vanemteadur/dotsent
01.09.2002–30.06.2006   
Tallinna Ülikool, Lektor (50,00)
01.01.1998–31.12.2003   
Keemilise ja Bioloogilise Füüsika Instituut, Keemilise ja Bioloogilise Füüsika Instituut,vanemteadur (100,00)
01.01.1995–31.01.1998   
Department of Medical Biochemitry, Umea University, Sweden, Umea Ülikool, Meditsiinilise Biokeemia Instituut, abiprofessor (100,00)
31.03.1991–31.12.1994   
Department of Medical Biochemistry, Umea University, Sweden, 1991-1995 Umea Ülikool, Meditsiinilise Biokeemia Instituut, külalisteadlane (100,00)
01.01.1985–31.12.1990   
Keemilise ja Bioloogilise Füüsika Instituut, Keemilise ja Bioloogilise Füüsika Instituut, nooremteadur (100,00)
01.11.1983–31.12.1984   
Keemilise ja Bioloogilise Füüsika Instituut, Keemilise ja Bioloogilise Füüsika Instituut, insener (100,00)
 
 
Haridustee
TA Keemia Instituut 1990 keemiakandidaat(kandidat nauk), eriala - orgaaniline keemia
Tartu Riiklik Ülikool 1983 keemik (bioorgaaniline keemia)/keemiaõpetaja
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
Eesti Biokeemia Seltsi liige
 
 
Loometöö
Osalesin õpiku "Biokeemia lühikursus" (J.L.Tymoczko, J.M.Berg, L.Stryer, TTÜ kirjastus, Tallinn 2016) tõlkimises. inglise keelest eesti keelde
 
 
Lisainfo
Osalemine õppetöös
Interaktoomika TTÜ, loeng+praktikum 2015-
Looduslike ühendite keemia TTÜ, neli loengut 2012-
Ensümoloogia TTÜ loeng + praktikum 2004-2008
Biokeemia Tallinna Ülikool loengud 2002-2006
Keskkonnakeemia Tallinna Ülikool loengud 2002-2006
Meditsiiniline biokeemia Umea Ülikool loengud 1995-1998

Kvalifikatsioon

Teaduskraadid
Aivar Lõokene, doktorikraad, 1990, (juh) Aaviksaar, A, Chemical modification of pancreatic lipase, Tallinn TA Keemiainstituut.
 
 
Teaduspreemiad ja tunnustused
2000, Aivar Lõokene, Rootsi Kuningliku Akadeemia stipendium
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; TÄPSUSTUS: valkude struktuur ja funktsioonid, lipoproteiinide metabolism
 
 
Lisainfo
doktorikraad (keemiakandidaat)
TA Keemiainstituut 1990

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Rump, A.; Risti, R.; Kristal M.-L.; Reut, J.; Syritski, V.; Lõokene, A., Rüütel Boudinot, S. (2021). Dual ELISA using SARS-CoV-2 N protein produced in E. coli and CHO cells reveals epitope masking by N-glycosylation. Biochemical and Biophysical Research Communications, 534, 457−460. DOI: 10.1016/j.bbrc.2020.11.060 .
1.1.
2020
Villo, Ly; Risti, Robert; Reimund, Mart; Kukk, Kaia; Samel, Nigulas; Lõokene, Aivar (2020). Calorimetric approach for comparison of Angiopoietin-like protein 4 with other pancreatic lipase inhibitors. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1865 (2), UNSP 158553.10.1016/j.bbalip.2019.158553.
1.1.
2019
Mihklepp, K.; Kivirand, K.; Juronen, D.; Lõokene, A.; Rinken, T. (2019). Immunodetection of Streptococcus uberis Pathogen in Raw Milk. Enzyme and Microbial Technology, 130, 109360.10.1016/j.enzmictec.2019.109360.
1.1.
2019
Reimund, Mart; Wolska, Anna; Risti, Robert; Wilson, Sierra; Sviridov, Denis; Remaley, Alan T.; Lõokene, Aivar (2019). Apolipoprotein C-II mimetic peptide is an efficient activator of lipoprotein lipase in human plasma as studied by a calorimetric approach. Biochemical and Biophysical Research Communications, 519 (1), 67−72.10.1016/j.bbrc.2019.08.130.
1.1.
2017
Reimund, M.; Kovrov, O.; Olivecrona, G.; Lõokene, A. (2017). Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry. Journal of Lipid Research, 58, 279−288.10.1194/jlr.D071787.
1.1.
2017
Kaabel, S.; Adamson, J.; Topić, F.; Kiesilä, A.; Kalenius, E.; Öeren, M.; Reimund, M.; Prigorchenko, E.; Lõokene, A.; Reich, H. J.; Rissanen, K.; Aav, R. (2017). Chiral hemicucurbit[8]uril as an anion receptor: selectivity to size, shape and charge distribution. Chemical Science, 8 (3), 2184−2190. DOI: 10.1039/C6SC05058A.
5.2.
2016
Kaabel, S.; Adamson, J.; Kalenius, E.; Topić, F.; Öeren, M.; Lõokene, A.; Rissanen, K.; Aav, R. (2016). Cyclohexanohemicucurbit[8]uril – a neutral host for anionic guest. International Conference in Organic Synthesis: Balticum Organicum Syntheticum, Riga, Lavia, 3-6. July 2016. BOS, 80.
5.2.
2016
Kaabel, S.; Adamson, J.; Kalenius, E.; Topic, F.; Öeren, M; Lõokene, A.; Rissanen, K.; Aav, R. (2016). Cyclohexanohemicucurbit[8]uril – a Neutral Host for Anionic Guests. 11th International Symposium on Macrocyclic and Supramolecular Chemistry: 11th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Seoul, Korea, 11-14. July 2016. ISMSC-2016, PA051.
1.1.
2015
Reimund, M.; Larsson, M.; Kovrov, O.; Kasvandik, S.; Olivecrona, G.; Lõokene, A. (2015). Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1). Journal of Biological Chemistry, 290 (22), 13919−13934. DOI: 10.1074/jbc.M114.634626.
1.1.
2014
Larsson, M.; Caraballo, R.; Ericsson, M.; Lookene, A.; Enquist, P.A.; Elofsson, M.; Nilsson, S.K.; Olivecrona, G. (2014). Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo. Biochemical and Biophysical Research Communications, 450 (2), 1063−1069.10.1016/j.bbrc.2014.06.114.
5.1.
2014
Larsson, M.; Vorrsjo, E.; Talmud, P.; Lookene, A.; Olivecrona, G. (2014). Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets. The FASEB Journal, 28, 1002.4−1002.4.
1.1.
2013
Larsson, M; Vorrsjö, E; Talmud, P; Lookene, A; Olivecrona, G. (2013). Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets. Journal of Biological Chemistry, 288 (47), 33997−34008.10.1074/jbc.M113.495366.
1.1.
2013
Mendoza-Barberá, E; Julve, J; Nilsson, SK; Lookene, A; Martín-Campos, JM; Roig, R; Lechuga-Sancho, AM; Sloan, JH; Fuentes-Prior, P; Blanco-Vaca, F. (2013). Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. Journal of Lipid Research, 54 (3), 649−661.
1.1.
2012
Robal, T.; Larsson, M.; Martin, M.; Olivecrona, G.; Lookene, A. (2012). Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase. Journal of Biological Chemistry, 287 (35), 29739−29752.10.1074/jbc.M111.303529.
1.1.
2012
Nilsson, S.K.; Anderson, F.; Ericsson, M.; Larsson, M.; Makoveichuk, E.; Lookene, A.; Heeren, J; Olivecrona, G. (2012). Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1821 (10), 1370−1378.10.1016/j.bbalip.2012.06.003.
1.1.
2012
Järving, R.; Lõokene, A.; Kurg, R.; Siimon, L.; Järving, I.; Samel, N. (2012). Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane. Biochemistry, 51 (15), 3310−3320.10.1021/bi201690z.
1.1.
2011
Nilsson, E.C.; Storm, R.J.; Bauer, J.; Johansson, S.M.; Lõokene, A.; Angström, J.; Hedenström, M.; Eriksson, T.L.; Frängsmyr, L.; Rinaldi, S.; Willison, H.J.; Domellöf, F.P.; Stehle, T.; Arnberg, N. (2011). The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nature Medicine, 17 (1), 105−109.10.1038/nm.2267.
5.1.
2011
Nilsson, S.; Larsson, M.; Worrsjo, E.; Lookene, A.; Suokonina, V.; Makoveichuk, E.; Heeren, J.; Olivecrona, G. (2011). TRIACYLGLYCEROL-RICH LIPOPROTEINS INFLUENCE ON THE INACTIVATION OF LIPOPROTEIN LIPASE BY ANGPTL 3 AND ANGPTL 4. Atherosclerosis Supplements, 12 (1), 30−31.
1.1.
2010
Shen, Y.; Lookene, A.; Zhang, L.; Olivecrona, G. (2010). Site-directed mutagenesis of apolipoprotein CII to probe the role of its secondary structure for activation of lipoprotein lipase. Journal of Biological Chemistry, 285 (10), 7484−7492.10.1074/jbc.M109.022046.
5.2.
2009
Nilsson, S.K.; Larsson, M.; Lookene, A.; Heeren, J; Olivecrona, G. (2009). Triacylglycerol-rich lipoproteins influence on the inactivation of lipoprotein lipase by angptl 3 and angptl 4. Atherosclerosis Supplements : Abstracts of the XV International Symposium on Atherosclerosis, 10. , e328. (2). DOI: 10.1016/S1567-5688(09)70327-7.
1.1.
2008
Dorfmeister, B.; Zeng, W.W.; Dichlberger, A.; Nilsson, S.K.; Schaap, F.G.; Hubacek, J.A.; Merke, M.; Cooper, J.A.; Lookene, A.; Putt, W.; Whittall, R.; Lee, P.J.; Lins, L.; Delsaux, N.; Nierman, M.; Kuivenhoven, J.A.; Kastelein, J.J.; Vrablik, M.; Olivecrona, G.; Schneider, W.J. ... Talmud, P.J. (2008). Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arteriosclerosis Thrombosis and Vascular Biology, 28 (10), 1866−1871. DOI: 10.1161/ATVBAHA.108.172866.
1.1.
2007
Nilsson, SK; Lookene, A; Beckstead, JA; Gliemann, J, Ryan, RO; Olivecrona, G. (2007). Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family. Biochemistry, 46 (12), 3896−3904.
1.1.
2006
Sukonina, V., Lõokene, A., Olivecrona, T., Olivecrona, G. (2006). Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proceedings of the National Academy of Sciences, 103 (46), 17450−17455.
1.1.
2006
Spillmann, D; Lõokene, A; Olivecrona, G. (2006). Isolation and characterization of low sulfated heparan sulfate sequences with affinity for lipoprotein lipase. Journal of Biological Chemistry, 281 (33), 23405−23413.
5.1.
2006
Beckstead, JA; Nilsson, SK; Lookene, A;Olivecrona, G; Ryan, RO (2006). Localization of the heparin binding site in human apolipoprotein A-V. The FASEB Journal, 20 (4, 1), A92.
5.1.
2006
Nilsson, S.K.; Lookene, A.; Beckstead, J.B.; Gliemann, J.; Ryan, R.O.; Olivecrona, G. (2006). Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Atherosclerosis Supplements, 7 (3), 514. DOI: 10.1016/S1567-5688(06)82056-8.
1.1.
2005
Lookene, A.; Beckstead, JA.; Nilsson, S.; Olivecrona, G.; Ryan, RO (2005). Apolipoprotein A-V-heparin interactions - Implications for plasma lipoprotein metabolism. Journal of Biological Chemistry, 280 (27), 25383−25387.
1.1.
2005
Zhang, LY.; Lookene, A.; Wu, GS.; Olivecrona, G (2005). Calcium triggers folding of lipoprotein lipase into active dimers. Journal of Biological Chemistry, 280 (52), 42580−42591.
1.1.
2004
Lookene, A.; Zhang, LY.; Hultin, M.; Olivecrona, G (2004). Rapid subunit exchange in dimeric lipoprotein lipase and properties of the inactive monomer. Journal of Biological Chemistry, 279 (48), 49964−49972.
1.1.
2003
Vallikivi, I.; Lille, Ü.; Lõokene, A.; Metsala, A.; Sikk, P.; Tõugu, V.; Vija, H.; Villo, L.; Parve, O. (2003). Lipase action on some non-triglyceride substrates. Journal of Molecular Catalysis B: Enzymatic, 22, 279−298. DOI: 10.1016/S1381-1177(03)00043-2.
1.1.
2003
Zhang, LY.; Wu, GS.; Tate, CG.; Lookene, A.; Olivecrona, G (2003). Calreticulin promotes folding/dimerization of human lipoprotein lipase expressed in insect cells (Sf21). Journal of Biological Chemistry, 278 (31), 29344−29351.
1.1.
2003
Lookene, A.; Zhang, LY.; Tougu, V.; Olivecrona, G (2003). 1,1 '-bis(anilino)-4-,4 '-bis(naphtalene)-8,8 '-disulfonate acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII. Journal of Biological Chemistry, 278 (39), 37183−37194.
1.1.
2002
Shen, Y.; Lookene, A.; Nilsson, S.; Olivecrona, G (2002). Functional analyses of human apolipoprotein CII by site-directed mutagenesis - Identification of residues important for activation of lipoprotein lipase. Journal of Biological Chemistry, 6, 4334−4342.
1.1.
2001
Boren, J.; Lookene, A.; Makoveichuk, E.; Xiang, SQ.; Gustafsson, M.; Liu, HQ.; Talmud, P.; Olivecrona, G (2001). Binding of low density lipoproteins to lipoprotein lipase is dependent on lipids but not on apolipoprotein B. Journal of Biological Chemistry, 29, 26916−26922.
1.1.
2000
Lookene, A.; Nielsen, MS.; Gliemann, J.; Olivecrona, G (2000). Contribution of the carboxy-terminal domain of lipoprotein lipase to interaction with heparin and lipoproteins. Biochemical and Biophysical Research Communications, 271 (1), 15−21.
1.1.
2000
Lookene, A.; Stenlund, P.; Tibell, LAE (2000). Characterization of heparin binding of human extracellular superoxide dismutase. Biochemistry, 39 (1), 230−236.
1.1.
1999
Neels, JG; van den Berg, BMM; Lookene, A; Olivecrona, G; Pannekoek, H; Zonneveld, AJ (1999). The second and fourth cluster of class A cysteine -rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. Journal of Biological Chemistry, 274 (44), 31305−31311.
5.1.
1999
Neels, JG, van den Berg, BMM, Lookene, A; Olivecrona, G; van Zonneveld, AJ (1999). The second and fourth cluster of class A cysteine -rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. Thrombosis and Haemostasis, Suppl S, 670.
5.1.
1999
Olivecrona, G; Makoveichuk, E; Lookene, A; Xiang, SQ (1999). Lipoprotein lipase as a ligand for binding to cell surfaces and receptors. Good or bad? Atherosclerosis, 144, 84.
1.1.
1998
Makoveichuk, E; Lookene, A; Olivecrona, G (1998). Mild oxidation of lipoproteins increases their affinity for surfaces covered by heparan sulfate and lipoprotein lipase. Biochemical and Biophysical Research Communications, 252 (3), 703−710.
1.1.
1997
Lookene, A; Groot, NB; Kastelein, JJP; Oliverona, G; Bruin, T (1997). Mutation of tryptophan residues in liporotein lipase - effects on stability, immunoreactivity, and catalytic properties. Journal of Biological Chemistry, 272 (2), 766−772.
1.1.
1997
Lookene, A; Savonen, R; Olivecorna, G (1997). Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. Studies by surface plasmon resonance. Biochemistry, 36 (17), 5267−5275.
1.1.
1997
Olivecrona, G; Lookene, A (1997). Noncatalytic functions of lipoprotein lipase. Methods in Enzymology, PT B, 286, 102−116.
1.1.
1997
Andersson, Y; Lookene, A; Shen, Y; Nilsson, S; Thelander, L; Olivecrona, G (1997). Guinea pig apolipoprotein C-II: expression in E-coli; functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins. Journal of Lipid Research, 38 (10), 2111−2124.
5.1.
1997
Tibell, L; Stenlund, P; Lookene, A; Sethson, I; Boevich, A (1997). Characterization of the heparin binding domain of human extracellular superoxide dismutase. The FASEB Journal, 11 (9), 1398.
5.1.
1997
Makoveichuk, E; Lookene, A; Olivecrona, G (1997). Lipoprotein lipase increases interaction of both heparan sulfate-covered surfaces and cells with oxidized lipoproteins. Atherosclerosis, 130, B128.
1.1.
1996
Lookene, A; Chevreuil, O; Ostergaard, P; Olivecrona, G (1996). Interaction of lipoprotein lipase with heparin fragments and wit heparan sulfate: Stoichiometry, stabilization and kinetics. Biochemistry, 35 (37), 12155−12163.
1.1.
1996
Groot, NB; Lookene, A; Olivecrona, G; Kastelein, JJP; Bruin, T (1996). The C-terminal tryptophan cluster in lipoprotein lipase is involved in the binding to lipoproteins. Circulation, 94 (8), 888.
1.1.
1995
Skottova, N; Savonen, R; Lookene, A; Hultin, M; Olivecrona, G (1995). Lipoprotein lipase enhances removal of chylomicrons and chylomicron remnants by the perfused rat liver. Journal of Lipid Research, 36 (6), 1334−1344.
1.1.
1994
Nykjaer, A; Nielsen, M; Lookene, A; Meyer, N; Roigaard, H; Etzerodt, M; Beisiegel, U; Olivecrona, G; Gliemann, J (1994). A carboxyterminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor related protein and inhibits lipase mediated uptake of lipoprotein in cells. Journal of Biological Chemistry, 269 (50), 31747−31755.
1.1.
1994
Lookene, A; Skottova, N; Olivecrona, G (1994). Interactions of lipoprotein lipase with the active site inhibitor tetrahydrolipstatin (Orlistat) (R). European Journal of Biochemistry, 222 (2), 395−403.
1.1.
1994
Nykjaer, A; Nielsen, M; Lookene, A; Meyer, N; Roigaard, H; Etzerodt, M; Beisiegel, U; Olivecrona, G; Gliemann, J (1994). Multiligand alpha(2)-macroglobulin receptor low density lipoprotein receptor related protein (alpha(2)MR/LRP) - binding and endocytosis of fluid-phase and membrane associated ligands. Annals of New York Academy of Sciences, 737, 20−38.
1.1.
1993
Parve, O; Pals, A; Kadarpik, V; Lahe, L; Lille, U; Sikk, P; Lookene, A; Valimae, T (1993). Enantioselective preparation of novel bicyclo[3.2.0]heptane derivatives using ester hydrolysis catalyzed by Novo lipolase. Bioorganic & Medicinal Chemistry Letters, 3 (2), 359−362.
1.1.
1993
Parve, O; Pals, A; Kadarpik, V; Lillle, U; Sikk, P; Lookene, A; Valimae, T (1993). High purity porcine pancreatic lipase - novel effects in catalyzing hydrolysis of esters derived from bicyclo [3.2.0]hept-2-en-6-ols. Bioorganic & Medicinal Chemistry Letters, 3 (2), 357−358.
1.1.
1993
Lookene, A; Bengtsson-Oilvecrona, G (1993). Chymotryptic cleavage of lipoprotein lipase. Identification of cleavage sites and functional studies of the truncated molecule. European Journal of Biochemistry, 213 (1), 185−194.
1.1.
1993
Nykjaer, A; Bengtsson-Olivecrona, G; Lookene, A; Moestrup, SK; Petersen, CM; Weber, W; Beisiegel, U; Gliemann, J (1993). The alpha(2)-macroglobulin receptor low density lipoprotein receptor related protein binds lipoprotein lipase and beta migrating very low density lipoprotein associated with the lipase. Journal of Biological Chemistry, 268 (20), 15048−15055.
1.1.
1986
Sikk, P. F.; Oza, A. V.; Lyokene, A. G.; Aaviksaar, A. A. (1986). The role of the N-terminal amino group in the activity of pancreatic lipase. Биоорганическая химия, 12, 985−987.

Tööstusomand

8.12.2020

Aivar Lõokene

https://etis.ee/CV/Aivar_Lõokene/eng
56159006
aivar.lookene@ttu.ee
A-1985-2019

Career

Institutions and positions
01.01.2017–...   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Research Professor (1,00)
01.09.2013–31.12.2016   
Tallinn University of Technology , Faculty of Science, Department of Chemistry, Chair of Bioorganic Chemistry, Research Professor (1,00)
01.01.2010–31.08.2013   
Tallinn University of Technology , Faculty of Science, Department of Chemistry, Chair of Bioorganic Chemistry, Senior Researcher (1,00)
01.01.2008–31.12.2009   
Tallinn University of Technology , Faculty of Science, Department of Chemistry, Chair of Bioorganic Chemistry, Senior Researcher (1,00)
01.01.2004–31.12.2008   
2003- Department of Gene Technology, Tallinn University of Technology, senior research scientist
01.09.2002–30.06.2006   
Tallinn University, Lecturer (50,00)
01.01.1998–31.12.2003   
National Institute of Chemical Physics and Biophysics, National Institute of Chemical Physics and Biophysics, senior reseacher (100,00)
01.01.1995–31.01.1998   
Department of Medical Biochemitry, Umea University, Sweden, Umea University (Sweden) Department of Medical Biochemistry,assistant professor (100,00)
31.03.1991–31.12.1994   
Department of Medical Biochemistry, Umea University, Sweden, 1991-1995 Umea University Department of Medical Biochemistry, visiting scientist (100,00)
01.01.1985–31.12.1990   
National Institute of Chemical Physics and Biophysics, Institute of Chemical Physics and Biophysics, junior reseacher (100,00)
01.11.1983–31.12.1984   
National Institute of Chemical Physics and Biophysics, Institute of Chemical Physics and Biophysics, engineer (100,00)
 
 
Education
Institute of Chemistry, Estonian Academy of Sciences 1990, PhD, (organic chemistry)
Tartu State University 1983, chemistry (bioorganic chemistry)
 
 
R&D related managerial and administrative work
member of Estonian Biochemical Society
 
 
Creative work
I participated in the translation of the book Biochemistry (authors J.L.Tymoczko, J.M.Berg, L.Stryer)
 
 
Additional information
Teaching qualifications
Interactomics TTU, lectures + practicum 2015-
Chemistry of natural compounds, lectures 2011-2018
Enzymology TTU, lectures + practicum
Biochemistry, Tallinn University, 2002-2006, lectures
Bioorganic chemitry, Tallinn University, 2002-2006, lectures
Medical Biochemistry, Umea University, 1995-1998, lectures

Qualifications

Academic degrees
Aivar Lõokene, Doctor's Degree, 1990, (sup) Aaviksaar, A, Chemical modification of pancreatic lipase (Chemical modification of pancreatic lipase), Tallinn TA Keemiainstituut.
 
 
Honours & awards
2000, Aivar Lõokene, Scholarship of the Swedish Royal Academy
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry
 
 
Additional information
PhD
Estonian Acadamy of Sciences
Insitute of Chemistry 1990

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2021
Rump, A.; Risti, R.; Kristal M.-L.; Reut, J.; Syritski, V.; Lõokene, A., Rüütel Boudinot, S. (2021). Dual ELISA using SARS-CoV-2 N protein produced in E. coli and CHO cells reveals epitope masking by N-glycosylation. Biochemical and Biophysical Research Communications, 534, 457−460. DOI: 10.1016/j.bbrc.2020.11.060 .
1.1.
2020
Villo, Ly; Risti, Robert; Reimund, Mart; Kukk, Kaia; Samel, Nigulas; Lõokene, Aivar (2020). Calorimetric approach for comparison of Angiopoietin-like protein 4 with other pancreatic lipase inhibitors. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1865 (2), UNSP 158553.10.1016/j.bbalip.2019.158553.
1.1.
2019
Mihklepp, K.; Kivirand, K.; Juronen, D.; Lõokene, A.; Rinken, T. (2019). Immunodetection of Streptococcus uberis Pathogen in Raw Milk. Enzyme and Microbial Technology, 130, 109360.10.1016/j.enzmictec.2019.109360.
1.1.
2019
Reimund, Mart; Wolska, Anna; Risti, Robert; Wilson, Sierra; Sviridov, Denis; Remaley, Alan T.; Lõokene, Aivar (2019). Apolipoprotein C-II mimetic peptide is an efficient activator of lipoprotein lipase in human plasma as studied by a calorimetric approach. Biochemical and Biophysical Research Communications, 519 (1), 67−72.10.1016/j.bbrc.2019.08.130.
1.1.
2017
Reimund, M.; Kovrov, O.; Olivecrona, G.; Lõokene, A. (2017). Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry. Journal of Lipid Research, 58, 279−288.10.1194/jlr.D071787.
1.1.
2017
Kaabel, S.; Adamson, J.; Topić, F.; Kiesilä, A.; Kalenius, E.; Öeren, M.; Reimund, M.; Prigorchenko, E.; Lõokene, A.; Reich, H. J.; Rissanen, K.; Aav, R. (2017). Chiral hemicucurbit[8]uril as an anion receptor: selectivity to size, shape and charge distribution. Chemical Science, 8 (3), 2184−2190. DOI: 10.1039/C6SC05058A.
5.2.
2016
Kaabel, S.; Adamson, J.; Kalenius, E.; Topić, F.; Öeren, M.; Lõokene, A.; Rissanen, K.; Aav, R. (2016). Cyclohexanohemicucurbit[8]uril – a neutral host for anionic guest. International Conference in Organic Synthesis: Balticum Organicum Syntheticum, Riga, Lavia, 3-6. July 2016. BOS, 80.
5.2.
2016
Kaabel, S.; Adamson, J.; Kalenius, E.; Topic, F.; Öeren, M; Lõokene, A.; Rissanen, K.; Aav, R. (2016). Cyclohexanohemicucurbit[8]uril – a Neutral Host for Anionic Guests. 11th International Symposium on Macrocyclic and Supramolecular Chemistry: 11th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Seoul, Korea, 11-14. July 2016. ISMSC-2016, PA051.
1.1.
2015
Reimund, M.; Larsson, M.; Kovrov, O.; Kasvandik, S.; Olivecrona, G.; Lõokene, A. (2015). Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1). Journal of Biological Chemistry, 290 (22), 13919−13934. DOI: 10.1074/jbc.M114.634626.
1.1.
2014
Larsson, M.; Caraballo, R.; Ericsson, M.; Lookene, A.; Enquist, P.A.; Elofsson, M.; Nilsson, S.K.; Olivecrona, G. (2014). Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo. Biochemical and Biophysical Research Communications, 450 (2), 1063−1069.10.1016/j.bbrc.2014.06.114.
5.1.
2014
Larsson, M.; Vorrsjo, E.; Talmud, P.; Lookene, A.; Olivecrona, G. (2014). Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets. The FASEB Journal, 28, 1002.4−1002.4.
1.1.
2013
Larsson, M; Vorrsjö, E; Talmud, P; Lookene, A; Olivecrona, G. (2013). Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets. Journal of Biological Chemistry, 288 (47), 33997−34008.10.1074/jbc.M113.495366.
1.1.
2013
Mendoza-Barberá, E; Julve, J; Nilsson, SK; Lookene, A; Martín-Campos, JM; Roig, R; Lechuga-Sancho, AM; Sloan, JH; Fuentes-Prior, P; Blanco-Vaca, F. (2013). Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia. Journal of Lipid Research, 54 (3), 649−661.
1.1.
2012
Robal, T.; Larsson, M.; Martin, M.; Olivecrona, G.; Lookene, A. (2012). Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase. Journal of Biological Chemistry, 287 (35), 29739−29752.10.1074/jbc.M111.303529.
1.1.
2012
Nilsson, S.K.; Anderson, F.; Ericsson, M.; Larsson, M.; Makoveichuk, E.; Lookene, A.; Heeren, J; Olivecrona, G. (2012). Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1821 (10), 1370−1378.10.1016/j.bbalip.2012.06.003.
1.1.
2012
Järving, R.; Lõokene, A.; Kurg, R.; Siimon, L.; Järving, I.; Samel, N. (2012). Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane. Biochemistry, 51 (15), 3310−3320.10.1021/bi201690z.
1.1.
2011
Nilsson, E.C.; Storm, R.J.; Bauer, J.; Johansson, S.M.; Lõokene, A.; Angström, J.; Hedenström, M.; Eriksson, T.L.; Frängsmyr, L.; Rinaldi, S.; Willison, H.J.; Domellöf, F.P.; Stehle, T.; Arnberg, N. (2011). The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nature Medicine, 17 (1), 105−109.10.1038/nm.2267.
5.1.
2011
Nilsson, S.; Larsson, M.; Worrsjo, E.; Lookene, A.; Suokonina, V.; Makoveichuk, E.; Heeren, J.; Olivecrona, G. (2011). TRIACYLGLYCEROL-RICH LIPOPROTEINS INFLUENCE ON THE INACTIVATION OF LIPOPROTEIN LIPASE BY ANGPTL 3 AND ANGPTL 4. Atherosclerosis Supplements, 12 (1), 30−31.
1.1.
2010
Shen, Y.; Lookene, A.; Zhang, L.; Olivecrona, G. (2010). Site-directed mutagenesis of apolipoprotein CII to probe the role of its secondary structure for activation of lipoprotein lipase. Journal of Biological Chemistry, 285 (10), 7484−7492.10.1074/jbc.M109.022046.
5.2.
2009
Nilsson, S.K.; Larsson, M.; Lookene, A.; Heeren, J; Olivecrona, G. (2009). Triacylglycerol-rich lipoproteins influence on the inactivation of lipoprotein lipase by angptl 3 and angptl 4. Atherosclerosis Supplements : Abstracts of the XV International Symposium on Atherosclerosis, 10. , e328. (2). DOI: 10.1016/S1567-5688(09)70327-7.
1.1.
2008
Dorfmeister, B.; Zeng, W.W.; Dichlberger, A.; Nilsson, S.K.; Schaap, F.G.; Hubacek, J.A.; Merke, M.; Cooper, J.A.; Lookene, A.; Putt, W.; Whittall, R.; Lee, P.J.; Lins, L.; Delsaux, N.; Nierman, M.; Kuivenhoven, J.A.; Kastelein, J.J.; Vrablik, M.; Olivecrona, G.; Schneider, W.J. ... Talmud, P.J. (2008). Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding. Arteriosclerosis Thrombosis and Vascular Biology, 28 (10), 1866−1871. DOI: 10.1161/ATVBAHA.108.172866.
1.1.
2007
Nilsson, SK; Lookene, A; Beckstead, JA; Gliemann, J, Ryan, RO; Olivecrona, G. (2007). Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family. Biochemistry, 46 (12), 3896−3904.
1.1.
2006
Sukonina, V., Lõokene, A., Olivecrona, T., Olivecrona, G. (2006). Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proceedings of the National Academy of Sciences, 103 (46), 17450−17455.
1.1.
2006
Spillmann, D; Lõokene, A; Olivecrona, G. (2006). Isolation and characterization of low sulfated heparan sulfate sequences with affinity for lipoprotein lipase. Journal of Biological Chemistry, 281 (33), 23405−23413.
5.1.
2006
Beckstead, JA; Nilsson, SK; Lookene, A;Olivecrona, G; Ryan, RO (2006). Localization of the heparin binding site in human apolipoprotein A-V. The FASEB Journal, 20 (4, 1), A92.
5.1.
2006
Nilsson, S.K.; Lookene, A.; Beckstead, J.B.; Gliemann, J.; Ryan, R.O.; Olivecrona, G. (2006). Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Atherosclerosis Supplements, 7 (3), 514. DOI: 10.1016/S1567-5688(06)82056-8.
1.1.
2005
Lookene, A.; Beckstead, JA.; Nilsson, S.; Olivecrona, G.; Ryan, RO (2005). Apolipoprotein A-V-heparin interactions - Implications for plasma lipoprotein metabolism. Journal of Biological Chemistry, 280 (27), 25383−25387.
1.1.
2005
Zhang, LY.; Lookene, A.; Wu, GS.; Olivecrona, G (2005). Calcium triggers folding of lipoprotein lipase into active dimers. Journal of Biological Chemistry, 280 (52), 42580−42591.
1.1.
2004
Lookene, A.; Zhang, LY.; Hultin, M.; Olivecrona, G (2004). Rapid subunit exchange in dimeric lipoprotein lipase and properties of the inactive monomer. Journal of Biological Chemistry, 279 (48), 49964−49972.
1.1.
2003
Vallikivi, I.; Lille, Ü.; Lõokene, A.; Metsala, A.; Sikk, P.; Tõugu, V.; Vija, H.; Villo, L.; Parve, O. (2003). Lipase action on some non-triglyceride substrates. Journal of Molecular Catalysis B: Enzymatic, 22, 279−298. DOI: 10.1016/S1381-1177(03)00043-2.
1.1.
2003
Zhang, LY.; Wu, GS.; Tate, CG.; Lookene, A.; Olivecrona, G (2003). Calreticulin promotes folding/dimerization of human lipoprotein lipase expressed in insect cells (Sf21). Journal of Biological Chemistry, 278 (31), 29344−29351.
1.1.
2003
Lookene, A.; Zhang, LY.; Tougu, V.; Olivecrona, G (2003). 1,1 '-bis(anilino)-4-,4 '-bis(naphtalene)-8,8 '-disulfonate acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII. Journal of Biological Chemistry, 278 (39), 37183−37194.
1.1.
2002
Shen, Y.; Lookene, A.; Nilsson, S.; Olivecrona, G (2002). Functional analyses of human apolipoprotein CII by site-directed mutagenesis - Identification of residues important for activation of lipoprotein lipase. Journal of Biological Chemistry, 6, 4334−4342.
1.1.
2001
Boren, J.; Lookene, A.; Makoveichuk, E.; Xiang, SQ.; Gustafsson, M.; Liu, HQ.; Talmud, P.; Olivecrona, G (2001). Binding of low density lipoproteins to lipoprotein lipase is dependent on lipids but not on apolipoprotein B. Journal of Biological Chemistry, 29, 26916−26922.
1.1.
2000
Lookene, A.; Nielsen, MS.; Gliemann, J.; Olivecrona, G (2000). Contribution of the carboxy-terminal domain of lipoprotein lipase to interaction with heparin and lipoproteins. Biochemical and Biophysical Research Communications, 271 (1), 15−21.
1.1.
2000
Lookene, A.; Stenlund, P.; Tibell, LAE (2000). Characterization of heparin binding of human extracellular superoxide dismutase. Biochemistry, 39 (1), 230−236.
1.1.
1999
Neels, JG; van den Berg, BMM; Lookene, A; Olivecrona, G; Pannekoek, H; Zonneveld, AJ (1999). The second and fourth cluster of class A cysteine -rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. Journal of Biological Chemistry, 274 (44), 31305−31311.
5.1.
1999
Neels, JG, van den Berg, BMM, Lookene, A; Olivecrona, G; van Zonneveld, AJ (1999). The second and fourth cluster of class A cysteine -rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. Thrombosis and Haemostasis, Suppl S, 670.
5.1.
1999
Olivecrona, G; Makoveichuk, E; Lookene, A; Xiang, SQ (1999). Lipoprotein lipase as a ligand for binding to cell surfaces and receptors. Good or bad? Atherosclerosis, 144, 84.
1.1.
1998
Makoveichuk, E; Lookene, A; Olivecrona, G (1998). Mild oxidation of lipoproteins increases their affinity for surfaces covered by heparan sulfate and lipoprotein lipase. Biochemical and Biophysical Research Communications, 252 (3), 703−710.
1.1.
1997
Lookene, A; Groot, NB; Kastelein, JJP; Oliverona, G; Bruin, T (1997). Mutation of tryptophan residues in liporotein lipase - effects on stability, immunoreactivity, and catalytic properties. Journal of Biological Chemistry, 272 (2), 766−772.
1.1.
1997
Lookene, A; Savonen, R; Olivecorna, G (1997). Interaction of lipoproteins with heparan sulfate proteoglycans and with lipoprotein lipase. Studies by surface plasmon resonance. Biochemistry, 36 (17), 5267−5275.
1.1.
1997
Olivecrona, G; Lookene, A (1997). Noncatalytic functions of lipoprotein lipase. Methods in Enzymology, PT B, 286, 102−116.
1.1.
1997
Andersson, Y; Lookene, A; Shen, Y; Nilsson, S; Thelander, L; Olivecrona, G (1997). Guinea pig apolipoprotein C-II: expression in E-coli; functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins. Journal of Lipid Research, 38 (10), 2111−2124.
5.1.
1997
Tibell, L; Stenlund, P; Lookene, A; Sethson, I; Boevich, A (1997). Characterization of the heparin binding domain of human extracellular superoxide dismutase. The FASEB Journal, 11 (9), 1398.
5.1.
1997
Makoveichuk, E; Lookene, A; Olivecrona, G (1997). Lipoprotein lipase increases interaction of both heparan sulfate-covered surfaces and cells with oxidized lipoproteins. Atherosclerosis, 130, B128.
1.1.
1996
Lookene, A; Chevreuil, O; Ostergaard, P; Olivecrona, G (1996). Interaction of lipoprotein lipase with heparin fragments and wit heparan sulfate: Stoichiometry, stabilization and kinetics. Biochemistry, 35 (37), 12155−12163.
1.1.
1996
Groot, NB; Lookene, A; Olivecrona, G; Kastelein, JJP; Bruin, T (1996). The C-terminal tryptophan cluster in lipoprotein lipase is involved in the binding to lipoproteins. Circulation, 94 (8), 888.
1.1.
1995
Skottova, N; Savonen, R; Lookene, A; Hultin, M; Olivecrona, G (1995). Lipoprotein lipase enhances removal of chylomicrons and chylomicron remnants by the perfused rat liver. Journal of Lipid Research, 36 (6), 1334−1344.
1.1.
1994
Nykjaer, A; Nielsen, M; Lookene, A; Meyer, N; Roigaard, H; Etzerodt, M; Beisiegel, U; Olivecrona, G; Gliemann, J (1994). A carboxyterminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor related protein and inhibits lipase mediated uptake of lipoprotein in cells. Journal of Biological Chemistry, 269 (50), 31747−31755.
1.1.
1994
Lookene, A; Skottova, N; Olivecrona, G (1994). Interactions of lipoprotein lipase with the active site inhibitor tetrahydrolipstatin (Orlistat) (R). European Journal of Biochemistry, 222 (2), 395−403.
1.1.
1994
Nykjaer, A; Nielsen, M; Lookene, A; Meyer, N; Roigaard, H; Etzerodt, M; Beisiegel, U; Olivecrona, G; Gliemann, J (1994). Multiligand alpha(2)-macroglobulin receptor low density lipoprotein receptor related protein (alpha(2)MR/LRP) - binding and endocytosis of fluid-phase and membrane associated ligands. Annals of New York Academy of Sciences, 737, 20−38.
1.1.
1993
Parve, O; Pals, A; Kadarpik, V; Lahe, L; Lille, U; Sikk, P; Lookene, A; Valimae, T (1993). Enantioselective preparation of novel bicyclo[3.2.0]heptane derivatives using ester hydrolysis catalyzed by Novo lipolase. Bioorganic & Medicinal Chemistry Letters, 3 (2), 359−362.
1.1.
1993
Parve, O; Pals, A; Kadarpik, V; Lillle, U; Sikk, P; Lookene, A; Valimae, T (1993). High purity porcine pancreatic lipase - novel effects in catalyzing hydrolysis of esters derived from bicyclo [3.2.0]hept-2-en-6-ols. Bioorganic & Medicinal Chemistry Letters, 3 (2), 357−358.
1.1.
1993
Lookene, A; Bengtsson-Oilvecrona, G (1993). Chymotryptic cleavage of lipoprotein lipase. Identification of cleavage sites and functional studies of the truncated molecule. European Journal of Biochemistry, 213 (1), 185−194.
1.1.
1993
Nykjaer, A; Bengtsson-Olivecrona, G; Lookene, A; Moestrup, SK; Petersen, CM; Weber, W; Beisiegel, U; Gliemann, J (1993). The alpha(2)-macroglobulin receptor low density lipoprotein receptor related protein binds lipoprotein lipase and beta migrating very low density lipoprotein associated with the lipase. Journal of Biological Chemistry, 268 (20), 15048−15055.
1.1.
1986
Sikk, P. F.; Oza, A. V.; Lyokene, A. G.; Aaviksaar, A. A. (1986). The role of the N-terminal amino group in the activity of pancreatic lipase. Биоорганическая химия, 12, 985−987.

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COVSGCOVSG34 Uued diagnostilised SARS-CoV-2 viirusnakkuse tuvastamise meetodid kliiniliseks ja portatiivseks kasutamiseks01.09.202031.12.2021Vitali SõritskiTallinna Tehnikaülikool, Inseneriteaduskond, Materjali- ja keskkonnatehnoloogia instituut200 000,00 EUR
MUU502FAlzheimeri tõve ravimite in vitro skriiningtesti väljatöötamine01.01.200531.12.2007Peep PalumaaTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Genoomika ja proteoomika õppetool714 924,71 EUR
ETFETF8300Angiopoietiini sarnaste valkude 3 ja 4 molekulaarsed toimemehhanismid lipoproteiinide metabolismis01.01.201031.12.2013Aivar LõokeneTallinna Tehnikaülikool, Matemaatika-loodusteaduskond49 084,64 EUR
MUUBF11Apolipoproteiinide A5, C2 ja E struktuur ja funktsioonid01.07.200531.12.2005Aivar LõokeneTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Genoomika ja proteoomika õppetool9 586,75 EUR
ETFETF6834Apolipoproteiinide apo A-V ja apo E struktuuri ja funktsioonide uurimine01.01.200631.12.2009Aivar LõokeneTallinna Tehnikaülikool, Matemaatika-loodusteaduskond30 938,35 EUR
SFSF0140010s08Bioaktiivsed lipiidid - metabolism, signaaliülekanne ja regulatsioon01.01.200831.12.2013Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond893 128,26 EUR
MUUBF106Biomolekulaarsete interaktsioonide uurimislabori väljaarendamine01.11.200831.01.2009Aivar LõokeneTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool9 107,41 EUR
IUTIUT19-9Lipiidide ja lipoproteiinide metabolismi struktuursed ja regulatoorsed aspektid01.01.201431.12.2019Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond; Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut1 182 000,00 EUR
MUUG4925 (ETF4925)Lipoproteiinlipaasi funktsioone reguleerivad molekulaarsed mehhanismid01.01.200131.12.2004Aivar LõokeneTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Genoomika ja proteoomika õppetool21 442,36 EUR
SFSF0142501s03Struktuurne ja meditsiiniline proteoomika01.01.200331.12.2007Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond206 498,53 EUR
MUUV17081Sulodexide'i määramiskatse väljatöötamine16.03.201731.08.2018Aivar LõokeneTallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut30 000,00 EUR
PRGPRG399Supramolekulaarsed kohandatavad kiraalsuse sensorid01.01.201931.12.2023Riina AavTallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut714 250,00 EUR
MUUT220A (0140220As98)Taimede transformeerimine ja kasutamine rekombinantsete valkude ekspresseerimiseks01.01.199831.12.2002Erkki TruveTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Geenitehnoloogia õppetool23 008,19 EUR
ETFETF5635Tsingi metabolismi roll Alzheimeri haiguses. Uue strateegia väljatöötamine Alzheimeri haiguse prventsiooniks ja raviks.01.01.200331.12.2006Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond35 115,91 EUR
ETFETF6911Tsüklooksügenaasi katalüüsi ja inhibeerimise iseärasused01.01.200731.12.2010Nigulas SamelTallinna Tehnikaülikool, Matemaatika-loodusteaduskond63 073,14 EUR