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Olen nõus

Denis Kaynov

https://etis.ee/CV/Denis_Kaynov/est
10.02.1979
denis.kaynov@ut.ee
01.01.2000−01.01.2009 Kainov, Denis

Teenistuskäik

Töökohad ja ametid
01.11.2017–31.12.2020   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia vanemteadur (0,75)
2010–2016   
Institute for Molecular Medicine Finland, FIMM, Vanemteadur (100,00)
2007–2009   
Luxembourg Institute of Health, Järeldoktor (100,00)
2005–2007   
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Järeldoktor (100,00)
2001–2005   
Institute of Biotechnology, Finland, Teadur (100,00)
2000–2001   
Moscow State University branch in Puschino, Tehniline töötaja (100,00)
 
 
Haridustee
01.01.2001–31.12.2005   
PhD in Genetics
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2010−...   
Grant evaluator for Medical Research Council, UK; Medical Research Council, Israel, The Netherlands Organization for Health Research and Development as well as for several Finnish foundations; invited speaker and chair at number of international meetings; ad hoc examiner for PhD students in Singapore and Finland; reviewing Editor at Frontiers in Cell and Dev. Biol., Guest Editor in Frontiers in Biosciences, Active reviewer for Mol. Microbiol., Emerging Microbes & Infections, NAR, Viruses, Virulence, TiPS, PloS One
2010−...   
Grants: 2019-2023 RCN, Globvac (subcontractor), TBA NOK • 2017-2021 European Regional Development Fund, Mobilitas Pluss grant, 903,000 euros • 2015-2017 University of Helsinki three year research grant, 150,000 euros • 2010-2015 J&A Erkko Foundation, 1,000,000 euros • 2013-2015 Research Council of Lithuania, 298,000 euros • 2012-2014 Academy of Finland/SHOK, 136,208 euros
 
 
Loometöö
Examples of our press releases:
2018: Exploring new uses for existing anti-viral drugs (https://geminiresearchnews.com/2018/04/exploring-new-uses-existing-antiviral-drugs/).
2016: A new model system to study the effect of antiviral drugs and drug candidates on innate immunity (www.fimm.fi/en/news/1452517963)
2015: A new approach to predict evolution of influenza viruses can enhance vaccine efficacy (www.fimm.fi/en/press-release/1449504710)
2012: Harnessing anticancer drugs for the future fight against influenza (www.sciencedaily.com/releases/2012/09/120905083903.htm).

Kvalifikatsioon

Teaduskraadid
Denis Kaynov, doktorikraad, 2005, (juh) Roman Tuma, Packaging motors of Cystoviruses, Helsingi Ülikool.
 
 
Teaduspreemiad ja tunnustused
2006, Denis Kaynov, Young investigator award IUBMB
2005, Denis Kaynov, EMBO LTF
2005, Denis Kaynov, Best PhD thesis award
2004, Denis Kaynov, FEBS STF
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.2. Mikrobioloogia; CERCS KLASSIFIKAATOR: B230 Mikrobioloogia, bakterioloogia, viroloogia, mükoloogia
 
 
Lisainfo
Docentship in infection biology from UH (2011)
Translator in professional communications (with honour)

Jooksvad projektid

Juhendatud väitekirjad

Juhendatud järeldoktorid

  • 01.01.2013−31.12.2016 Laura Kakkola "Microbiology" University of Helsinki
  • 01.01.2014−31.12.2015 Johanna Lampe "Microbiology" University of Helsinki

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Ianevski, A.; Andersen, P.I.; Merits, A.; Bjørås, M.; Kainov, D. (2019). Expanding the activity spectrum of antiviral agents. Drug Discovery Today, 24 (5), 1224−1228. DOI: 10.1016/j.drudis.2019.04.006.
1.1.
2019
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca J; Tenson, Tanel; Merits, Andres ... Kainov, Denis E (2019). Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses, 11 (3), 11(3). DOI: 10.3390/v11030207.
1.1.
2018
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Marten; Lysvand, Hilde; Teppor, Mona; Kakkola, Laura; Paavilainen, Henrik; Laajala, Mira; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Bjoras, Magnar; Nordbo, Svein Arne; Dumpis, Uga ... Kainov, Denis (2018). Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research, 154, 174−182. DOI: 10.1016/j.antiviral.2018.04.016.
1.1.
2018
Zusinaite, E.; Ianevski, A.; Niukkanen, D.; Poranen, M.M.; Bjørås, M.; Afset, J.E.; Tenson, T.; Velagapudi, V.; Merits, A.; Kainov, D.E. (2018). A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses, 10 (8). DOI: 10.3390/v10080423.
1.1.
2018
Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis E; Anthonsen, Marit W (2018). Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity. Genome Announcements, 6 (21), 18.10.1128/genomeA.00440-18.
1.1.
2017
Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis E (2017). Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis. Viruses, 9 (8), E223−E223. DOI: 10.3390/v9080223.
1.1.
2017
Kuivanen, Suvi; Bespalov, Maxim M; Nandania, Jatin; Ianevski, Aleksandr; Velagapudi, Vidya; De Brabander, Jef K; Kainov, Denis E; Vapalahti, Olli (2017). Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism. Antiviral Research, 139, 117−128.10.1016/j.antiviral.2016.12.022.
1.1.
2017
Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert; Lorey, Martina B; Tynell, Janne; Vande Ginste, Liesbeth; Le Goffic, Ronan; Miller, Matthew S; Kuisma, Marika; Marjomäki, Varpu; De Brabander, Jef; Matikainen, Sampsa; Nyman, Tuula A; Bamford, Dennis H; Saelens, Xavier; Julkunen, Ilkka; Paavilainen, Henrik ... Kainov, Denis E (2017). Regulation of kynurenine biosynthesis during influenza virus infection. FEBS Journal, 284 (2), 222−236. DOI: 10.1111/febs.13966.
1.1.
2017
Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M; Kuisma, Marika S; Honkimaa, Anni; Walton, Emma L; Oksenych, Valentyn; Lorey, Martina B; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee ... Kainov, Denis E (2017). Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins. Viruses, 9 (10), 10. DOI: 10.3390/v9100271.
1.1.
2016
Fu, Yu; Gaelings, Lana; Söderholm, Sandra; Belanov, Sergei; Nandania, Jatin; Nyman, Tuula A; Matikainen, Sampsa; Anders, Simon; Velagapudi, Vidya; Kainov, Denis E (2016). JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Research, 133, 23−31. DOI: 10.1016/j.antiviral.2016.07.008.
1.1.
2016
Fu, Yu; Gaelings, Lana; Jalovaara, Petri; Kakkola, Laura; Kinnunen, Mervi T; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Kainov, Denis E (2016). Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study. Cytokine, 86, 10−14. DOI: 10.1016/j.cyto.2016.07.003.
1.1.
2016
Söderholm, Sandra; Anastasina, Maria; Islam, Mohammad Majharul; Tynell, Janne; Poranen, Minna M; Bamford, Dennis H; Stenman, Jakob; Julkunen, Ilkka; Šaulienė, Ingrida; De Brabander, Jef K; Matikainen, Sampsa; Nyman, Tuula A; Saelens, Xavier; Kainov, Denis (2016). Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine. Antiviral Research, 126, 69−80. DOI: 10.1016/j.antiviral.2015.12.011.
1.1.
2016
Zinkevičienė, Auksė; Kainov, Denis; Girkontaitė, Irutė; Lastauskienė, Eglė; Kvedarienė, Violeta; Fu, Yu; Anders, Simon; Velagapudi, Vidya (2016). Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study. International Archives of Allergy and Immunology, 170 (4), 262−268.10.1159/000450789.
1.1.
2016
Söderholm, Sandra; Fu, Yu; Gaelings, Lana; Belanov, Sergey; Yetukuri, Laxman; Berlinkov, Mikhail; Cheltsov, Anton V; Anders, Simon; Aittokallio, Tero; Nyman, Tuula A; Matikainen, Sampsa; Kainov, Denis E (2016). Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction. Viruses, 8 (10), 10.10.3390/v8100269.
1.1.
2016
Söderholm, Sandra; Kainov, Denis E; Öhman, Tiina; Denisova, Oxana V; Schepens, Bert; Kulesskiy, Evgeny; Imanishi, Susumu Y; Corthals, Garry; Hintsanen, Petteri; Aittokallio, Tero; Saelens, Xavier; Matikainen, Sampsa; Nyman, Tuula A (2016). Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics, 15 (10), 3203−3219.10.1074/mcp.M116.057984.
1.1.
2016
Balistreri, Giuseppe; Viiliäinen, Johanna; Turunen, Mikko; Diaz, Raquel; Lyly, Lauri; Pekkonen, Pirita; Rantala, Juha; Ojala, Krista; Sarek, Grzegorz; Teesalu, Mari; Denisova, Oxana; Peltonen, Karita; Julkunen, Ilkka; Varjosalo, Markku; Kainov, Denis; Kallioniemi, Olli; Laiho, Marikki; Taipale, Jussi; Hautaniemi, Sampsa; Ojala, Päivi M (2016). Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. PLoS Pathogens, 12 (2), e1005424.10.1371/journal.ppat.1005424.
1.1.
2016
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttänen, Suvi; Barboric, Matjaz; Nyman, Tuula A; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J; Egly, Jean-Marc; Kainov, Denis E (2016). Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta, 1859 (11), 1440−1448. DOI: 10.1016/j.bbagrm.2016.09.005.
1.1.
2016
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E. (2016). Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1859 (11), 1440−1448. DOI: 10.1016/j.bbagrm.2016.09.005.
1.1.
2015
Zinkevičienė, Auksė; Kainov, Denis; Lastauskienė, Eglė; Kvedarienė, Violeta; Bychkov, Dmitrii; Byrne, Myles; Girkontaitė, Irutė (2015). Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study. International Archives of Allergy and Immunology, 168 (3), 161−164.10.1159/000442749.
1.1.
2015
Belanov, Sergei S; Bychkov, Dmitrii; Benner, Christian; Ripatti, Samuli; Ojala, Teija; Kankainen, Matti; Kai Lee, Hong; Wei-Tze Tang, Julian; Kainov, Denis E (2015). Genome-Wide Analysis of Evolutionary Markers of Human Influenza A(H1N1)pdm09 and A(H3N2) Viruses May Guide Selection of Vaccine Strain Candidates. Genome Biology and Evolution, 7 (12), 3472−3483.10.1093/gbe/evv240.
1.1.
2015
Šaulienė, Ingrida; Greičiuvienė, Jūratė; Šukienė, Laura; Juškevičiūtė, Neringa; Benner, Christian; Zinkevičienė, Auksė; Ripatti, Samuli; Donner, Kati; Kainov, Denis (2015). Genetic Loci Associated with Allergic Sensitization in Lithuanians. PLoS ONE, 10 (7), e0134188−e0134188. DOI: 10.1371/journal.pone.0134188.
1.1.
2015
Jalovaara, Petri; Mishel, Polina; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Ikonen, Niina; Julkunen, Ilkka; Kakkola, Laura; Kutsaya, Anna; Vuorinen, Tytti; Mattila, Pirkko; Almusa, Henrikki; Kainov, Denis (2015). Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland. Genome Announcements, 3 (2), e01523-14.10.1128/genomeA.01523-14.
1.1.
2015
Anastasina, Maria; Schepens, Bert; Söderholm, Sandra; Nyman, Tuula A; Matikainen, Sampsa; Saksela, Kalle; Saelens, Xavier; Kainov, Denis E (2015). The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice. Journal of General Virology, 96 (8), 2086−2091. DOI: 10.1099/vir.0.000171.
1.2.
2015
Mishel, P.; Ojalab, T.; Bennera, C.; Lakspere, T.; Bychkov, D.; Jalovaara, P.; Kakkola, L.; Kallio-Kokko, H.; Kantelee, A.; Kankainen, M.; Ikonen, N.; Ripattia, S.; Julkunen, I.; Kainov, DE. (2015). Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014. Genome Announcements, 3 (4), 1.10.1128/genomeA.00676-15.
1.1.
2014
Denisova, Oxana V; Söderholm, Sandra; Virtanen, Salla; Von Schantz, Carina; Bychkov, Dmitrii; Vashchinkina, Elena; Desloovere, Jens; Tynell, Janne; Ikonen, Niina; Theisen, Linda L; Nyman, Tuula A; Matikainen, Sampsa; Kallioniemi, Olli; Julkunen, Ilkka; Muller, Claude P; Saelens, Xavier; Verkhusha, Vladislav V; Kainov, Denis E (2014). Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrobial Agents and Chemotherapy, 58 (7), 3689−3696. DOI: 10.1128/AAC.02798-13.
1.1.
2014
Mishel, Polina; Bychkov, Dmitrii; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Jalovaara, Petri; Kainov, Denis (2014). Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells. Genome Announcements, 2 (6), e01349-14.10.1128/genomeA.01349-14.
1.1.
2014
Jalovaara, Petri; Bychkov, Dmitrii; Ahtiainen, Laura; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Kallioniemi, Olli; Kainov, Denis (2014). Genetic Instability of Influenza pH1N1 Viruses. Genome Announcements, 2 (5), e00841-14.10.1128/genomeA.00841-14.
1.1.
2014
Lakspere, Triin; Kallio-Kokko, Hannimari; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Kainov, Denis; Kakkola, Laura (2014). Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season. Genome Announcements, 27 (2), e00039-14. DOI: 10.1128/genomeA.00039-14.
1.1.
2014
Anastasina, Maria; Terenin, Ilya; Butcher, Sarah J; Kainov, Denis E (2014). A technique to increase protein yield in a rabbit reticulocyte lysate translation system. BioTechniques, 56 (1), 36−39. DOI: 10.2144/000114125.
1.1.
2014
Lakspere, Triin; Tynell, Janne; Kaloinen, Minttu; Vanlede, Maarten; Parsons, Alun; Ikonen, Niina; Kallio-Kokko, Hannimari; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Julkunen, Ilkka; Kainov, Denis; Kakkola, Laura (2014). Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013. Genome Announcements, 2 (1), e01004-13. DOI: 10.1128/genomeA.01004-13.
1.1.
2014
Anastasina, Maria; Terenin, Ilya; Butcher, Sarah J.; Kainov, Denis E. (2014). A technique to increase protein yield in a rabbit reticulocyte lysate translation system. BioTechniques, 56 (1), 36−39. DOI: 10.2144/000114125.
1.1.
2013
Kakkola, L.; Denisova, O. V.; Tynell, J.; Viiliainen, J.; Ysenbaert, T.; Matos, R. C.; Nagaraj, A.; Ohman, T.; Kuivanen, S.; Paavilainen, H.; Feng, L.; Yadav, B.; Julkunen, I.; Vapalahti, O.; Hukkanen, V.; Stenman, J.; Aittokallio, T.; Verschuren, E. W.; Ojala, P. M.; Nyman, T. ... Kainov, D. E. (2013). Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice. Cell Death and Disease, 4, ARTN e742.10.1038/cddis.2013.267.
1.1.
2013
Bimbo, Luis M.; Denisova, Oxana V.; Makila, Ermei; Kaasalainen, Martti; De Brabander, Jef K.; Hirvonen, Jouni; Salonen, Jarno; Kakkola, Laura; Kainov, Denis; Santos, Helder A. (2013). Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles. ACS Nano, 7 (8), 6884−6893.10.1021/nn402062f.
1.1.
2013
El Omari, Kamel; Meier, Christoph; Kainov, Denis; Sutton, Geoff; Grimes, Jonathan M; Poranen, Minna M; Bamford, Dennis H; Tuma, Roman; Stuart, David I; Mancini, Erika J (2013). Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution. Nucleic Acids Research, 41 (20), 9396−9410.10.1093/nar/gkt713.
1.1.
2013
Smura, Teemu; Kakkola, Laura; Blomqvist, Soile; Klemola, Päivi; Parsons, Alun; Kallio-Kokko, Hannimari; Savolainen-Kopra, Carita; Kainov, Denis E; Roivainen, Merja (2013). Molecular evolution and epidemiology of echovirus 6 in Finland. Infection Genetics and Evolution, 16, 234−247.10.1016/j.meegid.2013.02.011.
1.1.
2012
Denisova, Oxana V; Kakkola, Laura; Feng, Lin; Stenman, Jakob; Nagaraj, Ashwini; Lampe, Johanna; Yadav, Bhagwan; Aittokallio, Tero; Kaukinen, Pasi; Ahola, Tero; Kuivanen, Suvi; Vapalahti, Olli; Kantele, Anu; Tynell, Janne; Julkunen, Ilkka; Kallio-Kokko, Hannimari; Paavilainen, Henrik; Hukkanen, Veijo; Elliott, Richard M; De Brabander, Jef K ... Kainov, Denis E (2012). Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. Journal of Biological Chemistry, 287 (42), 35324−35332. DOI: 10.1074/jbc.M112.392142.
1.1.
2012
Müller, Konstantin H; Kakkola, Laura; Nagaraj, Ashwini S; Cheltsov, Anton V; Anastasina, Maria; Kainov, Denis E (2012). Emerging cellular targets for influenza antiviral agents. Trends in Pharmacological Sciences, 33 (2), 89−99.10.1016/j.tips.2011.10.004.
1.1.
2012
Feng, Lin; Lintula, Susanna; Ho, Tho Huu; Anastasina, Maria; Paju, Annukka; Haglund, Caj; Stenman, Ulf-Hakan; Hotakainen, Kristina; Orpana, Arto; Kainov, Denis; Stenman, Jakob (2012). Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription. BioTechniques, 52 (4), 263−270.10.2144/0000113842.
1.1.
2011
Kainov, Denis E; Müller, Konstantin H; Theisen, Linda L; Anastasina, Maria; Kaloinen, Minttu; Muller, Claude P (2011). Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation. Journal of Biological Chemistry, 286 (9), 7239−7247. DOI: 10.1074/jbc.M110.203489.
1.1.
2011
Müller, Konstantin H; Kainov, Denis E; El Bakkouri, Karim; Saelens, Xavier; De Brabander, Jef K; Kittel, Christian; Samm, Elisabeth; Muller, Claude P (2011). The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections. British Journal of Pharmacology, 164 (2), 344−357.10.1111/j.1476-5381.2011.01346.x.
1.1.
2010
Kainov, Denis E; Cura, Vincent; Vitorino, Marc; Nierengarten, Helène; Poussin, Pierre; Kieffer, Bruno; Cavarelli, Jean; Poterszman, Arnaud (2010). Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study. Acta Crystallographica Section D Biological Crystallography, 66 (Pt 7), 745−755.10.1107/S0907444910009844.
1.1.
2010
Kainov, Denis E; Selth, Luke A; Svejstrup, Jesper Q; Egly, Jean-Marc; Poterzsman, Arnaud (2010). Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair, 9 (1), 33−39. DOI: 10.1016/j.dnarep.2009.10.002.
1.1.
2008
Kainov, Denis E; Vitorino, Marc; Cavarelli, Jean; Poterszman, Arnaud; Egly, Jean-Marc (2008). Structural basis for group A trichothiodystrophy. Nature Structural & Molecular Biology, 15 (9), 980−984. DOI: 10.1038/nsmb.1478.
1.1.
2008
Kainov, Denis E; Mancini, Erika J; Telenius, Jelena; Lísal, Jirí; Grimes, Jonathan M; Bamford, Dennis H; Stuart, David I; Tuma, Roman (2008). Structural basis of mechanochemical coupling in a hexameric molecular motor. Journal of Biological Chemistry, 283 (6), 3607−3617. DOI: 10.1074/jbc.M706366200.
1.1.
2007
Astier, Yann; Kainov, Denis E; Bayley, Hagan; Tuma, Roman; Howorka, Stefan (2007). Stochastic detection of motor protein-RNA complexes by single-channel current recording. ChemPhysChem, 8 (15), 2189−2194. DOI: 10.1002/cphc.200700179.
1.1.
2006
Kainov, D E; Tuma, R; Mancini, E J (2006). Hexameric molecular motors: P4 packaging ATPase unravels the mechanism. Cellular and Molecular Life Sciences, 63 (10), 1095−1105.
1.1.
2006
Lísal, Jirí; Kainov, Denis E; Lam, TuKiet T; Emmett, Mark R; Wei, Hui; Gottlieb, Paul; Marshall, Alan G; Tuma, Roman (2006). Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage. Virology, 351 (1), 73−79. DOI: 10.000454510.1016/j.virol.2006.03.025.
1.1.
2005
Lísal, Jirí; Lam, Tukiet T; Kainov, Denis E; Emmett, Mark R; Marshall, Alan G; Tuma, Roman (2005). Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nature Structural & Molecular Biology, 12 (5), 460−466.
1.1.
2004
Mancini, Erika J; Kainov, Denis E; Grimes, Jonathan M; Tuma, Roman; Bamford, Dennis H; Stuart, David I (2004). Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell, 118 (6), 743−755.
1.1.
2004
Kainov, Denis E; Lísal, Jirí; Bamford, Dennis H; Tuma, Roman (2004). Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription. Nucleic Acids Research, 32 (12), 3515−3521.
1.1.
2004
Lísal, Jíri; Kainov, Denis E; Bamford, Dennis H; Thomas, George J; Tuma, Roman (2004). Enzymatic mechanism of RNA translocation in double-stranded RNA bacteriophages. Journal of Biological Chemistry, 279 (2), 1343−1350.
1.1.
2003
Zheleznaya, L A; Kainov, D E; Yunusova, A K; Matvienko, N I (2003). Regulatory C protein of the EcoRV modification-restriction system. Biokhimiya (Moscow), 68 (1), 105−110.
1.1.
2003
Kainov, Denis E; Pirttimaa, Markus; Tuma, Roman; Butcher, Sarah J; Thomas, George J; Bamford, Dennis H; Makeyev, Eugene V (2003). RNA packaging device of double-stranded RNA bacteriophages, possibly as simple as hexamer of P4 protein. Journal of Biological Chemistry, 278 (48), 48084−48091.
1.1.
2003
Kainov, Denis E; Butcher, Sarah J; Bamford, Dennis H; Tuma, Roman (2003). Conserved intermediates on the assembly pathway of double-stranded RNA bacteriophages. Journal of Molecular Biology, 328 (4), 791−804.
25.05.2020

Denis Kaynov

https://etis.ee/CV/Denis_Kaynov/eng
10.02.1979
denis.kaynov@ut.ee
01.01.2000−01.01.2009 Kainov, Denis
Denis Kainov received his PhD in Genetics from the University of Helsinki in 2005. He performed his postdoctoral training in IGBMC, France and in CRP-Sante, Luxembourg during 2005-2009. He then returned to Finland, and worked as FIMM-EMBL group leader during 2010-2016.​ He is now working as senior reearcher at TUIT. His group develops novel modalities against viral diseases.

Career

Institutions and positions
01.11.2017–31.12.2020   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Senior Research Fellow in Virology (0,75)
2010–2016   
Institute for Molecular Medicine Finland, FIMM, Senior Researcher (100,00)
2007–2009   
Luxembourg Institute of Health, Post-Doc (100,00)
2005–2007   
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Post-Doc (100,00)
2001–2005   
Institute of Biotechnology, Finland, Researcher (100,00)
2000–2001   
Moscow State University branch in Puschino, Technical staff (100,00)
 
 
Education
01.01.2001–31.12.2005   
PhD in Genetics
 
 
R&D related managerial and administrative work
2010−...   
Grant evaluator for Medical Research Council, UK; Medical Research Council, Israel, The Netherlands Organization for Health Research and Development as well as for several Finnish foundations; invited speaker and chair at number of international meetings; ad hoc examiner for PhD students in Singapore and Finland; reviewing Editor at Frontiers in Cell and Dev. Biol., Guest Editor in Frontiers in Biosciences, Active reviewer for Mol. Microbiol., Emerging Microbes & Infections, NAR, Viruses, Virulence, TiPS, PloS One
2010−...   
Grants: 2019-2023 RCN, Globvac (subcontractor), TBA NOK • 2017-2021 European Regional Development Fund, Mobilitas Pluss grant, 903,000 euros • 2015-2017 University of Helsinki three year research grant, 150,000 euros • 2010-2015 J&A Erkko Foundation, 1,000,000 euros • 2013-2015 Research Council of Lithuania, 298,000 euros • 2012-2014 Academy of Finland/SHOK, 136,208 euros
 
 
Creative work
Examples of our press releases:
2018: Exploring new uses for existing anti-viral drugs (https://geminiresearchnews.com/2018/04/exploring-new-uses-existing-antiviral-drugs/).
2016: A new model system to study the effect of antiviral drugs and drug candidates on innate immunity (www.fimm.fi/en/news/1452517963)
2015: A new approach to predict evolution of influenza viruses can enhance vaccine efficacy (www.fimm.fi/en/press-release/1449504710)
2012: Harnessing anticancer drugs for the future fight against influenza (www.sciencedaily.com/releases/2012/09/120905083903.htm).

Qualifications

Academic degrees
Denis Kaynov, Doctor's Degree, 2005, (sup) Roman Tuma, Packaging motors of Cystoviruses, University of Helsinki.
 
 
Honours & awards
2006, Denis Kaynov, Young investigator award IUBMB
2005, Denis Kaynov, EMBO LTF
2005, Denis Kaynov, Best PhD thesis award
2004, Denis Kaynov, FEBS STF
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.2. Microbiology; CERCS CLASSIFICATION: B230 Microbiology, bacteriology, virology, mycology
 
 
Additional information
Docentship in infection biology from UH (2011)
Translator in professional communications (2001)

Projects in progress

Supervised dissertations

Supervision of postdoctoral researchers

  • 01.01.2013−31.12.2016    Laura Kakkola  "Microbiology" (University of Helsinki)
  • 01.01.2014−31.12.2015    Johanna Lampe  "Microbiology" (University of Helsinki)

Publications

Category
Year
Publication
 
1.1.
2019
Ianevski, A.; Andersen, P.I.; Merits, A.; Bjørås, M.; Kainov, D. (2019). Expanding the activity spectrum of antiviral agents. Drug Discovery Today, 24 (5), 1224−1228. DOI: 10.1016/j.drudis.2019.04.006.
1.1.
2019
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca J; Tenson, Tanel; Merits, Andres ... Kainov, Denis E (2019). Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses, 11 (3), 11(3). DOI: 10.3390/v11030207.
1.1.
2018
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Marten; Lysvand, Hilde; Teppor, Mona; Kakkola, Laura; Paavilainen, Henrik; Laajala, Mira; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Bjoras, Magnar; Nordbo, Svein Arne; Dumpis, Uga ... Kainov, Denis (2018). Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research, 154, 174−182. DOI: 10.1016/j.antiviral.2018.04.016.
1.1.
2018
Zusinaite, E.; Ianevski, A.; Niukkanen, D.; Poranen, M.M.; Bjørås, M.; Afset, J.E.; Tenson, T.; Velagapudi, V.; Merits, A.; Kainov, D.E. (2018). A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses, 10 (8). DOI: 10.3390/v10080423.
1.1.
2018
Loevenich, Simon; Ianevski, Aleksandr; Oitmaa, Eneli; Kainov, Denis E; Anthonsen, Marit W (2018). Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity. Genome Announcements, 6 (21), 18.10.1128/genomeA.00440-18.
1.1.
2017
Shim, Jung Min; Kim, Jinhee; Tenson, Tanel; Min, Ji-Young; Kainov, Denis E (2017). Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis. Viruses, 9 (8), E223−E223. DOI: 10.3390/v9080223.
1.1.
2017
Kuivanen, Suvi; Bespalov, Maxim M; Nandania, Jatin; Ianevski, Aleksandr; Velagapudi, Vidya; De Brabander, Jef K; Kainov, Denis E; Vapalahti, Olli (2017). Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism. Antiviral Research, 139, 117−128.10.1016/j.antiviral.2016.12.022.
1.1.
2017
Gaelings, Lana; Söderholm, Sandra; Bugai, Andrii; Fu, Yu; Nandania, Jatin; Schepens, Bert; Lorey, Martina B; Tynell, Janne; Vande Ginste, Liesbeth; Le Goffic, Ronan; Miller, Matthew S; Kuisma, Marika; Marjomäki, Varpu; De Brabander, Jef; Matikainen, Sampsa; Nyman, Tuula A; Bamford, Dennis H; Saelens, Xavier; Julkunen, Ilkka; Paavilainen, Henrik ... Kainov, Denis E (2017). Regulation of kynurenine biosynthesis during influenza virus infection. FEBS Journal, 284 (2), 222−236. DOI: 10.1111/febs.13966.
1.1.
2017
Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M; Kuisma, Marika S; Honkimaa, Anni; Walton, Emma L; Oksenych, Valentyn; Lorey, Martina B; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee ... Kainov, Denis E (2017). Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins. Viruses, 9 (10), 10. DOI: 10.3390/v9100271.
1.1.
2016
Fu, Yu; Gaelings, Lana; Söderholm, Sandra; Belanov, Sergei; Nandania, Jatin; Nyman, Tuula A; Matikainen, Sampsa; Anders, Simon; Velagapudi, Vidya; Kainov, Denis E (2016). JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Research, 133, 23−31. DOI: 10.1016/j.antiviral.2016.07.008.
1.1.
2016
Fu, Yu; Gaelings, Lana; Jalovaara, Petri; Kakkola, Laura; Kinnunen, Mervi T; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Kainov, Denis E (2016). Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study. Cytokine, 86, 10−14. DOI: 10.1016/j.cyto.2016.07.003.
1.1.
2016
Söderholm, Sandra; Anastasina, Maria; Islam, Mohammad Majharul; Tynell, Janne; Poranen, Minna M; Bamford, Dennis H; Stenman, Jakob; Julkunen, Ilkka; Šaulienė, Ingrida; De Brabander, Jef K; Matikainen, Sampsa; Nyman, Tuula A; Saelens, Xavier; Kainov, Denis (2016). Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine. Antiviral Research, 126, 69−80. DOI: 10.1016/j.antiviral.2015.12.011.
1.1.
2016
Zinkevičienė, Auksė; Kainov, Denis; Girkontaitė, Irutė; Lastauskienė, Eglė; Kvedarienė, Violeta; Fu, Yu; Anders, Simon; Velagapudi, Vidya (2016). Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study. International Archives of Allergy and Immunology, 170 (4), 262−268.10.1159/000450789.
1.1.
2016
Söderholm, Sandra; Fu, Yu; Gaelings, Lana; Belanov, Sergey; Yetukuri, Laxman; Berlinkov, Mikhail; Cheltsov, Anton V; Anders, Simon; Aittokallio, Tero; Nyman, Tuula A; Matikainen, Sampsa; Kainov, Denis E (2016). Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction. Viruses, 8 (10), 10.10.3390/v8100269.
1.1.
2016
Söderholm, Sandra; Kainov, Denis E; Öhman, Tiina; Denisova, Oxana V; Schepens, Bert; Kulesskiy, Evgeny; Imanishi, Susumu Y; Corthals, Garry; Hintsanen, Petteri; Aittokallio, Tero; Saelens, Xavier; Matikainen, Sampsa; Nyman, Tuula A (2016). Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Molecular & Cellular Proteomics, 15 (10), 3203−3219.10.1074/mcp.M116.057984.
1.1.
2016
Balistreri, Giuseppe; Viiliäinen, Johanna; Turunen, Mikko; Diaz, Raquel; Lyly, Lauri; Pekkonen, Pirita; Rantala, Juha; Ojala, Krista; Sarek, Grzegorz; Teesalu, Mari; Denisova, Oxana; Peltonen, Karita; Julkunen, Ilkka; Varjosalo, Markku; Kainov, Denis; Kallioniemi, Olli; Laiho, Marikki; Taipale, Jussi; Hautaniemi, Sampsa; Ojala, Päivi M (2016). Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. PLoS Pathogens, 12 (2), e1005424.10.1371/journal.ppat.1005424.
1.1.
2016
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Söderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttänen, Suvi; Barboric, Matjaz; Nyman, Tuula A; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J; Egly, Jean-Marc; Kainov, Denis E (2016). Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta, 1859 (11), 1440−1448. DOI: 10.1016/j.bbagrm.2016.09.005.
1.1.
2016
Anastasina, Maria; Le May, Nicolas; Bugai, Andrii; Fu, Yu; Soderholm, Sandra; Gaelings, Lana; Ohman, Tiina; Tynell, Janne; Kyttanen, Suvi; Barboric, Matjaz; Nyman, Tuula A.; Matikainen, Sampsa; Julkunen, Ilkka; Butcher, Sarah J.; Egly, Jean-Marc; Kainov, Denis E. (2016). Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1859 (11), 1440−1448. DOI: 10.1016/j.bbagrm.2016.09.005.
1.1.
2015
Zinkevičienė, Auksė; Kainov, Denis; Lastauskienė, Eglė; Kvedarienė, Violeta; Bychkov, Dmitrii; Byrne, Myles; Girkontaitė, Irutė (2015). Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study. International Archives of Allergy and Immunology, 168 (3), 161−164.10.1159/000442749.
1.1.
2015
Belanov, Sergei S; Bychkov, Dmitrii; Benner, Christian; Ripatti, Samuli; Ojala, Teija; Kankainen, Matti; Kai Lee, Hong; Wei-Tze Tang, Julian; Kainov, Denis E (2015). Genome-Wide Analysis of Evolutionary Markers of Human Influenza A(H1N1)pdm09 and A(H3N2) Viruses May Guide Selection of Vaccine Strain Candidates. Genome Biology and Evolution, 7 (12), 3472−3483.10.1093/gbe/evv240.
1.1.
2015
Šaulienė, Ingrida; Greičiuvienė, Jūratė; Šukienė, Laura; Juškevičiūtė, Neringa; Benner, Christian; Zinkevičienė, Auksė; Ripatti, Samuli; Donner, Kati; Kainov, Denis (2015). Genetic Loci Associated with Allergic Sensitization in Lithuanians. PLoS ONE, 10 (7), e0134188−e0134188. DOI: 10.1371/journal.pone.0134188.
1.1.
2015
Jalovaara, Petri; Mishel, Polina; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Ikonen, Niina; Julkunen, Ilkka; Kakkola, Laura; Kutsaya, Anna; Vuorinen, Tytti; Mattila, Pirkko; Almusa, Henrikki; Kainov, Denis (2015). Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland. Genome Announcements, 3 (2), e01523-14.10.1128/genomeA.01523-14.
1.1.
2015
Anastasina, Maria; Schepens, Bert; Söderholm, Sandra; Nyman, Tuula A; Matikainen, Sampsa; Saksela, Kalle; Saelens, Xavier; Kainov, Denis E (2015). The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice. Journal of General Virology, 96 (8), 2086−2091. DOI: 10.1099/vir.0.000171.
1.2.
2015
Mishel, P.; Ojalab, T.; Bennera, C.; Lakspere, T.; Bychkov, D.; Jalovaara, P.; Kakkola, L.; Kallio-Kokko, H.; Kantelee, A.; Kankainen, M.; Ikonen, N.; Ripattia, S.; Julkunen, I.; Kainov, DE. (2015). Comparative Analysis of Whole-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Hospitalized and Nonhospitalized Patients Identifies Missense Mutations That Might Be Associated with Patient Hospital Admissions in Finland during 2009 to 2014. Genome Announcements, 3 (4), 1.10.1128/genomeA.00676-15.
1.1.
2014
Denisova, Oxana V; Söderholm, Sandra; Virtanen, Salla; Von Schantz, Carina; Bychkov, Dmitrii; Vashchinkina, Elena; Desloovere, Jens; Tynell, Janne; Ikonen, Niina; Theisen, Linda L; Nyman, Tuula A; Matikainen, Sampsa; Kallioniemi, Olli; Julkunen, Ilkka; Muller, Claude P; Saelens, Xavier; Verkhusha, Vladislav V; Kainov, Denis E (2014). Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrobial Agents and Chemotherapy, 58 (7), 3689−3696. DOI: 10.1128/AAC.02798-13.
1.1.
2014
Mishel, Polina; Bychkov, Dmitrii; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Jalovaara, Petri; Kainov, Denis (2014). Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells. Genome Announcements, 2 (6), e01349-14.10.1128/genomeA.01349-14.
1.1.
2014
Jalovaara, Petri; Bychkov, Dmitrii; Ahtiainen, Laura; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Kallioniemi, Olli; Kainov, Denis (2014). Genetic Instability of Influenza pH1N1 Viruses. Genome Announcements, 2 (5), e00841-14.10.1128/genomeA.00841-14.
1.1.
2014
Lakspere, Triin; Kallio-Kokko, Hannimari; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Kainov, Denis; Kakkola, Laura (2014). Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season. Genome Announcements, 27 (2), e00039-14. DOI: 10.1128/genomeA.00039-14.
1.1.
2014
Anastasina, Maria; Terenin, Ilya; Butcher, Sarah J; Kainov, Denis E (2014). A technique to increase protein yield in a rabbit reticulocyte lysate translation system. BioTechniques, 56 (1), 36−39. DOI: 10.2144/000114125.
1.1.
2014
Lakspere, Triin; Tynell, Janne; Kaloinen, Minttu; Vanlede, Maarten; Parsons, Alun; Ikonen, Niina; Kallio-Kokko, Hannimari; Kantele, Anu; Mattila, Pirkko; Almusa, Henrikki; Julkunen, Ilkka; Kainov, Denis; Kakkola, Laura (2014). Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013. Genome Announcements, 2 (1), e01004-13. DOI: 10.1128/genomeA.01004-13.
1.1.
2014
Anastasina, Maria; Terenin, Ilya; Butcher, Sarah J.; Kainov, Denis E. (2014). A technique to increase protein yield in a rabbit reticulocyte lysate translation system. BioTechniques, 56 (1), 36−39. DOI: 10.2144/000114125.
1.1.
2013
Kakkola, L.; Denisova, O. V.; Tynell, J.; Viiliainen, J.; Ysenbaert, T.; Matos, R. C.; Nagaraj, A.; Ohman, T.; Kuivanen, S.; Paavilainen, H.; Feng, L.; Yadav, B.; Julkunen, I.; Vapalahti, O.; Hukkanen, V.; Stenman, J.; Aittokallio, T.; Verschuren, E. W.; Ojala, P. M.; Nyman, T. ... Kainov, D. E. (2013). Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice. Cell Death and Disease, 4, ARTN e742.10.1038/cddis.2013.267.
1.1.
2013
Bimbo, Luis M.; Denisova, Oxana V.; Makila, Ermei; Kaasalainen, Martti; De Brabander, Jef K.; Hirvonen, Jouni; Salonen, Jarno; Kakkola, Laura; Kainov, Denis; Santos, Helder A. (2013). Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles. ACS Nano, 7 (8), 6884−6893.10.1021/nn402062f.
1.1.
2013
El Omari, Kamel; Meier, Christoph; Kainov, Denis; Sutton, Geoff; Grimes, Jonathan M; Poranen, Minna M; Bamford, Dennis H; Tuma, Roman; Stuart, David I; Mancini, Erika J (2013). Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution. Nucleic Acids Research, 41 (20), 9396−9410.10.1093/nar/gkt713.
1.1.
2013
Smura, Teemu; Kakkola, Laura; Blomqvist, Soile; Klemola, Päivi; Parsons, Alun; Kallio-Kokko, Hannimari; Savolainen-Kopra, Carita; Kainov, Denis E; Roivainen, Merja (2013). Molecular evolution and epidemiology of echovirus 6 in Finland. Infection Genetics and Evolution, 16, 234−247.10.1016/j.meegid.2013.02.011.
1.1.
2012
Denisova, Oxana V; Kakkola, Laura; Feng, Lin; Stenman, Jakob; Nagaraj, Ashwini; Lampe, Johanna; Yadav, Bhagwan; Aittokallio, Tero; Kaukinen, Pasi; Ahola, Tero; Kuivanen, Suvi; Vapalahti, Olli; Kantele, Anu; Tynell, Janne; Julkunen, Ilkka; Kallio-Kokko, Hannimari; Paavilainen, Henrik; Hukkanen, Veijo; Elliott, Richard M; De Brabander, Jef K ... Kainov, Denis E (2012). Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. Journal of Biological Chemistry, 287 (42), 35324−35332. DOI: 10.1074/jbc.M112.392142.
1.1.
2012
Müller, Konstantin H; Kakkola, Laura; Nagaraj, Ashwini S; Cheltsov, Anton V; Anastasina, Maria; Kainov, Denis E (2012). Emerging cellular targets for influenza antiviral agents. Trends in Pharmacological Sciences, 33 (2), 89−99.10.1016/j.tips.2011.10.004.
1.1.
2012
Feng, Lin; Lintula, Susanna; Ho, Tho Huu; Anastasina, Maria; Paju, Annukka; Haglund, Caj; Stenman, Ulf-Hakan; Hotakainen, Kristina; Orpana, Arto; Kainov, Denis; Stenman, Jakob (2012). Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription. BioTechniques, 52 (4), 263−270.10.2144/0000113842.
1.1.
2011
Kainov, Denis E; Müller, Konstantin H; Theisen, Linda L; Anastasina, Maria; Kaloinen, Minttu; Muller, Claude P (2011). Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation. Journal of Biological Chemistry, 286 (9), 7239−7247. DOI: 10.1074/jbc.M110.203489.
1.1.
2011
Müller, Konstantin H; Kainov, Denis E; El Bakkouri, Karim; Saelens, Xavier; De Brabander, Jef K; Kittel, Christian; Samm, Elisabeth; Muller, Claude P (2011). The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections. British Journal of Pharmacology, 164 (2), 344−357.10.1111/j.1476-5381.2011.01346.x.
1.1.
2010
Kainov, Denis E; Cura, Vincent; Vitorino, Marc; Nierengarten, Helène; Poussin, Pierre; Kieffer, Bruno; Cavarelli, Jean; Poterszman, Arnaud (2010). Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study. Acta Crystallographica Section D Biological Crystallography, 66 (Pt 7), 745−755.10.1107/S0907444910009844.
1.1.
2010
Kainov, Denis E; Selth, Luke A; Svejstrup, Jesper Q; Egly, Jean-Marc; Poterzsman, Arnaud (2010). Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair, 9 (1), 33−39. DOI: 10.1016/j.dnarep.2009.10.002.
1.1.
2008
Kainov, Denis E; Vitorino, Marc; Cavarelli, Jean; Poterszman, Arnaud; Egly, Jean-Marc (2008). Structural basis for group A trichothiodystrophy. Nature Structural & Molecular Biology, 15 (9), 980−984. DOI: 10.1038/nsmb.1478.
1.1.
2008
Kainov, Denis E; Mancini, Erika J; Telenius, Jelena; Lísal, Jirí; Grimes, Jonathan M; Bamford, Dennis H; Stuart, David I; Tuma, Roman (2008). Structural basis of mechanochemical coupling in a hexameric molecular motor. Journal of Biological Chemistry, 283 (6), 3607−3617. DOI: 10.1074/jbc.M706366200.
1.1.
2007
Astier, Yann; Kainov, Denis E; Bayley, Hagan; Tuma, Roman; Howorka, Stefan (2007). Stochastic detection of motor protein-RNA complexes by single-channel current recording. ChemPhysChem, 8 (15), 2189−2194. DOI: 10.1002/cphc.200700179.
1.1.
2006
Kainov, D E; Tuma, R; Mancini, E J (2006). Hexameric molecular motors: P4 packaging ATPase unravels the mechanism. Cellular and Molecular Life Sciences, 63 (10), 1095−1105.
1.1.
2006
Lísal, Jirí; Kainov, Denis E; Lam, TuKiet T; Emmett, Mark R; Wei, Hui; Gottlieb, Paul; Marshall, Alan G; Tuma, Roman (2006). Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage. Virology, 351 (1), 73−79. DOI: 10.000454510.1016/j.virol.2006.03.025.
1.1.
2005
Lísal, Jirí; Lam, Tukiet T; Kainov, Denis E; Emmett, Mark R; Marshall, Alan G; Tuma, Roman (2005). Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states. Nature Structural & Molecular Biology, 12 (5), 460−466.
1.1.
2004
Mancini, Erika J; Kainov, Denis E; Grimes, Jonathan M; Tuma, Roman; Bamford, Dennis H; Stuart, David I (2004). Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell, 118 (6), 743−755.
1.1.
2004
Kainov, Denis E; Lísal, Jirí; Bamford, Dennis H; Tuma, Roman (2004). Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription. Nucleic Acids Research, 32 (12), 3515−3521.
1.1.
2004
Lísal, Jíri; Kainov, Denis E; Bamford, Dennis H; Thomas, George J; Tuma, Roman (2004). Enzymatic mechanism of RNA translocation in double-stranded RNA bacteriophages. Journal of Biological Chemistry, 279 (2), 1343−1350.
1.1.
2003
Zheleznaya, L A; Kainov, D E; Yunusova, A K; Matvienko, N I (2003). Regulatory C protein of the EcoRV modification-restriction system. Biokhimiya (Moscow), 68 (1), 105−110.
1.1.
2003
Kainov, Denis E; Pirttimaa, Markus; Tuma, Roman; Butcher, Sarah J; Thomas, George J; Bamford, Dennis H; Makeyev, Eugene V (2003). RNA packaging device of double-stranded RNA bacteriophages, possibly as simple as hexamer of P4 protein. Journal of Biological Chemistry, 278 (48), 48084−48091.
1.1.
2003
Kainov, Denis E; Butcher, Sarah J; Bamford, Dennis H; Tuma, Roman (2003). Conserved intermediates on the assembly pathway of double-stranded RNA bacteriophages. Journal of Molecular Biology, 328 (4), 791−804.
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