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"Muu" projekt MSHPH11033
MSHPH11033 "Neurobiology of positive affect in depression: the role of inter-individual differences in temperament in the pathogenesis, and intervention strategies (1.03.2011−28.02.2013)", Jaanus Harro, Tartu Ülikool, Tartu Ülikool, Sotsiaal- ja haridusteaduskond, Psühholoogia instituut.
MSHPH11033
Neurobiology of positive affect in depression: the role of inter-individual differences in temperament in the pathogenesis, and intervention strategies
Neurobiology of positive affect in depression: the role of inter-individual differences in temperament in the pathogenesis, and intervention strategies
1.03.2011
28.02.2013
Teadus- ja arendusprojekt
Muu
grandileping
ETIS klassifikaatorAlamvaldkondCERCS klassifikaatorFrascati Manual’i klassifikaatorProtsent
2. Ühiskonnateadused ja kultuur2.8. PsühholoogiaS260 Psühholoogia5.1 Psühholoogia ja tunnetusteadused50,0
3. Terviseuuringud3.3. FarmaatsiaB740 Farmakoloogia, farmakognoosia, farmaatsia, toksikoloogia 3.1. Biomeditsiin (anatoomia, tsütoloogia, füsioloogia, geneetika, farmaatsia, farmakoloogia, kliiniline keemia, kliiniline mikrobioloogia, patoloogia)50,0
AsutusRollPeriood
Tartu Ülikoolpartner01.03.2011−28.02.2013
Tartu Ülikool, Sotsiaal- ja haridusteaduskond, Psühholoogia instituutpartner01.03.2011−28.02.2013
AsutusRiikTüüp
University of Haifa
PerioodSumma
01.03.2011−28.02.201381 337,00 EUR
81 337,00 EUR

Depression develops through interaction of neurobiological vulnerability and adverse life events, and the actions that individuals take to mitigate the effect of adversities. Of the persistent inter-individual differences, those pertinent to negative affect are under active investigation, while the role of low positive affect has remained neglected. Rats differ in emitting 50-kHz ultrasonic vocalizations that reflect positive emotionality, and animals with low 50-kHz response are more affected by chronic variable stress in adulthood both behaviourally and regarding regional changes in cerebral oxidative metabolism. In this proposal we aim at 1) detailing which genes are involved in stress response dependent upon positive affect, by means of microarray technique comparing the results with the corresponding rat database of the European Commission NEWMOOD consortium; 2) comparing the effect of stress in juvenile animals and adults and at both life stages dependent upon the positive affect, in consideration of possible mitigating influence of social environment; 3) elucidating how responses to stress in the JOY circuit underlying the positive affect are associated with responses in other circuits by comparison of oxidative metabolism, immediate early gene expression, and selected neurochemical measures; 4) enquire which intervention strategies could be more effective as compared to standard antidepressant therapy.
Depression develops through interaction of neurobiological vulnerability and adverse life events, and the actions that individuals take to mitigate the effect of adversities. Of the persistent inter-individual differences, those pertinent to negative affect are under active investigation, while the role of low positive affect has remained neglected. Rats differ in emitting 50-kHz ultrasonic vocalizations that reflect positive emotionality, and animals with low 50-kHz response are more affected by chronic variable stress in adulthood both behaviourally and regarding regional changes in cerebral oxidative metabolism. In this proposal we aim at 1) detailing which genes are involved in stress response dependent upon positive affect, by means of microarray technique comparing the results with the corresponding rat database of the European Commission NEWMOOD consortium; 2) comparing the effect of stress in juvenile animals and adults and at both life stages dependent upon the positive affect, in consideration of possible mitigating influence of social environment; 3) elucidating how responses to stress in the JOY circuit underlying the positive affect are associated with responses in other circuits by comparison of oxidative metabolism, immediate early gene expression, and selected neurochemical measures; 4) enquire which intervention strategies could be more effective as compared to standard antidepressant therapy.
KirjeldusProtsent
Alusuuring100,0