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Andres Männik

https://etis.ee/CV/Andres_Männik/est
15.05.1972
+37256153144
andres.mannik@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2021–31.12.2022   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, molekulaarviroloogia kaasprofessor (0,40)
01.02.2018–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, molekulaarviroloogia (0,40)
01.11.2013–...   
Icosagen Cell Factory OÜ, Tehnoloogiadirektor (1,00)
01.02.2018–31.12.2020   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, molekulaarviroloogia vanemteadur (0,40)
29.08.2011–30.10.2013   
Icosagen Cell Factory OÜ, Vanemteadur (1,00)
01.01.2004–31.12.2011   
FIT Biotech Oy, vanemteadur (1,00)
01.01.2000–31.12.2004   
FIT Biotech Oy, teadur (1,00)
 
 
Haridustee
1979-1990 Tallinna 3. Keskkool
1990-1995 bioloogia eriala üliõpilane Tartu Ülikooli bioloogia-geograafia teaduskonnas, lõpetanud biotehnoloogia ja biomeditsiini õppesuuna bakalaureusekraadiga
1995-1997 magistrant Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituudis, omandanud magistrikraadi viroloogia erialal
1997-2002 doktorant Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituudis
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2019−...   
Eesti Inimesegeneetika Ühingu liige juhatuse liige

Kvalifikatsioon

Teaduskraadid
Andres Männik, doktorikraad, 2003, (juh) Mart Ustav, Design and characterization of a novel vector system based on the stable replicator of bovine papillomavirus type 1, Tartu Ülikool.
Andres Männik, magistrikraad (teaduskraad), 1997, (juh) Mart Ustav, Transkriptsiooni aktivatsioonil baseeruvate vektorite konstrueerimine ja testimine, Tartu Ülikool.
 
 
Lisainfo
Ph.D
Tartu Ülikool, 2003

Jooksvad projektid

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Velásquez Pereira, Leydi Carolina; Roose, Elien; Graça, Nuno A.G.; Sinkovits, György; Kangro, Kadri; Joly, Bérangère S.; Tellier, Edwige; Kaplanski, Gilles; Falter, Tanja; Von Auer, Charis; Rossmann, Heidi; Feys, Hendrik B.; Reti, Marienn; Prohászka, Zoltán; Lämmle, Bernhard; Voorberg, Jan; Coppo, Paul; Veyradier, Agnès; De Meyer, Simon F.; Männik, Andres ... Vanhoorelbeke, Karen (2021). Immunogenic hotspots in the spacer domain of ADAMTS13 in immune‐mediated thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis, 19 (2), 478−488. DOI: 10.1111/jth.15170.
1.1.
2021
Ercig, Bogac; Gomes Graca, Nuno Alexandre; Kangro, Kadri; Arfman, Tom; Wichapong, Kanin; Hrdinova, Johana; Kaijen, Paul; van Alphen, Floris; van den Biggelaar, Maartje; Vanhoorelbeke, Karen; Veyradier, Agnès; Coppo, Paul; Reutelingsperger, Chris; Nicolaes, Gerry A.F.; Männik, Andres; Voorberg, Jan (2021). N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP. Blood, 137 (19), 2694−2698. DOI: 10.1182/blood.2020007972.
1.1.
2021
Dekimpe, Charlotte; Roose, Elien; Kangro, Kadri; Bonnez, Quintijn; Vandenbulcke, Aline; Tellier, Edwige; Kaplanski, Gilles; Feys, Hendrik B.; Tersteeg, Claudia; Männik, Andres; De Meyer, Simon F.; Vanhoorelbeke, Karen (2021). Determination of anti‐ADAMTS13 autoantibody titers in ELISA: Influence of ADAMTS13 presentation and autoantibody detection. Journal of Thrombosis and Haemostasis. DOI: 10.1111/jth.15297 [ilmumas].
1.1.
2020
Graça, Nuno A G; Ercig, Bogac; Velásquez Pereira, Leydi Carolina; Kangro, Kadri; Kaijen, Paul; Nicolaes, Gerry A F; Veyradier, Agnès; Coppo, Paul; Vanhoorelbeke, Karen; Männik, Andres; Voorberg, Jan (2020). Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura. Haematologica. DOI: 10.3324/haematol.2019.226068.
1.1.
2020
Kangro, Kadri; Roose, Elien; Schelpe, An‐Sofie; Tellier, Edwige; Kaplanski, Gilles; Voorberg, Jan; De Meyer, Simon F.; Männik, Andres; Vanhoorelbeke, Karen (2020). Generation and validation of small ADAMTS13 fragments for epitope mapping of anti‐ADAMTS13 autoantibodies in immune‐mediated thrombotic thrombocytopenic purpura. Research and Practice in Thrombosis and Haemostasis, 4 (5), 918−930. DOI: 10.1002/rth2.12379.
1.1.
2020
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart, Jr.; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Loseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskiene, Astra ... Kainov, Denis E. (2020). Identification and Tracking of Antiviral Drug Combinations. Viruses, 12 (10), ARTN 1178. DOI: 10.3390/v12101178.
1.1.
2019
Tombak, EM.; Männik, A.; Burk, RD.; Le Grand, R.; Ustav, E.; Ustav M. (2019). The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing. PLoS ONE, 14 (1).10.1371/journal.pone.0211235.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93. DOI: 10.1128/JVI.00794-19.
1.1.
2018
Öhlund, Pontus; García-Arriaza, Juan; Zusinaite, Eva; Szurgot, Inga; Männik, Andres; Kraus, Annette; Ustav, Mart; Merits, Andres; Esteban, Mariano; Liljeström, Peter; Ljungberg, Karl (2018). DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost. Scientific Reports, 8 (1), 12459−12459. DOI: 10.1038/s41598-018-31003-6.
1.1.
2017
Toots, Mart; Ustav, Mart Jr.; Männik, Andres; Mumm, Karl; Tämm, Kaido; Tamm, Tarmo; Ustav, Ene; Ustav, Mart. (2017). Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. PLoS Pathogens, 13 (2), e1006168. DOI: 10.1371/journal.ppat.1006168.
1.1.
2016
Kivi, Gaily; Teesalu, Kaupo; Parik, Jüri; Kontkar, Elen; Ustav, Mart; Noodla, Liis; Ustav, Mart; Männik, Andres (2016). HybriFree: a robust and rapid method for the development of monoclonal antibodies from different host species. BMC Biotechnology, 16 (1), 2−2. DOI: 10.1186/s12896-016-0232-6.
1.1.
2015
Ustav, Mart Jr; Castaneda, Fernando-Rodriguez; Reinson, Tormi; Männik, Andres; Ustav, Mart (2015). Human Papillomavirus Type 18 cis-Elements Crucial for Segregation and Latency. PLoS ONE, 10 (8), 1−24. DOI: 10.1371/journal.pone.0135770.
1.1.
2015
Isok-Paas, Helen; Männik, Andres; Ustav, Ene; Ustav, Mart. (2015). The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome. Virology Journal, 1−15.
3.1.
2015
Karro, Kristiina; Männik, Tiiu; Männik, Andres; Ustav, Mart (2015). DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent. In: Ülo Langel (Ed.). Cell-Penetrating Peptides (435−445). New York: Springer. (Methods in Molecular Biology; 1324).10.1007/978-1-4939-2806-4_29.
1.1.
2014
Sankovski E, Männik A, Geimanen J, Ustav E, Ustav M. (2014). Mapping of betapapillomavirus human papillomavirus 5 transcription and characterization of viral-genome replication function. Journal of Virology, 88 (2), 961−973.10.1128/JVI.01841-13.
1.1.
2014
Toots, Mart; Männik, Andres; Kivi, Gaili; Ustav, Mart JR.; Ustav, Ene; Ustav, Mart (2014). The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS Cells. PLoS ONE, 9 (12), 1−31.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610. DOI: 10.1371/journal.ppat.1003610.
1.1.
2013
Toots, Mart; Männik, Andres; Kivi, Gaily; Ustav Jr., Mart; Ustav, Ene; Ustav, Mart (2013). http://www.ncbi.nlm.nih.gov/pubmed/25548925. PLoS ONE, 9 (12), 1−31.10.1371/journal.pone.0116151.
1.1.
2010
Silla, Toomas; Männik, Andres; Ustav, Mart (2010). Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division. Journal of Virology, 84 (21), 11175−11188. DOI: 10.1128/JVI.01366-10.
1.1.
2009
Martinon, F.; Kaldma, K.; Sikut, R.; Culina, S.; Romain, G.; Tuomela, M.; Adojaan, M.; Männik, A.; Toots, U.; Kivisild, T.; Morin, J.; Brochard, P.; Delache, B.; Tripiciano, A.; Ensoli, F.; Stanescu, I.; Le Grand, R.; Ustav, M. (2009). Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates. Human Gene Therapy, 20 (11), 1291−1307. DOI: 10.1089/hum.2009.044.
1.1.
2007
Adojaan, M.; Mölder, T.; Männik, A.; Kivisild, T.; Villems, R.; Krispin, T.; Ustav, M. (2007). High prevalence of the CCR5delta32 HIV-resistance mutation among Estonian HIV-1-infected individuals. Aids Research and Human Retroviruses, 23 (2), 193−197. DOI: 10.1089/aid.2006.0113.
1.1.
2003
Mannik, A.; Piirsoo, M.; Nordstrom, K.; Ustav, E.; Vennstrom, B.; Ustav, M. (2003). Effective generation of transgenic mice by Bovine papillomavirus type 1 based self-replicating plasmid that is maintained as extrachromosomal genetic element in three generations of animals. Plasmid, 49 (3), 193−204.
1.1.
2002
Mannik, A.; Runkorg, K.; Jaanson, N.; Ustav, M.; Ustav, E. (2002). Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo. Journal of Virology, 76 (11), 5835−5845.
1.2.
2001
Raasmaja, A.; Soosaar, A.; Lampela, P.; Kõks, S.; Männik, A.; Volke, V.; Huotari, M.; Joki, S.; Ustav, E.; Vasar, E.; Ustav, M.; Männistö, P. (2001). Tyrosine Hydroxylase gene Transfer to Rat Striatum Using Bovine Papilloma Virus-1 Expression Plasmids in the Experimental Model of Parkinson's Disease. In: Pharmaceutical and Pharmacological Letters (83−86). . (2).

Tööstusomand

10.06.2021

Andres Männik

https://etis.ee/CV/Andres_Männik/eng
15.05.1972
+37256153144
andres.mannik@ut.ee

Career

Institutions and positions
01.01.2021–31.12.2022   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Associate Professor of Molecular Virology (0,40)
01.02.2018–...   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Senior Researcher (0,40)
01.11.2013–...   
Icosagen Cell Factory OÜ, Chief Technology Officer (1,00)
01.02.2018–31.12.2020   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Senior Research Fellow in Molecular Virology (0,40)
29.08.2011–30.10.2013   
Icosagen Cell Factory OÜ, Senior Researcher (1,00)
01.01.2004–31.12.2011   
FIT Biotech Oy, Senior Researcher (1,00)
01.01.2000–31.12.2004   
FIT Biotech Oy, Researcher (1,00)
 
 
Education
1979-1990 Tallinn Secondary School No. 3
1990-1995 BSc student in Tartu University; Faculty of Biology and Geography, graduated in speciality of biotechnology and biomedicine
1995-1997 MSc student in Tartu University, Institute of Molecular and Cell Biology; graduated as virologist
1997-2002 PhD student in Tartu University, Institute of Molecular and Cell Biology
 
 
R&D related managerial and administrative work
2019−...   
Estonian Society of Human Genetics, Member of the Management Board

Qualifications

Academic degrees
Andres Männik, Doctor's Degree, 2003, (sup) Mart Ustav, Design and characterization of a novel vector system based on the stable replicator of bovine papillomavirus type 1, University of Tartu.
Andres Männik, Research Master's Degree, 1997, (sup) Mart Ustav, Transkriptsiooni aktivatsioonil baseeruvate vektorite konstrueerimine ja testimine, University of Tartu.
 
 
Additional information
Ph.D
Tartu University, 2003

Projects in progress

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2021
Velásquez Pereira, Leydi Carolina; Roose, Elien; Graça, Nuno A.G.; Sinkovits, György; Kangro, Kadri; Joly, Bérangère S.; Tellier, Edwige; Kaplanski, Gilles; Falter, Tanja; Von Auer, Charis; Rossmann, Heidi; Feys, Hendrik B.; Reti, Marienn; Prohászka, Zoltán; Lämmle, Bernhard; Voorberg, Jan; Coppo, Paul; Veyradier, Agnès; De Meyer, Simon F.; Männik, Andres ... Vanhoorelbeke, Karen (2021). Immunogenic hotspots in the spacer domain of ADAMTS13 in immune‐mediated thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis, 19 (2), 478−488. DOI: 10.1111/jth.15170.
1.1.
2021
Ercig, Bogac; Gomes Graca, Nuno Alexandre; Kangro, Kadri; Arfman, Tom; Wichapong, Kanin; Hrdinova, Johana; Kaijen, Paul; van Alphen, Floris; van den Biggelaar, Maartje; Vanhoorelbeke, Karen; Veyradier, Agnès; Coppo, Paul; Reutelingsperger, Chris; Nicolaes, Gerry A.F.; Männik, Andres; Voorberg, Jan (2021). N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP. Blood, 137 (19), 2694−2698. DOI: 10.1182/blood.2020007972.
1.1.
2021
Dekimpe, Charlotte; Roose, Elien; Kangro, Kadri; Bonnez, Quintijn; Vandenbulcke, Aline; Tellier, Edwige; Kaplanski, Gilles; Feys, Hendrik B.; Tersteeg, Claudia; Männik, Andres; De Meyer, Simon F.; Vanhoorelbeke, Karen (2021). Determination of anti‐ADAMTS13 autoantibody titers in ELISA: Influence of ADAMTS13 presentation and autoantibody detection. Journal of Thrombosis and Haemostasis. DOI: 10.1111/jth.15297 [forthcoming].
1.1.
2020
Graça, Nuno A G; Ercig, Bogac; Velásquez Pereira, Leydi Carolina; Kangro, Kadri; Kaijen, Paul; Nicolaes, Gerry A F; Veyradier, Agnès; Coppo, Paul; Vanhoorelbeke, Karen; Männik, Andres; Voorberg, Jan (2020). Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura. Haematologica. DOI: 10.3324/haematol.2019.226068.
1.1.
2020
Kangro, Kadri; Roose, Elien; Schelpe, An‐Sofie; Tellier, Edwige; Kaplanski, Gilles; Voorberg, Jan; De Meyer, Simon F.; Männik, Andres; Vanhoorelbeke, Karen (2020). Generation and validation of small ADAMTS13 fragments for epitope mapping of anti‐ADAMTS13 autoantibodies in immune‐mediated thrombotic thrombocytopenic purpura. Research and Practice in Thrombosis and Haemostasis, 4 (5), 918−930. DOI: 10.1002/rth2.12379.
1.1.
2020
Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart, Jr.; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Loseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskiene, Astra ... Kainov, Denis E. (2020). Identification and Tracking of Antiviral Drug Combinations. Viruses, 12 (10), ARTN 1178. DOI: 10.3390/v12101178.
1.1.
2019
Tombak, EM.; Männik, A.; Burk, RD.; Le Grand, R.; Ustav, E.; Ustav M. (2019). The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing. PLoS ONE, 14 (1).10.1371/journal.pone.0211235.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93. DOI: 10.1128/JVI.00794-19.
1.1.
2018
Öhlund, Pontus; García-Arriaza, Juan; Zusinaite, Eva; Szurgot, Inga; Männik, Andres; Kraus, Annette; Ustav, Mart; Merits, Andres; Esteban, Mariano; Liljeström, Peter; Ljungberg, Karl (2018). DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost. Scientific Reports, 8 (1), 12459−12459. DOI: 10.1038/s41598-018-31003-6.
1.1.
2017
Toots, Mart; Ustav, Mart Jr.; Männik, Andres; Mumm, Karl; Tämm, Kaido; Tamm, Tarmo; Ustav, Ene; Ustav, Mart. (2017). Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. PLoS Pathogens, 13 (2), e1006168. DOI: 10.1371/journal.ppat.1006168.
1.1.
2016
Kivi, Gaily; Teesalu, Kaupo; Parik, Jüri; Kontkar, Elen; Ustav, Mart; Noodla, Liis; Ustav, Mart; Männik, Andres (2016). HybriFree: a robust and rapid method for the development of monoclonal antibodies from different host species. BMC Biotechnology, 16 (1), 2−2. DOI: 10.1186/s12896-016-0232-6.
1.1.
2015
Ustav, Mart Jr; Castaneda, Fernando-Rodriguez; Reinson, Tormi; Männik, Andres; Ustav, Mart (2015). Human Papillomavirus Type 18 cis-Elements Crucial for Segregation and Latency. PLoS ONE, 10 (8), 1−24. DOI: 10.1371/journal.pone.0135770.
1.1.
2015
Isok-Paas, Helen; Männik, Andres; Ustav, Ene; Ustav, Mart. (2015). The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome. Virology Journal, 1−15.
3.1.
2015
Karro, Kristiina; Männik, Tiiu; Männik, Andres; Ustav, Mart (2015). DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent. In: Ülo Langel (Ed.). Cell-Penetrating Peptides (435−445). New York: Springer. (Methods in Molecular Biology; 1324).10.1007/978-1-4939-2806-4_29.
1.1.
2014
Sankovski E, Männik A, Geimanen J, Ustav E, Ustav M. (2014). Mapping of betapapillomavirus human papillomavirus 5 transcription and characterization of viral-genome replication function. Journal of Virology, 88 (2), 961−973.10.1128/JVI.01841-13.
1.1.
2014
Toots, Mart; Männik, Andres; Kivi, Gaili; Ustav, Mart JR.; Ustav, Ene; Ustav, Mart (2014). The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS Cells. PLoS ONE, 9 (12), 1−31.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610. DOI: 10.1371/journal.ppat.1003610.
1.1.
2013
Toots, Mart; Männik, Andres; Kivi, Gaily; Ustav Jr., Mart; Ustav, Ene; Ustav, Mart (2013). http://www.ncbi.nlm.nih.gov/pubmed/25548925. PLoS ONE, 9 (12), 1−31.10.1371/journal.pone.0116151.
1.1.
2010
Silla, Toomas; Männik, Andres; Ustav, Mart (2010). Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division. Journal of Virology, 84 (21), 11175−11188. DOI: 10.1128/JVI.01366-10.
1.1.
2009
Martinon, F.; Kaldma, K.; Sikut, R.; Culina, S.; Romain, G.; Tuomela, M.; Adojaan, M.; Männik, A.; Toots, U.; Kivisild, T.; Morin, J.; Brochard, P.; Delache, B.; Tripiciano, A.; Ensoli, F.; Stanescu, I.; Le Grand, R.; Ustav, M. (2009). Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates. Human Gene Therapy, 20 (11), 1291−1307. DOI: 10.1089/hum.2009.044.
1.1.
2007
Adojaan, M.; Mölder, T.; Männik, A.; Kivisild, T.; Villems, R.; Krispin, T.; Ustav, M. (2007). High prevalence of the CCR5delta32 HIV-resistance mutation among Estonian HIV-1-infected individuals. Aids Research and Human Retroviruses, 23 (2), 193−197. DOI: 10.1089/aid.2006.0113.
1.1.
2003
Mannik, A.; Piirsoo, M.; Nordstrom, K.; Ustav, E.; Vennstrom, B.; Ustav, M. (2003). Effective generation of transgenic mice by Bovine papillomavirus type 1 based self-replicating plasmid that is maintained as extrachromosomal genetic element in three generations of animals. Plasmid, 49 (3), 193−204.
1.1.
2002
Mannik, A.; Runkorg, K.; Jaanson, N.; Ustav, M.; Ustav, E. (2002). Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo. Journal of Virology, 76 (11), 5835−5845.
1.2.
2001
Raasmaja, A.; Soosaar, A.; Lampela, P.; Kõks, S.; Männik, A.; Volke, V.; Huotari, M.; Joki, S.; Ustav, E.; Vasar, E.; Ustav, M.; Männistö, P. (2001). Tyrosine Hydroxylase gene Transfer to Rat Striatum Using Bovine Papilloma Virus-1 Expression Plasmids in the Experimental Model of Parkinson's Disease. In: Pharmaceutical and Pharmacological Letters (83−86). . (2).

Industrial property

10.06.2021

Otsi projekti

  • {{item.Name}}
Asutus on projekti finantseerija   Asutus on projekti teostaja  
  • {{searchListItem.Name}}
Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Uus otsing (Beetaversioon) Lihtotsing Tühjenda
  • Leitud 6 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF9467Inimese papilloomiviiruse genoomi segregatsiooni uurimine latentse nakkuse faasis01.01.201231.12.2015Mart UstavTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut76 800,00 EUR
PRGPRG198Inimese papilloomiviirusega (HPV) nakatumise ja replikatsiooni inhibiitorite märklaudade ja ravimite otsinguks kõrge läbilaskvusega rakulise süsteemi konstrueerimine ning loommudeli loomine pre-kliiniliseks HPV ravimite testimiseks.01.01.201831.12.2022Marko PiirsooTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut914 250,00 EUR
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