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Andres Merits

https://etis.ee/CV/Andres_Merits/est
9.03.1967
737 5007
andres.merits@ut.ee
H-3125-2015

Teenistuskäik

Töökohad ja ametid
01.01.2016–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, rakendusviroloogia professor (1,00)
01.01.1994 – 31.05.1995; teadur, Keemilise ja Bioloogilise Füüsika Instituut, Tallinn
01.06.1995 – 30.06.1996; teadur (osalise koormusega), Keemilise ja Bioloogilise Füüsika Instituut, Tallinn
01.07.1996 – 31.03.2001; vanemteadur (osalise koormusega), Keemilise ja Bioloogilise Füüsika Instituut, Tallinn
01.09.1998 - 31.12.1998; vanemteadur (osalise koormusega), Tallinna Tehnikaülikool
01.06.1995 - 31.12.1998; järeldoktor (taimeviroloogia), Helsingi Ülikooli Biotehnoloogia Instituut, Soome Vabariik
01.01.1999 – 31.01.2002; teadur (loomaviroloogia), Helsingi Ülikooli Biotehnoloogia Instituut, Soome Vabariik
01.09.1999 –31.12.2002; dotsent (osalise koormusega), Tallinn Tehnikaülikool
01.02.2019–31.01.2022   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, uurija-professor (1,00)
01.02.2012–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia professor (1,00)
01.01.2008–31.01.2012   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia professor (1,00)
01.03.2007–31.12.2007   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, rakendusviroloogia professor (1,00)
01.01.2006–28.02.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, mikrobioloogia ja viroloogia erakorraline professor (1,00)
01.01.2003–31.12.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline professor (1,00)
01.01.2002–31.12.2002   
Eesti Biokeskus, 01.05.2001 - 31.12.2005; vanemteadur, Eesti Biokeskus, Tartu (1,00)
 
 
Haridustee
1985-1990; üliõpilane, Moskva Riiklik Ülikool, Bioloogia teaduskond, Viroloogia õppetool
1990-1993; aspirant, Moskva Riiklik Ülikool, Bioloogia teaduskond, Viroloogia õppetool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2012−...   
Ajakirja "journal of General Virology" toimetuskollegiumi liige
2012−...   
Eesti esindaja Ülemaalimsete Viirusuuringute võrgustikus
2008−...   
TÜTI nõukogu liige

Kvalifikatsioon

Teaduskraadid
Andres Merits, doktorikraad, 1994, (juh) -, Taimede nanoviiruse genoomi keemilis-ensümaatiline süntees ja funktsionaalne iseloomustamine, Moscow State University, Russia.
 
 
Teaduspreemiad ja tunnustused
2019, Andres Merits, Eesti Teaduste Akadeemia uurija-professor
2015, Andres Merits, Riiklik aastapreemia keemia ja molekulaarbioloogia alal
 
 
Lisainfo
PhD (viroloogia)
Moskva Riiklik Ülikool, Venemaa, 1994

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2022
Varghese, F.S.; Meutiawati, F.; Teppor, M.; Jacobs, S.; de Keyzer, C.; Taşköprü, E.; van Woudenbergh, E.; Overheul, G.J.; Bouma, E.; Smit, J.M.; Delang, L.; Merits, A.; van Rij, R.P. (2022). Posaconazole inhibits multiple steps of the alphavirus replication cycle. Antiviral Research, 197. DOI: 10.1016/j.antiviral.2021.105223.
1.1.
2022
Tan, Yaw Bia; Lello, Laura Sandra; Liu, Xin; Law, Yee-Song; Kang, Congbao; Lescar, Julien; Zheng, Jie; Merits, Andres; Luo, Dahai (2022). Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Research, 50 (2), 1000−1016. DOI: 10.1093/nar/gkab1302.
1.1.
2022
De Caluwe, Lien; Heyndrickx, Leo; Coppens, Sandra; Vereecken, Katleen; Quinones-Mateu, Miguel E.; Merits, Andres; Arien, Kevin K.; Bartholomeeusen, Koen (2022). Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells. Viruses, 14 (2), ARTN 282. DOI: 10.3390/v14020282.
1.1.
2022
Lefteri, Daniella A.; Bryden, Steven R.; Pingen, Marieke; Terry, Sandra; McCafferty, Ailish; Beswick, Emily F.; Georgiev, Georgi; Van der Laan, Marleen; Mastrullo, Valeria; Campagnolo, Paola; Waterhouse, Robert M.; Varjak, Margus; Merits, Andres; Fragkoudis, Rennos; Griffin, Stephen; Shams, Kave; Pondeville, Emilie; McKimmie, Clive S. (2022). Mosquito  saliva enhances virus infection through sialokinin-dependent vascular leakage. Proceedings of the National Academy of Sciences, 119 (24). DOI: 10.1073/pnas.2114309119.
1.1.
2022
Zeng, Miao; Zhang, Wei; Jiang, Bowen; Lu, Tong; Hu, Tao; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Ou, Xumin; Mao, Sai; Gao, Qun; Sun, Di; Zhang, Ling; Cheng, Anchun ... Chen, Shun (2022). Role of the homologous MTase-RdRp interface of flavivirus intramolecular NS5 on duck tembusu virus. Veterinary Microbiology, 269, ARTN 109433. DOI: 10.1016/j.vetmic.2022.109433.
1.1.
2022
Kangro, K.; Kurašin, M; Glideman, K.; Sankovski, E.; Žusinaite, E.; Lello, L.S.; Pert, R.; Kavak, A.; Poikalainen, V.; Lepasalu, L.; Kuusk, M.; Pau, R.; Piiskop. S., Rom; A., Oltjer; R., Tiirik; K., Kogerman; K., Plaas; M., Tiirats; T., Aasmäe; B., Plaas ... M. Jr., Ustav, M. (2022). Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agents. PLoS ONE, 17. DOI: 10.1101/2021.06.08.21258069.
1.1.
2022
Cherkashchenko, L.; Rausalu; K.; Basu; S.; Alphey; L.; Merits, A. (2022). Expression of alphavirus nonstructural protein 2 (nsP2) in mosquito cells inhibits viral RNA replication in both a protease activity-dependent and -independent manner. Viruses, 14. DOI: 10.3390/v14061327.
1.1.
2021
Law, Yee-Song; Wang, Sainan; Tan, Yaw Bia; Shih, Orion; Utt, Age; Goh, Wei Yang; Lian, Bing-Jun; Chen, Ming Wei; Jeng, U-Ser; Merits, Andres; Luo, Dahai (2021). Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity. Journal of Virology, 95 (6), ARTN e01470-20. DOI: 10.1128/JVI.01470-20.
1.1.
2021
Teppor, M.; Žusinaite, E., Merits, A. (2021). Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication. Journal of Virology, 95. DOI: 10.1128/JVI.02276-20.
1.1.
2021
Rihn, Suzannah J.; Merits, Andres; Bakshi, Siddharth; Turnbull, Matthew L.; Wickenhagen, Arthur; Alexander, Akira J. T.; Baillie, Carla; Brennan, Benjamin; Brown, Fiona; Brunker, Kirstyn; Bryden, Steven R.; Burness, Kerry A.; Carmichael, Stephen; Cole, Sarah J.; Cowton, Vanessa M.; Davies, Paul; Davis, Chris; De Lorenzo, Giuditta; Donald, Claire L.; Dorward, Mark ... Mahalingam, Suresh (2021). A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19 (2), ARTN e3001091. DOI: 10.1371/journal.pbio.3001091.
1.1.
2021
Ivanova, Larisa; Rausalu, Kai; Žusinaite, Eva; Tammiku-Taul, Jaana; Merits, Andres; Karelson, Mati (2021). 1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors. ACS Omega, 6 (8), 5786−5794. DOI: 10.1021/acsomega.0c06191.
1.1.
2021
Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing; Martikainen, Minttu-Maria; Dimberg, Anna; Yu, Di; Merits, Andres; Essand, Magnus (2021). IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma. Molecular theraphy oncolytics, 21, 37−46. DOI: 10.1016/j.omto.2021.03.008.
1.1.
2021
Santos, I.A.; Shimizu, J.F.; de Oliveira, D.M.; Martins, D.O.S.; Cardoso-Sousa, L.; Cintra, A.C.O.; Aquino, V.H.; Sampaio, S.V.; Nicolau-Junior, N.; Sabino-Silva, R.; Merits, A.; Harris, M.; Jardim, A.C.G. (2021). Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus. Scientific Reports, 11. DOI: 10.1038/s41598-021-88039-4.
1.1.
2021
Ivanova, L.; Rausalu, K.; Ošeka, M.; Kananovich, D. G.; Žusinaite, E.; Tammiku-Taul, J.; Lopp, M.; Merits, A.; Karelson, M. (2021). Novel Analogues of the Chikungunya Virus Protease Inhibitor: Molecular Design, Synthesis, and Biological Evaluation. ACS Omega, 6 (16), 10884−10896. DOI: 10.1021/acsomega.1c00625.
1.1.
2021
Gestuveo, Rommel J.; Royle, Jamie; Donald, Claire L.; Lamont, Douglas J.; Hutchinson, Edward C.; Merits, Andres; Kohl, Alain; Varjak, Margus (2021). Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12 (1), ARTN 2766. DOI: 10.1038/s41467-021-22966-8.
1.1.
2021
Selberg, Simona; Žusinaite, Eva; Herodes, Koit; Seli, Neinar; Kankuri, Esko; Merits, Andres; Karelson, Mati (2021). HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators. ACS Omega, 6 (24), 15957−15963. DOI: 10.1021/acsomega.1c01626.
1.1.
2021
Scherer, Christina; Knowles, Jack; Sreenu, Vattipally B.; Fredericks, Anthony C.; Fuss, Janina; Maringer, Kevin; Fernandez-Sesma, Ana; Merits, Andres; Varjak, Margus; Kohl, Alain; Schnettler, Esther (2021). An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections. Viruses-basel, 13 (6), ARTN 1066. DOI: 10.3390/v13061066.
1.1.
2021
Teppor, Mona; Zusinaite, Eva; Karo-Astover, Liis; Omler, Ailar; Rausalu, Kai; Lulla, Valeria; Lulla, Aleksei; Merits, Andres (2021). Semliki Forest virus chimeras with functional replicase modules from related alphaviruses survive by adaptive mutations in functionally important hotspots. Journal of Virology. DOI: 10.1128/JVI.00973-21.
1.1.
2021
Lello, Laura Sandra; Bartholomeeusen, Koen; Wang, Sainan; Coppens, Sandra; Fragkoudis, Rennos; Alphey, Luke; Ariën, Kevin K.; Merits, Andres; Utt, Age (2021). nsP4 is a major determinant of alphavirus replicase activity and template selectivity. Journal of Virology. DOI: 10.1128/JVI.00355-21.
1.1.
2021
Yang, Siwy Ling; DeFalco, Louis; Anderson, Danielle E.; Zhang, Yu; Aw, Jong Ghut Ashley; Lim, Su Ying; Lim, Xin Ni; Tan, Kiat Yee; Zhang, Tong; Chawla, Tanu; Su, Yan; Lezhava, Alexander; Merits, Andres; Wang, Lin-Fa; Huber, Roland G.; Wan, Yue (2021). Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions. Nature Communications, 12 (1). DOI: 10.1038/s41467-021-25357-1.
1.1.
2021
Szemiel, Agnieszka M.; Merits, Andres; Orton, Richard J.; MacLean, Oscar A.; Pinto, Rute Maria; Wickenhagen, Arthur; Lieber, Gauthier; Turnbull, Matthew L.; Wang, Sainan; Furnon, Wilhelm; Suarez, Nicolas M.; Mair, Daniel; da Silva Filipe, Ana; Willett, Brian J.; Wilson, Sam J.; Patel, Arvind H.; Thomson, Emma C.; Palmarini, Massimo; Kohl, Alain; Stewart, Meredith E. (2021). In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. PLoS Pathogens, 17 (9), e1009929. DOI: 10.1371/journal.ppat.1009929.
1.1.
2021
Troost-Kind, Berit; van Hemert, Martijn J.; van de Pol, Denise; van der Ende-Metselaar, Heidi; Merits, Andres; Borggrewe, Malte; Rodenhuis-Zybert, Izabela A.; Smit, Jolanda M. (2021). Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression. PLoS Neglected Tropical Diseases, 15 (11), e0009916. DOI: 10.1371/journal.pntd.0009916.
1.1.
2021
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji; Yang, Jaewon; Ravlo, Erlend; Wang, Wei; Lysvand, Hilde; Loseth, Kirsti; Oksenych, Valentyn; Tenson, Tanel; Windisch, Marc P.; Poranen, Minna M.; Nieminen, Anni I.; Nordbo, Svein Arne; Fenstad, Mona Hoysaeter; Grodeland, Gunnveig; Aukrust, Pal ... Kainov, Denis E. (2021). Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections. Viruses, 13 (12), ARTN 2489. DOI: 10.3390/v13122489.
1.1.
2020
Bryden, Steven R.; Pingen, Marieke; Lefteri, Daniella A.; Miltenburg, Janne; Delang, Leen; Jacobs, Sofie; Abdelnabi, Rana; Neyts, Johan; Pondeville, Emilie; Major, Jack; Mueller, Marietta; Khalid, Henna; Tuplin, Andrew; Varjak, Margus; Merits, Andres; Edgar, Julia; Graham, Gerard J.; Shams, Kave; McKimmie, Clive S. (2020). Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12 (527), ARTN eaax2421. DOI: 10.1126/scitranslmed.aax2421.
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2020
Liu, Xiang; Mutso, Margit; Cherkashchenko, Liubov; Zusinaite, Eva; Herrero, Lara J.; Doggett, Stephen L.; Haniotis, John; Merits, Andres; Herring, Belinda L.; Taylor, Adam; Mahalingam, Suresh (2020). Identification of natural molecular determinants of Ross River virus type I IFN modulation. Journal of Virology, 94e. DOI: 10.1128/JVI.01788-19.
1.1.
2020
Bakhache, W.; Neyret, A.; Bernard, E.; Merits, A.; Briant, L. (2020). Palmitoylated Cysteines in Chikungunya Virus nsP1 Are Critical for Targeting to Cholesterol-Rich Plasma Membrane Microdomains With Functional Consequences for Viral Genome Replication. Journal of Virology. DOI: 10.1128/JVI.02183-19.
1.1.
2020
Mutso, Margit; St John, James A.; Ling, Zheng Lung; Burt, Felicity J.; Poo, Yee Suan; Liu, Xiang; Žusinaite, Eva; Grau, Georges E.; Hueston, Linda; Merits, Andres; King, Nicholas J.C.; Ekberg, Jenny A.K.; Mahalingam, Suresh (2020). Basic insights into Zika virus infection of neuroglial and brain endothelial cells. Journal of General Virology. DOI: 10.1099/jgv.0.001416.
1.1.
2020
Shimizu, Jacqueline Farinha; Martins, Daniel Oliveira Silva; McPhillie, Martin J.; Roberts, Grace C.; Zothner, Carsten; Merits, Andres; Harris, Mark; Jardim, Ana Carolina Gomes (2020). Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches? Acta Tropica, 207, 105490. DOI: 10.1016/j.actatropica.2020.105490.
1.1.
2020
Kaur, Parveen; Lello, Laura Sandra; Utt, Age; Dutta, Sujit Krishna; Merits, Andres; Chu, Justin Jang Hann (2020). Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis. PLoS Neglected Tropical Diseases, 14 (5), e0008336. DOI: 10.1371/journal.pntd.0008336.
1.1.
2020
Royle, Jamie; Ramírez-Santana, Carolina; Akpunarlieva, Snezhana; Donald, Claire L.; Gestuveo, Rommel J.; Anaya, Juan-Manuel; Merits, Andres; Burchmore, Richard; Kohl, Alain; Varjak, Margus (2020). Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection. Viruses, 12 (5), 524. DOI: 10.3390/v12050524.
1.1.
2020
Wang, Tao; Merits, Andres; Wu, Yuanyuan; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Liu, Yunya; Zhang, Ling; Yu, Yanling; Pan, Leichang; Chen, Shun; Cheng, Anchun (2020). Cis-acting sequences and secondary structures in untranslated regions of duck Tembusu virus RNA are important for cap-independent translation and viral proliferation. Journal of Virology, 94 (16). DOI: 10.1128/JVI.00906-20.
1.1.
2020
Tng, Priscilla Ying Lei; Paladino, Leonela Carabajal; Verkuijl, Sebald Alexander Nkosana; Purcell, Jessica; Merits, Andres; Leftwich, Philip Thomas; Fragkoudis, Rennos; Noad, Rob; Alphey, Luke (2020). Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications Biology, 3 (1), ARTN 413. DOI: 10.1038/s42003-020-01142-6.
1.1.
2020
Wu, Zhen; Wu, Yuanyuan; Zhang, Wei; Merits, Andres; Simmonds, Peter; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, ShaQiu; Huang, Juan; Ou, Xumin; Mao, Sai; Liu, YunYa; Zhang, Ling; Yu, YanLing; Tian, Bin ... Cheng, Anchun (2020). The first nonmammalian pegivirus demonstrates efficient in vitro replication and high lymphotropism. Journal of Virology. DOI: 10.1128/JVI.01150-20.
1.1.
2020
Lello, Laura Sandra; Utt, Age; Bartholomeeusen, Koen; Wang, Sainan; Rausalu, Kai; Kendall, Catherine; Coppens, Sandra; Fragkoudis, Rennos; Tuplin, Andrew; Alphey, Luke; Ariën, Kevin K.; Merits, Andres (2020). Cross-utilisation of template RNAs by alphavirus replicases. PLoS Pathogens, 16 (9), e1008825. DOI: 10.1371/journal.ppat.1008825.
1.1.
2020
Gwon, Yong-Dae; Zusinaite, Eva; Merits, Andres; Överby, Anna K.; Evander, Magnus (2020). N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle. Viruses, 12 (9), 925. DOI: 10.3390/v12090925.
1.1.
2020
Oliveira, Debora Moraes de; Santos, Igor de Andrade; Silva Martins, Daniel Oliveira; Goncalves, Yasmim Garcia; Cardoso-Sousa, Leia; Sabino-Silva, Robinson; Von Poelhsitz, Gustavo; Franca, Eduardo de Faria; Nicolau-Junior, Nilson; Pacca, Carolina Colombelli; Merits, Andres; Harris, Mark; Gomes Jardim, Ana Carolina (2020). Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells. Frontiers in Microbiology, 11, ARTN 608924. DOI: 10.3389/fmicb.2020.608924.
1.1.
2019
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca J; Tenson, Tanel; Merits, Andres ... Kainov, Denis E (2019). Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses, 11 (3), 11(3). DOI: 10.3390/v11030207.
1.1.
2019
Ianevski, A.; Andersen, P.I.; Merits, A.; Bjørås, M.; Kainov, D. (2019). Expanding the activity spectrum of antiviral agents. Drug Discovery Today, 24 (5), 1224−1228. DOI: 10.1016/j.drudis.2019.04.006.
1.1.
2019
Matkovic, R.; Bernard, E.; Fontanel, S.; Eldin, P.; Chazal, N.; Hassan Hersi, D.; Merits, A.; Péloponèse, J.M.Jr.; Briant, L. (2019). The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation. Journal of Virology, 93 (4), e01764. DOI: 10.1128/JVI.01764-18.
1.1.
2019
Wichit, S.; Hamel, R.; Zanzoni, A.; Diop, F.; Cribier, A.; Talignani, L.; Diack, A.; Ferraris, P.; Liegeois, F.; Urbach, S.; Ekchariyawat, P.; Merits, A.; Yssel, H.; Benkirane, M.; Missé, D. (2019). SAMHD1 enhances chikungunya and Zika virus replication in human skin fibroblasts. International Journal of Molecular Sciences, 20 (7), 1695. DOI: 10.3390/ijms20071695.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine. DOI: 10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567. DOI: 10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93. DOI: 10.1128/JVI.00794-19.
1.1.
2019
Kendall, C.; Khalid, H.; Müller, M.; Banda, D.H.;, Kohl, A.; Merits, A.; Stonehouse, N.J.; Tuplin, A. (2019). Structural and phenotypic analysis of Chikungunya virus RNA replication elements. Nucleic Acids Research. DOI: 10.1093/nar/gkz640.
1.1.
2019
Müller, M.; Slivinski, N.; Todd, E.J.A.A.; Khalid, H.; Lia, R.; Merits, A.; Mankouri, J.; Tuplin, A. (2019). Chikungunya virus requires cellular chloride channels for efficient genome replication. PLoS Neglected Tropical Diseases, 13. DOI: 10.1371/journal.pntd.0007703.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236. DOI: 10.3389/fmicb.2019.02236.
1.1.
2019
Bösl, K.; Ianevski, A.; Than, T.T.; Andersen, P.I.; Kuivanen, S.; Teppor, M.; Zusinaite, E.; Dumpis, U.; Vitkauskiene, A.; Cox, R.J.; Kallio-Kokko, H.; Bergqvist, A.; Tenson, T.; Merits, A.; Oksenych, V.; Bjørås, M.; Anthonsen, M.W.; Shum, D.; Kaarbø, M.; Vapalahti, O. ... Kandasamy, R.K. (2019). Common nodes of virus–host interaction revealed through an integrated network analysis. Frontiers in Immunology, 10 (2186). DOI: 10.3389/fimmu.2019.02186.
1.1.
2019
Wu, Zhen; Zhang, Wei; Wu, Yuanyuan; Wang, Tao; Wu, Shaoxiong; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Liu, Yunya; Zhang, Ling; Yu, Yanling; Pan, Leichang; Merits, Andres; Chen, Shun; Cheng, Anchun (2019). Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-beta. The Journal of Immunology, 203 (12), 3374−3385. DOI: 10.4049/jimmunol.1900956.
1.1.
2019
Silva, Suely; Shimizu, Jacqueline Farinha; de Oliveira, Debora Moraes; de Assis, Leticia Ribeiro; Bittar, Cintia; Mottin, Melina; de Paula Sousa, Bruna Katiele; de Moraes Roso Mesquita, Nathalya Cristina; Regasini, Luis Octavio; Rahal, Paula; Oliva, Glaucius; Perryman, Alexander Luke; Ekins, Sean; Andrade, Carolina Horta; Goulart, Luiz Ricardo; Sabino-Silva, Robinson; Merits, Andres; Harris, Mark; Gomes Jardim, Ana Carolina (2019). A diarylamine derived from anthranilic acid inhibits ZIKV replication. Scientific Reports, 9, ARTN 17703. DOI: 10.1038/s41598-019-54169-z.
1.1.
2018
Oo, A.; Rausalu, K.; Merits, A.; Higgs, S.; Vanlandingham, D.: Abu Bakar, S.; Zandi, K. (2018). Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection. Antiviral Research, 150, 101−111. DOI: 10.1016/j.antiviral.2017.12.012.
1.1.
2018
Mutso, Margit; Morro, Ainhoa Moliner; Smedberg, Cecilia; Kasvandik, Sergo; Aquilimeba, Muriel; Teppor, Mona; Tarve, Liisi; Lulla, Aleksei; Lulla, Valeria; Saul, Sirle; Thaa, Bastian; McInerney, Gerald M.; Merits, Andres; Varjak, Margus (2018). Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses, 10 (5), ARTN 226. DOI: 10.3390/v10050226.
1.1.
2018
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Marten; Lysvand, Hilde; Teppor, Mona; Kakkola, Laura; Paavilainen, Henrik; Laajala, Mira; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Bjoras, Magnar; Nordbo, Svein Arne; Dumpis, Uga ... Kainov, Denis (2018). Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research, 154, 174−182. DOI: 10.1016/j.antiviral.2018.04.016.
1.1.
2018
Varjak, Margus; Dietrich, Isabelle; Sreenu, Vattipally B.; Till, Bethan Eluned; Merits, Andres; Kohl, Alain; Schnettler, Esther (2018). Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells. Viruses, 10 (2), ARTN 88. DOI: 10.3390/v10020088.
1.1.
2018
Lulla, Valeria; Karo-Astover, Liis; Rausalu, Kai; Saul, Sirle; Merits, Andres; Lulla, Aleksei (2018). Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase. Journal of Virology, 92 (14), ARTN e00151-18. DOI: 10.1128/JVI.00151-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18. DOI: 10.1128/JVI.00152-18.
1.1.
2018
Chen, Rubing; Mukhopadhyay, Suchetana; Merits, Andres; Bolling, Bethany; Nasar, Farooq; Coffey, Lark L.; Powers, Ann; Weaver, Scott C. (2018). ICTV Virus Taxonomy Profile: Togaviridae. Journal of General Virology, 99 (6), 761−762. DOI: 10.1099/jgv.0.001072.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18. DOI: 10.1128/mBio.00044-18.
1.1.
2018
Zusinaite, E.; Ianevski, A.; Niukkanen, D.; Poranen, M.M.; Bjørås, M.; Afset, J.E.; Tenson, T.; Velagapudi, V.; Merits, A.; Kainov, D.E. (2018). A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses, 10 (8). DOI: 10.3390/v10080423.
1.1.
2018
Remenyi, Roland; Gao, Yanni; Hughes, Ruth E.; Curd, Alistair; Zothner, Carsten; Peckham, Michelle; Merits, Andres; Harris, Mark (2018). Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3. Journal of Virology, 92 (16), ARTN e00477-18. DOI: 10.1128/JVI.00477-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2018
Öhlund, Pontus; García-Arriaza, Juan; Zusinaite, Eva; Szurgot, Inga; Männik, Andres; Kraus, Annette; Ustav, Mart; Merits, Andres; Esteban, Mariano; Liljeström, Peter; Ljungberg, Karl (2018). DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost. Scientific Reports, 8 (1), 12459−12459. DOI: 10.1038/s41598-018-31003-6.
1.1.
2017
Ramachandran, M.; Yu, D.; Dyczynski, M.; Baskaran, S.; Zhang, L.; Saul, S.; Lulla, A.; Lulla, V.; Nelander, S.; Dimberg, A.; Merits, A.; Leja-Jarblad, J.; Essand, M. (2017). Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-targeted oncolytic Semliki Forest virus. Clinical Cancer Research, 26 (3), 1519−1530. DOI: 10.1158/1078-0432.CCR-16-0925.
1.1.
2017
Taylor, A.; Liu, X.; Zaid, A.; Goh, L.; Hobson-Peters, J.; Hall, R.; Merits, A.M.; Mahalingam, S. (2017). Mutation of the N-terminal region of chikungunya virus capsid protein: implications for vaccine design. mBio, 8 (1), -−-. DOI: 10.1128/mBio.01970-16.
1.1.
2017
Varghese, F.S.; Rausalu, K.; Hakanen, M.; Saul, S.; Kümmerer, B.; Susi, P.; Merits, A.; Ahola, T. (2017). Obatoclax inhibits alphavirus membrane fusion by neutralizing the acidic environment of endocytic compartments. Antimicrobial Agents and Chemotherapy, 61 (3), -−-. DOI: 10.1128/AAC.02227-16.
1.1.
2017
Ehteshami, M.; Tao, S.; Zandi, K.; Hsiao, H.M.; Jiang, Y.; Hammond, E.; Amblard, F.; Russell, O.O.; Merits, A.; Schinazi, R.F. (2017). Characterization of β-D-N4-hydroxycytidine as a novel inhibitor of Chikungunya virus. Antimicrobial Agents and Chemotherapy, 61 (4), xx−xx. DOI: 10.1128/AAC.02395-16.
1.1.
2017
Burt F.J.; Chen, W.; Miner, J.J.; Lenschow, D.J.; Merits, A.; Schnettler, E.; Kohl, A.; Rudd, P.A.; Taylor, A.; Herrero, L.J.; Zaid, A.; Ng, L.F.; Mahalingam, S. (2017). Chikungunya virus: an update on biology and pathogenesis of this emerging pathogen (review). The Lancet: Infectious Diseases, 17 (4), e107−e117. DOI: 10.1016/S1473-3099(16)30385-1.
1.1.
2017
Teo, T.H.; Chan, Y.H.; Lee, W.W.; Lum, F.M.; Amrun, S.N.; Her, Z.; Rajarethinam, R.; Merits, A.; Rötzschke, O.; Rénia, L.; Ng, L.F (2017). Fingolimod treatment abrogates chikungunya virus-induced arthralgia. Science Translational Medicine, 9 (357), 1−11. DOI: 10.1126/scitranslmed.aal1333.
1.1.
2017
Roques, P.; Ljungberg, K.; Kummerer, B.M.; Gosse, L.; Dereuddre-Bosquet, N.; Tchitchek, N.; Hallengard, D.; Garcia-Arriaza, J.; Meinke, A.; Esteban, M.; Merits, A.; Le Grand, R.; Liljestrom, P. (2017). Attenuated and vectored vaccines 1 protect non-human primates against Chikungunya virus. JCI Insight, 2 (6), e83527. DOI: 10.1172/jci.insight.83527.
1.1.
2017
Royle, J.; Donald, C.L.; Merits, A.; Kohl, A.; Varjak, M. (2017). Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. The Veterinary Journal, 230, 62−64. DOI: 10.1016/j.tvjl.2017.10.009.
1.1.
2017
Wichit, S.; Hamel, R.; Bernard, E.; Talignani, L.; Diop, F.; Ferraris, P.; Liegeois, F.; Ekchariyawat, P.; Luplertlop, N.; Surasombatpattana, P.; Thomas, F.; Merits, A.; Choumet, V.; Roques, P.; Yssel, H.; Briant, L.; Misse, D. (2017). Imipramine inhibits chikungunya virus replication in human skin fibroblasts through interference with intracellular cholesterol trafficking. Scientific Reports, 7. DOI: 10.1038/s41598-017-03316-5.
1.1.
2017
Lum, F.-M.; Lin, C.; Susova, O.Y.; Teo, T.-H.; Fong, S.-W.; Mak, T.-M.; Lee, L.K.; Chong, C.-Y.; Lye, D.C.B.; Lin, R.T.P.; Merits, A.; Leo, Y.-S.; Ng, L.F.P. (2017). Sensitive detection of Zika virus antigen in patients’ whole blood as an alternative diagnostic approach. The Journal of Infectious Diseases, 216 (2), 182−190. DOI: 10.1093/infdis/jix276.
1.1.
2017
Remenyi, R.; Roberts, G.C.; Zothner, C.; Merits, A.; Harris, M. (2017). SNAP-tagged chikungunya virus replicons improve visualisation of non-structural protein 3 by fluorescence microscopy. Scientific Reports, 7. DOI: 10.1038/s41598-017-05820-0.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91. DOI: 10.1128/JVI.00787-17.
1.1.
2017
Mutso, M.; Saul, S.; Rausalu, K.; Susova, O.; Žusinaite, E.; Mahalingam, S.; Merits, A. (2017). Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on Brazilian Zika virus isolate. Journal of General Virology, 98, 2712−2724. DOI: 10.1099/jgv.0.000938.
1.1.
2017
Varjak, M.; Donald, C.L.; Mottram, T.; Sreenu, V.B.; Merits, A.; Maringer, K.; Schnettler, E.; Kohl, A. (2017). Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11 (10). DOI: 10.1371/journal.pntd.0006010.
1.1.
2017
Roberts, G.; Zothner, C.; Remenyi, R.; Merits, A.; Stonehouse, N.J.; Harris, M. (2017). Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research. Scientific Reports, 7. DOI: 10.1038/s41598-017-15269-w.
1.1.
2016
Taylor, A.; Melton, J.; Herrero, L.; Thaa, B.; Karo-Astover, L.; Gage, P.; Nelson, M.; Sheng, K.C.; Lidbury, B.; Ewart, G.; McInerney, G.; Merits, A.; Mahalingam, S. (2016). Effects of an in-frame deletion of the 6k gene locus from the genome of Ross River virus. Journal of Virology, 87 (XXX), 4150−4159. DOI: 10.1128/JVI.03192-15.
1.1.
2016
Viira, Birgit; Selyutina, Anastasia; García-Sosa, Alfonso T.; Karonen, Maarit; Sinkkonen, Jari; Merits, Andres; Maran Uko (2016). Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry, 24 (11), 2519−2529. DOI: 10.1016/j.bmc.2016.04.018.
1.1.
2016
Rainey, S.M.; Martinez, J.; Juneja, P.; Sarkies, P.; Lulla, A.; McFarlane, M.; Schnettler, E.; Varjak, M.; Merits, A.; Jiggins, F.M.; Kohl, A. (2016). Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12, e1005536. DOI: 10.1371/journal.ppat.1005536.
1.1.
2016
Pingen, M.; Bryden, S.R.; Pondeville, E.; Schnettler, E.; Kohl, A.; Merits, A.; Fazakerley, J.K.; Graham, G.J.; McKimmie, C.S (2016). Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection. Immunity, 44 (6), 1455−1469. DOI: 10.1016/j.immuni.2016.06.002.
1.1.
2016
Karlas, A.; Berre, S.; Couderc, T.; Varjak, M., Braun, P.; Meyer, M., Gangneux, N; Karo-Astover, L.; Weege, F.; Raftery, M.; Schönrich, G.; Klemm, U.; Wurzlbauer, A.; Bracher, F.; Merits, A.; Meyer, T.F.; Lecuit, M. (2016). A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, 11320. DOI: 10.1038/ncomms11320.
1.1.
2016
Chua, C.-L.; Sam, I.C.; Merits, A.; Chan, Y.F. (2016). Antigenic variation of East/Central/South African and Asian Chikungunya virus genotypes in neutralization by immune sera. PLoS Neglected Tropical Diseases, 10, e0004960. DOI: 10.1371/journal.pntd.0004960.
1.1.
2016
Varghese, F.; Thaa, B.; Amrun, S.; Simarmata, D.; Rausalu, K.; Nyman, T.; Merits, A.; McInerney, G.; Ng, L.F.P.; Ahola, T. (2016). The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling. Journal of Virology, 90 (21), 9743−9757. DOI: 10.1128/JVI.01382-16.
1.1.
2016
Maillard, P.V.; Van der Veen, A.G.; Deddouche-Grass, S.; Rogers, N.C.; Merits, A.; Reis E Sousa, C. (2016). Inactivation of the type I interferon pathway reveals long dsRNA-mediated RNA interference. The EMBO Journal, 35 (23), 2505−2518. DOI: 10.15252/embj.201695086.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Allas, Ü.; Toom, L.; Selyutina, A.; Mäeorg, U.; Medina, R.; Merits, A.; Rinken, A.; Hauryliuk, V.; Kaldalu, N.; Tenson, T. (2016). Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products. Scientific Reports, 6, 36844. DOI: 10.1038/srep36844.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124. DOI: 10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437. DOI: 10.1128/JVI.01579-15.
1.1.
2015
Stapleford, K.; Rozen-Gagnon, K.; Das, P.K.; Saul, S.; Poirier, E.; Blanc, H.; Vidalain, P.O.; Merits, A.; Vignuzzi, M. (2015). Viral polymerase-helicase complexes regulate replication fidelity to overcome intracellular nucleotide depletion. Journal of Virology, 89 (22), 11233−11244. DOI: 10.1128/JVI.01553-15.
1.1.
2015
Saul, S.; Ferguson, M.; Cordonin, C.; Fragkoudis, R.; Ool, M.; Tamberg, N.; Sherwood, K.; Fazakerley, J.K.; Merits, A. (2015). Differences in processing determinants of non-structural polyprotein and in the sequence of non-structural protein 3 affect neurovirulence of Semliki Forest virus. Journal of Virology, 89 (21), 11030−11045. DOI: 10.1128/JVI.01186-15.
1.1.
2015
Lani, R.; Hassandarvish, P.; Chun Wei, C.; Moghaddam, E.; Chu, J.J.H.; Rausalu, K.; Merits, A.; Higgs, S.; Vanlandingham, D.; Abu Bakar, S.; Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 11421. DOI: 10.1038/srep11421.
1.1.
2015
Ahola, T.; Courderc, T.; Ng, L.F.; Hallengärd, D.; Powers, A.; Lecuit, M.; Esteban, M.; Merits, A.; Roques, P.; Liljeström, P. (2015). Therapeutics and vaccines against chikungunya virus. Vector-Borne and Zoonotic Diseases, 15 (4), 250−257. DOI: 10.1089/vbz.2014.1681.
1.1.
2015
Ferguson, M.C.; Saul, S.; Fragkoudis, R.; Weisheit, S.; Cox, J.; Patabendige, A.; Sherwood, K.; Watson, M.; Merits, A.; Fazakerley, J.K. (2015). The ability of the encephalitic arbovirus Semliki Forest virus to cross the blood brain barrier is determined by the charge of the E2 glycoprotein. Journal of Virology, 89 (15), 7536−7549. DOI: 10.1128/JVI.03645-14.
1.1.
2015
Mutso, M.; Nikonov, A.; Pihlak, A.; Žusinaite, E.; Viru, L.; Selyutina, A.; Reintamm, T.; Kelve, M.; Saarma, M.; Karelson, M.; Merits, A. (2015). RNA interference-guided targeting of hepatitis C virus replication with antisense locked nucleic acid-based oligonucleotides containing 8-oxo-dG modifications. PLoS ONE, 10 (6), xUNSP e0128686. DOI: 10.1371/journal.pone.0128686.
1.1.
2015
Scholte, F.E.M.; Tas, A.; Albulescu, I.C., Žusinaite, E.; Merits, A.; Snijder, E.J.; van Hemert, M.J. (2015). Stress granule components G3BP1 and G3BP2 play a proviral role early in chikungunya virus replication. Journal of Virology, 89 (8), 4457−4469. DOI: 10.1128/JVI.03612-14.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162. DOI: 10.1128/JVI.03213-14.
1.1.
2015
Chen, V.V.; Foo, S.S.; Taylor, A.; Lulla, A.; Merits, A.; Hueston, L.; Forwood, M.R.; Walsh, N.C.; Sims, N.A.; Herrero, L.J.; Mahalingam, S. (2015). Bindarit, an inhibitor of monocyte chemotactic proteins (MCPs) synthesis, protects against bone loss induced by Chikungunya virus infection. Journal of Virology, 89 (1), 581−593. DOI: 10.1128/JVI.02114-15.
1.1.
2015
Her, Zhisheng; Teng, Terk-Shin; Tan, Jeslin J. L.; Teo, Teck-Hui; Kam, Yiu-Wing; Lum, Fok-Moon; Lee, Wendy W. L.; Gabriel, Christelle; Melchiotti, Rossella; Andiappan, Anand K.; Lulla, Valeria; Lulla, Aleksei; Win, Mar K.; Chow, Angela; Biswas, Subhra K.; Leo, Yee-Sin; Lecuit, Marc; Merits, Andres; Renia, Laurent; Ng, Lisa F. P. (2015). Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. EMBO Molecular Medicine, 7 (1), 24−41. DOI: doi.org/10.15252/emmm.201404459.
1.1.
2015
Ching, K.C.; Kam, Y.W.; Merits, A.; Ng, L.; Chai, C. (2015). Tri-substituted thieno[3,2-b]pyrrole 5-carboxamides as potent inhibitors of alphaviruses. Journal of Medicinal Chemistry, 58 (23), 9196−9213. DOI: 10.1021/acs.jmedchem.5b01047.
1.1.
2014
Balistreri, G.; Horvath, P.; Schweingruber, C.; Zünd, D.; McInerney, G.; Merits, A.; Mühelmann, O.; Azzalin, C.; Helenius, A. (2014). The host nonsense-mediated mRNA decay pathway restricts mammalian RNA virus replication. Cell Host & Microbe, 16 (3), 403−411. DOI: 10.1016/j.chom.2014.08.007.
1.1.
2014
Hallengärd, D.; Lum, F.M.; Kümmerer, B.; Lulla, A.; Lulla, V.; García-Arriaza, J.; Fazakerley, J.; Roques, P.; Le Grand, R.; Merits, A.; Ng, L.F.P.; Esteban, M.; Liljeström, P. (2014). Prime-boost immunization strategies against Chikungunya virus. Journal of Virology, 88 (19), 13333−13343. DOI: 10.1128/JVI.01926-14.
1.1.
2014
Knudsen, M.L.; Ljungberg, K.; Kakoulidou, M.; Kostic, L.; Hallengärd, D.; Garcia-Arriza, J.; Merits, A.; Esteban, M.; Liljeström, P. (2014). Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations. Journal of Virology, 88 (21), 12438−12451. DOI: 10.1128/JVI.02223-14.
1.1.
2014
McFarlane, M.; Arias-Goeta, C.; Martin, E.; O'Hara, Z.; Lulla, A.; Mousson, L.; Rainey, S.M.; Misbah, S.; Schnettler, E.; Donald, C.L.; Merits, A.; Kohl, A.; Failloux, A.B. (2014). Characterization of aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8, e2994. DOI: 10.1371/journal.pntd.0002994.
1.1.
2014
Kam, Y.W.; Lee, W.W.; Simarmata, D.; Le Grand, R.; Tolou, H.; Merits, A.; Roques, P.; Ng, L.F. (2014). Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development. PLoS ONE, 9 (4), e95647. DOI: 10.1371/journal.pone.0095647.
1.1.
2014
Ustinova, J.; Zusinaite, E.; Utt, M.; Metsküla, K.; Reimand, K.; Huchaiah, V.; Merits, A.; Uibo, R. (2014). Development of a luciferase-based system for detection of ZnT8 autoantibodies. Journal of Immunological Methods, 405, 67−73. DOI: 10.1016/j.jim.2014.01.009.
1.1.
2014
Das, P.K.; Merits, A.; Lulla, A. (2014). Functional crosstalk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity. Journal of Biological Chemistry, 289, 5635−5653. DOI: 10.1074/jbc.M113.503433.
1.1.
2014
Rathore, A.P.S.; Haystead, T.; Das, P.K.; Merits, A.; Ng, M.-L.; Vasudevan, S.G. (2014). Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. Antiviral Research, 103, 7−16. DOI: 10.1016/j.antiviral.2013.12.010.
1.1.
2014
Hallengärd, D.; Kakoulidou, M.; Lulla, A.; Kümmerer, B.; Johansson, D.; Mutso, M.; Lulla, V.; Fazakerley, F.; Roques, P.; Le Grand, R.; Merits, A; Liljeström, P. (2014). Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice. Journal of Virology, 88 (5), 2858−2866. DOI: 10.1128/JVI.03453-13.
1.1.
2013
Ratnik, K.; Viru, L.; Merits, A. (2013). Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences. PLoS ONE, 8 (9), e−e. DOI: 10.1371/journal.pone.0075802.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610. DOI: 10.1371/journal.ppat.1003610.
1.1.
2013
Gläsker, S; Lulla, A.; Lulla, V.; Couderc, T.; Drexler, J.F.; Liljeström, P.; Lecuit, M.; Drosten, C.; Merits, A.; Kümmerer, B.M. (2013). Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout. Virology Journal, 10, e235. DOI: 10.1186/1743-422X-10-235.
1.1.
2013
Varjak, M.; Saul, S.; Arike, L.; Lulla, A.; Peil, L.; Merits, A. (2013). Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87 (18), 10293−10312. DOI: 10.1128/JVI.01105-13.
1.1.
2013
Lulla, V; Karo-Astover, L.; Rausalu, K.; Merits, A; Lulla, A. (2013). Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis. Journal of Virology, 87 (18), 10207−10220. DOI: 10.1128/JVI.01485-13.
1.1.
2013
Pärn, K.; Viru, L.; Lehto, T.; Oskolkov, N.; Langel, Ü.; Merits, A. (2013). Transfection of Infectious RNA and DNA/RNA Layered Vectors of Semliki Forest Virus by the Cell-Penetrating Peptide Based Reagent PepFect6. PLoS ONE, 8 (7), e69659. DOI: 10.1371/journal.pone.0069659.
1.1.
2013
Teo, T.-H.; Lum, F.-M.; Claser, C.; Lulla, V.; Lulla, A.; Merits, A.; Renia, L.; Ng, L.F.P. (2013). A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. The Journal of Immunology, 190 (1), 259−269. DOI: 10.4049/jimmunol.1202177.
5.2.
2013
Ustinova, Julia; Zusinaite, Eva; Utt, Meeme; Merits, Andres; Uibo, Raivo (2013). Lutsiferaasiga märgistatud autoantigeeni kasutamine ZnT8 autoantikehade määramiseks T1D-patsientide seerumites. (26−26). Tartu Ülikooli arstiteaduskonna aastapäeva teaduskonverents 2013. Eesti Arst.
1.1.
2012
Lulla, A., Lulla, V., Merits, A. (2012). Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein. Journal of Virology, 86 (1), 553−565. DOI: 10.1128/JVI.05195-11.
1.1.
2012
Kumar, S.; Jaffar-Bandjee, M.C.; Giry, C.; Connen de Kerillis, L.; Merits, A.; Gasque, P.; Hoarau, J.J. (2012). Mouse macrophage innate immune response to chikungunya virus infection. Virology Journal, 9 (1), e303. DOI: 10.1186/1743-422X-9-313.
1.1.
2012
Panas, M.D.; Varjak, M.; Lulla, A.; Eng, K.E.; Merits, A.; Karlsson-Hedestam, G.B.; McInerney, G.M. (2012). Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23 (24), 4701−4712. DOI: 10.1091/mbc.E12-08-0619.
1.1.
2012
Rodriguez-Andres, J.; Rani, S.; Varjak, M.; Chase-Topping, M.E.; Beck, M.H.; Ferguson, M.C.; Schnettler, E.; Fragkoudis, R.; Barry, G.; Merits, A.; Fazakerley, J.K.; Strand, M.R.; Kohl, A. (2012). Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus. PLoS Pathogens, 8 (11), e1002977. DOI: 10.1371/journal.ppat.1002977.
1.1.
2012
Teng, T.-S.; Foo, S.-S.; Simarmata, D.; Lum, F.-M.; Teo, T.-H.; Lulla, A.; Yeo, N.K.W.; Koh, E.G.L.; Chow, A.; Leo, Y.-S.; Merits, A.; Chin, K.-C.; Ng, L.F.P. (2012). Viperin controls chikungunya-virus replication and pathology in humans and mice. Journal of Clinical Investigation, 122 (12), 4447−4460. DOI: 10.1172/JCI63120.
1.1.
2012
Karelson, M.; Dobchev, D.A.; Karelson, G.; Tamm, T.; Tämm, K.; Nikonov, A.; Mutso, M.; Merits, A. (2012). Fragment-based development of HCV protease inhibitors for the treatment of hepatitis C. Current Computer - Aided Drug Design, 8 (1), 55−61. DOI: 10.2174/157340912799218516.
1.1.
2011
Ausmees, K.; Selyutina, A.; Kütt, K.; Lippur, K.; Pehk, T.; Lopp, M.; Žusinaite, E.; Merits, A.; Kanger, T. (2011). Synthesis and biological activity of bimorpholine and its carbanucleoside. Nucleosides Nucleotides & Nucleic Acids, 30 (11), 897−907. DOI: 10.1080/15257770.2011.621919.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923. DOI: 10.1371/journal.pone.0028923.
1.1.
2011
Viru, L.; Heller, G.; Lehto, T.; Pärn, K.; El Andaloussi, S.; Langel, Ü.; Merits, A. (2011). Novel viral vectors utilizing intron splice-switch to activate genome rescue, expression and replication in targeted cells. Virology Journal, 8 (1), 243.
1.1.
2011
Siu, R.W.; Fragkoudis, R.; Simmonds, P.; Donald, C.L.; Chase-Topping, M.E.; Barry, G.; Atterzadeh-Yazardi, G.; Rodrigues-Andres, J.; Nash, A.A.; Merits, A.; Fazakerley, J.K.; Kohl, A. (2011). Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin and frequency-dependent functions of viRNAs. Journal of Virology, 85 (6), 2907−2917.
1.1.
2010
Karo-Astover, L.; Šarova, O.; Merits, A.; Žusinaite, E. (2010). The infection of mammalian and insect cells with SFV bearing nsP1 palmitoylation mutations. Virus Research, 153 (2), 277−287. DOI: 10.1016/j.virusres.2010.08.019.
1.1.
2010
Paju, A.; Päri, M.; Selyutina, A.; Zusinaite, E.; Merits, A.; Pehk, T.; Siirde, K.; Müürisepp, A.M.; Kailas, T.; Lopp, M. (2010). Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity. Nucleosides Nucleotides & Nucleic Acids, 29 (9), 707−720. DOI: 10.1080/15257770.2010.501776.
1.1.
2010
Barry, G.; Fragkoudis, R., Ferguson, M.C.; Lulla, A.; Merits, A.; Kohl, A.; Fazakerley, J.K. (2010). Semliki Forest virus induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells. Journal of Virology, 84 (14), 7369−7377. DOI: 10.1128/JVI.02310-09.
1.1.
2010
Varjak, M., Žusinaite, E.; Merits, A. (2010). Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84, 2352−2364. DOI: 10.1128/JVI.01540-09.
1.1.
2009
Rausalu, K.; Iofik, A., Ülper, L.; Karo-Astover, L.; Lulla, V.; Merits, A. (2009). Properties and use of novel replication-competent vectors based on Semliki Forest virus. Virology Journal, 6 (33), 6−33. DOI: 10.1186/1743-422X-6-33.
1.1.
2009
Attarzadeh-Yazdi, G.; Fragkoudis, R.; Ricky, Y.C.; Siu, W.C.; Ülper, L.; Barry, G.; Rodriguez-Andres, J.; Nash, A.A.; Bouloy, M.; Merits, A.; Fazakerley, J.K.; Kohl, A. (2009). Cell to cell spread of the RNAi response suppresses Semliki Forest virus infection of mosquito cell cultures and cannot be antagonised by this virus. Journal of Virology, 83, 5735−5748. DOI: 10.1128/JVI.02440-08.
1.1.
2008
Lulla, V.; Sawicki, D.L.; Sawicki, S.G.; Lulla, A.; Merits, A.; Ahola, T. (2008). Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1. Journal of Virology, 82 (18), 9236−9244. DOI: 10.1128/JVI.00711-08.
1.1.
2008
Tamm, K.; Merits, A.; Sarand, I. (2008). Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus. Journal of General Virology, 89, 676−686.
1.1.
2008
Kiiver, K.; Tagen, I.; Zusinaite, E.; Tamberg, N.; Fazakerley, J.; Merits, A. (2008). Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication. Journal of General Virology, 89, 1457−1466. DOI: 10.1099/vir.0.2008/000299-0.
1.1.
2008
Tamm, K.; Merits, A.; Sarand, I. (2008). Mutations in nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest Virus. Journal of General Virology, 676−686.
1.1.
2008
Ülper, L.; Sarand, I.; Rausalu, K.; Merits, A. (2008). Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron. Journal of Virological Methods, 148, 265−270.
1.1.
2008
Kiiver, K.; Merits, A.; Sarand, I. (2008). Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells. Virus Research, 131, 54−64.
1.1.
2008
Kont, V.; Laan, M.; Kisand, K.; Merits, A.; Scott, H.S.; Peterson, P. (2008). Modulation of Aire regulates the expression of tissue-restriced antigens. Molecular Immunology, 45 (1), 25−33.
1.1.
2007
Fragkoudis, R.; Breakwell, L.; McKimmie, C.; Boyd, A.; Barry, G.; Merits, A.; Fazakerley, J.K. (2007). The type-I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues but does not mediate the restricted replication of avirulent virus in CNS neurons. Journal of General Virology, 88 (12), 3373−3384. DOI: 10.1099/vir.0.83191-0.
1.1.
2007
Tamberg, N.; Lulla, V.; Fragkoudis, R.; Lulla, A.; Fazakerley, J.; Merits, A. (2007). Insertion of EGFP into the replicase gene of Semliki Forest virus results in novel, genetically stable marker virus. Journal of General Virology, 88 (4), 1225−1230.
1.1.
2007
Zusinaite, E.; Tints, K.; Kiiver, K.; Spuul, P.; Karo-Astover, L.; Merits, A.; Sarand, I. (2007). Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations. Journal of General Virology, 88 (7), 1977−1985. DOI: 10.1099/vir.0.82865-0.
1.1.
2007
Spuul, P.; Salonen, A.; Merits, A.; Jokitalo, E.; Kaariainen, L.; Ahola, T. (2007). Role of the amphipathic peptide of Semliki Forest virus replicase protein nsP1 in membrane association and virus replication. Journal of Virology, 81 (2), 872−883.
1.1.
2006
Lulla, V.; Merits, A.; Sarin, P.; Kääriäinen, L.; Keränen, S.; Ahola, T (2006). Identification of Mutations Causing Temperature-Sensitive Defects in Semliki Forest Virus RNA Synthesis. Journal of Virology, 80 (6), 3108−3111.
1.1.
2006
Kiiver, K.; Merits, A.; Ustav, M.; Žusinaite, E. (2006). Complex formation between hepatitis C virus NS2 and NS3 proteins. Virus Research, 117 (2), 264−272.
1.1.
2006
Lulla, A.; Lulla, V.; Tints, K.; Ahola, T.; Merits, A. (2006). Molecular Determinants of Substrate Specificity for Semliki Forest Virus Nonstructural Protease. Journal of Virology, 80 (11), 5413−5422.
1.1.
2004
Leppanen, V.M.; Bespalov, M.M.; Runeberg-Roos, P.; Puurand, U.; Merits, A.; Saarma, M.; Goldman, A. (2004). The structure of GFR alpha 1 domain 3 reveals new insights into GDNF binding and RET activation. The EMBO Journal, 23 (7), 1452−1462.
1.1.
2003
Salonen, A.; Vasiljeva, L.; Merits, A.; Magden, Y.; Jokitalo, E.; Kääriäinen, L (2003). Properly folded nonstructural polyprotein directs the Semliki Forest virus replication complex to endosomal compartment. Journal of Virology, 77 (3), 1691−1702.
1.1.
2003
Vasiljeva, L.; Merits, A.; Golubtsov, A.; Sizemskaja, V.; Ahola, T. (2003). Regulation of the sequential processing of Semliki Forest virus replicase polyprotein. Journal of Biological Chemistry, 278 (43), 41636−41645.
1.1.
2002
Dorokhov, Y.L.; Skulachev, M.V.; Ivanov, P.A.; Zvereva, S.D.; Tjulkina, L.G.; Merits, A.; Gleba, Y.Y.; Hohn, T.; Atabekov, J.G. (2002). Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry. Proceedings of the National Academy of Sciences, 99 (8), 5301−5306.
1.1.
2002
Merits, A.; Rajamaki, ML.; Lindholm, P.; Runeberg-Roos, P.; Kekarainen, T.; Puustinen, P.; Makelainen, K.; Valkonen, JPT.; Saarma, M. (2002). Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells. Journal of General Virology, 83, 1211−1221.
1.1.
2001
Vasiljeva, L.; Valmu, L.; Kääriäinen, L.; Merits, A. (2001). Site-specific protease activity of the carboxy-terminal domain of semliki forest virus replicase protein nsP2. Journal of Biological Chemistry, 276 (33), 30786−30793.
1.1.
2001
Ivanov, K.I.; Puustinen, P.; Merits, A.; Saarma, M.; Mäkinen, K.M. (2001). Phosphorylation down-regulates the RNA-binding function of the coat protein of potato virus A. Journal of Biological Chemistry, 276 (17), 13530−13540.
1.1.
2001
Merits, A.; Vasiljeva, L.; Ahola, T.; Kääriäinen, L.; Auvinen, P. (2001). Protyeolytic processing of the Semliki Forest virus-specific non-structural polyprotein by NSP2. Journal of General Virology, 82 (4), 765−773.
1.1.
2001
Oruetxebarria, I.; Guo, D.; Merits, A.; Mäkinen, K.; Saarma, M.; Valkonen, J.P.T. (2001). Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus. Virus Research, 73 (2), 103−112.
1.1.
2001
Vihinen, H.; Ahola, T.; Tuittila, M.; Merits, A.; Kääriäinen, L. (2001). Elimination of Phosphorylation Sites of Semliki Forest Virus Replicase Protein nsP3. Journal of Biological Chemistry, 276 (8), 5745−5752.
1.1.
2001
Magden, J.; Takeda, N.; Auvinen, P.; Ahola, T.; Miyamura, T.; Merits, A.; Kaariainen, L. (2001). Virus-specific mRNA capping enzyme encoded by hepatitis E virus. Journal of Virology, 75, 6249−6255.
1.1.
2000
Makinen, K.; Makelainen, K.; Arshava, N.; Tamm, T.; Merits, A.; Truve, E.; Zavriev, S.; Saarma, M. (2000). Characterization of VPS and the polyprotein processing of Cocksfoot mottle virus (genus Sobemovirus). Journal of General Virology, 81, 2783−2789.
1.1.
2000
Merits, A.; Fedorkin, ON.; Guo, D.; Kalinina, NO.; Morozov, SY. (2000). Activities associated with the putative replication initiation protein of Coconut foliar decay virus, a tentative member of the genus Nanovirus. Journal of General Virology, 81, 3099−3106.
1.1.
2000
Lucchesi, J.; Makelainen, K.; Merits, A.; Tamm, T.; Makinen, K. (2000). Regulation of-1 ribosomal frameshifting directed by Cocksfoot mottle sobemovirus genome. European Journal of Biochemistry, 267 (12), 3523−3529.
1.1.
2000
Vasiljeva, L.; Merits, A.; Auvinen, P.; Kääriäinen, L. (2000). Identification of a novel function of the alphavirus capping apparatus-RNA 5' triphosphatase activity of Nsp2. Journal of Biological Chemistry, 275 (23), 17281−17287.
1.1.
2000
Fedorkin, O.N.; Merits, A.; Lucchesi, J.; Solovyev, A.G.; Saarma, M.; Morozov, S.Y.; Mäkinen, K. (2000). Complementation of the movement-deficient mutations in potato virus X: Potyvirus coat protein mediates cell-to-cell trafficking of C-terminal truncation but not deletion mutant of potexvirus coat protein. Virology, 270 (1), 31−42.
1.1.
2000
Lindholm, P.; Kuittinen, T.; Sorri, O.; Guo, D.; Merits, A.; Törmäkangas, K.; Runeberg-Roos, P. (2000). Glycosylation of phytepsin and expression of dad1, dad2 and ost1 during onset of cell death in germinating barley scutella. Mechanisms of Development, 93, 169−173.
1.1.
1999
Schubert, J.; Fauquet, C.; Merits, A.; Rabenstein, F. (1999). The complete nucleotide sequence of the Ryegrass mosaic potyvirus indicates that it is a recombinant between members of two different genera in the family Potyviridae. Zeitschrift für Pflanzenkrankheiten und Pflanzenschutz-Journal of Plant Diseases and Protection, 106 (4), 392−404.
1.1.
1999
Andrejeva, J.; Puurand, U.; Merits, A.; Rabenstein, F.; Jarvekulg, L.; Valkonen, JPT. (1999). Potyvirus helper component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions and the same CP motif affects virus transmission and accumulation. Journal of General Virology, 80, 1133−1139.
1.1.
1999
Merits, A., Guo, G., Järvekülg,L., and Saarma, M. (1999). (1999). Biochemical and genetic evidence for interactions between potato A Potyvirus -encoded proteins P1 and P3 and proteins of the putative replication complex. Virology, 263, 15−22.
1.1.
1999
Dorokhov, Yu.L.; Mäkinen, K.; Frolova, O.Yu.; Merits, A.; Saarinen, J.; Kalkkinen, N.; Atabekov, I.G.; Saarma, M. (1999). A novel function for a ubiquitous plant enzyme pectin methylesterase: the host-cell receptor for the tobacco mosaic virus movement protein. FEBS Letters, 461 (3), 223−228.
1.1.
1999
Kekarainen, T.; Merits, A.; Oruetxebarria, I.; Rajamäki, M.-L.; Valkonen, J.P.T. (1999). Comparison of the complete sequences of five different isolates of potato virus A (PVA), genus Potyvirus. Archives of Virology, 144 (12), 2355−2366.
1.1.
1999
Merits, A.; Kettunen, R.; Mäkinen, K.; Lampio, A.; Auvinen, P.; Kääriäinen, L.; Ahola, T. (1999). Virus-specific capping of tobacco mosaic virus RNA: methylation of GTP prior to formation of covalent complex p126-m7GMP. FEBS Letters, 455, 45−48.
1.1.
1999
Guo, D.; Merits, A.; Saarma, M. (1999). Self-association and mapping of interaction domains of helper component proteinase of potato A potyvirus. Journal of General Virology, 80 (5), 1127−1131.
1.1.
1998
Rajamaki, M.; Merits, A.; Rabenstein, F.; Andrejeva, J.; Paulin, L.; Kekarainen, T.; Kreuze, JF.; Forster, RLS.; Valkonen, JPT. (1998). Biological, serological, and molecular differences among isolates of potato a potyvirus. Phytopathology, 88 (4), 311−321.
1.1.
1998
Merits, A.; Guo, DY.; Saarma, M. (1998). VPg, coat protein and five non-structural proteins of potato A potyvirus bind RNA in a sequence-unspecific manner. Journal of General Virology, 79, 3123−3127.
1.1.
1996
Andrejeva, J.; Merits, A.; Rabenstein, F.; Puurand, U.; Jarvekulg, L. (1996). Comparison of the nucleotide sequences of the 3'-terminal regions of one aphid and two non-aphid transmissible isolates of potato A potyvirus. Archives of Virology, 141 (7), 1207−1219.
1.1.
1995
Merits, A.; Zelenina, D.A.; Mizenina, O.A.; Chernov, B.K.; Morozov, S.Yu (1995). Poly(A) addition site mapping and polyadenylation signal analysis in plant circovirus replication related gene. Virology, 211 (1), 345−349.
1.1.
1994
Morozov, S.Yu.; Chernov, B.K.; Merits, A.; Blinov, V.M. (1994). Computer-assisted predictions of the secondary structure in plant virus single stranded DNA genome. Journal of Biomolecular Structure and Dynamics, 11 (4), 837−847.
1.1.
1994
Morozov, S.Yu.; Merits, A; Chernov, B.K (1994). Computer search of transcription control sequence in small plant virus DNA reveals a sequence highly homologous to the enhancer element of histone promoters. DNA Sequence, 4 (6), 395−397.
1.1.
1994
Solovyev, A.G; Novikov, V.K; Merits, A; Savenkov, E.I; Zelenina, D.A; Tyulkina, L.G; Morozov, S.Yu (1994). Genome characterization and taxonomy of Plantago asiatica mosaic potexvirus. Journal of General Virology, 75 (2), 259−267.
1.1.
1992
Chernov, B; Merits, A; Mizenina, O; Morozov, S.Yu (1992). Chemico-enzymatic synthesis and cloning a full length genome of DNA containing plant virus. Bioorganic Chemistry, 18 (12), 1487−1495.

Tööstusomand

18.06.2022

Andres Merits

https://etis.ee/CV/Andres_Merits/eng
9.03.1967
737 5007
andres.merits@ut.ee
H-3125-2015

Career

Institutions and positions
01.01.2016–...   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Professor of Applied Virology (1,00)
01.01.1994 – 31.05.1995; scientist, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
01.06.1995 – 30.06.1996; scientist (part time), National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
01.07.1996 – 31.03.2001; senior scientist (part time), National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
01.09.1998 - 31.12.1998; senior scientist (part time), Tallinn Technical University, Estonia
01.06.1995 - 31.12.1998; post-doctoral fellow (plant virology), Institute of Biotechnology, University of Helsinki, Finland
01.01.1999 – 31.01.2002; scientist (animal virology), Institute of Biotechnology, University of Helsinki, Finland
01.09.1999 –31.12.2002; docent (part time), Tallinn Technical University, Estonia
01.02.2019–31.01.2022   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Research Professor (1,00)
01.02.2012–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor of Applied Virology (1,00)
01.01.2008–31.01.2012   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor of Applied Virology (1,00)
01.03.2007–31.12.2007   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor (1,00)
01.01.2006–28.02.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor extraordinarius (1,00)
01.01.2003–31.12.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor extraordinarius (1,00)
01.01.2002–31.12.2002   
Estonian Biocentre, 01.05.2001 - 31.12.2005; senior scientist, Estonian Biocentre, Tartu, Estonia (1,00)
 
 
Education
1985-1990; undergraduate student at the Department of Virology, Moscow State University, Russia
1990-1993; PhD-student at the Department of Virology, Moscow State University, Russia
 
 
R&D related managerial and administrative work
2012−...   
Member of editorial board of "Journal of General Virology"
2012−...   
Representative of Estonia in Global Virus Network
2008−...   
Member of scientific council of Institute of Technology, University of Tartu

Qualifications

Academic degrees
Andres Merits, Doctor's Degree, 1994, (sup) -, Taimede nanoviiruse genoomi keemilis-ensümaatiline süntees ja funktsionaalne iseloomustamine (“Chemical-enzymatic synthesis, cloning and functional analysis of DNA genome of plant nanovirus”.), Moscow State University, Russia.
 
 
Honours & awards
2019, Andres Merits, Esotonian Academy of Sciences Research professor
2015, Andres Merits, State award in Chemistry and Molecular Biology
 
 
Fields of research
ETIS RESEARCH FIELD: 1. Biosciences and Environment; 1.2. Microbiology; CERCS RESEARCH FIELD: B230 Microbiology, bacteriology, virology, mycology
 
 
Additional information
PhD (virology)
Moscow State University, Russia, 1994

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2022
Varghese, F.S.; Meutiawati, F.; Teppor, M.; Jacobs, S.; de Keyzer, C.; Taşköprü, E.; van Woudenbergh, E.; Overheul, G.J.; Bouma, E.; Smit, J.M.; Delang, L.; Merits, A.; van Rij, R.P. (2022). Posaconazole inhibits multiple steps of the alphavirus replication cycle. Antiviral Research, 197. DOI: 10.1016/j.antiviral.2021.105223.
1.1.
2022
Tan, Yaw Bia; Lello, Laura Sandra; Liu, Xin; Law, Yee-Song; Kang, Congbao; Lescar, Julien; Zheng, Jie; Merits, Andres; Luo, Dahai (2022). Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Research, 50 (2), 1000−1016. DOI: 10.1093/nar/gkab1302.
1.1.
2022
De Caluwe, Lien; Heyndrickx, Leo; Coppens, Sandra; Vereecken, Katleen; Quinones-Mateu, Miguel E.; Merits, Andres; Arien, Kevin K.; Bartholomeeusen, Koen (2022). Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells. Viruses, 14 (2), ARTN 282. DOI: 10.3390/v14020282.
1.1.
2022
Lefteri, Daniella A.; Bryden, Steven R.; Pingen, Marieke; Terry, Sandra; McCafferty, Ailish; Beswick, Emily F.; Georgiev, Georgi; Van der Laan, Marleen; Mastrullo, Valeria; Campagnolo, Paola; Waterhouse, Robert M.; Varjak, Margus; Merits, Andres; Fragkoudis, Rennos; Griffin, Stephen; Shams, Kave; Pondeville, Emilie; McKimmie, Clive S. (2022). Mosquito  saliva enhances virus infection through sialokinin-dependent vascular leakage. Proceedings of the National Academy of Sciences, 119 (24). DOI: 10.1073/pnas.2114309119.
1.1.
2022
Zeng, Miao; Zhang, Wei; Jiang, Bowen; Lu, Tong; Hu, Tao; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Ou, Xumin; Mao, Sai; Gao, Qun; Sun, Di; Zhang, Ling; Cheng, Anchun ... Chen, Shun (2022). Role of the homologous MTase-RdRp interface of flavivirus intramolecular NS5 on duck tembusu virus. Veterinary Microbiology, 269, ARTN 109433. DOI: 10.1016/j.vetmic.2022.109433.
1.1.
2022
Kangro, K.; Kurašin, M; Glideman, K.; Sankovski, E.; Žusinaite, E.; Lello, L.S.; Pert, R.; Kavak, A.; Poikalainen, V.; Lepasalu, L.; Kuusk, M.; Pau, R.; Piiskop. S., Rom; A., Oltjer; R., Tiirik; K., Kogerman; K., Plaas; M., Tiirats; T., Aasmäe; B., Plaas ... M. Jr., Ustav, M. (2022). Bovine colostrum-derived antibodies against SARS-CoV-2 show great potential to serve as prophylactic agents. PLoS ONE, 17. DOI: 10.1101/2021.06.08.21258069.
1.1.
2022
Cherkashchenko, L.; Rausalu; K.; Basu; S.; Alphey; L.; Merits, A. (2022). Expression of alphavirus nonstructural protein 2 (nsP2) in mosquito cells inhibits viral RNA replication in both a protease activity-dependent and -independent manner. Viruses, 14. DOI: 10.3390/v14061327.
1.1.
2021
Law, Yee-Song; Wang, Sainan; Tan, Yaw Bia; Shih, Orion; Utt, Age; Goh, Wei Yang; Lian, Bing-Jun; Chen, Ming Wei; Jeng, U-Ser; Merits, Andres; Luo, Dahai (2021). Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity. Journal of Virology, 95 (6), ARTN e01470-20. DOI: 10.1128/JVI.01470-20.
1.1.
2021
Teppor, M.; Žusinaite, E., Merits, A. (2021). Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication. Journal of Virology, 95. DOI: 10.1128/JVI.02276-20.
1.1.
2021
Rihn, Suzannah J.; Merits, Andres; Bakshi, Siddharth; Turnbull, Matthew L.; Wickenhagen, Arthur; Alexander, Akira J. T.; Baillie, Carla; Brennan, Benjamin; Brown, Fiona; Brunker, Kirstyn; Bryden, Steven R.; Burness, Kerry A.; Carmichael, Stephen; Cole, Sarah J.; Cowton, Vanessa M.; Davies, Paul; Davis, Chris; De Lorenzo, Giuditta; Donald, Claire L.; Dorward, Mark ... Mahalingam, Suresh (2021). A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19 (2), ARTN e3001091. DOI: 10.1371/journal.pbio.3001091.
1.1.
2021
Ivanova, Larisa; Rausalu, Kai; Žusinaite, Eva; Tammiku-Taul, Jaana; Merits, Andres; Karelson, Mati (2021). 1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors. ACS Omega, 6 (8), 5786−5794. DOI: 10.1021/acsomega.0c06191.
1.1.
2021
Martikainen, Miika; Ramachandran, Mohanraj; Lugano, Roberta; Ma, Jing; Martikainen, Minttu-Maria; Dimberg, Anna; Yu, Di; Merits, Andres; Essand, Magnus (2021). IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma. Molecular theraphy oncolytics, 21, 37−46. DOI: 10.1016/j.omto.2021.03.008.
1.1.
2021
Santos, I.A.; Shimizu, J.F.; de Oliveira, D.M.; Martins, D.O.S.; Cardoso-Sousa, L.; Cintra, A.C.O.; Aquino, V.H.; Sampaio, S.V.; Nicolau-Junior, N.; Sabino-Silva, R.; Merits, A.; Harris, M.; Jardim, A.C.G. (2021). Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus. Scientific Reports, 11. DOI: 10.1038/s41598-021-88039-4.
1.1.
2021
Ivanova, L.; Rausalu, K.; Ošeka, M.; Kananovich, D. G.; Žusinaite, E.; Tammiku-Taul, J.; Lopp, M.; Merits, A.; Karelson, M. (2021). Novel Analogues of the Chikungunya Virus Protease Inhibitor: Molecular Design, Synthesis, and Biological Evaluation. ACS Omega, 6 (16), 10884−10896. DOI: 10.1021/acsomega.1c00625.
1.1.
2021
Gestuveo, Rommel J.; Royle, Jamie; Donald, Claire L.; Lamont, Douglas J.; Hutchinson, Edward C.; Merits, Andres; Kohl, Alain; Varjak, Margus (2021). Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection. Nature Communications, 12 (1), ARTN 2766. DOI: 10.1038/s41467-021-22966-8.
1.1.
2021
Selberg, Simona; Žusinaite, Eva; Herodes, Koit; Seli, Neinar; Kankuri, Esko; Merits, Andres; Karelson, Mati (2021). HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators. ACS Omega, 6 (24), 15957−15963. DOI: 10.1021/acsomega.1c01626.
1.1.
2021
Scherer, Christina; Knowles, Jack; Sreenu, Vattipally B.; Fredericks, Anthony C.; Fuss, Janina; Maringer, Kevin; Fernandez-Sesma, Ana; Merits, Andres; Varjak, Margus; Kohl, Alain; Schnettler, Esther (2021). An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections. Viruses-basel, 13 (6), ARTN 1066. DOI: 10.3390/v13061066.
1.1.
2021
Teppor, Mona; Zusinaite, Eva; Karo-Astover, Liis; Omler, Ailar; Rausalu, Kai; Lulla, Valeria; Lulla, Aleksei; Merits, Andres (2021). Semliki Forest virus chimeras with functional replicase modules from related alphaviruses survive by adaptive mutations in functionally important hotspots. Journal of Virology. DOI: 10.1128/JVI.00973-21.
1.1.
2021
Lello, Laura Sandra; Bartholomeeusen, Koen; Wang, Sainan; Coppens, Sandra; Fragkoudis, Rennos; Alphey, Luke; Ariën, Kevin K.; Merits, Andres; Utt, Age (2021). nsP4 is a major determinant of alphavirus replicase activity and template selectivity. Journal of Virology. DOI: 10.1128/JVI.00355-21.
1.1.
2021
Yang, Siwy Ling; DeFalco, Louis; Anderson, Danielle E.; Zhang, Yu; Aw, Jong Ghut Ashley; Lim, Su Ying; Lim, Xin Ni; Tan, Kiat Yee; Zhang, Tong; Chawla, Tanu; Su, Yan; Lezhava, Alexander; Merits, Andres; Wang, Lin-Fa; Huber, Roland G.; Wan, Yue (2021). Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions. Nature Communications, 12 (1). DOI: 10.1038/s41467-021-25357-1.
1.1.
2021
Szemiel, Agnieszka M.; Merits, Andres; Orton, Richard J.; MacLean, Oscar A.; Pinto, Rute Maria; Wickenhagen, Arthur; Lieber, Gauthier; Turnbull, Matthew L.; Wang, Sainan; Furnon, Wilhelm; Suarez, Nicolas M.; Mair, Daniel; da Silva Filipe, Ana; Willett, Brian J.; Wilson, Sam J.; Patel, Arvind H.; Thomson, Emma C.; Palmarini, Massimo; Kohl, Alain; Stewart, Meredith E. (2021). In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2. PLoS Pathogens, 17 (9), e1009929. DOI: 10.1371/journal.ppat.1009929.
1.1.
2021
Troost-Kind, Berit; van Hemert, Martijn J.; van de Pol, Denise; van der Ende-Metselaar, Heidi; Merits, Andres; Borggrewe, Malte; Rodenhuis-Zybert, Izabela A.; Smit, Jolanda M. (2021). Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression. PLoS Neglected Tropical Diseases, 15 (11), e0009916. DOI: 10.1371/journal.pntd.0009916.
1.1.
2021
Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lello, Laura Sandra; Wang, Sainan; Jo, Eunji; Yang, Jaewon; Ravlo, Erlend; Wang, Wei; Lysvand, Hilde; Loseth, Kirsti; Oksenych, Valentyn; Tenson, Tanel; Windisch, Marc P.; Poranen, Minna M.; Nieminen, Anni I.; Nordbo, Svein Arne; Fenstad, Mona Hoysaeter; Grodeland, Gunnveig; Aukrust, Pal ... Kainov, Denis E. (2021). Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections. Viruses, 13 (12), ARTN 2489. DOI: 10.3390/v13122489.
1.1.
2020
Bryden, Steven R.; Pingen, Marieke; Lefteri, Daniella A.; Miltenburg, Janne; Delang, Leen; Jacobs, Sofie; Abdelnabi, Rana; Neyts, Johan; Pondeville, Emilie; Major, Jack; Mueller, Marietta; Khalid, Henna; Tuplin, Andrew; Varjak, Margus; Merits, Andres; Edgar, Julia; Graham, Gerard J.; Shams, Kave; McKimmie, Clive S. (2020). Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site. Science Translational Medicine, 12 (527), ARTN eaax2421. DOI: 10.1126/scitranslmed.aax2421.
1.1.
2020
Götte, Benjamin; Utt, Age; Fragkoudis, Rennos; Merits, Andres; McInerney, Gerald M (2020). Sensitivity of alphaviruses to G3BP deletion correlates with efficiency of replicase polyprotein processing. Journal of Virology, 94e. DOI: 10.1128/JVI.01681-19.
1.1.
2020
Liu, Xiang; Mutso, Margit; Cherkashchenko, Liubov; Zusinaite, Eva; Herrero, Lara J.; Doggett, Stephen L.; Haniotis, John; Merits, Andres; Herring, Belinda L.; Taylor, Adam; Mahalingam, Suresh (2020). Identification of natural molecular determinants of Ross River virus type I IFN modulation. Journal of Virology, 94e. DOI: 10.1128/JVI.01788-19.
1.1.
2020
Bakhache, W.; Neyret, A.; Bernard, E.; Merits, A.; Briant, L. (2020). Palmitoylated Cysteines in Chikungunya Virus nsP1 Are Critical for Targeting to Cholesterol-Rich Plasma Membrane Microdomains With Functional Consequences for Viral Genome Replication. Journal of Virology. DOI: 10.1128/JVI.02183-19.
1.1.
2020
Mutso, Margit; St John, James A.; Ling, Zheng Lung; Burt, Felicity J.; Poo, Yee Suan; Liu, Xiang; Žusinaite, Eva; Grau, Georges E.; Hueston, Linda; Merits, Andres; King, Nicholas J.C.; Ekberg, Jenny A.K.; Mahalingam, Suresh (2020). Basic insights into Zika virus infection of neuroglial and brain endothelial cells. Journal of General Virology. DOI: 10.1099/jgv.0.001416.
1.1.
2020
Shimizu, Jacqueline Farinha; Martins, Daniel Oliveira Silva; McPhillie, Martin J.; Roberts, Grace C.; Zothner, Carsten; Merits, Andres; Harris, Mark; Jardim, Ana Carolina Gomes (2020). Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches? Acta Tropica, 207, 105490. DOI: 10.1016/j.actatropica.2020.105490.
1.1.
2020
Kaur, Parveen; Lello, Laura Sandra; Utt, Age; Dutta, Sujit Krishna; Merits, Andres; Chu, Justin Jang Hann (2020). Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis. PLoS Neglected Tropical Diseases, 14 (5), e0008336. DOI: 10.1371/journal.pntd.0008336.
1.1.
2020
Royle, Jamie; Ramírez-Santana, Carolina; Akpunarlieva, Snezhana; Donald, Claire L.; Gestuveo, Rommel J.; Anaya, Juan-Manuel; Merits, Andres; Burchmore, Richard; Kohl, Alain; Varjak, Margus (2020). Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection. Viruses, 12 (5), 524. DOI: 10.3390/v12050524.
1.1.
2020
Wang, Tao; Merits, Andres; Wu, Yuanyuan; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Liu, Yunya; Zhang, Ling; Yu, Yanling; Pan, Leichang; Chen, Shun; Cheng, Anchun (2020). Cis-acting sequences and secondary structures in untranslated regions of duck Tembusu virus RNA are important for cap-independent translation and viral proliferation. Journal of Virology, 94 (16). DOI: 10.1128/JVI.00906-20.
1.1.
2020
Tng, Priscilla Ying Lei; Paladino, Leonela Carabajal; Verkuijl, Sebald Alexander Nkosana; Purcell, Jessica; Merits, Andres; Leftwich, Philip Thomas; Fragkoudis, Rennos; Noad, Rob; Alphey, Luke (2020). Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications Biology, 3 (1), ARTN 413. DOI: 10.1038/s42003-020-01142-6.
1.1.
2020
Wu, Zhen; Wu, Yuanyuan; Zhang, Wei; Merits, Andres; Simmonds, Peter; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, ShaQiu; Huang, Juan; Ou, Xumin; Mao, Sai; Liu, YunYa; Zhang, Ling; Yu, YanLing; Tian, Bin ... Cheng, Anchun (2020). The first nonmammalian pegivirus demonstrates efficient in vitro replication and high lymphotropism. Journal of Virology. DOI: 10.1128/JVI.01150-20.
1.1.
2020
Lello, Laura Sandra; Utt, Age; Bartholomeeusen, Koen; Wang, Sainan; Rausalu, Kai; Kendall, Catherine; Coppens, Sandra; Fragkoudis, Rennos; Tuplin, Andrew; Alphey, Luke; Ariën, Kevin K.; Merits, Andres (2020). Cross-utilisation of template RNAs by alphavirus replicases. PLoS Pathogens, 16 (9), e1008825. DOI: 10.1371/journal.ppat.1008825.
1.1.
2020
Gwon, Yong-Dae; Zusinaite, Eva; Merits, Andres; Överby, Anna K.; Evander, Magnus (2020). N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle. Viruses, 12 (9), 925. DOI: 10.3390/v12090925.
1.1.
2020
Oliveira, Debora Moraes de; Santos, Igor de Andrade; Silva Martins, Daniel Oliveira; Goncalves, Yasmim Garcia; Cardoso-Sousa, Leia; Sabino-Silva, Robinson; Von Poelhsitz, Gustavo; Franca, Eduardo de Faria; Nicolau-Junior, Nilson; Pacca, Carolina Colombelli; Merits, Andres; Harris, Mark; Gomes Jardim, Ana Carolina (2020). Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells. Frontiers in Microbiology, 11, ARTN 608924. DOI: 10.3389/fmicb.2020.608924.
1.1.
2019
Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca J; Tenson, Tanel; Merits, Andres ... Kainov, Denis E (2019). Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018. Viruses, 11 (3), 11(3). DOI: 10.3390/v11030207.
1.1.
2019
Ianevski, A.; Andersen, P.I.; Merits, A.; Bjørås, M.; Kainov, D. (2019). Expanding the activity spectrum of antiviral agents. Drug Discovery Today, 24 (5), 1224−1228. DOI: 10.1016/j.drudis.2019.04.006.
1.1.
2019
Matkovic, R.; Bernard, E.; Fontanel, S.; Eldin, P.; Chazal, N.; Hassan Hersi, D.; Merits, A.; Péloponèse, J.M.Jr.; Briant, L. (2019). The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation. Journal of Virology, 93 (4), e01764. DOI: 10.1128/JVI.01764-18.
1.1.
2019
Wichit, S.; Hamel, R.; Zanzoni, A.; Diop, F.; Cribier, A.; Talignani, L.; Diack, A.; Ferraris, P.; Liegeois, F.; Urbach, S.; Ekchariyawat, P.; Merits, A.; Yssel, H.; Benkirane, M.; Missé, D. (2019). SAMHD1 enhances chikungunya and Zika virus replication in human skin fibroblasts. International Journal of Molecular Sciences, 20 (7), 1695. DOI: 10.3390/ijms20071695.
1.1.
2019
Chan, Y.-H.; Teo, T.-H.; Utt, A.; Tan, J.J.L.; Amrun, S.N.; Abu Bakar, F.; Yee W.-X.; Becht, E.; Lee C.Y.-P.; Lee, B.; Rajarethinam, R.; Newell, E.; Merits, A.; Carissimo, G.; Lum, F.-M.; Ng, L.F.P. (2019). Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate. EMBO Molecular Medicine. DOI: 10.15252/emmm.201810092.
1.1.
2019
Law, Y.-S.; Utt, A.; Tan, Y.B.; Zheng, J.; Wang, S.; Chen, M.W.; Griffin, P.R.; Merits, A.; Luo, D. (2019). Structural insights into RNA recognition by the chikungunya virus nsP2 helicase. Proceedings of the National Academy of Sciences, 116 (19), 9558−9567. DOI: 10.1073/pnas.1900656116.
1.1.
2019
Utt, Age; Rausalu, Kai; Jakobson, Madis; Männik, Andres; Alphey, Luke; Fragkoudis, Rennos; Merits, Andres (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93. DOI: 10.1128/JVI.00794-19.
1.1.
2019
Kendall, C.; Khalid, H.; Müller, M.; Banda, D.H.;, Kohl, A.; Merits, A.; Stonehouse, N.J.; Tuplin, A. (2019). Structural and phenotypic analysis of Chikungunya virus RNA replication elements. Nucleic Acids Research. DOI: 10.1093/nar/gkz640.
1.1.
2019
Müller, M.; Slivinski, N.; Todd, E.J.A.A.; Khalid, H.; Lia, R.; Merits, A.; Mankouri, J.; Tuplin, A. (2019). Chikungunya virus requires cellular chloride channels for efficient genome replication. PLoS Neglected Tropical Diseases, 13. DOI: 10.1371/journal.pntd.0007703.
1.1.
2019
Carissimo, Guillaume; Chan, Yi-Hao; Utt, Age; Chua, Tze-Kwang; Abu Bakar, Farhana; Merits, Andres; Ng, Lisa F. P. (2019). VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses. Frontiers in Microbiology, 10, ARTN 2236. DOI: 10.3389/fmicb.2019.02236.
1.1.
2019
Bösl, K.; Ianevski, A.; Than, T.T.; Andersen, P.I.; Kuivanen, S.; Teppor, M.; Zusinaite, E.; Dumpis, U.; Vitkauskiene, A.; Cox, R.J.; Kallio-Kokko, H.; Bergqvist, A.; Tenson, T.; Merits, A.; Oksenych, V.; Bjørås, M.; Anthonsen, M.W.; Shum, D.; Kaarbø, M.; Vapalahti, O. ... Kandasamy, R.K. (2019). Common nodes of virus–host interaction revealed through an integrated network analysis. Frontiers in Immunology, 10 (2186). DOI: 10.3389/fimmu.2019.02186.
1.1.
2019
Wu, Zhen; Zhang, Wei; Wu, Yuanyuan; Wang, Tao; Wu, Shaoxiong; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Liu, Yunya; Zhang, Ling; Yu, Yanling; Pan, Leichang; Merits, Andres; Chen, Shun; Cheng, Anchun (2019). Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-beta. The Journal of Immunology, 203 (12), 3374−3385. DOI: 10.4049/jimmunol.1900956.
1.1.
2019
Silva, Suely; Shimizu, Jacqueline Farinha; de Oliveira, Debora Moraes; de Assis, Leticia Ribeiro; Bittar, Cintia; Mottin, Melina; de Paula Sousa, Bruna Katiele; de Moraes Roso Mesquita, Nathalya Cristina; Regasini, Luis Octavio; Rahal, Paula; Oliva, Glaucius; Perryman, Alexander Luke; Ekins, Sean; Andrade, Carolina Horta; Goulart, Luiz Ricardo; Sabino-Silva, Robinson; Merits, Andres; Harris, Mark; Gomes Jardim, Ana Carolina (2019). A diarylamine derived from anthranilic acid inhibits ZIKV replication. Scientific Reports, 9, ARTN 17703. DOI: 10.1038/s41598-019-54169-z.
1.1.
2018
Oo, A.; Rausalu, K.; Merits, A.; Higgs, S.; Vanlandingham, D.: Abu Bakar, S.; Zandi, K. (2018). Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection. Antiviral Research, 150, 101−111. DOI: 10.1016/j.antiviral.2017.12.012.
1.1.
2018
Mutso, Margit; Morro, Ainhoa Moliner; Smedberg, Cecilia; Kasvandik, Sergo; Aquilimeba, Muriel; Teppor, Mona; Tarve, Liisi; Lulla, Aleksei; Lulla, Valeria; Saul, Sirle; Thaa, Bastian; McInerney, Gerald M.; Merits, Andres; Varjak, Margus (2018). Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses, 10 (5), ARTN 226. DOI: 10.3390/v10050226.
1.1.
2018
Ianevski, Aleksandr; Zusinaite, Eva; Kuivanen, Suvi; Strand, Marten; Lysvand, Hilde; Teppor, Mona; Kakkola, Laura; Paavilainen, Henrik; Laajala, Mira; Kallio-Kokko, Hannimari; Valkonen, Miia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Bjoras, Magnar; Nordbo, Svein Arne; Dumpis, Uga ... Kainov, Denis (2018). Novel activities of safe-in-human broad-spectrum antiviral agents. Antiviral Research, 154, 174−182. DOI: 10.1016/j.antiviral.2018.04.016.
1.1.
2018
Varjak, Margus; Dietrich, Isabelle; Sreenu, Vattipally B.; Till, Bethan Eluned; Merits, Andres; Kohl, Alain; Schnettler, Esther (2018). Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells. Viruses, 10 (2), ARTN 88. DOI: 10.3390/v10020088.
1.1.
2018
Lulla, Valeria; Karo-Astover, Liis; Rausalu, Kai; Saul, Sirle; Merits, Andres; Lulla, Aleksei (2018). Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase. Journal of Virology, 92 (14), ARTN e00151-18. DOI: 10.1128/JVI.00151-18.
1.1.
2018
Bartholomeeusen, Koen; Utt, Age; Coppens, Sandra; Rausalu, Kai; Vereecken, Katleen; Arien, Kevin K.; Merits, Andres (2018). A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. Journal of Virology, 92 (14), ARTN e00152-18. DOI: 10.1128/JVI.00152-18.
1.1.
2018
Chen, Rubing; Mukhopadhyay, Suchetana; Merits, Andres; Bolling, Bethany; Nasar, Farooq; Coffey, Lark L.; Powers, Ann; Weaver, Scott C. (2018). ICTV Virus Taxonomy Profile: Togaviridae. Journal of General Virology, 99 (6), 761−762. DOI: 10.1099/jgv.0.001072.
1.1.
2018
Liu, Xiang; Mutso, Margit; Utt, Age; Lepland, Anni; Herrero, Lara J.; Taylor, Adam; Bettadapura, Jayaram; Rudd, Penny A.; Merits, Andres; Mahalingam, Suresh (2018). Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 9 (4), ARTN e00044-18. DOI: 10.1128/mBio.00044-18.
1.1.
2018
Zusinaite, E.; Ianevski, A.; Niukkanen, D.; Poranen, M.M.; Bjørås, M.; Afset, J.E.; Tenson, T.; Velagapudi, V.; Merits, A.; Kainov, D.E. (2018). A systems approach to study immuno- and neuro-modulatory properties of antiviral agents. Viruses, 10 (8). DOI: 10.3390/v10080423.
1.1.
2018
Remenyi, Roland; Gao, Yanni; Hughes, Ruth E.; Curd, Alistair; Zothner, Carsten; Peckham, Michelle; Merits, Andres; Harris, Mark (2018). Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3. Journal of Virology, 92 (16), ARTN e00477-18. DOI: 10.1128/JVI.00477-18.
1.1.
2018
Abraham, R.; Hauer, D.; McPherson R.L.; Utt, A.; Kirby, I.; Cohen, M.S.; Merits, A.; Leung, A.K.L.; Griffin, D.E. (2018). ADP ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proceedings of the National Academy of Sciences of the USA, 115, E10457−E10466. DOI: 10.1073/pnas.1812130115.
1.1.
2018
Öhlund, Pontus; García-Arriaza, Juan; Zusinaite, Eva; Szurgot, Inga; Männik, Andres; Kraus, Annette; Ustav, Mart; Merits, Andres; Esteban, Mariano; Liljeström, Peter; Ljungberg, Karl (2018). DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost. Scientific Reports, 8 (1), 12459−12459. DOI: 10.1038/s41598-018-31003-6.
1.1.
2017
Ramachandran, M.; Yu, D.; Dyczynski, M.; Baskaran, S.; Zhang, L.; Saul, S.; Lulla, A.; Lulla, V.; Nelander, S.; Dimberg, A.; Merits, A.; Leja-Jarblad, J.; Essand, M. (2017). Safe and effective treatment of experimental neuroblastoma and glioblastoma using systemically administered triple microRNA-targeted oncolytic Semliki Forest virus. Clinical Cancer Research, 26 (3), 1519−1530. DOI: 10.1158/1078-0432.CCR-16-0925.
1.1.
2017
Taylor, A.; Liu, X.; Zaid, A.; Goh, L.; Hobson-Peters, J.; Hall, R.; Merits, A.M.; Mahalingam, S. (2017). Mutation of the N-terminal region of chikungunya virus capsid protein: implications for vaccine design. mBio, 8 (1), -−-. DOI: 10.1128/mBio.01970-16.
1.1.
2017
Varghese, F.S.; Rausalu, K.; Hakanen, M.; Saul, S.; Kümmerer, B.; Susi, P.; Merits, A.; Ahola, T. (2017). Obatoclax inhibits alphavirus membrane fusion by neutralizing the acidic environment of endocytic compartments. Antimicrobial Agents and Chemotherapy, 61 (3), -−-. DOI: 10.1128/AAC.02227-16.
1.1.
2017
Ehteshami, M.; Tao, S.; Zandi, K.; Hsiao, H.M.; Jiang, Y.; Hammond, E.; Amblard, F.; Russell, O.O.; Merits, A.; Schinazi, R.F. (2017). Characterization of β-D-N4-hydroxycytidine as a novel inhibitor of Chikungunya virus. Antimicrobial Agents and Chemotherapy, 61 (4), xx−xx. DOI: 10.1128/AAC.02395-16.
1.1.
2017
Burt F.J.; Chen, W.; Miner, J.J.; Lenschow, D.J.; Merits, A.; Schnettler, E.; Kohl, A.; Rudd, P.A.; Taylor, A.; Herrero, L.J.; Zaid, A.; Ng, L.F.; Mahalingam, S. (2017). Chikungunya virus: an update on biology and pathogenesis of this emerging pathogen (review). The Lancet: Infectious Diseases, 17 (4), e107−e117. DOI: 10.1016/S1473-3099(16)30385-1.
1.1.
2017
Teo, T.H.; Chan, Y.H.; Lee, W.W.; Lum, F.M.; Amrun, S.N.; Her, Z.; Rajarethinam, R.; Merits, A.; Rötzschke, O.; Rénia, L.; Ng, L.F (2017). Fingolimod treatment abrogates chikungunya virus-induced arthralgia. Science Translational Medicine, 9 (357), 1−11. DOI: 10.1126/scitranslmed.aal1333.
1.1.
2017
Roques, P.; Ljungberg, K.; Kummerer, B.M.; Gosse, L.; Dereuddre-Bosquet, N.; Tchitchek, N.; Hallengard, D.; Garcia-Arriaza, J.; Meinke, A.; Esteban, M.; Merits, A.; Le Grand, R.; Liljestrom, P. (2017). Attenuated and vectored vaccines 1 protect non-human primates against Chikungunya virus. JCI Insight, 2 (6), e83527. DOI: 10.1172/jci.insight.83527.
1.1.
2017
Royle, J.; Donald, C.L.; Merits, A.; Kohl, A.; Varjak, M. (2017). Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. The Veterinary Journal, 230, 62−64. DOI: 10.1016/j.tvjl.2017.10.009.
1.1.
2017
Wichit, S.; Hamel, R.; Bernard, E.; Talignani, L.; Diop, F.; Ferraris, P.; Liegeois, F.; Ekchariyawat, P.; Luplertlop, N.; Surasombatpattana, P.; Thomas, F.; Merits, A.; Choumet, V.; Roques, P.; Yssel, H.; Briant, L.; Misse, D. (2017). Imipramine inhibits chikungunya virus replication in human skin fibroblasts through interference with intracellular cholesterol trafficking. Scientific Reports, 7. DOI: 10.1038/s41598-017-03316-5.
1.1.
2017
Lum, F.-M.; Lin, C.; Susova, O.Y.; Teo, T.-H.; Fong, S.-W.; Mak, T.-M.; Lee, L.K.; Chong, C.-Y.; Lye, D.C.B.; Lin, R.T.P.; Merits, A.; Leo, Y.-S.; Ng, L.F.P. (2017). Sensitive detection of Zika virus antigen in patients’ whole blood as an alternative diagnostic approach. The Journal of Infectious Diseases, 216 (2), 182−190. DOI: 10.1093/infdis/jix276.
1.1.
2017
Remenyi, R.; Roberts, G.C.; Zothner, C.; Merits, A.; Harris, M. (2017). SNAP-tagged chikungunya virus replicons improve visualisation of non-structural protein 3 by fluorescence microscopy. Scientific Reports, 7. DOI: 10.1038/s41598-017-05820-0.
1.1.
2017
Hellström, K.; Kallio, K.; Utt, A.; Quirin, T.; Jokitalo, E.; Merits, A.; Ahola, T. (2017). Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template. Journal of Virology, 91. DOI: 10.1128/JVI.00787-17.
1.1.
2017
Mutso, M.; Saul, S.; Rausalu, K.; Susova, O.; Žusinaite, E.; Mahalingam, S.; Merits, A. (2017). Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on Brazilian Zika virus isolate. Journal of General Virology, 98, 2712−2724. DOI: 10.1099/jgv.0.000938.
1.1.
2017
Varjak, M.; Donald, C.L.; Mottram, T.; Sreenu, V.B.; Merits, A.; Maringer, K.; Schnettler, E.; Kohl, A. (2017). Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11 (10). DOI: 10.1371/journal.pntd.0006010.
1.1.
2017
Roberts, G.; Zothner, C.; Remenyi, R.; Merits, A.; Stonehouse, N.J.; Harris, M. (2017). Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research. Scientific Reports, 7. DOI: 10.1038/s41598-017-15269-w.
1.1.
2016
Taylor, A.; Melton, J.; Herrero, L.; Thaa, B.; Karo-Astover, L.; Gage, P.; Nelson, M.; Sheng, K.C.; Lidbury, B.; Ewart, G.; McInerney, G.; Merits, A.; Mahalingam, S. (2016). Effects of an in-frame deletion of the 6k gene locus from the genome of Ross River virus. Journal of Virology, 87 (XXX), 4150−4159. DOI: 10.1128/JVI.03192-15.
1.1.
2016
Viira, Birgit; Selyutina, Anastasia; García-Sosa, Alfonso T.; Karonen, Maarit; Sinkkonen, Jari; Merits, Andres; Maran Uko (2016). Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry, 24 (11), 2519−2529. DOI: 10.1016/j.bmc.2016.04.018.
1.1.
2016
Rainey, S.M.; Martinez, J.; Juneja, P.; Sarkies, P.; Lulla, A.; McFarlane, M.; Schnettler, E.; Varjak, M.; Merits, A.; Jiggins, F.M.; Kohl, A. (2016). Wolbachia blocks viral genome replication early in infection without a transcriptional response by the endosymbiont or host small RNA pathways. PLoS Pathogens, 12, e1005536. DOI: 10.1371/journal.ppat.1005536.
1.1.
2016
Pingen, M.; Bryden, S.R.; Pondeville, E.; Schnettler, E.; Kohl, A.; Merits, A.; Fazakerley, J.K.; Graham, G.J.; McKimmie, C.S (2016). Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection. Immunity, 44 (6), 1455−1469. DOI: 10.1016/j.immuni.2016.06.002.
1.1.
2016
Karlas, A.; Berre, S.; Couderc, T.; Varjak, M., Braun, P.; Meyer, M., Gangneux, N; Karo-Astover, L.; Weege, F.; Raftery, M.; Schönrich, G.; Klemm, U.; Wurzlbauer, A.; Bracher, F.; Merits, A.; Meyer, T.F.; Lecuit, M. (2016). A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nature Communications, 7, 11320. DOI: 10.1038/ncomms11320.
1.1.
2016
Chua, C.-L.; Sam, I.C.; Merits, A.; Chan, Y.F. (2016). Antigenic variation of East/Central/South African and Asian Chikungunya virus genotypes in neutralization by immune sera. PLoS Neglected Tropical Diseases, 10, e0004960. DOI: 10.1371/journal.pntd.0004960.
1.1.
2016
Varghese, F.; Thaa, B.; Amrun, S.; Simarmata, D.; Rausalu, K.; Nyman, T.; Merits, A.; McInerney, G.; Ng, L.F.P.; Ahola, T. (2016). The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase (MAPK) signaling. Journal of Virology, 90 (21), 9743−9757. DOI: 10.1128/JVI.01382-16.
1.1.
2016
Maillard, P.V.; Van der Veen, A.G.; Deddouche-Grass, S.; Rogers, N.C.; Merits, A.; Reis E Sousa, C. (2016). Inactivation of the type I interferon pathway reveals long dsRNA-mediated RNA interference. The EMBO Journal, 35 (23), 2505−2518. DOI: 10.15252/embj.201695086.
1.1.
2016
Das, P.K.; Puusepp, L.; Varghese, F.S.; Utt, A.; Ahola, T.; Kananovich, D.G.; Lopp, M.; Merits, A.; Karelson, M. (2016). Design and validation of novel chikungunya virus protease inhibitors. Antimicrobial Agents and Chemotherapy, 60 (12), 7382−7395. DOI: 10.1128/AAC.01421-16.
1.1.
2016
Allas, Ü.; Toom, L.; Selyutina, A.; Mäeorg, U.; Medina, R.; Merits, A.; Rinken, A.; Hauryliuk, V.; Kaldalu, N.; Tenson, T. (2016). Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products. Scientific Reports, 6, 36844. DOI: 10.1038/srep36844.
1.1.
2016
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Žusinaite, E.; Das, P.K.; Ahola, T.; Merits, A. (2016). Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue. Scientific Reports, 6, 37124−37124. DOI: 10.1038/srep37124.
1.1.
2016
Utt, Age; Quirin, Tania; Saul, Sirle; Hellström, Kirsi; Ahola, Tero; Merits, Andres (2016). Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE, 11 (3), e0151616−e0151616. DOI: 10.1371/journal.pone.0151616.
1.1.
2015
Thaa, B.; Biasiotto, R.; Eng, K.; Neuvonen, M.; Götte, B.; Rheinemann, L.; Mutso, M.; Utt, A.; Varghese, F.; Balistreri, G.; Merits, A.; Ahola, T.; McInerney, G. (2015). Differential PI3K-Akt-mTOR activation by Semliki Forest and chikungunya virus, dependent on nsP3 and connected to replication complex internalisation. Journal of Virology, 89 (22), 11420−11437. DOI: 10.1128/JVI.01579-15.
1.1.
2015
Stapleford, K.; Rozen-Gagnon, K.; Das, P.K.; Saul, S.; Poirier, E.; Blanc, H.; Vidalain, P.O.; Merits, A.; Vignuzzi, M. (2015). Viral polymerase-helicase complexes regulate replication fidelity to overcome intracellular nucleotide depletion. Journal of Virology, 89 (22), 11233−11244. DOI: 10.1128/JVI.01553-15.
1.1.
2015
Saul, S.; Ferguson, M.; Cordonin, C.; Fragkoudis, R.; Ool, M.; Tamberg, N.; Sherwood, K.; Fazakerley, J.K.; Merits, A. (2015). Differences in processing determinants of non-structural polyprotein and in the sequence of non-structural protein 3 affect neurovirulence of Semliki Forest virus. Journal of Virology, 89 (21), 11030−11045. DOI: 10.1128/JVI.01186-15.
1.1.
2015
Lani, R.; Hassandarvish, P.; Chun Wei, C.; Moghaddam, E.; Chu, J.J.H.; Rausalu, K.; Merits, A.; Higgs, S.; Vanlandingham, D.; Abu Bakar, S.; Zandi, K. (2015). Antiviral activity of silymarin against chikungunya virus. Scientific Reports, 5, 11421. DOI: 10.1038/srep11421.
1.1.
2015
Ahola, T.; Courderc, T.; Ng, L.F.; Hallengärd, D.; Powers, A.; Lecuit, M.; Esteban, M.; Merits, A.; Roques, P.; Liljeström, P. (2015). Therapeutics and vaccines against chikungunya virus. Vector-Borne and Zoonotic Diseases, 15 (4), 250−257. DOI: 10.1089/vbz.2014.1681.
1.1.
2015
Ferguson, M.C.; Saul, S.; Fragkoudis, R.; Weisheit, S.; Cox, J.; Patabendige, A.; Sherwood, K.; Watson, M.; Merits, A.; Fazakerley, J.K. (2015). The ability of the encephalitic arbovirus Semliki Forest virus to cross the blood brain barrier is determined by the charge of the E2 glycoprotein. Journal of Virology, 89 (15), 7536−7549. DOI: 10.1128/JVI.03645-14.
1.1.
2015
Mutso, M.; Nikonov, A.; Pihlak, A.; Žusinaite, E.; Viru, L.; Selyutina, A.; Reintamm, T.; Kelve, M.; Saarma, M.; Karelson, M.; Merits, A. (2015). RNA interference-guided targeting of hepatitis C virus replication with antisense locked nucleic acid-based oligonucleotides containing 8-oxo-dG modifications. PLoS ONE, 10 (6), xUNSP e0128686. DOI: 10.1371/journal.pone.0128686.
1.1.
2015
Scholte, F.E.M.; Tas, A.; Albulescu, I.C., Žusinaite, E.; Merits, A.; Snijder, E.J.; van Hemert, M.J. (2015). Stress granule components G3BP1 and G3BP2 play a proviral role early in chikungunya virus replication. Journal of Virology, 89 (8), 4457−4469. DOI: 10.1128/JVI.03612-14.
1.1.
2015
Utt, A.; Das, P.K.; Varjak, M.; Lulla, V.; Lulla, A.; Merits, A. (2015). Mutations conferring a non-cytotoxic phenotype on Chikungunya virus replicons compromise enzymatic properties of non-structural protein 2. Journal of Virology, 89 (6), 3145−3162. DOI: 10.1128/JVI.03213-14.
1.1.
2015
Chen, V.V.; Foo, S.S.; Taylor, A.; Lulla, A.; Merits, A.; Hueston, L.; Forwood, M.R.; Walsh, N.C.; Sims, N.A.; Herrero, L.J.; Mahalingam, S. (2015). Bindarit, an inhibitor of monocyte chemotactic proteins (MCPs) synthesis, protects against bone loss induced by Chikungunya virus infection. Journal of Virology, 89 (1), 581−593. DOI: 10.1128/JVI.02114-15.
1.1.
2015
Her, Zhisheng; Teng, Terk-Shin; Tan, Jeslin J. L.; Teo, Teck-Hui; Kam, Yiu-Wing; Lum, Fok-Moon; Lee, Wendy W. L.; Gabriel, Christelle; Melchiotti, Rossella; Andiappan, Anand K.; Lulla, Valeria; Lulla, Aleksei; Win, Mar K.; Chow, Angela; Biswas, Subhra K.; Leo, Yee-Sin; Lecuit, Marc; Merits, Andres; Renia, Laurent; Ng, Lisa F. P. (2015). Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response. EMBO Molecular Medicine, 7 (1), 24−41. DOI: doi.org/10.15252/emmm.201404459.
1.1.
2015
Ching, K.C.; Kam, Y.W.; Merits, A.; Ng, L.; Chai, C. (2015). Tri-substituted thieno[3,2-b]pyrrole 5-carboxamides as potent inhibitors of alphaviruses. Journal of Medicinal Chemistry, 58 (23), 9196−9213. DOI: 10.1021/acs.jmedchem.5b01047.
1.1.
2014
Balistreri, G.; Horvath, P.; Schweingruber, C.; Zünd, D.; McInerney, G.; Merits, A.; Mühelmann, O.; Azzalin, C.; Helenius, A. (2014). The host nonsense-mediated mRNA decay pathway restricts mammalian RNA virus replication. Cell Host & Microbe, 16 (3), 403−411. DOI: 10.1016/j.chom.2014.08.007.
1.1.
2014
Hallengärd, D.; Lum, F.M.; Kümmerer, B.; Lulla, A.; Lulla, V.; García-Arriaza, J.; Fazakerley, J.; Roques, P.; Le Grand, R.; Merits, A.; Ng, L.F.P.; Esteban, M.; Liljeström, P. (2014). Prime-boost immunization strategies against Chikungunya virus. Journal of Virology, 88 (19), 13333−13343. DOI: 10.1128/JVI.01926-14.
1.1.
2014
Knudsen, M.L.; Ljungberg, K.; Kakoulidou, M.; Kostic, L.; Hallengärd, D.; Garcia-Arriza, J.; Merits, A.; Esteban, M.; Liljeström, P. (2014). Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations. Journal of Virology, 88 (21), 12438−12451. DOI: 10.1128/JVI.02223-14.
1.1.
2014
McFarlane, M.; Arias-Goeta, C.; Martin, E.; O'Hara, Z.; Lulla, A.; Mousson, L.; Rainey, S.M.; Misbah, S.; Schnettler, E.; Donald, C.L.; Merits, A.; Kohl, A.; Failloux, A.B. (2014). Characterization of aedes aegypti innate-immune pathways that limit Chikungunya virus replication. PLoS Neglected Tropical Diseases, 8, e2994. DOI: 10.1371/journal.pntd.0002994.
1.1.
2014
Kam, Y.W.; Lee, W.W.; Simarmata, D.; Le Grand, R.; Tolou, H.; Merits, A.; Roques, P.; Ng, L.F. (2014). Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development. PLoS ONE, 9 (4), e95647. DOI: 10.1371/journal.pone.0095647.
1.1.
2014
Ustinova, J.; Zusinaite, E.; Utt, M.; Metsküla, K.; Reimand, K.; Huchaiah, V.; Merits, A.; Uibo, R. (2014). Development of a luciferase-based system for detection of ZnT8 autoantibodies. Journal of Immunological Methods, 405, 67−73. DOI: 10.1016/j.jim.2014.01.009.
1.1.
2014
Das, P.K.; Merits, A.; Lulla, A. (2014). Functional crosstalk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity. Journal of Biological Chemistry, 289, 5635−5653. DOI: 10.1074/jbc.M113.503433.
1.1.
2014
Rathore, A.P.S.; Haystead, T.; Das, P.K.; Merits, A.; Ng, M.-L.; Vasudevan, S.G. (2014). Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. Antiviral Research, 103, 7−16. DOI: 10.1016/j.antiviral.2013.12.010.
1.1.
2014
Hallengärd, D.; Kakoulidou, M.; Lulla, A.; Kümmerer, B.; Johansson, D.; Mutso, M.; Lulla, V.; Fazakerley, F.; Roques, P.; Le Grand, R.; Merits, A; Liljeström, P. (2014). Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice. Journal of Virology, 88 (5), 2858−2866. DOI: 10.1128/JVI.03453-13.
1.1.
2013
Ratnik, K.; Viru, L.; Merits, A. (2013). Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences. PLoS ONE, 8 (9), e−e. DOI: 10.1371/journal.pone.0075802.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610. DOI: 10.1371/journal.ppat.1003610.
1.1.
2013
Gläsker, S; Lulla, A.; Lulla, V.; Couderc, T.; Drexler, J.F.; Liljeström, P.; Lecuit, M.; Drosten, C.; Merits, A.; Kümmerer, B.M. (2013). Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout. Virology Journal, 10, e235. DOI: 10.1186/1743-422X-10-235.
1.1.
2013
Varjak, M.; Saul, S.; Arike, L.; Lulla, A.; Peil, L.; Merits, A. (2013). Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. Journal of Virology, 87 (18), 10293−10312. DOI: 10.1128/JVI.01105-13.
1.1.
2013
Lulla, V; Karo-Astover, L.; Rausalu, K.; Merits, A; Lulla, A. (2013). Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis. Journal of Virology, 87 (18), 10207−10220. DOI: 10.1128/JVI.01485-13.
1.1.
2013
Pärn, K.; Viru, L.; Lehto, T.; Oskolkov, N.; Langel, Ü.; Merits, A. (2013). Transfection of Infectious RNA and DNA/RNA Layered Vectors of Semliki Forest Virus by the Cell-Penetrating Peptide Based Reagent PepFect6. PLoS ONE, 8 (7), e69659. DOI: 10.1371/journal.pone.0069659.
1.1.
2013
Teo, T.-H.; Lum, F.-M.; Claser, C.; Lulla, V.; Lulla, A.; Merits, A.; Renia, L.; Ng, L.F.P. (2013). A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. The Journal of Immunology, 190 (1), 259−269. DOI: 10.4049/jimmunol.1202177.
5.2.
2013
Ustinova, Julia; Zusinaite, Eva; Utt, Meeme; Merits, Andres; Uibo, Raivo (2013). Lutsiferaasiga märgistatud autoantigeeni kasutamine ZnT8 autoantikehade määramiseks T1D-patsientide seerumites. (26−26). Tartu Ülikooli arstiteaduskonna aastapäeva teaduskonverents 2013. Eesti Arst.
1.1.
2012
Lulla, A., Lulla, V., Merits, A. (2012). Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein. Journal of Virology, 86 (1), 553−565. DOI: 10.1128/JVI.05195-11.
1.1.
2012
Kumar, S.; Jaffar-Bandjee, M.C.; Giry, C.; Connen de Kerillis, L.; Merits, A.; Gasque, P.; Hoarau, J.J. (2012). Mouse macrophage innate immune response to chikungunya virus infection. Virology Journal, 9 (1), e303. DOI: 10.1186/1743-422X-9-313.
1.1.
2012
Panas, M.D.; Varjak, M.; Lulla, A.; Eng, K.E.; Merits, A.; Karlsson-Hedestam, G.B.; McInerney, G.M. (2012). Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Molecular Biology of the Cell, 23 (24), 4701−4712. DOI: 10.1091/mbc.E12-08-0619.
1.1.
2012
Rodriguez-Andres, J.; Rani, S.; Varjak, M.; Chase-Topping, M.E.; Beck, M.H.; Ferguson, M.C.; Schnettler, E.; Fragkoudis, R.; Barry, G.; Merits, A.; Fazakerley, J.K.; Strand, M.R.; Kohl, A. (2012). Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus. PLoS Pathogens, 8 (11), e1002977. DOI: 10.1371/journal.ppat.1002977.
1.1.
2012
Teng, T.-S.; Foo, S.-S.; Simarmata, D.; Lum, F.-M.; Teo, T.-H.; Lulla, A.; Yeo, N.K.W.; Koh, E.G.L.; Chow, A.; Leo, Y.-S.; Merits, A.; Chin, K.-C.; Ng, L.F.P. (2012). Viperin controls chikungunya-virus replication and pathology in humans and mice. Journal of Clinical Investigation, 122 (12), 4447−4460. DOI: 10.1172/JCI63120.
1.1.
2012
Karelson, M.; Dobchev, D.A.; Karelson, G.; Tamm, T.; Tämm, K.; Nikonov, A.; Mutso, M.; Merits, A. (2012). Fragment-based development of HCV protease inhibitors for the treatment of hepatitis C. Current Computer - Aided Drug Design, 8 (1), 55−61. DOI: 10.2174/157340912799218516.
1.1.
2011
Ausmees, K.; Selyutina, A.; Kütt, K.; Lippur, K.; Pehk, T.; Lopp, M.; Žusinaite, E.; Merits, A.; Kanger, T. (2011). Synthesis and biological activity of bimorpholine and its carbanucleoside. Nucleosides Nucleotides & Nucleic Acids, 30 (11), 897−907. DOI: 10.1080/15257770.2011.621919.
1.1.
2011
Pohjala, L.; Utt, A.; Varjak, M.; Merits, A.; Lulla, A.; Ahola, T.; Tammela, P. (2011). Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays. PLoS ONE, 6 (12), e28923. DOI: 10.1371/journal.pone.0028923.
1.1.
2011
Viru, L.; Heller, G.; Lehto, T.; Pärn, K.; El Andaloussi, S.; Langel, Ü.; Merits, A. (2011). Novel viral vectors utilizing intron splice-switch to activate genome rescue, expression and replication in targeted cells. Virology Journal, 8 (1), 243.
1.1.
2011
Siu, R.W.; Fragkoudis, R.; Simmonds, P.; Donald, C.L.; Chase-Topping, M.E.; Barry, G.; Atterzadeh-Yazardi, G.; Rodrigues-Andres, J.; Nash, A.A.; Merits, A.; Fazakerley, J.K.; Kohl, A. (2011). Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin and frequency-dependent functions of viRNAs. Journal of Virology, 85 (6), 2907−2917.
1.1.
2010
Karo-Astover, L.; Šarova, O.; Merits, A.; Žusinaite, E. (2010). The infection of mammalian and insect cells with SFV bearing nsP1 palmitoylation mutations. Virus Research, 153 (2), 277−287. DOI: 10.1016/j.virusres.2010.08.019.
1.1.
2010
Paju, A.; Päri, M.; Selyutina, A.; Zusinaite, E.; Merits, A.; Pehk, T.; Siirde, K.; Müürisepp, A.M.; Kailas, T.; Lopp, M. (2010). Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity. Nucleosides Nucleotides & Nucleic Acids, 29 (9), 707−720. DOI: 10.1080/15257770.2010.501776.
1.1.
2010
Barry, G.; Fragkoudis, R., Ferguson, M.C.; Lulla, A.; Merits, A.; Kohl, A.; Fazakerley, J.K. (2010). Semliki Forest virus induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells. Journal of Virology, 84 (14), 7369−7377. DOI: 10.1128/JVI.02310-09.
1.1.
2010
Varjak, M., Žusinaite, E.; Merits, A. (2010). Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region. Journal of Virology, 84, 2352−2364. DOI: 10.1128/JVI.01540-09.
1.1.
2009
Rausalu, K.; Iofik, A., Ülper, L.; Karo-Astover, L.; Lulla, V.; Merits, A. (2009). Properties and use of novel replication-competent vectors based on Semliki Forest virus. Virology Journal, 6 (33), 6−33. DOI: 10.1186/1743-422X-6-33.
1.1.
2009
Attarzadeh-Yazdi, G.; Fragkoudis, R.; Ricky, Y.C.; Siu, W.C.; Ülper, L.; Barry, G.; Rodriguez-Andres, J.; Nash, A.A.; Bouloy, M.; Merits, A.; Fazakerley, J.K.; Kohl, A. (2009). Cell to cell spread of the RNAi response suppresses Semliki Forest virus infection of mosquito cell cultures and cannot be antagonised by this virus. Journal of Virology, 83, 5735−5748. DOI: 10.1128/JVI.02440-08.
1.1.
2008
Lulla, V.; Sawicki, D.L.; Sawicki, S.G.; Lulla, A.; Merits, A.; Ahola, T. (2008). Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1. Journal of Virology, 82 (18), 9236−9244. DOI: 10.1128/JVI.00711-08.
1.1.
2008
Tamm, K.; Merits, A.; Sarand, I. (2008). Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus. Journal of General Virology, 89, 676−686.
1.1.
2008
Kiiver, K.; Tagen, I.; Zusinaite, E.; Tamberg, N.; Fazakerley, J.; Merits, A. (2008). Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication. Journal of General Virology, 89, 1457−1466. DOI: 10.1099/vir.0.2008/000299-0.
1.1.
2008
Tamm, K.; Merits, A.; Sarand, I. (2008). Mutations in nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest Virus. Journal of General Virology, 676−686.
1.1.
2008
Ülper, L.; Sarand, I.; Rausalu, K.; Merits, A. (2008). Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron. Journal of Virological Methods, 148, 265−270.
1.1.
2008
Kiiver, K.; Merits, A.; Sarand, I. (2008). Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells. Virus Research, 131, 54−64.
1.1.
2008
Kont, V.; Laan, M.; Kisand, K.; Merits, A.; Scott, H.S.; Peterson, P. (2008). Modulation of Aire regulates the expression of tissue-restriced antigens. Molecular Immunology, 45 (1), 25−33.
1.1.
2007
Fragkoudis, R.; Breakwell, L.; McKimmie, C.; Boyd, A.; Barry, G.; Merits, A.; Fazakerley, J.K. (2007). The type-I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues but does not mediate the restricted replication of avirulent virus in CNS neurons. Journal of General Virology, 88 (12), 3373−3384. DOI: 10.1099/vir.0.83191-0.
1.1.
2007
Tamberg, N.; Lulla, V.; Fragkoudis, R.; Lulla, A.; Fazakerley, J.; Merits, A. (2007). Insertion of EGFP into the replicase gene of Semliki Forest virus results in novel, genetically stable marker virus. Journal of General Virology, 88 (4), 1225−1230.
1.1.
2007
Zusinaite, E.; Tints, K.; Kiiver, K.; Spuul, P.; Karo-Astover, L.; Merits, A.; Sarand, I. (2007). Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations. Journal of General Virology, 88 (7), 1977−1985. DOI: 10.1099/vir.0.82865-0.
1.1.
2007
Spuul, P.; Salonen, A.; Merits, A.; Jokitalo, E.; Kaariainen, L.; Ahola, T. (2007). Role of the amphipathic peptide of Semliki Forest virus replicase protein nsP1 in membrane association and virus replication. Journal of Virology, 81 (2), 872−883.
1.1.
2006
Lulla, V.; Merits, A.; Sarin, P.; Kääriäinen, L.; Keränen, S.; Ahola, T (2006). Identification of Mutations Causing Temperature-Sensitive Defects in Semliki Forest Virus RNA Synthesis. Journal of Virology, 80 (6), 3108−3111.
1.1.
2006
Kiiver, K.; Merits, A.; Ustav, M.; Žusinaite, E. (2006). Complex formation between hepatitis C virus NS2 and NS3 proteins. Virus Research, 117 (2), 264−272.
1.1.
2006
Lulla, A.; Lulla, V.; Tints, K.; Ahola, T.; Merits, A. (2006). Molecular Determinants of Substrate Specificity for Semliki Forest Virus Nonstructural Protease. Journal of Virology, 80 (11), 5413−5422.
1.1.
2004
Leppanen, V.M.; Bespalov, M.M.; Runeberg-Roos, P.; Puurand, U.; Merits, A.; Saarma, M.; Goldman, A. (2004). The structure of GFR alpha 1 domain 3 reveals new insights into GDNF binding and RET activation. The EMBO Journal, 23 (7), 1452−1462.
1.1.
2003
Salonen, A.; Vasiljeva, L.; Merits, A.; Magden, Y.; Jokitalo, E.; Kääriäinen, L (2003). Properly folded nonstructural polyprotein directs the Semliki Forest virus replication complex to endosomal compartment. Journal of Virology, 77 (3), 1691−1702.
1.1.
2003
Vasiljeva, L.; Merits, A.; Golubtsov, A.; Sizemskaja, V.; Ahola, T. (2003). Regulation of the sequential processing of Semliki Forest virus replicase polyprotein. Journal of Biological Chemistry, 278 (43), 41636−41645.
1.1.
2002
Dorokhov, Y.L.; Skulachev, M.V.; Ivanov, P.A.; Zvereva, S.D.; Tjulkina, L.G.; Merits, A.; Gleba, Y.Y.; Hohn, T.; Atabekov, J.G. (2002). Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry. Proceedings of the National Academy of Sciences, 99 (8), 5301−5306.
1.1.
2002
Merits, A.; Rajamaki, ML.; Lindholm, P.; Runeberg-Roos, P.; Kekarainen, T.; Puustinen, P.; Makelainen, K.; Valkonen, JPT.; Saarma, M. (2002). Proteolytic processing of potyviral proteins and polyprotein processing intermediates in insect and plant cells. Journal of General Virology, 83, 1211−1221.
1.1.
2001
Vasiljeva, L.; Valmu, L.; Kääriäinen, L.; Merits, A. (2001). Site-specific protease activity of the carboxy-terminal domain of semliki forest virus replicase protein nsP2. Journal of Biological Chemistry, 276 (33), 30786−30793.
1.1.
2001
Ivanov, K.I.; Puustinen, P.; Merits, A.; Saarma, M.; Mäkinen, K.M. (2001). Phosphorylation down-regulates the RNA-binding function of the coat protein of potato virus A. Journal of Biological Chemistry, 276 (17), 13530−13540.
1.1.
2001
Merits, A.; Vasiljeva, L.; Ahola, T.; Kääriäinen, L.; Auvinen, P. (2001). Protyeolytic processing of the Semliki Forest virus-specific non-structural polyprotein by NSP2. Journal of General Virology, 82 (4), 765−773.
1.1.
2001
Oruetxebarria, I.; Guo, D.; Merits, A.; Mäkinen, K.; Saarma, M.; Valkonen, J.P.T. (2001). Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus. Virus Research, 73 (2), 103−112.
1.1.
2001
Vihinen, H.; Ahola, T.; Tuittila, M.; Merits, A.; Kääriäinen, L. (2001). Elimination of Phosphorylation Sites of Semliki Forest Virus Replicase Protein nsP3. Journal of Biological Chemistry, 276 (8), 5745−5752.
1.1.
2001
Magden, J.; Takeda, N.; Auvinen, P.; Ahola, T.; Miyamura, T.; Merits, A.; Kaariainen, L. (2001). Virus-specific mRNA capping enzyme encoded by hepatitis E virus. Journal of Virology, 75, 6249−6255.
1.1.
2000
Makinen, K.; Makelainen, K.; Arshava, N.; Tamm, T.; Merits, A.; Truve, E.; Zavriev, S.; Saarma, M. (2000). Characterization of VPS and the polyprotein processing of Cocksfoot mottle virus (genus Sobemovirus). Journal of General Virology, 81, 2783−2789.
1.1.
2000
Merits, A.; Fedorkin, ON.; Guo, D.; Kalinina, NO.; Morozov, SY. (2000). Activities associated with the putative replication initiation protein of Coconut foliar decay virus, a tentative member of the genus Nanovirus. Journal of General Virology, 81, 3099−3106.
1.1.
2000
Lucchesi, J.; Makelainen, K.; Merits, A.; Tamm, T.; Makinen, K. (2000). Regulation of-1 ribosomal frameshifting directed by Cocksfoot mottle sobemovirus genome. European Journal of Biochemistry, 267 (12), 3523−3529.
1.1.
2000
Vasiljeva, L.; Merits, A.; Auvinen, P.; Kääriäinen, L. (2000). Identification of a novel function of the alphavirus capping apparatus-RNA 5' triphosphatase activity of Nsp2. Journal of Biological Chemistry, 275 (23), 17281−17287.
1.1.
2000
Fedorkin, O.N.; Merits, A.; Lucchesi, J.; Solovyev, A.G.; Saarma, M.; Morozov, S.Y.; Mäkinen, K. (2000). Complementation of the movement-deficient mutations in potato virus X: Potyvirus coat protein mediates cell-to-cell trafficking of C-terminal truncation but not deletion mutant of potexvirus coat protein. Virology, 270 (1), 31−42.
1.1.
2000
Lindholm, P.; Kuittinen, T.; Sorri, O.; Guo, D.; Merits, A.; Törmäkangas, K.; Runeberg-Roos, P. (2000). Glycosylation of phytepsin and expression of dad1, dad2 and ost1 during onset of cell death in germinating barley scutella. Mechanisms of Development, 93, 169−173.
1.1.
1999
Schubert, J.; Fauquet, C.; Merits, A.; Rabenstein, F. (1999). The complete nucleotide sequence of the Ryegrass mosaic potyvirus indicates that it is a recombinant between members of two different genera in the family Potyviridae. Zeitschrift für Pflanzenkrankheiten und Pflanzenschutz-Journal of Plant Diseases and Protection, 106 (4), 392−404.
1.1.
1999
Andrejeva, J.; Puurand, U.; Merits, A.; Rabenstein, F.; Jarvekulg, L.; Valkonen, JPT. (1999). Potyvirus helper component-proteinase and coat protein (CP) have coordinated functions in virus-host interactions and the same CP motif affects virus transmission and accumulation. Journal of General Virology, 80, 1133−1139.
1.1.
1999
Merits, A., Guo, G., Järvekülg,L., and Saarma, M. (1999). (1999). Biochemical and genetic evidence for interactions between potato A Potyvirus -encoded proteins P1 and P3 and proteins of the putative replication complex. Virology, 263, 15−22.
1.1.
1999
Dorokhov, Yu.L.; Mäkinen, K.; Frolova, O.Yu.; Merits, A.; Saarinen, J.; Kalkkinen, N.; Atabekov, I.G.; Saarma, M. (1999). A novel function for a ubiquitous plant enzyme pectin methylesterase: the host-cell receptor for the tobacco mosaic virus movement protein. FEBS Letters, 461 (3), 223−228.
1.1.
1999
Kekarainen, T.; Merits, A.; Oruetxebarria, I.; Rajamäki, M.-L.; Valkonen, J.P.T. (1999). Comparison of the complete sequences of five different isolates of potato virus A (PVA), genus Potyvirus. Archives of Virology, 144 (12), 2355−2366.
1.1.
1999
Merits, A.; Kettunen, R.; Mäkinen, K.; Lampio, A.; Auvinen, P.; Kääriäinen, L.; Ahola, T. (1999). Virus-specific capping of tobacco mosaic virus RNA: methylation of GTP prior to formation of covalent complex p126-m7GMP. FEBS Letters, 455, 45−48.
1.1.
1999
Guo, D.; Merits, A.; Saarma, M. (1999). Self-association and mapping of interaction domains of helper component proteinase of potato A potyvirus. Journal of General Virology, 80 (5), 1127−1131.
1.1.
1998
Rajamaki, M.; Merits, A.; Rabenstein, F.; Andrejeva, J.; Paulin, L.; Kekarainen, T.; Kreuze, JF.; Forster, RLS.; Valkonen, JPT. (1998). Biological, serological, and molecular differences among isolates of potato a potyvirus. Phytopathology, 88 (4), 311−321.
1.1.
1998
Merits, A.; Guo, DY.; Saarma, M. (1998). VPg, coat protein and five non-structural proteins of potato A potyvirus bind RNA in a sequence-unspecific manner. Journal of General Virology, 79, 3123−3127.
1.1.
1996
Andrejeva, J.; Merits, A.; Rabenstein, F.; Puurand, U.; Jarvekulg, L. (1996). Comparison of the nucleotide sequences of the 3'-terminal regions of one aphid and two non-aphid transmissible isolates of potato A potyvirus. Archives of Virology, 141 (7), 1207−1219.
1.1.
1995
Merits, A.; Zelenina, D.A.; Mizenina, O.A.; Chernov, B.K.; Morozov, S.Yu (1995). Poly(A) addition site mapping and polyadenylation signal analysis in plant circovirus replication related gene. Virology, 211 (1), 345−349.
1.1.
1994
Morozov, S.Yu.; Chernov, B.K.; Merits, A.; Blinov, V.M. (1994). Computer-assisted predictions of the secondary structure in plant virus single stranded DNA genome. Journal of Biomolecular Structure and Dynamics, 11 (4), 837−847.
1.1.
1994
Morozov, S.Yu.; Merits, A; Chernov, B.K (1994). Computer search of transcription control sequence in small plant virus DNA reveals a sequence highly homologous to the enhancer element of histone promoters. DNA Sequence, 4 (6), 395−397.
1.1.
1994
Solovyev, A.G; Novikov, V.K; Merits, A; Savenkov, E.I; Zelenina, D.A; Tyulkina, L.G; Morozov, S.Yu (1994). Genome characterization and taxonomy of Plantago asiatica mosaic potexvirus. Journal of General Virology, 75 (2), 259−267.
1.1.
1992
Chernov, B; Merits, A; Mizenina, O; Morozov, S.Yu (1992). Chemico-enzymatic synthesis and cloning a full length genome of DNA containing plant virus. Bioorganic Chemistry, 18 (12), 1487−1495.

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18.06.2022

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MUULLOTI14140Alfaviirus replikaas kui geneetiline adjuvant15.09.201431.12.2014Andres MeritsTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut5 000,00 EUR
ETFETF7407Alfaviiruste replikatsioon, interaktsioonid peremeestega ja nende protsesside inhibiitorid01.01.200831.12.2011Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond66 495,46 EUR
MUULLOTI08198Application of modified oligonucleotides in the development of antiviral therapy01.04.200830.11.2008Andres MeritsTartu Ülikool3 195,58 EUR
PRGPRG1154Arboviiruste replikaasi valkude roll viiruse RNA sünteesil, viiruse ja peremehe vahelistest interaktsioonides ning viiruse vektorlevikus01.01.202131.12.2025Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut514 250,00 EUR
MUUMP1TI07219Arendustöö: Construcyion of System for mRNA production and amplification23.10.200730.04.2008Andres MeritsTartu Ülikool36 000,09 EUR
1.1.5.2.SLOTI13143TEesti osalus ülemaailmses viirusuuringute võrgustikus (GVN)01.09.201331.08.2015Andres MeritsTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut316 660,00 EUR
1.2.5.MLTTI18455Flaviviiruste inimesle ülekandumise ennustamine ja takistamine01.10.201828.02.2021Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut294 196,67 EUR
MUULLOTI08198/1Geenitehnoloogial põhinevate viirusevastaste ravimikanditaatide struktuuri optimeerimine (OLIGO-MOD)16.12.200831.12.2011Andres MeritsTartu Ülikool192 937,12 EUR
MUUMLTTI16313Geneetiliste meetodite kasutamine vähendamaks Aedes aegypti võimet üle kanda Chikungunya viirust01.09.201628.02.2022Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut178 800,00 EUR
MUUSLOTI11182T (3.2.0701.11-0016)Hepatiit C viiruse vastaste ravimikandidaatide väljatöötamise platvorm01.01.201231.12.2013Andres MeritsTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond872 230,20 EUR
MUUMLOTI10208RICRES - Integration of Chikungunya Research01.12.201030.11.2014Andres MeritsTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut219 774,00 EUR
TKRLOTITIPPKeemilise bioloogia tippkeskus07.07.200831.08.2015Tanel TensonTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut5 597 382,18 EUR
1.2.5.VLTTI20223Kõrgelt patogeense alfaviiruse loommudeli arendamine 01.01.202031.03.2021Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut75 774,46 EUR
MUULP1TI07010Modifitseeritud oligonukleotiidide rakendused viirusvastase teraapia väljaarendamisel01.01.200731.03.2007Andres MeritsTartu Ülikool124 435,98 EUR
TKSLTTI16143T (TK143)Molekulaarse Rakutehnoloogia Tippkeskus (TK143)01.01.201601.03.2023Tanel TensonTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut3 917 568,00 EUR
MUUMLTMR22314R (101057961)Patogeensete mikroobide levik pindadel01.09.202231.08.2026Angela IvaskTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut399 950,00 EUR
ETFETF9400Peremeesraku radade ja resursside hõivamine alfaviiruste poolt lühikeste lineaarsete interaktsioonimotiivide kaudu vahendatud interaktsioonide abil 01.01.201231.12.2014Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut29 736,00 EUR
HOSPICOVI; RITA2RITA2/126Prognostiliste meetmete ning võimalike ravimeetodite väljatöötamine raskekujuliste COVID-19 haigusjuhtumite baasil01.02.202131.07.2022Joel StarkopfTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut166 666,67 EUR
MUULMVCM21079Prognostiliste meetmete ning võimalike ravimeetodite väljatöötamine raskekujuliste COVID-19 haigusjuhtumite baasil01.02.202131.07.2022Joel StarkopfTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut166 666,67 EUR
SFSF0180087s08RNA genoomsete viiruste replikatsiooni, viirus-peremees interaktsioonide ja patogeneesi uurimine ning nende protsesside inhibeerimine ja praktiline kasutamine.01.01.200831.12.2013Andres MeritsTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut653 945,96 EUR
SFSF0182566Bs03RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine B01.01.200331.12.2007Mart UstavTartu Ülikool, Bioloogia-geograafiateaduskond309 651,94 EUR
2.2.1.VLTTI20265SARS-CoV-2 vastase geneetiliselt nõrgestatud vaktsiinikandidaadi arendamine04.05.202031.12.2020Andres MeritsTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut80 000,00 EUR
ETFETF6609Semliki Forest viiruse replikatsioonisüsteemi ning viirus-peremees interaktsioonide uurimine ja kasutamine01.01.200631.12.2007Andres MeritsTartu Ülikool, Bioloogia-geograafiateaduskond23 291,96 EUR
MUUQLK3-CT-2002-02052Semliki Forest viirusel põhineva terapeutilised süsteemid01.11.200231.10.2005Andres MeritsEesti Biokeskus330 239,99 EUR
MUUT220A (0140220As98)Taimede transformeerimine ja kasutamine rekombinantsete valkude ekspresseerimiseks01.01.199831.12.2002Erkki TruveTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Geenitehnoloogia õppetool23 008,19 EUR