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Olen nõus

Merike Kelve

https://etis.ee/CV/Merike_Kelve/est
16.02.1947
51 52470
merike.kelve@ttu.ee

Teenistuskäik

Töökohad ja ametid
01.01.2017–31.12.2017   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, Juhtivteadur (0,10)
01.04.2008–31.12.2016   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, Juhtivteadur (0,75)
2008–31.03.2008   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, Erakorraline vanemteadur (0,75)
2005–31.12.2015   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, Dotsent (0,25)
01.01.2001–31.12.2007   
KBFI, vanemteadur, juhtivteadur
01.01.1997–31.12.2000   
Tallinna Tehnikaülikool, Geenitehnoloogia Keskus, molekulaardiagnostika õppetooli dotsent (0,5 koormusega)
01.01.1993–31.12.2001   
KBFI molekulaargeneetika laboratooriumi juhataja
01.01.1984–31.12.1992   
Keemilise ja Bioloogilise Füüsika Instituut (KBFI), Tallinn, molekulaargeneetika laboratoorium, vanemteadur
01.01.1978–31.12.1984   
Eksperimentaalbioloogia Instituut, Harku; molekulaarbioloogia laboratoorium, teadur, vanemteadur
01.01.1974–31.12.1978   
Tartu Riiklik Ülikool, arstiteaduskond, biokeemia kateeder; nooremteadur
 
 
Haridustee
01.09.1970–31.08.1973   
Aspirantuur Tartu Riiklikus Ülikoolis
1965–1970   
Tartu Riiklik Ülikool, Füüsika-Keemiateaduskond, orgaaniline keemia
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
1994−2001   
Eesti Teadusfondi Nõukogu keemia ja molekulaarbioloogia ekspertkomisjoni liige
 
 
Loometöö
1974 bioloogiakandidaat (eriala: biokeemia). Väitekiri: "Roti maksa 5S ribosomaalse ribonukleiinhappe uurimine", Tartu Riiklik Ülikool
 
 
Lisainfo
Koormus muutunud

Kvalifikatsioon

Teaduskraadid
Merike Kelve, doktorikraad, 1974, (juh) Artur Lind, Issledovanije konformatsii 5S ribosomalnoi RNK iz petšeni krõsõ (Roti maksa 5S RNA konformatsiooni uurimine), Tartu Ülikool, Arstiteaduskond.
 
 
Teaduspreemiad ja tunnustused
1980, Merike Kelve, Eesti NSV riiklik teadus- ja tehnikapreemia
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; CERCS KLASSIFIKAATOR: P310 Proteiinid, ensümoloogia
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud
 
 
Lisainfo
Merike Kelve, doktorikraad, 1974, (juh) Artur Lind, Issledovanije konformatsii 5S ribosomalnoi RNK iz petšeni krõsõ (Roti maksa 5S RNA konformatsiooni uurimine), Tartu Ülikool, Arstiteaduskond.

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Reintamm, T.; Aas-Valleriani, N.; Kelve, M. (2019). Evolutionary distribution of deoxynucleoside 5-monophosphate Nglycosidase, DNPH1. Gene, 683, 1−11.10.1016/j.gene.2018.10.005.
1.1.
2019
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Olspert, A.; Kelve, M. (2019). Identification of a novel member of 2H phosphoesterases, 2',5'-oligoadenylate degrading ribonuclease from the oyster Crassostrea gigas. Biochimie, 156, 181−195.10.1016/j.biochi.2018.09.003.
1.1.
2019
Reintamm, T.; Vallmann, K. Kolk, K.; Päri, M.; Lopp, A.; Aas-Valleriani, N.; Kelve, M. (2019). Cloning and expression of ATP N-glycosidase from the freshwater sponge Ephydatia muelleri. Biochimie, 158, 126−129.10.1016/j.biochi.2018.12.018.
1.1.
2018
Aas-Valleriani, N.; Reintamm, T.; Kelve, M. (2018). Deoxynucleoside 5-monophosphate N-glycosidase from a phylogenetically distant metazoa, sponge. Biochimie, 146, 113−118.10.1016/j.biochi.2017.12.005.
1.1.
2016
Vallmann, K.; Kivisild, C.; Lopp, A.; Rapp, H.T.; Kelve, M. (2016). The stress protein HSP70 from the marine sponge Thenea muricata. Journal of the Marine Biological Association of the United Kingdom, 96 (2), 573−581.10.1017/S0025315415002234.
1.1.
2015
Mutso, M.; Nikonov, A.; Pihlak, A.; Žusinaite, E.; Viru, L.; Selyutina, A.; Reintamm, T.; Kelve, M.; Saarma, M.; Karelson, M.; Merits, A. (2015). RNA interference-guided targeting of hepatitis C virus replication with antisense locked nucleic acid-based oligonucleotides containing 8-oxo-dG modifications. PLoS ONE, 10 (6), xUNSP e0128686. DOI: 10.1371/journal.pone.0128686.
1.1.
2014
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Hansen Kjaer, Karina; Justesen, Just; Kelve, Merike (2014). Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage. Biochimie, 97, 200−209. DOI: 10.1016/j.biochi.2013.10.015.
1.1.
2014
Dymerska, D.; Kurzawski, G.; Suchy, J., Roomere, H.; Toome, K.; Metspalu, A.; Janavičius, R.; Elsakov, P.; Irmejs, A.; Berzina, D.; Miklaševičs, E.; Gardovskis, J.; Rebane, E.; Kelve, M. et al. (2014). Lynch syndrome mutations shared by the Baltic States and Poland. Clinical Genetics, 86 (2), 190−193. DOI: 10.1111/cge.12251.
1.1.
2013
Liisi Karlep, Tõnu Reintamm, Merike Kelve (2013). Intragenomic profiling using multicopy genes: the rDNA internal transcribed spacer sequences of the freshwater sponge Ephydatia fluviatilis. PLoS ONE, 8 (6), 1−12.10.1371/journal.pone.0066601.
1.1.
2012
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; de Rosa, Salvatore; Kelve, Merike (2012). A novel endoribonuclease from the marine sponge Tethya aurantium specific to 2',5'-phosphodiester bond. Biochimie, 94, 1635−1646.10.1016/j.biochi.2012.04.002.
1.1.
2011
Vallmann, Kerli; Aas, Nele; Reintamm, Tõnu; Lopp, Annika; Kuusksalu, Anne; Kelve, Merike (2011). Expressed 2-5A synthetase genes and pseudogenes in the marine sponge Geodia barretti. Gene, 478, 42−49.10.1016/j.gene.2011.01.014.
1.1.
2011
Luthringer, B.; Isbert, S.; Müller, W.E.; Zilberberg, C.; Thakur, N.L.; Wörheide, G.; Stauber, R.H.; Kelve, M.; Wiens, M. (2011). Poriferan survivin exhibits a conserved regulatory role in the interconnected pathways of cell cycle and apoptosis. Cell Death and Differentiation, 18 (2), 201−213.10.1038/cdd.2010.87.
6.3.
2011
Lopp, Annika; Kelve, Merike (2011). Lihtsad, aga mitte primitiivsed loomad. Eesti Loodus, 62, 12−18.
1.1.
2010
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; Tammiste, Indrek; Pihlak, Arno; Kelve, Merike (2010). Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges. Marine Drugs, 8, 235−254.10.3390/md8020235.
5.2.
2010
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Tammiste, I.; Pihlak, A.; Kelve, M. (2010). Synthesis of 2',5'-linked nucleotides by OAS from marine sponges. VIII World Sponge Conference. Book of Abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 September 2010. 257.
5.2.
2010
Kuusksalu, A.; Reintamm, T.; Lopp, A.; Päri, M.; Kelve, M. (2010). Sponge 2-5A synthetases form the distinct subgroup of the 2-5A synthetase family. VIII World Sponge Conference. Book of abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 September 2010. 239.
5.2.
2010
Karlep, L.; Aas, N.; Salonen, S.; Lopp, A.; Reintamm, T.; Kelve, M. (2010). A set of ribosomal RNA gene copies in a single individual of Ephydatia fluviatilis. VIII World Sponge Conference. Book of Abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 spetember 2010. Girona, Spain, 228.
1.1.
2009
Kjaer, Karina; Poulsen, Jesper; Reintamm, Tõnu; Saby, Emilie; Martensen, Pia; Kelve, Merike; Justesen, Just (2009). Evolution of the 2'-5' Oligoadenylate Synthetase Family in Eukaryotes and Bacteria. Journal of Molecular Evolution, 69, 612−624.
1.1.
2009
Saby, Emilie; Poulsen, Jesper Buchhave; Justesen, Just; Kelve, Merike; Uriz, Maria Jesus (2009). 2'-phosphodiesterase amd 2',5'-oligoadenylate synthetase activities in the lowest metazoans, sponge [porifera]. Biochimie, 91, 1531−1534. DOI: 10.1016/j.biochi.2009.07.015.
1.1.
2009
Saby, Emilie; Justesen, Just; Kelve, Merike; Uriz, Maria J (2009). In vitro effects of metal pollution on Mediterranean sponges: Species-specific inhibition of 2',5'-oligoadenylate synthetase. Aquatic Toxicology, 94 (3), 204−210. DOI: 10.1016/j.aquatox.2009.07.002.
5.1.
2009
Kuusksalu, A.; Lopp, A.; Päri, M.; Reintamm, T.; Kelve, M. (2009). Interferon-induced 2',5'-oligoadenylate synthetases versus those from sponges, evolutionarily lowest multicellyular animals. Cytokine, 48: Tri-Society Annual Conference 2009 of SLB, ICS and ISICR: Cellular and Cytokine Interactions in Health and Disease. Lisbon, Portugal. Ed. Sir Gordon W. Duff; Scott K. Durum. Oxford, UK: Elsevier, 85−86. (1-2). DOI: 10.1016/j.cyto.2009.07.308.
5.2.
2009
Lopp, Annika; Reintamm, Tõnu; Rapp, Hans Tore; Hoffmann, Friederike; Kelve, Merike (2009). Natural 2',5'-linked oligoribonucleotides from marine sponges. 6th European Conference on Marine Natural Products, Programme & Abstracts Book: 6th European Conference on Marine Natural Products. Porto, Portugal, 19-23 July 2009. _EditorsAbbr Vieira, L., Martins, G.M. and Cravo, S. Porto, Portugal,.
1.1.
2008
Reintamm, Tõnu; Kuusksalu, Anne; Metsis, Madis; Päri, Mailis; Vallmann, Kerli; Lopp, Annika; Justesen, Just; Kelve, Merike (2008). Sponge OAS has a distinct genomic structure within the 2-5A synthetase family. Molecular Genetics and Genomics, 280, 453−466. DOI: 10.1007/s00438-008-0379-5.
1.1.
2007
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Reintamm, Tõnu; Justesen, Just; Kelve, Merike (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge < EM >Geodia cydonium< /EM >. FEBS Journal, 274, 3462−3474. DOI: 10.1111/j.1742-4658.2007.05878.x.
1.1.
2007
Lopp, A.; Reintamm, T.; Vallmann, K.; Päri, M.; Mikli, V.; Richelle-Maurer, E.; Kelve, M. (2007). Moelcular identification, characterization and distribution of freshwater sponges (Porifera: Spongillidae) in Estonia. Fundamental and Applied Limnology / Archiv für Hydrobiologie, 168 (1), 93−103. DOI: 10.1127/1863-9135/2007/0168-0093.
1.3.
2007
Kuusksalu, Anne; Metsis, Madis; Reintamm, Tõnu; Kelve, Merike (2007). Construction and characterization of a cDNA library from the marine sponge Chondrosia reniformis. In: Custodio, M.R.; Lobo-Hajdu, G.; Hajdu, E.; Muricy, G (_EditorsAbbr). Porifera Research - Biodiversity, Innovation and Sustainability (405−412).. Rio de Janeiro: Museu Nacional. (Serie Livros).
5.1.
2007
Saby, E., Reintamm, T., Kelve, M. (2007). Purification of the 2',5'-oligoadenylate synthetase from the marine sponges < EM >Geodia cydonium< /EM > and < EM >Chondrosia reniformis. Journal of Interferon & Cytokine Research, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
5.1.
2007
Lopp, A.; Päri, M.; Kuusksalu, A.; Reintamm, T.; Justesen, J.; Kelve, M. (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge< EM > Geodia cydonium< /EM >. Journal of Interferon & Cytokine Reseach, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
5.2.
2007
Reintamm, T., Lopp, A., Kelve, M. (2007). < P >1-methyladenine - the major adenylate derived seondary metabolite of the marine sponge < EM >Geodia cydonium< /EM >. 5th European Conference on Marine Natural Products. Abstracts: 5th European Conference on Marine Natural Products. Sept. 16-21, 2007, Ischia, Naples, Italy. Napoli, Italy: Edizioni Ziino, Italy, 183.
1.3.
2006
Roovere, T.; Lopp, A.; Reintamm, T.; Kuusksalu, A.; Richelle-Maurer, E.; Kelve, M. (2006). Freshwater sponges in Estonia: genetic and morphological identification. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 55, 216−227.
5.2.
2006
Kuusksalu, A., reintamm, T., Metsis, M., Kelve, M. (2006). Construction and screening of cDNA library from a marine sponge Chondrosia reniformis. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brazil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 157. (Serie Livros; 16).
5.2.
2006
Lopp, A., Reintamm, T., Vallmann, K., Päri, M., Mikli, V., Richelle-Maurer, E., Kelve, M. (2006). Freshwater sponges in Estonia: Distribution, morphological and genetic identification. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brasil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 224. (Serie Livros; 16).
5.2.
2006
Reintamm, Tõnu; Kelve, Merike (2006). Partial purification and preliminary characterization of ATP N-glycosidase from a marine sponge Axinella polypoides. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts.: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability, Buzios/Rio de janeiro, Brasil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 164. (Serie Livros; 16).
3.4.
2004
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Rosa, S.; Kelve, M. (2004). Non-traditional enzymatic pathway of ATP utilization by the marine sponge Tedania sp. Proceedings of the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004: the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004. Sorrento, Italy, 65−65.
5.2.
2004
Kelve, M.; Lopp, A.; Reintamm, T.; Kuusksalu, A. (2004). Freshwater sponge cell cultures as model systems for biochemical pathways present in marine sponges. Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004. EAS (European Aquaculture Society) Special Publication, 34: Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004..
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Subbi, J.; Kelve, M. (2003). Qualitative and quantitative aspects of 2-5A synthesizing capacity of different marine sponges. Biomolecular Engineering, 20, 389−399.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Pehk, T.; Kelve, M. (2003). ATP N-glycosidase – a novel ATP converting activity from marine sponge Axinella polypoides. European Journal of Biochemistry, 270, 4122−4132.
1.1.
2003
Kelve, M.; Kuusksalu, A.; Lopp, A.; Reintamm, T. (2003). Sponge (2',5')oligoadenylate synthetase activity in the whole sponge organism and in a primary cell culture. Journal of Biotechnology, 100, 177−180.
3.1.
2003
Aaspõllu, A.; Kelve, M. (2003). The first criminal case in Estonia with dog's DNA data admitted as evidence. Progress in Forensic Genetics (847−851).. Elsevier. (International Congress Series; vol 1239).
1.1.
2002
Grebenjuk, V.A.; Kuusksalu, A.; Kelve, M.; Schütze, J.; Schröder, H.C.; Müller, W.E. (2002). Induction of (2'-5')oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide. European Journal of Biochemistry, 269, 1382−1392.
1.1.
2002
Lopp, A.; Kuusksalu, A.; Reintamm, T.; Müller, W.E.; Kelve, M. (2002). 2',5'-oligoadenylate synthetase from a lower invertebrate, the marine sponge Geodia cydonium, does not need dsRNA for its enzymatic activity. Biochimica et Biophysica Acta, 1590, 140−149.
5.2.
2002
Roovere, Tiiu; Aaspõllu, Anu; Kelve, Merike (2002). Y kromosoomi STR lookuste alleelide jaotus Eesti populatsiooni näitel. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 119−120.
5.2.
2002
Masing, Esther; Aaspõllu, Anu; Kelve, Merike (2002). Mikrosatelliitsete markerite analüüs ja geneetiline mitmekesisus Soome pruunkaru näitel. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 83−84.
5.2.
2002
Lagemaa, Kadri; Aaspõllu, Anu; Kelve, Merike (2002). Lühikese DNA kordusjärjestuste analüüs eestlaste populatsioonis PowerPlexTM 16 abil. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 74−75.
1.1.
2001
Sak, K.; Samuel, K.; Kelve, M.; Webb, TE. (2001). Pharmacological characterisation of pyrimidinoceptor responses in NG108-15 cells. European Journal of Pharmacology, 415, 127−133.
3.2.
2001
"Aaspõllu, Anu;Sumeri, Ingrid;Kelve, Merike" (2001). The allelic distribution of the Y cromosomal STR loci in an Estonian population sample. Problems of Forensic Science (103−109).. Krakow: Institute of Forensic Research Publishers.
1.1.
2000
Lopp, A.; Kuusksalu, A.; Samuel, K.; Kelve, M. (2000). Expression and activity of 2-5A synthetase in the course of differentiation and apoptosis of PC12 cells. Cytokine, 12, 737−741.
1.1.
2000
Sak, K.; Uri, A.; Enkvist, E.; Raidaru, G.; Subbi, J.; Kelve, M.; Jarv, J. (2000). Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors. Biochemical and Biophysical Research Communications, 272 (2), 327−331.
3.1.
2000
"Aaspõllu, Anu;Sumeri, Ingrid;Kelve, Merike" (2000). Allele distribution at nine STR loci - D3S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317 and D7S820 - in an Estonian population sample. Progress in forensic genetics, 129−131.
1.1.
1999
Kalinichenko, E.N.; Podkopaeva, T.L.; Kelve, Merike; Saarma, Mart; Mikhailopulo, I.A. (1999). 3 '-deoxy-3 '-fluoro analogues of 2-5A core trimers: Their effect on the lytic activity of human NK lymphocytes. Bioorganicheskaya Khimiya, 25 (4), 282−289.
1.1.
1999
Wiens, M.; Kuusksalu, A.; Kelve, M.; Müller, W.E.G. (1999). Origin of the interferon-inducible (2'-5')oligoadenylate synthetase in vertebrates : cloning of the (2'-5') oligoadenylate synthetase from the marine sponge Geodia cydonium. FEBS Letters, 462, 12−18.
1.1.
1999
Kalinichenko, EN.; Podkopaeva, TL.; Mikhailopulo, IA.; Kelve, M.; Saarma, M.; van den Boogaart, J.; Altona, C. (1999). The stereochemical aspect of the interaction of 3 '-fluoro-3 '-deoxy analogues of the (2 '-5 ')oligoadenylic acid trimer with (2 '-5 ')A(3) antibodies. Bioorganicheskaya Khimiya, 25 (10), 763−767.
1.2.
1999
Sak, K.; Webb, T.; Samuel, K.; Kelve, M.; Järv, J. (1999). Only Pyrimidinoceptors are Functionally Expressed in Mouse Neuroblastoma Cell Cines. Molecular Cell Biology Research Communications, 1 (3), 203−208.
1.3.
1999
Lopp, Annika; Kuusksalu, Anne; Samuel, Külli; Kelve, Merike (1999). 2-5A synthetase induction during PC12 cell death induced by serum starvation. Proceedings of the Estonian Academy of Sciences. Chemistry, 48, 109−118.
1.1.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Müller, W.E.G.; Kelve, Merike (1998). Identification of the reaction products of (2`-5`)-oligoadenylate synthetase in marine sponge. European Journal of Biochemistry, 257 (2), 420−426.
1.1.
1998
Sak, K.; Kelve, M.; Uri, A.; Jarv, J. (1998). Pyrimidinoceptor potentiation by ATP in NG108-15 cells. FEBS Letters, 439, 107−109.
5.1.
1998
Lopp, A.; Samuel, K.; Kelve, Merike (1998). Expression and activity of 2-5A synthetase in course of differentiation and apoptosis of PC12 cells. European cytokine network, 447−447.
1.1.
1997
Schröder, H.C.; Wiens, M.; Kuusksalu, A.; Kelve, M.; Mueller, W.E.G (1997). Modulation of 2´-5' oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. Environmental Toxicology and Chemistry, 16 (7), 1403−1409.
1.1.
1997
Kiss, C.; Li, J.; Szeles, A.; Gizatullin, R.Z.; Kashuba, V.I.; Lushnikova, T.; Protopopov, A.I.; Kelve, M.; Kiss, H.; Kholodnyuk, I.D.; Imreh, S.; Klein, G.; Zabarovsky, E.R. (1997). Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids. Cytogenet Cell Genet.1997;79(3-4):228-30. Cytogenetics and Cell Genetics, 79, 228−230.
1.1.
1997
Kujala, P.; Rikkonen, M.; Ahola, T.; Kelve, M.; Saarma, M.; Kaariainen, L (1997). Monoclonal antibodies specific for Semliki Forest virus replicase protein nsp2. Journal of General Virology, 78, 343−351.
1.1.
1997
Mikhailopulo, IA.; Kalinichenko, EN.; Podkopaeva, TL.; Kelve, M.; Saarma, M.; Lidaks, MY.; Rosemeyer, H.; Seela, F (1997). A 2'->5'-adenylate trimer with a positively charged 2'(3')-terminal 8-(4-aminobutyl)aminoadenosine residue: Synthesis, conformation and rnase L binding. Nucleosides & Nucleotides, 16, 1855−1873.
1.1.
1996
Truve, E.; Nigul, L.; Teeri, T. H.; Kelve, M. (1996). The effects of 2-5A on protein synthesis in wheat germ extracts and tobacco protoplasts. Nucleosides & Nucleotides, 15, 1097−1111.
1.2.
1996
Müller, W.E.; Pergande, G.; Ushijima, H.; Schleger, C.; Kelve, M.; Perovic, S. (1996). Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention. Prog Mol Subcell Biol. 1996;16:44-57. Progress in Molecular and Subcellular Biology, 16, 44-57.
1.1.
1995
Kuusksalu, A.; Pihlak, A.; Müller, W.E.; Kelve, M. (1995). The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges. Demonstration of the existence and identification of its reaction products. European Journal of Biochemistry, 232, 351−357.
1.1.
1995
Perovic, S.; Pergande, G.; Ushijima, H.; Kelve, M.; Forrest, J.; Müller, W.E. (1995). Flupirtine partially prevents neuronal injury induced by prion protein fragment and lead acetate. Neurodegeneration, 4, 369−374.
1.1.
1995
Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Müller, W. E. G. (1995). Impairment of intracellular antiviral defence with age: age-dependent changes in expression of interferon-induced and double-stranded RNA-activated 2-5A synthetase in rat. Mechanisms of Ageing and Development, 78, 103−115.
1.1.
1995
Kalinichenko, En.; Podkopaeva, Tl.; Poopeiko, Ne.; Kelve, M.; Saarma, M.; Mikhailopulo, Ia.; Vandenboogaart, Je.; Altona, C (1995). Role of the stereochemistry of 3'-fluoro-3'-deoxy analogs of 2-5a in binding to and activation of mouse rnase l. Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands Chemical Society, 114 (2), 43−50.
1.1.
1994
Schröder, H.C.; Kelve, M.; Schäcke, H.; Pfleiderer, W.; Charubala, R.; Suhadolnik, R.J.; Müller, W.E. (1994). Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells. Chemico-Biological Interactions, 90, 169−183.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Schröder, H. C.; Müller, W. E. G. (1994). Homologies between different forms of 2-5A synthetase. Progress in Molecular and Subcellular Biology, 14, 139−149.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Kuusksalu, A.; Seppänen, P.; Saarma, M. (1994). Principles and background for the construction of transgenic plants displaying multiple virus resistance. Archives of Virology, S9, 41−50.
1.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G.; Schröder, H. C. (1994). Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis. Cellular and Molecular Biology, 40, 165−173.
3.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G. (1994). Reduction of 2’-5’-oligoadenylate synthetase mRNA level in rat pheochromocytoma PC12 cells during apoptosis. Müller, W. E. G.. Use of Aquatic Invertebrates as Tools for Monitoring of Environmental Hazards (97−108).. Gustav Fischer Verlag.
1.1.
1993
Schröder, H.C.; Kelve, M.; Pfeifer, K.; Flögel-Mrsic, M.; Müller, W.E. (1993). Age-dependent changes in "intracellular immunity" to virus infections. Zeitsschrift für Gerontologie, 26, 232−237.
1.1.
1993
Truve, E.; Aaspõllu, A.; Honkanen, J.; Puska, R.; Mehto, M.; Hassi, A.; Teeri, T. H.; Kelve, M.; Seppänen, P.; Saarma, M. (1993). Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under the field conditions. Bio-Technology, 11, 1048−1052.
1.1.
1990
Kalinichenko, E.N.; Podkopaeva, T.L.; Kelve, M.; Saarma, M.; Mikhailopulo, I.A. (1990). 3'-Fluoro-3'-deoxy analogs of 2-5A 5'-monophosphate: binding to 2-5A-dependent endoribonuclease and susceptibility to (2'-5')phosphodiesterase degradation. Biochemical and Biophysical Research Communications, 167, 20−26.
1.1.
1987
Kelve, M.; Aruja, A.; Kooli, K.; Männik, J.; Raukas, E. (1987). Cooperative thermal denaturation of the assembly origin region of TMV RNA. Journal of Biomolecular Structure and Dynamics, 5, 105−117.
1.1.
1978
Kelve, MB.; Saarma, MY.; Metspalu, AK.; Lind, AY.; Villems, RL. (1978). Conformational isomers of 5s RNA of rat-liver ribosomes. Molecular Biology, 12 (3), 528−531.

Tööstusomand

3.09.2020

Merike Kelve

https://etis.ee/CV/Merike_Kelve/eng
16.02.1947
51 52470
merike.kelve@ttu.ee
http://

Career

Institutions and positions
01.01.2017–31.12.2017   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Research Professor (0,10)
01.04.2008–31.12.2016   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Research Professor (0,75)
2008–31.03.2008   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Extraordinary Senior Researcher (0,75)
2005–31.12.2015   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Associate Professor (0,25)
01.01.2001–31.12.2007   
NICPB, senior research scientist
01.01.1997–31.12.2000   
Tallinn University of Technology, Gene Technology Centre; assistant professor (half time, 0,5)
01.01.1993–31.12.2001   
NICPB, head of the Laboratory of molecular genetics
01.01.1984–31.12.1992   
National Institute of Chemical Physics and Biophysics (NICPB), Laboratory of molecular genetics; senior research scientist
01.01.1978–31.12.1984   
Institute of Experimental Biology, Harku; Laboratory of molecular biology; research scientist, senior research scientist
01.01.1974–31.12.1978   
Tartu State University, Medical faculty; Department of biochemistry, research scientist
 
 
Education
01.09.1970–31.08.1973   
postgraduate studies at Tartu State University
1965–1970   
Tartu State University, Faculty of Phyics and Chemistry, organic chemistry
 
 
R&D related managerial and administrative work
1994−2001   
Member of the chemistry and molecular biology expert comission of the Estonian Science Foundation
 
 
Creative work
1974 PhD in biology (biochemistry). PhD thesis: The studies on the 5S ribosomal ribonucleic acid from rat liver. Tartu State University.
 
 
Additional information
Changed

Qualifications

Academic degrees
Merike Kelve, Doctor's Degree, 1974, (sup) Artur Lind, Issledovanije konformatsii 5S ribosomalnoi RNK iz petšeni krõsõ (Studies of the conformation of 5S RNA from the rat liver), University of Tartu, Faculty of Medicine.
 
 
Honours & awards
1980, Merike Kelve, Estonian State Award for research and development
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; CERCS CLASSIFICATION: P310 Proteins, enzymology
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences
 
 
Additional information
Merike Kelve, Doctor's Degree, 1974, (sup) Artur Lind, Issledovanije konformatsii 5S ribosomalnoi RNK iz petšeni krõsõ (Studies of the conformation of 5S RNA from the rat liver), University of Tartu, Faculty of Medicine.

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Reintamm, T.; Aas-Valleriani, N.; Kelve, M. (2019). Evolutionary distribution of deoxynucleoside 5-monophosphate Nglycosidase, DNPH1. Gene, 683, 1−11.10.1016/j.gene.2018.10.005.
1.1.
2019
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Olspert, A.; Kelve, M. (2019). Identification of a novel member of 2H phosphoesterases, 2',5'-oligoadenylate degrading ribonuclease from the oyster Crassostrea gigas. Biochimie, 156, 181−195.10.1016/j.biochi.2018.09.003.
1.1.
2019
Reintamm, T.; Vallmann, K. Kolk, K.; Päri, M.; Lopp, A.; Aas-Valleriani, N.; Kelve, M. (2019). Cloning and expression of ATP N-glycosidase from the freshwater sponge Ephydatia muelleri. Biochimie, 158, 126−129.10.1016/j.biochi.2018.12.018.
1.1.
2018
Aas-Valleriani, N.; Reintamm, T.; Kelve, M. (2018). Deoxynucleoside 5-monophosphate N-glycosidase from a phylogenetically distant metazoa, sponge. Biochimie, 146, 113−118.10.1016/j.biochi.2017.12.005.
1.1.
2016
Vallmann, K.; Kivisild, C.; Lopp, A.; Rapp, H.T.; Kelve, M. (2016). The stress protein HSP70 from the marine sponge Thenea muricata. Journal of the Marine Biological Association of the United Kingdom, 96 (2), 573−581.10.1017/S0025315415002234.
1.1.
2015
Mutso, M.; Nikonov, A.; Pihlak, A.; Žusinaite, E.; Viru, L.; Selyutina, A.; Reintamm, T.; Kelve, M.; Saarma, M.; Karelson, M.; Merits, A. (2015). RNA interference-guided targeting of hepatitis C virus replication with antisense locked nucleic acid-based oligonucleotides containing 8-oxo-dG modifications. PLoS ONE, 10 (6), xUNSP e0128686. DOI: 10.1371/journal.pone.0128686.
1.1.
2014
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Hansen Kjaer, Karina; Justesen, Just; Kelve, Merike (2014). Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage. Biochimie, 97, 200−209. DOI: 10.1016/j.biochi.2013.10.015.
1.1.
2014
Dymerska, D.; Kurzawski, G.; Suchy, J., Roomere, H.; Toome, K.; Metspalu, A.; Janavičius, R.; Elsakov, P.; Irmejs, A.; Berzina, D.; Miklaševičs, E.; Gardovskis, J.; Rebane, E.; Kelve, M. et al. (2014). Lynch syndrome mutations shared by the Baltic States and Poland. Clinical Genetics, 86 (2), 190−193. DOI: 10.1111/cge.12251.
1.1.
2013
Liisi Karlep, Tõnu Reintamm, Merike Kelve (2013). Intragenomic profiling using multicopy genes: the rDNA internal transcribed spacer sequences of the freshwater sponge Ephydatia fluviatilis. PLoS ONE, 8 (6), 1−12.10.1371/journal.pone.0066601.
1.1.
2012
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; de Rosa, Salvatore; Kelve, Merike (2012). A novel endoribonuclease from the marine sponge Tethya aurantium specific to 2',5'-phosphodiester bond. Biochimie, 94, 1635−1646.10.1016/j.biochi.2012.04.002.
1.1.
2011
Vallmann, Kerli; Aas, Nele; Reintamm, Tõnu; Lopp, Annika; Kuusksalu, Anne; Kelve, Merike (2011). Expressed 2-5A synthetase genes and pseudogenes in the marine sponge Geodia barretti. Gene, 478, 42−49.10.1016/j.gene.2011.01.014.
1.1.
2011
Luthringer, B.; Isbert, S.; Müller, W.E.; Zilberberg, C.; Thakur, N.L.; Wörheide, G.; Stauber, R.H.; Kelve, M.; Wiens, M. (2011). Poriferan survivin exhibits a conserved regulatory role in the interconnected pathways of cell cycle and apoptosis. Cell Death and Differentiation, 18 (2), 201−213.10.1038/cdd.2010.87.
6.3.
2011
Lopp, Annika; Kelve, Merike (2011). Lihtsad, aga mitte primitiivsed loomad. Eesti Loodus, 62, 12−18.
1.1.
2010
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; Tammiste, Indrek; Pihlak, Arno; Kelve, Merike (2010). Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges. Marine Drugs, 8, 235−254.10.3390/md8020235.
5.2.
2010
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Tammiste, I.; Pihlak, A.; Kelve, M. (2010). Synthesis of 2',5'-linked nucleotides by OAS from marine sponges. VIII World Sponge Conference. Book of Abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 September 2010. 257.
5.2.
2010
Kuusksalu, A.; Reintamm, T.; Lopp, A.; Päri, M.; Kelve, M. (2010). Sponge 2-5A synthetases form the distinct subgroup of the 2-5A synthetase family. VIII World Sponge Conference. Book of abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 September 2010. 239.
5.2.
2010
Karlep, L.; Aas, N.; Salonen, S.; Lopp, A.; Reintamm, T.; Kelve, M. (2010). A set of ribosomal RNA gene copies in a single individual of Ephydatia fluviatilis. VIII World Sponge Conference. Book of Abstracts: VIII World Sponge Conference: Ancient animals, new challenges. Girona (Spain), 20-24 spetember 2010. Girona, Spain, 228.
1.1.
2009
Kjaer, Karina; Poulsen, Jesper; Reintamm, Tõnu; Saby, Emilie; Martensen, Pia; Kelve, Merike; Justesen, Just (2009). Evolution of the 2'-5' Oligoadenylate Synthetase Family in Eukaryotes and Bacteria. Journal of Molecular Evolution, 69, 612−624.
1.1.
2009
Saby, Emilie; Poulsen, Jesper Buchhave; Justesen, Just; Kelve, Merike; Uriz, Maria Jesus (2009). 2'-phosphodiesterase amd 2',5'-oligoadenylate synthetase activities in the lowest metazoans, sponge [porifera]. Biochimie, 91, 1531−1534. DOI: 10.1016/j.biochi.2009.07.015.
1.1.
2009
Saby, Emilie; Justesen, Just; Kelve, Merike; Uriz, Maria J (2009). In vitro effects of metal pollution on Mediterranean sponges: Species-specific inhibition of 2',5'-oligoadenylate synthetase. Aquatic Toxicology, 94 (3), 204−210. DOI: 10.1016/j.aquatox.2009.07.002.
5.1.
2009
Kuusksalu, A.; Lopp, A.; Päri, M.; Reintamm, T.; Kelve, M. (2009). Interferon-induced 2',5'-oligoadenylate synthetases versus those from sponges, evolutionarily lowest multicellyular animals. Cytokine, 48: Tri-Society Annual Conference 2009 of SLB, ICS and ISICR: Cellular and Cytokine Interactions in Health and Disease. Lisbon, Portugal. Ed. Sir Gordon W. Duff; Scott K. Durum. Oxford, UK: Elsevier, 85−86. (1-2). DOI: 10.1016/j.cyto.2009.07.308.
5.2.
2009
Lopp, Annika; Reintamm, Tõnu; Rapp, Hans Tore; Hoffmann, Friederike; Kelve, Merike (2009). Natural 2',5'-linked oligoribonucleotides from marine sponges. 6th European Conference on Marine Natural Products, Programme & Abstracts Book: 6th European Conference on Marine Natural Products. Porto, Portugal, 19-23 July 2009. _EditorsAbbr Vieira, L., Martins, G.M. and Cravo, S. Porto, Portugal,.
1.1.
2008
Reintamm, Tõnu; Kuusksalu, Anne; Metsis, Madis; Päri, Mailis; Vallmann, Kerli; Lopp, Annika; Justesen, Just; Kelve, Merike (2008). Sponge OAS has a distinct genomic structure within the 2-5A synthetase family. Molecular Genetics and Genomics, 280, 453−466. DOI: 10.1007/s00438-008-0379-5.
1.1.
2007
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Reintamm, Tõnu; Justesen, Just; Kelve, Merike (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge < EM >Geodia cydonium< /EM >. FEBS Journal, 274, 3462−3474. DOI: 10.1111/j.1742-4658.2007.05878.x.
1.1.
2007
Lopp, A.; Reintamm, T.; Vallmann, K.; Päri, M.; Mikli, V.; Richelle-Maurer, E.; Kelve, M. (2007). Moelcular identification, characterization and distribution of freshwater sponges (Porifera: Spongillidae) in Estonia. Fundamental and Applied Limnology / Archiv für Hydrobiologie, 168 (1), 93−103. DOI: 10.1127/1863-9135/2007/0168-0093.
1.3.
2007
Kuusksalu, Anne; Metsis, Madis; Reintamm, Tõnu; Kelve, Merike (2007). Construction and characterization of a cDNA library from the marine sponge Chondrosia reniformis. In: Custodio, M.R.; Lobo-Hajdu, G.; Hajdu, E.; Muricy, G (_EditorsAbbr). Porifera Research - Biodiversity, Innovation and Sustainability (405−412).. Rio de Janeiro: Museu Nacional. (Serie Livros).
5.1.
2007
Saby, E., Reintamm, T., Kelve, M. (2007). Purification of the 2',5'-oligoadenylate synthetase from the marine sponges < EM >Geodia cydonium< /EM > and < EM >Chondrosia reniformis. Journal of Interferon & Cytokine Research, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
5.1.
2007
Lopp, A.; Päri, M.; Kuusksalu, A.; Reintamm, T.; Justesen, J.; Kelve, M. (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge< EM > Geodia cydonium< /EM >. Journal of Interferon & Cytokine Reseach, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
5.2.
2007
Reintamm, T., Lopp, A., Kelve, M. (2007). < P >1-methyladenine - the major adenylate derived seondary metabolite of the marine sponge < EM >Geodia cydonium< /EM >. 5th European Conference on Marine Natural Products. Abstracts: 5th European Conference on Marine Natural Products. Sept. 16-21, 2007, Ischia, Naples, Italy. Napoli, Italy: Edizioni Ziino, Italy, 183.
1.3.
2006
Roovere, T.; Lopp, A.; Reintamm, T.; Kuusksalu, A.; Richelle-Maurer, E.; Kelve, M. (2006). Freshwater sponges in Estonia: genetic and morphological identification. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 55, 216−227.
5.2.
2006
Kuusksalu, A., reintamm, T., Metsis, M., Kelve, M. (2006). Construction and screening of cDNA library from a marine sponge Chondrosia reniformis. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brazil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 157. (Serie Livros; 16).
5.2.
2006
Lopp, A., Reintamm, T., Vallmann, K., Päri, M., Mikli, V., Richelle-Maurer, E., Kelve, M. (2006). Freshwater sponges in Estonia: Distribution, morphological and genetic identification. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brasil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 224. (Serie Livros; 16).
5.2.
2006
Reintamm, Tõnu; Kelve, Merike (2006). Partial purification and preliminary characterization of ATP N-glycosidase from a marine sponge Axinella polypoides. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts.: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability, Buzios/Rio de janeiro, Brasil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 164. (Serie Livros; 16).
3.4.
2004
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Rosa, S.; Kelve, M. (2004). Non-traditional enzymatic pathway of ATP utilization by the marine sponge Tedania sp. Proceedings of the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004: the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004. Sorrento, Italy, 65−65.
5.2.
2004
Kelve, M.; Lopp, A.; Reintamm, T.; Kuusksalu, A. (2004). Freshwater sponge cell cultures as model systems for biochemical pathways present in marine sponges. Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004. EAS (European Aquaculture Society) Special Publication, 34: Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004..
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Subbi, J.; Kelve, M. (2003). Qualitative and quantitative aspects of 2-5A synthesizing capacity of different marine sponges. Biomolecular Engineering, 20, 389−399.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Pehk, T.; Kelve, M. (2003). ATP N-glycosidase – a novel ATP converting activity from marine sponge Axinella polypoides. European Journal of Biochemistry, 270, 4122−4132.
1.1.
2003
Kelve, M.; Kuusksalu, A.; Lopp, A.; Reintamm, T. (2003). Sponge (2',5')oligoadenylate synthetase activity in the whole sponge organism and in a primary cell culture. Journal of Biotechnology, 100, 177−180.
3.1.
2003
Aaspõllu, A.; Kelve, M. (2003). The first criminal case in Estonia with dog's DNA data admitted as evidence. Progress in Forensic Genetics (847−851).. Elsevier. (International Congress Series; vol 1239).
1.1.
2002
Grebenjuk, V.A.; Kuusksalu, A.; Kelve, M.; Schütze, J.; Schröder, H.C.; Müller, W.E. (2002). Induction of (2'-5')oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide. European Journal of Biochemistry, 269, 1382−1392.
1.1.
2002
Lopp, A.; Kuusksalu, A.; Reintamm, T.; Müller, W.E.; Kelve, M. (2002). 2',5'-oligoadenylate synthetase from a lower invertebrate, the marine sponge Geodia cydonium, does not need dsRNA for its enzymatic activity. Biochimica et Biophysica Acta, 1590, 140−149.
5.2.
2002
Roovere, Tiiu; Aaspõllu, Anu; Kelve, Merike (2002). Y kromosoomi STR lookuste alleelide jaotus Eesti populatsiooni näitel. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 119−120.
5.2.
2002
Masing, Esther; Aaspõllu, Anu; Kelve, Merike (2002). Mikrosatelliitsete markerite analüüs ja geneetiline mitmekesisus Soome pruunkaru näitel. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 83−84.
5.2.
2002
Lagemaa, Kadri; Aaspõllu, Anu; Kelve, Merike (2002). Lühikese DNA kordusjärjestuste analüüs eestlaste populatsioonis PowerPlexTM 16 abil. XXVIII Eesti keemiapäevad : teaduskonverentsi ettekannete teesid = 28th Estonian Chemistry Days : abstracts of scientific conference. Tallinn: Tallinna Tehnikaülikooli Kirjastus, 74−75.
1.1.
2001
Sak, K.; Samuel, K.; Kelve, M.; Webb, TE. (2001). Pharmacological characterisation of pyrimidinoceptor responses in NG108-15 cells. European Journal of Pharmacology, 415, 127−133.
3.2.
2001
"Aaspõllu, Anu;Sumeri, Ingrid;Kelve, Merike" (2001). The allelic distribution of the Y cromosomal STR loci in an Estonian population sample. Problems of Forensic Science (103−109).. Krakow: Institute of Forensic Research Publishers.
1.1.
2000
Lopp, A.; Kuusksalu, A.; Samuel, K.; Kelve, M. (2000). Expression and activity of 2-5A synthetase in the course of differentiation and apoptosis of PC12 cells. Cytokine, 12, 737−741.
1.1.
2000
Sak, K.; Uri, A.; Enkvist, E.; Raidaru, G.; Subbi, J.; Kelve, M.; Jarv, J. (2000). Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors. Biochemical and Biophysical Research Communications, 272 (2), 327−331.
3.1.
2000
"Aaspõllu, Anu;Sumeri, Ingrid;Kelve, Merike" (2000). Allele distribution at nine STR loci - D3S1358, vWA, FGA, TH01, TPOX, CSF1PO, D5S818, D13S317 and D7S820 - in an Estonian population sample. Progress in forensic genetics, 129−131.
1.1.
1999
Kalinichenko, E.N.; Podkopaeva, T.L.; Kelve, Merike; Saarma, Mart; Mikhailopulo, I.A. (1999). 3 '-deoxy-3 '-fluoro analogues of 2-5A core trimers: Their effect on the lytic activity of human NK lymphocytes. Bioorganicheskaya Khimiya, 25 (4), 282−289.
1.1.
1999
Wiens, M.; Kuusksalu, A.; Kelve, M.; Müller, W.E.G. (1999). Origin of the interferon-inducible (2'-5')oligoadenylate synthetase in vertebrates : cloning of the (2'-5') oligoadenylate synthetase from the marine sponge Geodia cydonium. FEBS Letters, 462, 12−18.
1.1.
1999
Kalinichenko, EN.; Podkopaeva, TL.; Mikhailopulo, IA.; Kelve, M.; Saarma, M.; van den Boogaart, J.; Altona, C. (1999). The stereochemical aspect of the interaction of 3 '-fluoro-3 '-deoxy analogues of the (2 '-5 ')oligoadenylic acid trimer with (2 '-5 ')A(3) antibodies. Bioorganicheskaya Khimiya, 25 (10), 763−767.
1.2.
1999
Sak, K.; Webb, T.; Samuel, K.; Kelve, M.; Järv, J. (1999). Only Pyrimidinoceptors are Functionally Expressed in Mouse Neuroblastoma Cell Cines. Molecular Cell Biology Research Communications, 1 (3), 203−208.
1.3.
1999
Lopp, Annika; Kuusksalu, Anne; Samuel, Külli; Kelve, Merike (1999). 2-5A synthetase induction during PC12 cell death induced by serum starvation. Proceedings of the Estonian Academy of Sciences. Chemistry, 48, 109−118.
1.1.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Müller, W.E.G.; Kelve, Merike (1998). Identification of the reaction products of (2`-5`)-oligoadenylate synthetase in marine sponge. European Journal of Biochemistry, 257 (2), 420−426.
1.1.
1998
Sak, K.; Kelve, M.; Uri, A.; Jarv, J. (1998). Pyrimidinoceptor potentiation by ATP in NG108-15 cells. FEBS Letters, 439, 107−109.
5.1.
1998
Lopp, A.; Samuel, K.; Kelve, Merike (1998). Expression and activity of 2-5A synthetase in course of differentiation and apoptosis of PC12 cells. European cytokine network, 447−447.
1.1.
1997
Schröder, H.C.; Wiens, M.; Kuusksalu, A.; Kelve, M.; Mueller, W.E.G (1997). Modulation of 2´-5' oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. Environmental Toxicology and Chemistry, 16 (7), 1403−1409.
1.1.
1997
Kiss, C.; Li, J.; Szeles, A.; Gizatullin, R.Z.; Kashuba, V.I.; Lushnikova, T.; Protopopov, A.I.; Kelve, M.; Kiss, H.; Kholodnyuk, I.D.; Imreh, S.; Klein, G.; Zabarovsky, E.R. (1997). Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids. Cytogenet Cell Genet.1997;79(3-4):228-30. Cytogenetics and Cell Genetics, 79, 228−230.
1.1.
1997
Kujala, P.; Rikkonen, M.; Ahola, T.; Kelve, M.; Saarma, M.; Kaariainen, L (1997). Monoclonal antibodies specific for Semliki Forest virus replicase protein nsp2. Journal of General Virology, 78, 343−351.
1.1.
1997
Mikhailopulo, IA.; Kalinichenko, EN.; Podkopaeva, TL.; Kelve, M.; Saarma, M.; Lidaks, MY.; Rosemeyer, H.; Seela, F (1997). A 2'->5'-adenylate trimer with a positively charged 2'(3')-terminal 8-(4-aminobutyl)aminoadenosine residue: Synthesis, conformation and rnase L binding. Nucleosides & Nucleotides, 16, 1855−1873.
1.1.
1996
Truve, E.; Nigul, L.; Teeri, T. H.; Kelve, M. (1996). The effects of 2-5A on protein synthesis in wheat germ extracts and tobacco protoplasts. Nucleosides & Nucleotides, 15, 1097−1111.
1.2.
1996
Müller, W.E.; Pergande, G.; Ushijima, H.; Schleger, C.; Kelve, M.; Perovic, S. (1996). Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention. Prog Mol Subcell Biol. 1996;16:44-57. Progress in Molecular and Subcellular Biology, 16, 44-57.
1.1.
1995
Kuusksalu, A.; Pihlak, A.; Müller, W.E.; Kelve, M. (1995). The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges. Demonstration of the existence and identification of its reaction products. European Journal of Biochemistry, 232, 351−357.
1.1.
1995
Perovic, S.; Pergande, G.; Ushijima, H.; Kelve, M.; Forrest, J.; Müller, W.E. (1995). Flupirtine partially prevents neuronal injury induced by prion protein fragment and lead acetate. Neurodegeneration, 4, 369−374.
1.1.
1995
Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Müller, W. E. G. (1995). Impairment of intracellular antiviral defence with age: age-dependent changes in expression of interferon-induced and double-stranded RNA-activated 2-5A synthetase in rat. Mechanisms of Ageing and Development, 78, 103−115.
1.1.
1995
Kalinichenko, En.; Podkopaeva, Tl.; Poopeiko, Ne.; Kelve, M.; Saarma, M.; Mikhailopulo, Ia.; Vandenboogaart, Je.; Altona, C (1995). Role of the stereochemistry of 3'-fluoro-3'-deoxy analogs of 2-5a in binding to and activation of mouse rnase l. Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands Chemical Society, 114 (2), 43−50.
1.1.
1994
Schröder, H.C.; Kelve, M.; Schäcke, H.; Pfleiderer, W.; Charubala, R.; Suhadolnik, R.J.; Müller, W.E. (1994). Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells. Chemico-Biological Interactions, 90, 169−183.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Schröder, H. C.; Müller, W. E. G. (1994). Homologies between different forms of 2-5A synthetase. Progress in Molecular and Subcellular Biology, 14, 139−149.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Kuusksalu, A.; Seppänen, P.; Saarma, M. (1994). Principles and background for the construction of transgenic plants displaying multiple virus resistance. Archives of Virology, S9, 41−50.
1.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G.; Schröder, H. C. (1994). Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis. Cellular and Molecular Biology, 40, 165−173.
3.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G. (1994). Reduction of 2’-5’-oligoadenylate synthetase mRNA level in rat pheochromocytoma PC12 cells during apoptosis. Müller, W. E. G.. Use of Aquatic Invertebrates as Tools for Monitoring of Environmental Hazards (97−108).. Gustav Fischer Verlag.
1.1.
1993
Schröder, H.C.; Kelve, M.; Pfeifer, K.; Flögel-Mrsic, M.; Müller, W.E. (1993). Age-dependent changes in "intracellular immunity" to virus infections. Zeitsschrift für Gerontologie, 26, 232−237.
1.1.
1993
Truve, E.; Aaspõllu, A.; Honkanen, J.; Puska, R.; Mehto, M.; Hassi, A.; Teeri, T. H.; Kelve, M.; Seppänen, P.; Saarma, M. (1993). Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under the field conditions. Bio-Technology, 11, 1048−1052.
1.1.
1990
Kalinichenko, E.N.; Podkopaeva, T.L.; Kelve, M.; Saarma, M.; Mikhailopulo, I.A. (1990). 3'-Fluoro-3'-deoxy analogs of 2-5A 5'-monophosphate: binding to 2-5A-dependent endoribonuclease and susceptibility to (2'-5')phosphodiesterase degradation. Biochemical and Biophysical Research Communications, 167, 20−26.
1.1.
1987
Kelve, M.; Aruja, A.; Kooli, K.; Männik, J.; Raukas, E. (1987). Cooperative thermal denaturation of the assembly origin region of TMV RNA. Journal of Biomolecular Structure and Dynamics, 5, 105−117.
1.1.
1978
Kelve, MB.; Saarma, MY.; Metspalu, AK.; Lind, AY.; Villems, RL. (1978). Conformational isomers of 5s RNA of rat-liver ribosomes. Molecular Biology, 12 (3), 528−531.

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF5932Adenosiiniderivaatide ebatraditsioonilised signaalrajad alamates loomades01.01.200431.12.2007Merike KelveKeemilise ja Bioloogilise Füüsika Instituut51 970,40 EUR
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MUUV306KÄSNAD. Käsnade jätkusuutlik tootmine, füsioloogia, okeanograafia, looduslikud produktid, geneetika ja majandus.01.12.200530.11.2007Merike KelveTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool95 257,12 EUR
HLKHLK04-4Loodusteaduslikud kogud rakubioloogilistes ja –toksikoloogilistes uuringutes01.01.200431.12.2008Anne KahruKeemilise ja Bioloogilise Füüsika Instituut63 763,07 EUR
SFSF0140108s08Nukleotiidide metabolismis osalevad ensüümid - võrdlev biokeemia, molekulaarbioloogia ja evolutsioonilised aspektid 01.01.200831.12.2013Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond302 690,08 EUR
ETFETF7421Nukleotiidide metabolismis osalevate ensüümide genoomse struktuuri ja aktiivsuse iseloomustamine madalaimates hulkraksetes loomades - käsnades 01.01.200831.12.2011Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond86 296,05 EUR
APSF0140108s08APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0140108s08 raames01.01.201031.12.2011Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond36 429,64 EUR